Decursinol angelate relieves inflammatory bowel disease by inhibiting the ROS/TXNIP/NLRP3 pathway and pyroptosis by Yudi Wang, Yudi Wang, Jiamin Wang, Yonghu Chen, Xuezheng Li, Xuezheng Li, Zhe Jiang, Zhe Jiang

“…Molecular docking technique and co-immunoprecipitation (Co-IP) method assay were applied to evaluate the targeting effect of DA on NLRP3 proteins, and MCC950, a specific inhibitor of NLRP3, was used as a positive control for validation.ResultsOur research indicates that DA’s distinctive molecular mechanism could entail binding to the NLRP3 protein, thereby suppressing the activation of the NLRP3 pathway and diminishing the assembly and activation of the NLRP3 inflammasome, thus functioning as an anti-inflammatory agent.ConclusionDA may play a role in improving BD by inhibiting the activation of the ROS/TXNIP/NLRP3 signaling pathway and the release of inflammatory mediators, and by repairing the intestinal barrier function.…”
Get full text

Implementation of eco-control system by Indonesian manufacturing firms: Understanding the mediating role of organizational culture by Muhammad Try Dharsana, Andi Iqra Pradipta Natsir, Fakhrul Indra Hermansyah, Khaerunnisa Nur Fatimah Syahnur

“…All variables used in the research model are significant for a formative measurement model, and an internal model applied met all criteria. …”
Get full text

Investigating the Relationship Between Orthodontic Treatment and Temporomandibular Joint Disorders in Adolescents by Mohammad Khursheed Alam, Mohammad Younis Hajeer, Renad Atallah Alruwaili, Almas Ali Alfaleh, Ola Bassam Alhashash

“…The presence and severity of TMDs were assessed using the Research Diagnostic Criteria for Temporomandibular Disorders at baseline, 6 months, and 12 months post-treatment initiation. …”
Get full text

Two-stage deep reinforcement learning method for agile optical satellite scheduling problem by Zheng Liu, Wei Xiong, Zhuoya Jia, Chi Han

“…Abstract This paper investigates the agile optical satellite scheduling problem, which aims to arrange an observation sequence and observation actions for observation tasks. Existing research mainly aims to maximize the number of completed tasks or the total priorities of the completed tasks but ignores the influence of the observation actions on the imaging quality. …”
Get full text

Evaluation of the Knowledge and Attitudes of Dentists Working in a University Hospital in Afyonkarahisar Regarding Rational Drug Use by Ömer Ekici

“…Results: Fifty-two dentists (16 academics, and 36 research assistants) participated in the study (The participation rate was 89.65%). …”
Get full text

Towards Transformation of the Nigerian Youths: The Place of Yoruba Popular Music by Kayode Olusola

“…Relying on Femi Adedeji’s Transformation musicological theory, this work explicates the song themes and other lyrical contents of selected popular music in the Yoruba language fashioned towards positive transformative direction, for the purpose of socio-cultural analysis. The research findings show that some Nigerian popular musicians have for over three decades, been making use of the message in their music to sustain the positive transformation of lives and behavior of people of Nigeria, especially the youths. …”
Get full text

Artificial intelligence in higher education: problems, opportunities, risks by Renata R. Gasanova, Ekaterina A. Romanova

“…Analytical and theoretical research methods (literature analysis, data synthesis, generalization, induction, deduction, establishment of cause-and-effect relationships) were applied to assess the current state of the educational sphere regarding the widespread introduction of AI capabilities, and an express survey was conducted in the number of 105 people: students of additional education programs “Teacher” and “Teacher of a higher educational institution” on the topic of psychological adaptation to the active use of AI technologies in the framework of pedagogical practice. …”
Get full text

Analysis of the Influencing Factor on Steady-state Temperature Field of Axlebox Bearing for High Speed Train by Jiang Jiulin Xu Honghai Jiang Xingjia Ke Mengfu

“…The temperature of the temperature measuring hole and maximum temperature of the bearing decrease with the increase of the wind speed, and increase with the increase of the driving speed and ambient temperature, however, the wind speed and ambient temperature have little effect on the maximum bearing temperature. The research results provide a reference for the analysis of the cause of the temperature warning of the axle box bearing and the reasonable setting of the reasonable setting of the warning threshold of the temperature sensor.…”
Get full text

Rift Valley Fever in Rwanda Is Urging for Enhancing Global Health Security Through Multisectoral One Health Strategy by Claude Mambo Muvunyi, Jean Claude Semuto Ngabonziza, Emmanuel Edwar Siddig, Ayman Ahmed

“…This underscores the urgent need for prospective research to inform evidence-based health policymaking, strategic planning, and the development and implementation of cost-effective preventive and control measures, including diagnosis and surveillance for early detection and response. …”
Get full text

FORMATION OF THE READINESS OF MASTERS FOR THE DEVELOPMENT OF ECOLOGICAL CULTURE OF PEOPLE WITH LIMITED ABILITIES BY MEANS OF THE MUSEUM by Larisa A. Kolyvanova, Tamara M. Nosova

“…The main types of vocational training of undergraduates are: pedagogical, designing, methodical, administrative cultural and educational, research activity focused on the requirements of labor market. …”
Get full text

Unraveling Biogeographic Boundaries Within the Sierra Madre Oriental, México: An Endemicity Analysis Using a Taxonomically Diverse Dataset by Irene Goyenechea Mayer‐Goyenechea, Gustavo Montiel‐Canales, Juan Márquez, Claudia T. Hornung‐Leoni, Jesús M. Castillo‐Cerón, Norma L. Manríquez‐Morán

“…This new regionalization can be useful for prioritizing conservation areas and designing more effective strategies. Future research should include more distribution data of mammals and birds to strengthen these results and better define the subprovinces and biogeographical districts of the SMO.…”
Get full text

Digitalisation to zero-waste: the interplay of open eco-innovation and the circular economy in agricultural enterprises by Wutthiya Aekthanate Srisathan, Wongsatorn Worrakittikul, Kanokon Rattanapon, Thippayarat Hongto, Apichai Phrommasakha Na Sakhonnakon, Phaninee Naruetharadhol

“…Using structural equation modelling with multigroup analysis, the research explores differences in adoption patterns between startups and established firms. …”
Get full text

THE ORGANIZATION OF EXTRACURRICULAR ACTIVITIES USING IT: TRAINING OF PEDAGOGICAL HIGH SCHOOL GRADUATES TO IMPLEMENT THE REQUIREMENTS OF THE EDUCATIONAL STANDARTS by Olesya V. Arzybova, Elena N. Tarakanova

“…According to the results of those tests, it can be concluded that almost all teachers have sufficient level of basic IT-competence, but pedagogical IT-competence is at its beginner stage. The present research allows the authors to speak about the necessity of improving the teacher's skill and perfecting the relevant skills.The article notes the importance of different elements in the preparation process of future teachers, mainly the formation of their skills in organization of extracurricular activities using IT. …”
Get full text

Patient, Family, and Health Professional Perspectives of How Families are Involved in Adult Inpatient Traumatic Brain Injury Rehabilitation by Kaylee Eady, Katherine Moreau, Shawn Marshall, Mary Egan

“…<strong>Objective</strong>: We aimed to answer the following research question: From the perspectives of patients, family members, and health professionals, how are families involved in the rehabilitation of adult patients with Traumatic Brain Injury at an inpatient Acquired Brain Injury service within an adult rehabilitation centre? …”
Get full text

Structural Design of City Railway Underground Depot with Reserved Conditions for Overlying Property Development by TAN Qifeng

“…［Objective］ To further improve land use efficiency, reduce the fragmentation of urban space, enhance the regional urban image, and avoid the impact of regional transportation three-dimensional development and pedestrian system, it is necessary to conduct research on the key technologies for city railway underground depot structural design with reserved conditions for the overlying property development. …”
Get full text

Miniaturization Potential of Additive-Manufactured 3D Mechatronic Integrated Device Components Produced by Stereolithography by Niklas Piechulek, Lei Xu, Jan Fröhlich, Patrick Bründl, Jörg Franke

“…However, their application in high-temperature environments remains limited due to material challenges. Existing research highlights the thermal stability of ceramic substrates; yet, their reliability under high-stress and complex mechanical loading conditions remains a challenge. …”
Get full text

Quality Comparison of Chicken Meat Treated with <i>Origanum syriacum</i> L. and <i>Origanum vulgare</i> L. Essential Oil Incorporated with <i>Aloe vera</i> Gel by Marwan A. Al-Hijazeen

“…The results of the current research will help to distinguish between both oil types accurately. …”
Get full text

A systematic review of Machine Learning and Deep Learning approaches in Mexico: challenges and opportunities by José Luis Uc Castillo, Ana Elizabeth Marín Celestino, Diego Armando Martínez Cruz, José Tuxpan Vargas, José Alfredo Ramos Leal, Janete Morán Ramírez

“…A total of 120 original research papers were included and details such as trends in publication, spatial location, institutions, publishing issues, subject areas, algorithms applied, and performance metrics were discussed. …”
Get full text

Novel application of an imageless robotic system in simultaneous unicompartmental knee arthroplasty and anterior cruciate ligament reconstruction by Joshua Yeuk Shun Tran, Rex Wang-Fung Mak, Kevin Ki-Wai Ho, Jonathan Patrick Ng, Cham Kit Wong, Gloria Yan-Ting Lam, Tsz Lung Choi, Michael Tim-Yun Ong, Patrick Shu-Hang Yung

“…Post-operative rehabilitation allowed full weight-bearing by the third week.This case represents the first reported instance of using an imageless robotic system for simultaneous UKA and ACLR, highlighting its potential to standardize and improve results in complex knee surgeries.This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.…”
Get full text

DETERMINING OF PARAMETERS OF HEAT EXCHANGE FOR VAPORIZATION OF THE MIXED REFRIGERANT ON THE HIGH THERMAL CONDUCTIVITY SINTERED POWDER CAPILLARY-POROUS COATINGS by A. V. Ovsyannik, E. N. Makeeva

“…The results of experimental research of heat exchange under the nucleate boiling of refrigerants R404a, R407c and R410a on the tubes with capillary-porous coating are presented. …”
Get full text