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4081
Human Primary Monocytes as a Model for in vitro Immunotoxicity Testing: Evaluation of the Regulatory Properties of TiO2 Nanoparticles
Published 2025-01-01“…Tereza Svadlakova,1,2 Martina Kolackova,1 Pavel Kulich,3 Jan Kotoucek,3,4 Michaela Rosecka,1 Jan Krejsek,1 Zdeněk Fiala,2 Ctirad Andrýs1 1Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; 2Department of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; 3Department of Pharmacology and Toxicology, Veterinary Research Institute, Brno, Czech Republic; 4Central European Institute of Technology, Brno University of Technology, Brno, Czech RepublicCorrespondence: Tereza Svadlakova, Department of Clinical Immunology and Allergology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University, Sokolska 581, Hradec Kralove, 50005, Czech Republic, Email svadlakovat@lfhk.cuni.czIntroduction: A critical step preceding the potential biomedical application of nanoparticles is the evaluation of their immunomodulatory effects. …”
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4082
Whole-genome sequencing surveillance of Siberian tick-borne encephalitis virus (TBEV) identifies an additional lineage in Kyrgyzstan
Published 2025-01-01“…Considering the emergence of new TBEV foci, the genetic characterisation of the virus in endemic regions is crucial to not only better understand its epidemiology, but also to identify possible genetic determinants of virulence, as well as develop accurate diagnostics and therapeutics.In our previous study, we identified TBEV in six localities of the Kyrgyz Republic (Kyrgyzstan), and Ala-Archa National Nature Park as a focus of TBEV transmission. …”
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4083
Gut Microbiome and Metabolite Characteristics Associated With Different Clinical Stages in Non-Small Cell Lung Cancer Patients
Published 2025-01-01“…Fan Liu,1 Xingbing Lu,2 Mengli Tang,2 Yuzuo Chen,2 Xi Zheng3,4 1Health Management Center, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Lung Cancer Center, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xi Zheng, Lung Cancer Center, Department of Thoracic Surgery, West China Hospital, Sichuan University, Guoxue Lane 37, Chengdu, Sichuan Province, People’s Republic of China, Tel +86-28-86298113, Email zhengxi@scu.edu.cnObjective: Our research has pinpointed the gut microbiome’s role in the progression of various pathological types of non-small cell lung cancer (NSCLC). …”
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Deciphering Immunometabolic Landscape in Rheumatoid Arthritis: Integrative Multiomics, Explainable Machine Learning and Experimental Validation
Published 2025-01-01“…Qiu Dong,1,* Jiayang Wu,2,3,* Huaguo Zhang,4,* Xinhui Chen,2,3 Xi Xu,2,3 Jifeng Chen,3 Changzheng Shi,2,3,5 Liangping Luo,3,5 Dong Zhang2,3 1Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 2Medical Imaging Centre, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 3The Guangzhou Key Laboratory of Molecular and Functional Imaging for Clinical Translation, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Ultrasonography, the First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, People’s Republic of China; 5Medical Imaging Centre, the Fifth Affiliated Hospital of Jinan University, Heyuan, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dong Zhang, Email lbzhangdong@126.comPurpose: Immunometabolism is pivotal in rheumatoid arthritis (RA) pathogenesis, yet the intricacies of its pathological regulatory mechanisms remain poorly understood. …”
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Osteoarthritis and Degree of Fatigue are Associated with Pain Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study of 394 Patients
Published 2025-01-01“…Zihan Wang,1,2,* Tianyi Lan,1,2,* Yuqiao Zhang,1,2 Zijia Guo,3 Hongwei Yu,4 Guiyao Sun,5 Zhitian Wang,6 Zeran Yan,1 Qingwen Tao,1 Yuan Xu1 1Traditional Chinese Medicine Department of Rheumatism, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Graduate School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Graduate School, Inner Mongolia Medical University, Hohhot, People’s Republic of China; 4Department of Radiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 5Department of Orthopedics, Shuangqiao Hospital, Beijing, People’s Republic of China; 6Science Faculty, University of Auckland, Auckland, New Zealand*These authors contributed equally to this workCorrespondence: Qingwen Tao; Yuan Xu, Email taoqg1@sina.com; xuyuan2004020@163.comObjective: To observe how osteoarthritis (OA) and degree of fatigue affect are associated with pain levels in patients with fibromyalgia syndrome (FMS).Methods: A cross-sectional study was conducted involving FMS patients. …”
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4087
Research on smoke diffusion and evacuation routes of mine fires with complex roadway networks
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4088
Investigating the Use of Generative Adversarial Networks-Based Deep Learning for Reducing Motion Artifacts in Cardiac Magnetic Resonance
Published 2025-02-01“…Ze-Peng Ma,1,2,* Yue-Ming Zhu,3,* Xiao-Dan Zhang,4 Yong-Xia Zhao,1 Wei Zheng,3 Shuang-Rui Yuan,1 Gao-Yang Li,1 Tian-Le Zhang1 1Department of Radiology, Affiliated Hospital of Hebei University/ Clinical Medical College, Hebei University, Baoding, 071000, People’s Republic of China; 2Hebei Key Laboratory of Precise Imaging of inflammation Tumors, Baoding, Hebei Province, 071000, People’s Republic of China; 3College of Electronic and Information Engineering, Hebei University, Baoding, Hebei Province, 071002, People’s Republic of China; 4Department of Ultrasound, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Dan Zhang, Department of Ultrasound, Affiliated Hospital of Hebei University, No. 212 of Yuhua East Road, Lianchi District, Baoding, 071000, People’s Republic of China, Tel +86 17325535302, Email xiaodanzhangzxd@126.comObjective: To evaluate the effectiveness of deep learning technology based on generative adversarial networks (GANs) in reducing motion artifacts in cardiac magnetic resonance (CMR) cine sequences.Methods: The training and testing datasets consisted of 2000 and 200 pairs of clear and blurry images, respectively, acquired through simulated motion artifacts in CMR cine sequences. …”
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4089
Mobile application adjunct to the WHO basic emergency care course: a mixed methods study
Published 2022-07-01Get full text
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4093
Early Neolithic of Southern Belarus: current state and prospects for study
Published 2024-08-01“…The first ceramics, according to the current dates from the territory of Belarus and the Belarusian-Ukrainian borderland, appears in the south of the republic in the middle of the second half of the VI millennium BC. …”
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4094
A Study on Intelligent User-Centric Logistics Service Model Using Ontology
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Monte Carlo Alpha Iteration Algorithm for a Subcritical System Analysis
Published 2015-01-01Get full text
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4099
An Adaptive Cauchy Differential Evolution Algorithm for Global Numerical Optimization
Published 2013-01-01Get full text
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