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  1. 4821

    Peripheral Blood NMLR Can Predict 5-Year All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease by Li Y, Ge S, Liu J, Li R, Zhang R, Wang J, Pan J, Zhang Q, Zhang J, Zhang M

    Published 2025-01-01
    “…Yuer Li,1 Shaobo Ge,1 Jin Liu,1 Rui Li,1 Rui Zhang,1 Juan Wang,2 Jianli Pan,3 Qiuhong Zhang,1 Jie Zhang,1 Ming Zhang1 1Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Ultrasound, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Special Need, Xi’an Children’s Hospital, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Ming Zhang, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West Fifth Road, Xi’an, Shaanxi, 710004, People’s Republic of China, Email zhangmingdr@163.comBackground: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. …”
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  2. 4822

    Clinical Features and Prognosis of Double-Positive Anti-MDA5 and Anti-CCP Antibodies in Dermatomyositis: A Retrospective Study by Xu X, Zhu L, Li S, Wang G, Ge Y

    Published 2025-02-01
    “…Xiayu Xu,1 Longyang Zhu,2 Sizhao Li,3 Guochun Wang,3 Yongpeng Ge3 1Department of Rheumatology and Immunology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan Province, People’s Republic of China; 2Peking University, China-Japan Friendship School of Clinical Medicine, Beijing, People’s Republic of China; 3Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yongpeng Ge, Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China, Email gyp2016@163.comObjective: To investigate the clinical features and prognosis of anti-melanoma differentiation-related gene 5 (MDA5) antibody and anti-cyclic citrullinated peptide (CCP) antibody double-positive dermatomyositis (DM) (MDA5+/CCP+ DM).Methods: A retrospective analysis of 264 consecutive cases of MDA5+ DM hospitalized from March 2018 to March 2022, and patients with anti-CCP antibodies were screened out. …”
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  3. 4823

    Metagenomic Sequencing Combined with Metabolomics to Explore Gut Microbiota and Metabolic Changes in Mice with Acute Myocardial Infarction and the Potential Mechanism of Allicin by Gao Y, Qin G, Liang S, Yin J, Wang B, Jiang H, Liu M, Luo F, Li X

    Published 2025-02-01
    “…Yijie Gao,1 Gaofeng Qin,2 Shichao Liang,3 Jiajie Yin,4 Baofu Wang,1 Hong Jiang,1 Mengru Liu,1 Fangyuan Luo,3 Xianlun Li1 1National Integrated Traditional and Western Medicine Center for Cardiovascular Disease, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Traditional Chinese Medicine, Binzhou Medical University Hospital, Shandong, People’s Republic of China; 3China-Japan Friendship Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 4Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xianlun Li, Email leexianlun@163.comBackground: Acute myocardial infarction (AMI) is a significant contributor to global morbidity and mortality. …”
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  4. 4824

    Impact of Food Physical Properties on Oral Drug Absorption: A Comprehensive Review by Wang Z, Xu W, Liu D, Li X, Liu S, Wu X, Wang H

    Published 2025-01-01
    “…Ziyang Wang,1 Wen Xu,2 Dan Liu,3 Xiuqi Li,1 Shupeng Liu,1 Xiaofei Wu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 2CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd, Shijiazhuang, People’s Republic of China; 3College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People’s Republic of ChinaCorrespondence: Hongyun Wang, Clinical Pharmacology Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China, Tel +8610-69154637, Email wanghy@pumch.cnAbstract: Food-Drug Interaction (FDI) refers to the phenomenon where food affects the pharmacokinetic or pharmacodynamic characteristics of a drug, significantly altering the drug’s absorption rate or absorption extent. …”
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  5. 4825

    ATF3 Knockdown Exacerbates Astrocyte Activation by Inhibiting Phosphorylation of Drp1 in Ischemic Stroke by Huang R, Huang X, Yang H, Wu H, Liu F, Saw PE, Cao M

    Published 2025-02-01
    “…Rong Huang,1 Xiaoyan Huang,1 Hongmei Yang,1 Haixuan Wu,1 Fan Liu,1 Phei Er Saw,2,3 Minghui Cao1,4 1Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 3Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 4Department of Anesthesiology, Shenshan Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, Shanwei, 516600, People’s Republic of ChinaCorrespondence: Phei Er Saw; Minghui Cao, Email caipeie@mail.sysu.edu.cn; caomh@mail.sysu.edu.cnIntroduction: ATF3, a stress-induced transcription factor, has been implicated in the injury processes of various cell types, including neurons. …”
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  6. 4826
  7. 4827
  8. 4828

    The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice by Song M, Han M, Zhang H, Yang Y, Tian Y, Li J, Zhao J

    Published 2025-01-01
    “…China, Henan University of Chinese Medicine, Zhengzhou, 450046, People’s Republic of China; 3Department of Respiratory Diseases, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Zhao, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, 156 Jinshui East Road, Zhengdong, Zhengzhou, Henan, 450046, People’s Republic of China, Tel +86-15100165967, Email Jiezhao1702@163.comPurpose: The effective compound combination of Bufei Yishen formula III (ECC-BYF III) has shown protective effects against chronic obstructive pulmonary disease (COPD). …”
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  9. 4829

    Analyzing Maternal Needs for “Internet+ Nursing Service” After Hospital Discharge: A SERVQUAL-KANO Model Approach by Ding L, Ding Y, Wang Y, Li X, Liu Y

    Published 2025-02-01
    “…Lei Ding,1,2,* Yajie Ding,2,* Yiting Wang,1,2 Xianwen Li,1 Ying Liu2 1School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China; 2Department of Obstetrics, Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, Jiangsu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianwen Li, School of Nursing, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu, 211166, People’s Republic of China, Email xwli0201@njmu.edu.cn Ying Liu, Department of Obstetrics, Women’s Hospital of Nanjing Medical University (Nanjing Women and Children’s Healthcare Hospital), Nanjing, Jiangsu, 210004, People’s Republic of China, Email 371768109@qq.comPurpose: The provision of postnatal continuity of care is of significant importance to new mothers. …”
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  10. 4830

    Thyroid Dysfunction After Intensity-Modulated Radiotherapy and PD⁃1 Inhibitor Treatment for Locally Advanced Nasopharyngeal Carcinoma by Shang K, He Q, Xu X, Luo X, Zhao C, Liu L, Li Z, Li Y, Jin F

    Published 2025-01-01
    “…Kai Shang,1,2,* Qianyong He,1– 3,* Xinyu Xu,2 Xunyan Luo,2 Chaofen Zhao,1,3 Lina Liu,1– 3 Zhuoling Li,1– 3 Yuanyuan Li,1– 3 Feng Jin1,3 1Department of Oncology, the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 2School of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China; 3Department of Oncology, the Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Jin, Department of Oncology, the Affiliated Hospital of Guizhou Medical University, 28 Guiyi Street, Guiyang, Guizhou, 550004, People’s Republic of China, Tel +851-86512802, Email tjzlk2023@163.comPurpose: Analyze the incidence and risk factors of thyroid dysfunction in patients with advanced nasopharyngeal carcinoma (LA-NPC) after intensity-modulated radiotherapy (IMRT) and PD⁃1 inhibitor treatment and their relationship with treatment efficacy and prognosis.Methods: Eighty-five LA-NPC patients treated with IMRT and PD-1 inhibitors were retrospectively collected from March 1, 2019, to May 30, 2022. …”
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  11. 4831

    Community Integration of Disability: A Bibliometric and Knowledge-Map Analysis by Wang S, Li D, Liu C, Sun X, Shi Y, Wang H, Zhang H

    Published 2025-01-01
    “…Shuaiyou Wang,1 Dingding Li,1 Chenjun Liu,1 Xueting Sun,1 Yage Shi,1 Hongru Wang,2 Huimin Zhang3 1School of Nursing, Xinxiang Medical University, Xinxiang, Henan, People’s Republic of China; 2Nursing of Department, Xinxiang First People’s Hospital, Xinxiang, Henan, People’s Republic of China; 3School of Nursing, Ningxia Medical University, Yinchuan, People’s Republic of ChinaCorrespondence: Huimin Zhang, School of Nursing, Ningxia Medical University, No.1160 Shengli South Street, Xingqing District, Yinchuan, 750001, People’s Republic of China, Email 35290915@qq.comBackground: Community integration (CI) is the ultimate goal of rehabilitation for individuals with disabilities. …”
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  12. 4832
  13. 4833
  14. 4834

    The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

    Published 2025-01-01
    “…Xiping Jiang,1,* Cheng Xu,2,* Chenrui Yuan,1,* Wenliang Gao,3 Wencai Liu,1 Yifei Wang,1 Haiming Wang,1 Weilin Yu,1 Yaohua He1,4 1Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China; 2Department of Anesthesiology, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China; 3Department of Orthopedics, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000, People’s Republic of China; 4Department of Orthopedic Surgery, Jinshan District Central Hospital Affiliated to Shanghai University of Medicine & Health Sciences, Jinshan Branch of Shanghai Sixth People’s Hospital, Shanghai, 201500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weilin Yu; Yaohua He, Department of Orthopedic Surgery, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, People’s Republic of China, Tel +86 021 64369181, Email yuweilin2008@163.com; heyaohua@sjtu.edu.cnPurpose: Arthroscopic rotator cuff repair (ARCR) commonly results in significant postoperative pain. …”
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  15. 4835

    Microwave-Assisted Synthesized ZnO@APTES Quantum Dots Exhibits Potent Antibacterial Efficacy Against Methicillin-Resistant Staphylococcus aureus Without Inducing Resistance by Du F, Niu J, Hong Y, Fang X, Geng Z, Liu J, Xu F, Liu T, Chen Q, Zhai J, Miao B, Liu S, Zhang Y, Chen Z

    Published 2025-01-01
    “…Fangyuan Du,1,* Jingqi Niu,1,* Yu Hong,1 Xue Fang,2 Zhihui Geng,1 Jing Liu,1 Fangqi Xu,1 Tingshu Liu,1 Qifan Chen,1 Jingbo Zhai,3 Beiliang Miao,4 Shiwei Liu,4 Yi Zhang,1 Zeliang Chen1 1Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, People’s Republic of China; 2College of Animal Husbandry & Veterinary Medicine, Jinzhou Medical University, Jinzhou, 121001, People’s Republic of China; 3Key Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region, Medical College, Inner Mongolia Minzu University, Tongliao, 028000, People’s Republic of China; 4Department of Nephrology and Endocrinology, Wangjing Hospital, Chinese Academy of Chinese Medical Science, Beijing, 100102, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Zhang; Zeliang Chen, Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang, 110866, Liaoning, People’s Republic of China, Email 2005500042@syau.edu.cn; chenzliang5@mail.sysu.edu.cnBackground: Antibiotic resistance of many bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), has become a major threat to global health. …”
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  16. 4836

    Five-Year Prospective Follow-Up of Patients with Hepatitis C Virus Infection Treated with Direct-Acting Antiviral Agents by Zhang Y, Xia H, Fan L, Jiang L, Yang B, Wang F

    Published 2025-01-01
    “…Yaping Zhang,1,2,* Huan Xia,3,* Luchang Fan,1 Lu Jiang,4 Bin Yang,2 Fengmei Wang4,5 1The Third Central Clinical College of Tianjin Medical University, Tianjin Medical University, Tianjin, 300170, People’s Republic of China; 2Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Institute of Hepatobiliary Disease, Nankai University Affiliated Third Central Hospital, Tianjin, 300072, People’s Republic of China; 3Department of Infectious Diseases, Tianjin Second People’s Hospital, Tianjin, 300192, People’s Republic of China; 4Department of Hepatology and Gastroenterology, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of China; 5Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer, Tianjin First Central Hospitial, Tianjin, 300192, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fengmei Wang; Bin Yang, Email wangfengmeitj@126.com; bioyang@126.comPurpose: The research intended to present prospective data on the long-term prognosis of individuals with hepatitis C virus (HCV) infection who received direct-acting antiviral agent (DAA) treatment.Patients and Methods: Patients who received DAA treatment at Tianjin Third Central Hospital and Tianjin Second People’s Hospital were prospectively enrolled and subsequently underwent a longitudinal follow-up. …”
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  17. 4837
  18. 4838

    Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

    Published 2025-02-01
    “…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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  19. 4839

    Idiopathic Retroperitoneal Fibrosis-Related Hydronephrosis: Evaluation of Comprehensive Management and Prediction of Inflammatory Markers for Stent-Free Outcomes by Huang Z, Liu Y, Xiao Y, Hu H, Xu T

    Published 2025-01-01
    “…Zixiong Huang,1– 3 Yanying Liu,4,5 Yunshu Xiao,5 Hao Hu,1,2 Tao Xu1,2 1Department of Urology, Peking University People’s Hospital, Beijing, 100044, People’s Republic of China; 2Applied Lithotripsy Institute, Peking University, Beijing, 100044, People’s Republic of China; 3Department of Urology, Michigan Medicine, Ann Arbor, MI, 48109, USA; 4Department of Rheumatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China; 5Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, 100044, People’s Republic of ChinaCorrespondence: Hao Hu; Tao Xu, Department of Urology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing, 100044, People’s Republic of China, Email huhao@bjmu.edu.cn; xutao@pkuph.edu.cnObjective: This study investigated the efficacy of comprehensive management and predictable inflammatory markers for idiopathic retroperitoneal fibrosis (iRPF)-related hydronephrosis outcomes.Methods: Patients with iRPF-related hydronephrosis underwent surgical (ureteral stent and/or nephrostomy tube placement) and medical (corticosteroid-based multiple immunosuppressants) management were classified according to stent-indwelling outcomes. …”
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  20. 4840