Intravitreal Brolucizumab for Choroidal Neovascularization Associated to Angioid Streaks by Somnath Chakraborty, Jay Umed Sheth

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Registration and Fusion of the Autofluorescent and Infrared Retinal Images by Radim Kolar, Libor Kubecka, Jiri Jan

“…This article deals with registration and fusion of multimodal opththalmologic images obtained by means of a laser scanning device (Heidelberg retina angiograph). The registration framework has been designed and tested for combination of autofluorescent and infrared images. …”
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Nonsteroidal Anti-Inflammatory Drugs for Retinal Disease by Scott D. Schoenberger, Stephen J. Kim

“…These changes may allow for greater drug penetration into the retina and thereby offer additional therapeutic advantages. …”
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Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection by Ruamviboonsuk V, Kongwattananon W, Chuaypen N

“…Varis Ruamviboonsuk,1,2 Wijak Kongwattananon,1,3 Natthaya Chuaypen4 1Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 2Medical Science Program, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; 3Center of Excellence in Retina, Department of Ophthalmology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; 4Metabolic Diseases in Gut and Urinary System Research Unit (MeDGURU), Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCorrespondence: Wijak Kongwattananon, Center of Excellence in Retina, Department of Ophthalmology, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, 1873 Rama IV Road, Pathum Wan, Bangkok, 10330, Thailand, Tel +662 256 4000, Email wijak.k@chula.ac.thPurpose: Intravitreal brolucizumab, approved for neovascular age-related macular degeneration (nAMD), may trigger immune responses leading to intraocular inflammation (IOI) by increasing pro-inflammatory cytokines. …”
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Lutein and inflammation: a comprehensive review of its mechanisms of action by Paradentavida Prathyusha, Geetha Viswanathan, Anjilikal Tomy Tomcy, Ponnamparambil P. Binitha, Smitha V. Bava, Edakkadath R. Sindhu

“…It is well-absorbed and systemically localized to the liver, lung, and retina, where it can cross the blood-retina barrier and accumulate in the macular pigment. …”
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Scutellarin Prevents Angiogenesis in Diabetic Retinopathy by Downregulating VEGF/ERK/FAK/Src Pathway Signaling by Lingli Long, Yubin Li, Shuang Yu, Xiang Li, Yue Hu, Tengfei Long, Liqin Wang, Wenwen Li, Xiaoxin Ye, Zunfu Ke, Haipeng Xiao

“…The protein levels of phospho-ERK, phospho-FAK, phospho-Src, VEGF, and PEDF were examined in HRECs and retina of diabetic rats. Result. Our results indicated that SCU attenuated diabetes-induced HREC proliferation, migration, and tube formation and decreased neovascularization and resistive index in the retina of diabetic rats by oral administration. …”
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Expression of VEGF-A, Otx Homeobox and p53 Family Genes in Proliferative Vitreoretinopathy by Claudio Azzolini, Ilaria Stefania Pagani, Cristina Pirrone, Davide Borroni, Simone Donati, Muna Al Oum, Diana Pigni, Anna Maria Chiaravalli, Riccardo Vinciguerra, Francesca Simonelli, Giovanni Porta

“…Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. …”
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Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis by Hadi Vahedi, Mirsaeed Abdollahi, Reza Moshfeghinia, Shima Emami, Navid Sobhi, Rana Sorkhabi, Ali Jafarizadeh

“…Although these changes do not currently influence treatment strategies, they offer valuable insights into the relationship between the retina and the cornea. Understanding these changes may be essential for future research focused on early detection, potential prognosis markers, and further exploration of the retina-corneal connection in KC.…”
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Metastasis of Ciliary Body Melanoma to the Contralateral Eye: A Case Report and Review of Uveal Melanoma Literature by Nouritza M. Torossian, Roy T. Wallace, Wen-Jen Hwu, Agop Y. Bedikian

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Susac Syndrome and Pregnancy by Yazan Al-Hasan, Justin L. Hoskin, John C. Wolf, Kamala Saha

“…Susac syndrome (SuS) is a rare poorly characterised disorder that affects the brain, retina, and cochlea. Here, we present a case of a 31-year-old pregnant female with a new diagnosis of SuS that was successfully managed to 36 weeks of gestation with minimal disease burden to both the mother and newborn. …”
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Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response—a scoping review by Nikolaos Dervenis, Eleftherios Agorogiannis, Panagiotis Dervenis

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Dark Signals in the Choroidal Vasculature on Optical Coherence Tomography Angiography: An Artefact or Not? by Rui Hua, Hailin Wang

“…Images obtained by OCTA are rendered under the assumption that the only moving entity in the retina is blood flow. Optical phenomena and image processing algorithms may create imaging artefacts. …”
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Extracellular-Matrix Mechanics Regulate the Ocular Physiological and Pathological Activities by Ran Zhang, Bo Li, Heng Li

“…In this review, we focus on describing the important role of ECM stiffness and its composition in multiple ocular structures (including cornea, retina, optic nerve, trabecular reticulum, and vitreous) from a new perspective. …”
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Treatment options for Leber hereditary optic neuropathy by I. Povilaitytė, R. Liutkevičienė

“…Due to this dysfunction, ATP synthesis decreases and the level of oxidative stress in ganglion cells of the retina increases, which leads to cell degeneration and apoptosis. …”
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The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa by Francesco Saverio Sorrentino, Claudio Bonifazzi, Paolo Perri

“…Haemodynamic studies in patients with retinitis pigmentosa have demonstrated ocular blood flow abnormalities both in retina-choroidal and in retroocular vascular system. …”
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Serous Macular Detachment Secondary to Optic Pit: Surgical Treatment and Long Time Results by Selim Cevher, Nedime Sahinoglu-Keskek, Fikret Unal, Selahaddin Demirduzen, Huseyin Oksuz

“…After vitrectomy the retina gradually flattened and vision was gradually improved. …”
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The Petri Dish-N2B27 Culture Condition Maintains RPE Phenotype by Inhibiting Cell Proliferation and mTOR Activation by Hui Lou, Chunpin Lian, Fanjun Shi, Liqun Chen, Sicheng Qian, Hui Wang, Xiaoyun Zhao, Xiaoyan Ji, Jingfa Zhang, Guoxu Xu

“…The eyeballs were incubated with dispase. The retina was isolated with RPE attached and cut into several pieces. …”
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CMV Pancreatitis in an Immunocompromised Patient by Jaffer Ahmad, Najia Sayedy, Raghavendra Sanivarapu, Jagadish Akella, Javed Iqbal

“…CMV more commonly affects the retina, lungs, liver, and GI tract; however, in rare cases, it is known to affect the pancreas as well. …”
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Shaggy Photoreceptors with Subfoveal Fluid Associated with a Distant Choroidal Melanoma by Ann Q. Tran, James A. Eadie, Michael M. Altaweel

“…A 45 year-old Caucasian male patient was referred to retina clinic for management of choroidal melanoma. …”
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Classification of diabetic retinopathy stages based on neural networks by M. M. Lukashevich, Y. I. Golub

“…Diabetic retinopathy can be detected much faster and more accurately by using machine learning methods for image analyzing of the human retina. The development of methods and algorithms for the detection and classification of this disease, the automation of this process are the actual and costeffective goals.The article focuses on the classification of the stages of diabetic retinopathy using neural networks based on human retinal images. …”
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