PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction by Simon Rauterberg, Simon Rauterberg, Carmen Härdtner, Jennifer Hein, Paola Schrepf, Remi Peyronnet, Christoph Koentges, Tamara A. Vico, Carolin Ehlert, Bianca Dufner, Diana Lindner, Constantin von zur Mühlen, Dennis Wolf, Dirk Westermann, Ingo Hilgendorf, Alexander von Ehr

“…Genetic deletion of PCSK9 confers protection against post-infarct mortality, whereas pharmacological inhibition with Alirocumab fails to reproduce these benefits and may exacerbate cardiac dysfunction. …”
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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…LEGEND-T2DM is dedicated to open science and transparency and will publicly share all analytic code from reproducible cohort definitions through turn-key software, enabling other research groups to leverage our methods, data and results to verify and extend our findings.…”
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Response of South Asia PM2.5 pollution to ammonia emission changes and associated impacts on human health by Yuanlin Wang, Eiko Nemitz, Samuel J. Tomlinson, Edward J. Carnell, Liquan Yao, Janice Scheffler, Tomas Liska, Clare Pearson, Ulrike Dragosits, Chandra Venkataraman, Srinidhi Balasubramanian, Rachel Beck, Mark A. Sutton, Massimo Vieno

“…Results show that WRF-EMEP can reproduce magnitudes and variations of PM2.5 well, with a high annual mean PM2.5 concentration that exceeds 120 µg/m2 and mainly appeared in the Indo-Gangetic Plain. …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…This study aims to develop fully characterized, reproducible, clinical-grade batches of sEV derived from umbilical cord (UC)-MSC for the treatment of OA while assessing its efficacy and safety. …”
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Pengembangan Aplikasi E-Learning Edu IT : Pembuatan Aplikasi Ujian Essay Online serta Upload Download Materi Kuliah by Maria Bellaniar Ismiati, Latius Hermawan

“…During this time in UKMC, exams are still done in conventional way, namely using paper that will reproduce the papers that are not used anymore. In addition, the distribution of lecture materials is still often done through flash or e-mail. …”
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INTERNATIONAL AND NATIONAL LEGAL MECHANISMS OF JUDICIAL LIABILITY IN THE CONDITIONS OF ECONOMIC GLOBALISATION OF MODERN SOCIETY by Konul Akhundova

“…Among the indicators that reproduce the productivity of all three branches of government, the following are highlighted: the government efficiency index - the executive branch, the legislation quality index - the legislative branch, the rule of law index - the judiciary. …”
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Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…The family is the main structure responsible for this “protection”, and the domestic space reproduces mechanisms of control that aim to regulate young women’s bodies and sexualities. …”
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El desafío de construir una Psicología del desarrollo crítica en sociedades inhóspitas / The Challenge of Constructing a Critical Developmental Psychology in Inhospitable Societies... by Carlos Iván Orellana

“…However, there is a mainstream Developmental Psychology that is reproduced in texts, lectures and discourses, while a different one, consistent with the historical reality where its study takes place, and is still a pending task. …”
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Estandarización de zimosán opsonizado como estímulo en la técnica de la 1,2,3-dihidrorrodamina para evaluar el estallido respiratorio del neutrófilo by Uriel Pérez-Blanco, Jenniffer Yissel Girón, Guillermo Juárez -Vega, María Jiménez, Carlos Sánchez, Ricardo Rioja, Sara Espinosa-Padilla, Lizbeth Blancas-Galicia

“…Entre las diferentes condiciones de zimosán probadas, la de 50 μg fue la cantidad óptima y reproducible en todos los controles por el análisis estadístico y los hallazgos citométricos. …”
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Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy by Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

“…These effects were reproduced by TAC in WT mice but restored to basal levels in β3‐AR expressing cells/mice. siRNA targeting of AMPK partly abrogated the anti‐hypertrophic effect of β3‐AR in response to PE in NRVM. …”
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Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…We replicated the significant associations of RALE scores with baseline disease severity and mortality in the independent validation data set.Conclusions With a reproducible method to measure radiographic severity in COVID-19, we found significant associations with clinical and physiologic severity, host inflammation and clinical outcomes. …”
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An efficient method for predicting the morphology of proppant packs based on a surrogate model by Tao ZHANG, Hangyu ZHOU, Yifan ZHANG, Jianchun GUO, Haoran GOU, Tang TANG

“…Currently, experimental and numerical methods are the main approaches for reproducing the proppant accumulation process and placement patterns in fractures. …”
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South to south collaboration: advancing quality of abortion care through health care professionals exchange program by Abraham Fessehaye Sium, Wondimu Gudu, Abrham Getachew, Diomede Ntasumbumuyange, Polyphile Nithinyurwa, Tamrat Endale Woldemichael, Delayehu Bekele

“…Participants from both sides agreed that the safe abortion care services provided in Ethiopia is far advanced, which can be reproduced in Rwanda by implementing the lessons learned from the exchange program. …”
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Analysis of the Spatial Pattern of Military River Defense on the Ming Great Wall: A Case Study of the Shanxi Section of the Yellow River by Tianlian WANG, Zhe LI

“…Ultimately, historical aerial films and real 3D point cloud data are utilized to reproduce the original appearance of defence facilities at river defence nodes. …”
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Elliptic and Quadrangular Flow of Protons in the High-Baryon-Density Region by Shaowei Lan, Zuowen Liu, Like Liu, Shusu Shi

“…Our results show that the inclusion of baryonic mean-field potential in the model successfully reproduces experimental data from the HADES experiment, indicating that baryonic interactions play an important role in shaping anisotropic flow. …”
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Warm and humid environment induces gut microbiota dysbiosis and bacterial translocation leading to inflammatory state and promotes proliferation and biofilm formation of certain ba... by Yinrui Guo, Jianlang He, Shaojie Li, Shiqi Zou, Haiting Zhang, Xin Yang, Jian Wang

“…Intraperitoneal injections of various bacterial strains in mice reproduced the sticky stool characteristics. Both mice and human subjects with “Dampness Syndrome” displayed elevated serum levels of inflammatory cytokines TNF-α and interleukin-17 A (IL-17A). …”
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The success of reforestation after experimental strip-shelterwood felling in the pine stands of the Eastern Polissia of Ukraine by Anatolyi Zhezhkun

“…It is expedient to carry out strip-shelterwood felling to reproduce natural stands and conduct Close-to-Nature forestry measures. …”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…QuestionCan previously reported, largely anecdotal associations between exposure to any of a comprehensive list of putative trigger drugs and the development of pemphigus be reproduced using population level data?FindingsIn this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine.MeaningEnvironmental exposures such as drugs are relevant players in the pathogenesis of autoimmune diseases and clinicians who treat patients with autoimmune blistering diseases such as pemphigus should consider performing a detailed medication history leveraging this information regarding deleterious drug-disease interactions at initial evaluation as well as longitudinal monitoring of patients to better inform clinical care decisions.ImportancePemphigus vulgaris (PV) is a rare, potentially fatal autoimmune disease with pathogenic contributions from both genetic as well as environmental factors, notably drug exposures. …”
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Characterization of RAP Signal Patterns, Temporal Relationships, and Artifact Profiles Derived from Intracranial Pressure Sensors in Acute Traumatic Neural Injury by Abrar Islam, Amanjyot Singh Sainbhi, Kevin Y. Stein, Nuray Vakitbilir, Alwyn Gomez, Noah Silvaggio, Tobias Bergmann, Mansoor Hayat, Logan Froese, Frederick A. Zeiler

“…Conclusions: RAP signals derived from ICP pressure sensor technology displayed reproducible behaviors across this population of TBI patients. …”
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Changes of Narrative: Osvald Sirén’s Photographic Modeling of Modern Research on Chinese Garden by Jiuwen GU, Yuanfeng SHI, Shan JIA

“…The first research path takes photography techniques and photographic images as the starting point, and analyzes the tone threshold of photographic images to figure out the technical points of Osvald Sirén’s photography, with a focus on the quality of shadow, as well as the characteristics of the images of gardens that are reproduced under the scenarios in which these photography techniques are applied. …”
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