Short Pulse Epiretinal Stimulation Allows Focal Activation of Retinal Ganglion Cells by Laurin X. Koppenwallner, Gunther Zeck, Paul Werginz

“…We determined thresholds for pulses ranging between 10 and <inline-formula> <tex-math notation="LaTeX">$500\mu $ </tex-math></inline-formula>s in retinal ganglion cells of both wild-type and photoreceptor-degenerated mouse retina. Ex-vivo stimulation using biphasic rectangular pulses was performed using a custom-built modified Howland-type current-controlled stimulator and a microelectrode. …”
Get full text

Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy by Esra Kızıldağ Özbay, Şenol Sabancı, Mehmet Fatih Küçük, Muhammet Kazım Erol

“…<b>Conclusions:</b> Chronic SRF in CSCR patients, even when not involving the peripapillary region, leads to significant structural changes in both the neural and vascular components of the retina. These findings suggest that SRF contributes to broader retinal alterations and supports the need for early detection and management of CSCR to prevent long-term visual impairment.…”
Get full text

Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment by Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers

“…Quantification of CD11b+ cell in the CNV area was performed, and mRNA levels of genes implicated in CNV growth were measured in the retina and RPE-choroid. Results. BKT130 reduced the CNV area and recruitment of CD11b+ cells by 30-35%. …”
Get full text

Comparative Study of Conventional Inverted ILM Flap Covering and ILM Flap Filling Technique in Idiopathic Macular Hole Treatment: A Meta-Analysis and Systematic Review by Mengying Tao, Guoqing Wang, Yueqin Gou, Ming Zhang

“…The inverted ILM flap covering technique was associated with the superior reconstitution of outer layers of the retina, including ELM and EZ, and more improvement in postoperative BCVA than the ILM flap filling technique.…”
Get full text

Synthesis and pharmacological properties of novel guanidine derivatives of quinazoline-2,4(1H,3H)-dione by Alexander A. Ozerov, Daria V. Merezhkina, Natalia A. Gurova, Lyudmila V. Naumenko, Denis A. Babkov, Victor S. Sirotenko, Roman A. Litvinov, Alena S. Taran, Nadezhda V. Stepanova, Umida M. Ibragimova, Alexander A. Spasov, Vadim A. Kosolapov

“…Conclusion: The investigated compounds represent a promising scaffold for development of agents for the treatment of cardiovascular pathologies, glaucoma, excessive inflammation, and late diabetic complications including retina diabetics and thrombosis.…”
Get full text

Long-Term Anatomic and Functional Outcomes after Macular Hole Surgery by Karolina Kaźmierczak, Joanna Stafiej, Joanna Stachura, Paweł Żuchowski, Grażyna Malukiewicz

“…After a successful closing of the MH, the restoration of the retina progresses at a slower pace than improvement in visual acuity.…”
Get full text

Mask-UnMask Regions (MUMR) Framework for Classifying AMD Grades Using Inter-Regional Interaction Analysis by Ibrahim Abdelhalim, Namuunaa Nadmid, Mohamed Elsharkawy, Mohammed Ghazal, Ali H. Mahmoud, Ayman El-Baz

“…This paper presents a novel framework, named Mask-UnMask Regions (MUMR), designed to differentiate between normal retina, intermediate AMD, geographic atrophy (GA), and wet AMD using standardized retinal fundus images with an input resolution of <inline-formula> <tex-math notation="LaTeX">$1024 \times 1024$ </tex-math></inline-formula> pixels. …”
Get full text

Clinical Evaluation of Faricimab in Real-World Diabetic Macular Edema in India- A Multicenter Observational Study by Chakraborty D, Das S, Maiti A, Sinha TK, Das A, Sheth J, Boral SK, Mondal S, Nandi K

“…Debdulal Chakraborty,1 Sudipta Das,2 Aniruddha Maiti,3 Tushar Kanti Sinha,1 Arnab Das,1 Jay Sheth,4 Subhendu Kumar Boral,1 Soumen Mondal,1 Krishnendu Nandi2 1Disha Eye Hospitals, Kolkata, India; 2Nethralayam Superspeciality Eye Care, Kolkata, India; 3Global Eye Hospitals, Kolkata, India; 4Department of Retina Services, Shantilal Shanghvi Eye Institute (SSEI), Mumbai, IndiaCorrespondence: Debdulal Chakraborty, Department of Vitreo-retinal Services, Disha Eye Hospitals, 88 Ghosh Para Road Barrackpore, Kolkata, West Bengal, 700120, India, Tel +91 33 6636 0000, Email devdc@rediffmail.comPurpose: To evaluate the efficacy of faricimab in real-world clinical settings in India for treating diabetic macular edema (DME) in treatment-naïve and recalcitrant eyes.Patients and Methods: This retrospective study involved 39 eyes (16 treatment-naive and 23 recalcitrant) treated with intravitreal faricimab at four centers in India. …”
Get full text

The Microbiota Determines Susceptibility to Experimental Autoimmune Uveoretinitis by Jarmila Heissigerova, Petra Seidler Stangova, Aneta Klimova, Petra Svozilkova, Tomas Hrncir, Renata Stepankova, Miloslav Kverka, Helena Tlaskalova-Hogenova, John V. Forrester

“…GF mice had lower numbers of infiltrating macrophages and significantly less T cell infiltration in the retina than CV mice with EAU. GF mice also had reduced numbers of IFN-γ and IL-17-producing T cells and increased numbers of regulatory T cells in the eye-draining lymph nodes. …”
Get full text

Diacerein Inhibits Myopia Progression through Lowering Inflammation in Retinal Pigment Epithelial Cell by Peng-Tai Tien, Chia-Hung Lin, Chih-Sheng Chen, Ching-Yao Chang, Hsiangyu Ku, Dekang Gan, Yi-Yu Tsai, Jamie Jiin-Yi Chen, Hui-Ju Lin, Lei Wan

“…Furthermore, we determined the level of transforming growth factor-beta- (TGF-) β1, matrix metalloproteinase- (MMP-) 2, type I collagen, interleukin- (IL-) 6, IL-8, and monocyte chemoattractant protein- (MCP-) 1 in the retina. Atropine and diacerein suppressed levels of the myopia-related TGF-β1 and MMP-2 while increasing type I collagen expression. …”
Get full text

The Effect of Corneal Refractive Power Area Changes on Myopia Progression during Orthokeratology by Minfeng Chen, Xinting Liu, Zhu Xie, Pengqi Wang, Miaoran Zheng, Xinjie Mao

“…This area might be formed by lens decentration to provide an additional myopia-defocusing influence on the retina to achieve better myopia control.…”
Get full text

Complex approach to the prevention and treatment of progressive myopia in school children by Tarutta E.P, Iomdina E.N, Tarasova N.A., Markosyan G.A., Maksimova M.V.

“…The modern methods of targeted optical correction with the use of spectacles (with the creation of low-myopic defocus in the center and on the periphery of the retina), optical reflex methods, training exercises for ciliary muscle, various physical and hardware methods for affecting the motor and sensory components of the accommodation disorders of the myopic eye are described. …”
Get full text

Long-Term Observations of Thickness Changes of Each Retinal Layer following Macular Hole Surgery by Atsushi Tada, Shigeki Machida, Yuji Hara, Satoshi Ebihara, Masahiko Ishizuka, Mana Gonmori

“…The ILM peeling does not affect only the thickness of the inner retina but also the middle and outer retinae in the parafoveal region. …”
Get full text

Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy by Jing Jiang, Yan Liu, Yingchao Chen, Bo Ma, Yiwen Qian, Zhenzhen Zhang, Dongqing Zhu, Zhiliang Wang, Xiaofang Xu

“…Subtle structural changes in the retina may occur in diabetes without DR. Decreased retinal thickness appeared to begin in the fovea and temporal areas. …”
Get full text

Human Umbilical Cord Mesenchymal Stem Cells Attenuate Ocular Hypertension-Induced Retinal Neuroinflammation via Toll-Like Receptor 4 Pathway by Shangli Ji, Jie Xiao, Jian Liu, Shibo Tang

“…OCT showed that the intravitreal transplantation of hUC-MSCs significantly increased the inner thickness of the retina. A TUNEL assay and the expression of Bax suggested that the apoptosis of retinal cells was decreased by hUC-MSCs 14 days following transplantation. …”
Get full text

Wearable electrodriven switch actively delivers macromolecular drugs to fundus in non-invasive and controllable manners by Xuan Qin, Haoliang Shi, Hongyang Li, Binbin Chu, Jiawei Zhang, Zhen Wen, Xuhui Sun, Houyu Wang, Yao He

“…The WES system, which integrates an electrodriven drug delivery lens with a square wave generator, leverages electrical stimulation to enhance drug penetration through the sclera-choroid-retina pathway. In our study, WES achieved a delivery efficiency of 14% for immunoglobulin G, comparable to that of intravitreal injection (16%). …”
Get full text

Combined surgery for large macular hole in complicated cataract: case report (retracted article) by M.M. Bikbov, O.I. Orenburkina, A.A. Zinnatullin, A.L. Yarmukhametova, A.E. Babushkin, M.R. Kalanov

“…</p> <p> <b>Keywords:</b> vision, idiopathic macular hole, retina, anterior les capsule, surgery, postoperative follow-up. …”
Get full text

Adherencia terapéutica de pacientes con hipertensión arterial y oclusión venosa retiniana by Caridad Chiang Rodríguez, Armando Angel Chirino Chiang, Iraisi Hormigo Puertas, Julia Maricela Torres Esperón, Ariadna Corral Martín

“…Métodos: Estudio descriptivo, transversal, en pacientes diagnosticados con oclusión venosa retiniana e hipertensión arterial, en el período de enero a diciembre de 2022, en el Servicio de Retina-Vítreo del Instituto Cubano de Oftalmología “Ramón Pando Ferrer”. …”
Get full text

Macular edema after retinal vein occlusions. Macular morphometry and chorioretinal hemodynamics by A.A. Fil', E.L. Sorokin, O.V. Kolenko

“…The paper addresses etiological factors of RVOs and pathogenesis of macular edema, technical tools for vital assessment of the retina, and choroidal/retinal hemodynamics. This provides great opportunities for a complex in-depth study of the development and course of macular edema to identify potential predictors of&nbsp;its development and persistence.…”
Get full text

Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…Although <i>OPA1</i> is broadly expressed, human <i>OPA1</i> mutations predominantly affect retinal ganglion cells (RGCs) that are responsible for transmitting visual information from the retina to the brain. Due to the scarcity of human RGCs, DOA has not been studied in depth using the disease affected neurons. …”
Get full text