A combination of topical and systemic administration of brimonidine is neuroprotective in the murine optic nerve crush model. by Ruta Maciulaitiene, Giedrius Kalesnykas, Dainius Haroldas Pauza, Ingrida Januleviciene

“…Glaucoma is a multifactorial optic neuropathy that primarily affecting retinal ganglion cells (RGC). Brimonidine is an intraocular pressure-lowering drug with reported neuroprotective properties. …”
Get full text

Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

Get full text

Choroidal Thickness in Eyes with Band Atrophy of the Optic Nerve from Chiasmal Compression by Luiz Guilherme Marchesi Mello, Ana Claudia F. Suzuki, Giuliana Rovito de Mello, Rony Carlos Preti, Leandro C. Zacharias, Mário L. R. Monteiro

“…The choroid is a vascular tissue that helps maintain retinal and prelaminar optic nerve head function. …”
Get full text

Describing the Clinical and Laboratory Features and HLA-B Pattern of Adult-Onset Idiopathic Autoimmune Uveitis at a Tertiary Hospital in South India: A Cross-Sectional Study by Jyothi Visalakshy, Sandeep Surendran, Salil Ganu, Kannisha Shah, C. B. Mithun, Vishal Marwaha, Lalitha Biswas, Niveditha Kartha, Gopal Pillai

“…The odds of finding HLA-B∗35 in retinal vasculitis were 33 times higher than odds of finding it in idiopathic autoimmune uveitis patients not having retinal vasculitis (OR 33; 95% CI 1.6–698). …”
Get full text

Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy by Martin Stattin, Stefan Hagen, Daniel Ahmed, Eva Smretschnig, Florian Frommlet, Katharina Krepler, Siamak Ansari-Shahrezaei

“…To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2). …”
Get full text

Complications Associated with the Use of Expandable Gases in Vitrectomy by Piotr Kanclerz, Andrzej Grzybowski

“…Nevertheless, gas tamponade remains a reasonable choice for patients suffering from retinal detachment.…”
Get full text

Visual Outcome after Vitrectomy with Subretinal tPA Injection to Treat Submacular Hemorrhage Secondary to Age-Related Macular Degeneration or Macroaneurysm by Yasmin Ali Said, Evelien Dewilde, Peter Stalmans

“…Complications consisted of 2 cases of retinal pigment epithelial tear, 7 vitreous hemorrhages, 4 hyphema, 6 cases of retinal detachment, and 2 subchoroidal hemorrhages during the follow-up period. …”
Get full text

Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…The anti-IAP antibody also decreased retinal vascular permeability (0.62±0.12 vs. 0.96±0.25%/g/h, p<0.001). …”
Get full text

Efficacy of Osthole in Management of Hypoperfused Retina by Ran Du, Zhao-yang Meng, Jia-lin Wang, Yan-ling Wang

“…Histological analysis of retinal tissue revealed an increase in retinal thickness in all treatment groups, and significant improvement was noticed in the osthole-IG group. …”
Get full text

Dynamic Expression of HDAC3 in db/db Mouse RGCs and Its Relationship with Apoptosis and Autophagy by Yuhong Fu, Ying Wang, Xinyuan Gao, Huiyao Li, Yue Yuan

“…The correlation between HDAC3 and retinal ganglion cells in diabetic retinopathy is still unclear yet. …”
Get full text

Subfoveal Choroidal Thickness after Panretinal Photocoagulation with Red and Green Laser in Bilateral Proliferative Diabetic Retinopathy Patients: Short Term Results by Ramak Roohipoor, Sina Dantism, Aliasghar Ahmadraji, Reza Karkhaneh, Mohammad Zarei, Fariba Ghasemi

“…To compare subfoveal choroidal, central retinal, and peripapillary nerve fiber layer (RNFL) thickness after panretinal photocoagulation (PRP) with red and green laser in diabetic patients. …”
Get full text

Culture and Characterization of Microglia from the Adult Murine Retina by Gayathri Devarajan, Mei Chen, Elizabeth Muckersie, Heping Xu

“…Method. Retinal single-cell suspensions were prepared from adult MF1 mice. …”
Get full text

Evaluation of Sutureless, Glueless, Flapless, Intrascleral Fixated Posterior Chamber Intraocular Lens in Children with Ectopia Lentis by Kannan NB, Piyush Kohli, Bhanu Pratap Singh Pangtey, Kim Ramasamy

“…No case of late endophthalmitis or retinal detachment was seen. Conclusion. Since refractive error induced is minimal, the procedure is suitable for IOL implantation in children, who are noncompliant with spectacles. …”
Get full text

Administration of Melatonin in Diabetic Retinopathy Is Effective and Improves the Efficacy of Mesenchymal Stem Cell Treatment by Samraa H. Abdel-Kawi, Khalid S. Hashem

“…Our results showed that administration of melatonin and/or stem cell restored the retinal oxidative/antioxidant redox and reduced retinal inflammatory mediators. …”
Get full text

Optical Coherence Tomography Biomarkers of the Outer Blood—Retina Barrier in Patients with Diabetic Macular Oedema by Ioana Damian, Simona Delia Nicoara

“…Numerous studies confirmed the main role of the inner blood-retinal barrier in the development of Diabetic Macular Oedema (DMO). …”
Get full text

Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems by Bart Jonckx, Michael Porcu, Aurelie Candi, Isabelle Etienne, Philippe Barbeaux, Jean H. M. Feyen

“…Retinal morphology was unaffected in all eyes. Cytokine profiles of ocriplasmin-treated eyes were not different from vehicle. …”
Get full text

Outer Retinopathies Associated with COVID-19 Infection: Case Reports and Review of Literature by Naima Zaheer, Mohammad O. Tallouzi, N. Ajith Kumar, Sreekanth Sreekantam

“…In conclusion, COVID-19-related thromboinflammatory response can result in localized vascular inflammation and hypoperfusion in any of the retinal capillary plexuses or choriocapillaris resulting in ischemia of the corresponding retinal or choroidal layers.…”
Get full text

Central Serous Chorioretinopathy: Multimodal Imaging and Management Options by Prashanth G. Iyer, Stephen G. Schwartz, Jonathan F. Russell, Harry W. Flynn

“…While usually self-limited with a good visual prognosis, recurrent and persistent CSCR can lead to outer retinal and/or retinal pigment epithelial atrophy, choroidal neovascularization, and visual loss. …”
Get full text

Assessing Errors Inherent in OCT-Derived Macular Thickness Maps by Daniel Odell, Adam M. Dubis, Jackson F. Lever, Kimberly E. Stepien, Joseph Carroll

“…Forty-three patients with various retinal pathologies and 113 normal subjects were imaged using Cirrus HD-OCT. …”
Get full text

Small Interfering RNA Targeted to ASPP2 Promotes Progression of Experimental Proliferative Vitreoretinopathy by Xiao-Li Chen, Yu-Jing Bai, Qin-Rui Hu, Shan-Shan Li, Lv-Zhen Huang, Xiao-Xin Li

“…Epithelial-mesenchymal transition (EMT) of retinal pigment epithelium (RPE) is vital in proliferative vitreoretinopathy (PVR) development. …”
Get full text