Identification and Clinical Validation of High HSP60 Expression Predicts Poor Prognosis in Patients with Ovarian Cancer by Zheng M, Li S, Deng J, Huang C, Zhang H

“…Min Zheng,1,* Shaoxing Li,1,* Jie Deng,1 Chaolin Huang,1 Hua Zhang2 1Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department of Rehabilitation Medicine, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hua Zhang; Chaolin Huang, Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, No. 278, The Middle Section of Baoguang Avenue, Xindu District, Chengdu City, Sichuan Province, 610500, People’s Republic of China, Email 2508034576@qq.com; huangchaolin1006@163.comObjective: This study aimed to investigate the clinical significance of heat shock protein 60 (HSP60) expression in ovarian cancer and evaluate its correlation with patient survival outcomes.Methods: A total of 260 ovarian cancer patients diagnosed between 2017 and 2019 were enrolled. …”
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The Relationship Between Insufficient Sleep and Depressive Symptoms in Chinese Adolescents: A National Survey of Contributing Factors by Yan C, Zheng W, Du Y, Li Y, Wang M, Qu M

“…Chuming Yan,1 Wancheng Zheng,1 Yun Du,1 Yi Li,2 Mengshu Wang,2 Miao Qu1 1Neurology Department, Xuanwu Hospital of Capital Medical University, Beijing, People’s Republic of China; 2Neurology Department, Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Miao Qu, Neurology Department, Xuanwu Hospital of Capital Medical University, Xicheng District, Beijing, 100053, People’s Republic of China, Email qumiao@xwhosp.orgPurpose: There is a lack of national studies examining the relationship between insufficient sleep and depression among Chinese adolescents, and previous research has not comprehensively considered related factors. …”
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Combined Impact of Canada Goldenrod Invasion and Soil Microplastic Contamination on Seed Germination and Root Development of Wheat: Evaluating the Legacy of Toxicity by Guanlin Li, Yi Tang, Hongliang Xie, Babar Iqbal, Yanjiao Wang, Ke Dong, Xin Zhao, Hyun-Jun Kim, Daolin Du, Chunwang Xiao

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The Use of Distance Learning in the Activities of Teacher of Informatics by L. Rybchinskaya

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The Use of Cloud Services for Creation an Electronic Abstract of Student by E. S. Rogalsky

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The results of the 10th Republican competition “Computer. Education. The Internet” by I. Vasilieva, I. Harevich

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The Decision of Tasks on Informatics on the Topic “Sorting” by M. S. Dolinsky

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Semiosis and the Culture of Rupture by Art Leete

“…Overview about the 7th Semiosis and Culture Conference organised in May 2010 by the Komi State Pedagogical Institute in Syktyvkar, Republic of Komi, Russia.…”
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Programming Interactive Graphic Applications in Program “Mathematica” by V. Taranchuk, V. Kulinkovich

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The Shaping of New Ethnic Clusters in Kalmykia, 1957–1991 by Sergey S. Belousov

“…Stable new ethnic communities emerged in rural areas, the majority of the migrants having arrived from neighboring North Caucasian republics then characterized by intense population growth and excess labor resources. …”
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A Pharmacokinetic/Pharmacodynamic Study of Esomeprazole Comparing a Dual Delayed-Release Formulation (YYD601) to a Conventional Formulation Following Multiple Administrations in He... by Lee HW, Kang WY, Park JS, Lee JH, Park JJ, Gwon MR, Yoon YR, Seong SJ

“…Hae Won Lee,1 Woo Youl Kang,2 Ji Seo Park,1 Jae Hwa Lee,1 Jin Ju Park,1 Mi-Ri Gwon,1 Young-Ran Yoon,1 Sook Jin Seong1 1School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, Daegu, 41944, Republic of Korea; 2Clinical Trial Dossier Evaluation Team, Innovative Products Support Department, National Institute of Food and Drug Safety Evaluation, Cheongju, 28159, Republic of KoreaCorrespondence: Young-Ran Yoon, Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongdeok-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-420-4950, +82-53-420-5218, Email yry@knu.ac.kr Sook Jin Seong, Clinical Associate Professor, School of Medicine, Kyungpook National University and Department of Clinical Pharmacology and Therapeutics, Kyungpook National University Hospital, 130 Dongduk-Ro, Jung-gu, Daegu, 41944, Republic of Korea, Tel +82-53-200-6351, +82-53-420-5218, Email wintersj@knu.ac.krBackground: YYD601 is a new dual delayed-release formulation of esomeprazole, developed to enhance plasma exposure and prolong the duration of acid suppression.Purpose: This study aimed to evaluate the safety, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of YYD601 20 mg following single and multiple oral administrations in healthy, fasting adult Koreans, and to compare these outcomes to those of the conventional esomeprazole 20 mg capsule.Methods: A randomized, open-label, two-period crossover study was conducted in 28 participants, who were divided into two treatment groups: one group received YYD601 20 mg, and the other received conventional esomeprazole 20 mg, once daily for five consecutive days. …”
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The Role of Thickening Agent Proportions in Optimizing Nanoemulsion Gel for Dermatophytosis Treatment by Zhang X, Wu CC, Jiang H, Zhao JF, Pan ZJ, Zheng Y

“…Xiao Zhang,1,* Chen-Chen Wu,1 Hua Jiang,2 Jia-Fu Zhao,1,3 Zhong-Jian Pan,1 Yin Zheng1,3,* 1College of Animal Science, Guizhou University, Guiyang, Guizhou, People’s Republic of China; 2College of Veterinary Medicine, Gansu Agriculture University, Lanzhou, Gansu, People’s Republic of China; 3Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin Zheng, College of Animal Science, Guizhou University, Mingyi Building (Teaching and Research Center), Room 428, West Campus of Guizhou University, Huaxi District, Guiyang City, Guizhou Province, 550025, People’s Republic of China, Email yzheng@gzu.edu.cnBackground: Adjusting thickening agent proportions in nanoemulsion gel (NG) balances its transdermal and topical delivery properties, making it more effective for dermatophytosis treatment.Methods: Carbomer 940 and α-pinene were used as model thickening agent and antifungal, respectively. …”
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Large-scale flood risk assessment in data-scarce areas: an application to Central Asia by P. Ceresa, G. Bussi, S. Denaro, G. Coccia, P. Bazzurro, P. Bazzurro, M. Martina, M. Martina, E. Fagà, C. Avelar, M. Ordaz, B. Huerta, O. Garay, Z. Raimbekova, K. Abdrakhmatov, S. Mirzokhonova, S. Mirzokhonova, V. Ismailov, V. Belikov

“…<p>The countries of Kazakhstan, Kyrgyz Republic, Tajikistan, Turkmenistan, and Uzbekistan in Central Asia are highly prone to natural hazards, particularly floods, earthquakes, and landslides. …”
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Selective phase growth of ultra-smooth Ti2O3 and TiO2 thin films at low growth temperature controlled by the oxygen partial pressure by Jiayi Tang, Okkyun Seo, Jaemyung Kim, Ibrahima Gueye, L.S.R. Kumara, Ho Jun Oh, Wan-Gil Jung, Won-Jin Moon, Yong Tae Kim, Satoshi Yasuno, Tappei Nishihara, Akifumi Matsuda, Osami Sakata

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Inhibition of microRNA-139-5p Improves Fibroblasts Viability and Enhances Wound Repair in Diabetic Rats Through AP-1 (c-Fos/c-Jun) by Mo J, Zhang J, Meng X, Wang F, Tang W, Liu Y, Fu L, Liang F, Mo Z

“…Jiake Mo,1,2,&ast; Jiaqi Zhang,1,2,&ast; Xubiao Meng,3 Fang Wang,1,2 Weian Tang,1,2 Ying Liu,1,2 Lanfang Fu,3 Fang Liang,4 Zhaohui Mo1,2 1Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan Province, People’s Republic of China; 2Diabetic Foot Research Center of Central South University, Changsha, Hunan Province, People’s Republic of China; 3Department of Endocrinology, Haikou People’s Hospital & Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, Hainan Province, People’s Republic of China; 4Department of Endocrinology, Xingtai People’s Hospital, Xingtai, Hebei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhaohui Mo; Fang Liang, Email easd04mzh@126.com; liangfang1024@163.comIntroductions: Diabetic foot ulcers (DFU) are notoriously difficult to heal, however, its underlying molecular mechanisms are unknown. …”
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Injectable Nanocomposite Hydrogel for Accelerating Diabetic Wound Healing Through Inflammatory Microenvironment Regulation by Chen Y, Li Y, Song H, Liu X, Zhang H, Jiang J, Liu H, Zhuo R, Cheng G, Fang J, Xu L, Qi Y, Sun D

“…Yuhui Chen,1,&ast; Ying Li,1,&ast; Haoning Song,1,&ast; Xiaochun Liu,1 Hongan Zhang,1 Jiaxin Jiang,2 Hongsheng Liu,2 Ribo Zhuo,1 Guoyun Cheng,1 Jia Fang,1 Lei Xu,1 Yong Qi,1 Dawei Sun1 1Department of Orthopedics and Traumatology, The Affiliated Guangdong second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510315, People’s Republic of China; 2Guangdong Huayi Biomedical Science and Technology Center, Guangzhou, Guangdong, 511450, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Xu, Department of Orthopedics and Traumatology, Guangdong second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou, Guangdong, People’s Republic of China, Email orthoxl@163.com Dawei Sun, Department of Orthopedics and Traumatology, Guangdong second Provincial General Hospital of Jinan University, No. 466 Xingang Middle Road, Haizhu District, Guangzhou, Guangdong, People’s Republic of China, Email sundw@gd2h.org.cnBackground: A paramount issue in the realm of chronic wound healing among diabetic patients is the pervasive inflammatory response that persistently thwarts angiogenesis, thereby precipitating protracted delays in the healing process of such wounds. …”
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Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea by Zhou YF, Chen SH, Wang WD, Chen JL, Cai PY, Li MM, Lin YL, Li WQ, Huang DH, Li J, Li YT, Lin HL

“…Yi-Fan Zhou,1,&ast; Shu-Han Chen,1,&ast; Wan-Da Wang,1 Jia-Le Chen,1 Ping-Yu Cai,1 Mei-Mei Li,1 Yue-Ling Lin,1 Wan-Qi Li,1 De-Hong Huang,1 Jun Li,1 Yue-Ting Li,2 Hui-Li Lin1 1Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People’s Republic of China; 2Department of Nephrology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hui-Li Lin, Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, Fujian Province, 362000, People’s Republic of China, Tel +86 18876598756, Email 1627974150@qq.com Yue-Ting Li, Department of Nephrology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, Fujian Province, 362000, People’s Republic of China, Tel +86 15359593070, Email liyt163@126.comPurpose: The effect of metabolic factors on cardiovascular risk in obstructive sleep apnea (OSA) is unclear. …”
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Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide by Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J

“…Yizhuo Xie,1 Ming Zhu,1 Han Bao,1 Kejia Chen,1 Shanshan Wang,1 Jingwen Dai,1 Hongzhu Chen,1 He Li,1 Qi Song,2 Xinlu Wang,2 Liangping Yu,2 Jin Pei1 1Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, Changchun, People’s Republic of China; 2Department of Clinical Pharmacy, the First Hospital of Jilin University, Changchun, People’s Republic of ChinaCorrespondence: Jin Pei, Department of Biopharmacy, School of Pharmaceutical Sciences, Jilin University, No. 1163 Xinmin Street, Changchun, 130021, People’s Republic of China, Tel +86-431-85619725, Email peijin@jlu.edu.cn Liangping Yu, Department of Clinical Pharmacy, the First Hospital of Jilin University, No. 1 Xinmin Street, Changchun, 130061, People’s Republic of China, Tel +86 431 81879802, Email liangpingyu@jlu.edu.cnPurpose: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. …”
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Older adults’ Internet use behavior and its association with accelerometer-derived physical activity by Yen-Yu Chung, Jiaren Chen, Mei-Chun Lin, Ruo-Lan Liu, Jenn-Bang Wu, Hsin-Chang Tsai, Ting-Fu Lai, Ting-Fu Lai, Yung Liao, Yung Liao, Jong-Hwan Park, Jong-Hwan Park, Jong-Hwan Park

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Sensitivity and Selectivity on Aptamer-Based Assay: The Determination of Tetracycline Residue in Bovine Milk by Sohee Jeong, Insook Rhee Paeng

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