Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study by Liye Lai, Dave Laurence Juntilla, Monica Del, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

“…Conclusions Our study identified novel differentially methylated loci linked to T2D as well as to changes in diabetes status through a longitudinal approach. We report CpG sites with different rates of annual methylation change and demonstrate that DNA methylation associated with T2D is linked to following transcriptional differences. …”
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Harnessing Big Heterogeneous Data to Evaluate the Potential Impact of HIV Responses Among Key Populations in Sub-Saharan Africa: Protocol for the Boloka Data Repository Initiative by Refilwe Nancy Phaswana Mafuya, Edith Phalane, Amrita Rao, Kalai Willis, Katherine Rucinski, K Alida Voet, Amal Abdulrahman, Claris Siyamayambo, Betty Sebati, Mohlago Seloka, Musa Jaiteh, Lerato Lucia Olifant, Katharine Journeay, Haley Sisel, Xiaoming Li, Bankole Olatosi, Neset Hikmet, Prashant Duhoon, Francois Wolmarans, Yegnanew A Shiferaw, Lifutso Motsieloa, Mashudu Rampilo, Stefan Baral

“…International Registered Report Identifier (IRRID)DERR1-10.2196/63583…”
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The two-component system ArlRS is essential for wall teichoic acid glycoswitching in Staphylococcus aureus by Marieke M. Kuijk, Emma Tusveld, Esther Lehmann, Rob van Dalen, Iñigo Lasa, Hanne Ingmer, Yvonne Pannekoek, Nina M. van Sorge

“…ArlRS was responsive to Mg2+, but not Na+, revealing its role in the previously reported salt-induced WTA glycoswitch from α1,4-GlcNAc to β1,4-GlcNAc. …”
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Diabetes distress among immigrants of south Asian descent living in New York City: baseline results from the DREAM randomized control trial by Farhan Mohsin, Laura Wyatt, Hayley Belli, Shahmir Ali, Deborah Onakomaiya, Supriya Misra, Yousra Yusuf, Shinu Mammen, Jennifer Zanowiak, Sarah Hussain, Haroon Zafar, Sahnah Lim, Nadia Islam, Naheed Ahmed

“…High emotional burden, regimen-related distress and physician-related distress were reported by 25.9%, 21.9%, and 6.2% of participants, respectively. …”
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Acceptability, feasibility, and effectiveness of internet-based cognitive behavior therapy for obsessive–compulsive disorder (OCD-NET): a naturalistic pilot trial during the COVID-... by Elisabeth Kohls, Sabrina Baldofski, Julia Scholl, Oskar Flygare, Lina Lundström, Ursula Beyrich-Kolbus, Marc Steinbrecher, Christian Rück, Christine Rummel-Kluge

“…Secondary outcomes were OCD symptoms at the end of treatment, assessed using the self-report Obsessive Compulsive Inventory – Revised (OCI-R) and self-rated measures of depressive symptoms, quality of life, self-efficacy, and psychological distress. …”
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Work performance, physiological and hemato-biochemical responses in working buffalo with different load weights by Visoky Paján-Jiménez, Fernando D. Pazmiño-Rodríguez, Patricia Roldán-Santiago, Cristian Larrondo-Cornejo, Anna Dutro-Aceves, Luis A. de la Cruz-Cruz

“…However, all changes remained within the physiological ranges reported for the buffaloes. Therefore, it is concluded that heavier loads increase work efficiency but generate greater physiological and metabolic demand. …”
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Clozapine for Treatment-Resistant Disruptive Behaviors in Youths With Autism Spectrum Disorder Aged 10-17 Years: Protocol for an Open-Label Trial by André Luiz Schuh Teixeira da Rosa, Marina Ribeiro Barreto da Costa, Gabriela Bezerra Sorato, Felipe de Moura Manjabosco, Érica Bonganhi de Bem, Lucas Dellazari, Arthur Bezerra Falcão, Lucas de Oliveira Cia, Olivia Sorato Bezerra, Rogério Boff Borges, Luis Augusto Rohde, Ana Soledade Graeff-Martins

“…Trial RegistrationBrazilian Clinical Trials Registry RBR-54j3726; https://ensaiosclinicos.gov.br/rg/RBR-54j3726 International Registered Report Identifier (IRRID)DERR1-10.2196/58031…”
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Effect of Traditional Chinese Medicine fumigation combined with acupoint massage in the prevention of deep venous thrombosis of lower limbs in elderly hospitalized patients in the... by DONG Fangfang (董芳芳), ZHANG Linying (张林英), HE Yan (贺艳), XU Man (许曼), LIU Zijing (刘紫荆), XIONG Qiuwan (熊秋婉)

“…Results After intervention, there was no DVT reported in either group. The level of D-dimer index of the study group decreased more significantly than that of the control group(P＜0. 05). …”
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Lutetium-177 labeled iPD-L1 as a novel immunomodulator for cancer-targeted radiotherapy by Myrna Luna-Gutiérrez, Erika Azorín-Vega, Rigoberto Oros-Pantoja, Blanca Ocampo-García, Pedro Cruz-Nova, Nallely Jiménez-Mancilla, Gerardo Bravo-Villegas, Clara Santos-Cuevas, Laura Meléndez-Alafort, Guillermina Ferro-Flores

“…Peptides that target specific pathways and cells involved in immunomodulation can potentially improve the efficacy of cancer therapy. Recently, we reported iPD-L1 as a novel inhibitor peptide that specifically targets the cancer cell ligand PD-L1 (programmed death ligand 1). …”
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Association between major depressive disorder or depressive symptoms and the risk of vascular complications among patients with type 2 diabetes, and the mediating role of metabolic... by Guochen Li, Yongfu Yu, Chunqing Lin, Shichen Zheng, Hong Tu, Wanghong Xu

“…Major depressive disorder (MDD) was ascertained according to the hospital admission records and self-report of doctor-diagnosed conditions, while the presence of depressive symptoms was assessed using the Patient Health Questionnaire-2. …”
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Effect of health education with a leaflet and demonstration on prevention of falls in elderly lymphoma patients during in-hospital chemotherapy for the first time (图文式健康教育在预防老年淋巴瘤患... by KUANG Meiling (邝梅玲), ZENG Xiujuan (曾秀娟)

“…There were three cases of falls reported in the control group. Patients in the observation group were more satisfied with nursing care than those in the control group (98. 33 vs. 88. 33%, P＜0. 05). …”
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Application of PDCA cycle management to improve the nursing quality and work enthusiasm of nursing staff in the Geriatric Department (运用PDCA循环管理法提升老年病科护理人员护理质量和工作积极性)... by LIU Yang (刘洋)

“…Nurses in the observation group had reported a higher level of e work enthusiasm compared with those in the control group(P<0. 01). …”
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Management of mangrove landscape and ecosystem for ecotourism by H.T. Silalahi, M. Basyuni, E.Y. Aritonang, B. Slamet, K.S. Hartini, A. Wee

“…BACKGROUND AND OBJECTIVES: Mangroves have high potential for advancing ecotourism because of their position at the intersection of land and sea. Many studies have reported that mangroves and coastal environments are the right places for the development of sustainable ecotourism. …”
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Evaluation of the adherence of municipalities and states to the Ministry of Health’s microplanning for high-quality vaccination activities and the increase in vaccination coverage... by Ana Catarina de Melo Araújo, Thales Philipe Rodrigues da Silva, Gustavo Velasquez-Melendez, Luciana Maiara Diogo Nascimento, Carla Conceição Ferraz, Fernanda Penido Matozinhos, Eder Gatti Fernandes

“…Methods Adopting an epidemiological approach with an ecological design, this study analyzed data on the adherence of the 27 Brazilian federative units to HQVA, as reported through the REDCap electronic form in 2023, as per an agreement with the Ministry of Health. …”
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Efficacy of the internet-based intervention “Cultivating our resilience” (CORE) for improving resilience and coping strategies in university students: A randomized controlled trial... by Rocio Herrero, Marvin Franke, Dennis Görlich, Azucena Garcia-Palacios, Rosa Baños, Corinna Jacobi, Thomas Berger, Michael P. Schaub, Tobias Krieger, David D. Ebert, Cristina Botella

“…Participants in the CORE condition reported a significant increase in resilience compared to WL condition (Differences post-BL: d = 0.34, p = .0005; 6 M-BL: d = 0.24, p = .0171; 12 M-BL: d = 0.33, p = .0031). …”
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South to south collaboration: advancing quality of abortion care through health care professionals exchange program by Abraham Fessehaye Sium, Wondimu Gudu, Abrham Getachew, Diomede Ntasumbumuyange, Polyphile Nithinyurwa, Tamrat Endale Woldemichael, Delayehu Bekele

“…Abstract Background South-South Cooperation (SSC) is recognized as a vital component of goal 17 – ‘Partnerships for the goals’ within the SDGs and countries in the global south has been utilizing this cooperation mainly in research. We report the first health care professional exchange program through this south-to-south collaboration focusing on advancing quality of abortion care in the Sub-Saharan region. …”
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Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial by Wei Lu, David Silvera-Tawil, Hwan-Jin Yoon, Liesel Higgins, Qing Zhang, Mohanraj Karunanithi, Julia Bomke, Joshua Byrnes, Jennifer Hewitt, Vanessa Smallbon, Jill Freyne, Deepa Prabhu, Marlien Varnfield

“…Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12618000829213; https://tinyurl.com/2n6a75em International Registered Report Identifier (IRRID)RR2-10.2196/31970…”
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Stress Reduction in Perioperative Care: Feasibility Randomized Controlled Trial by Haridimos Kondylakis, Irene Alice Chicchi Giglioli, Dimitrios Katehakis, Hatice Aldemir, Paul Zikas, George Papagiannakis, Santiago Hors-Fraile, Pedro L González-Sanz, Konstantinos Apostolakis, Constantine Stephanidis, Francisco J Núñez-Benjumea, Rosa M Baños-Rivera, Luis Fernandez-Luque, Angelina Kouroubali

“…Trial RegistrationClinicalTrials.gov NCT05184725; https://clinicaltrials.gov/study/NCT05184725 International Registered Report Identifier (IRRID)RR2-10.2196/38536…”
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Preindustrial-to-present-day changes in atmospheric carbon monoxide: agreement and gaps between ice archives and global model reconstructions by X. Faïn, S. Szopa, V. Naïk, P. Martinerie, D. M. Etheridge, D. M. Etheridge, R. H. Rhodes, C. M. Trudinger, C. M. Trudinger, V. V. Petrenko, K. Fourteau, P. Place, P. Place

“…Over the 1980–2010 CE period (common era; all subsequent years in the paper are reported in CE), trends in ice archive and firn air observations and AerChemMIP outputs align remarkably well at northern and southern high latitudes, indicating improved quantification of anthropogenic CO emissions and the main CO sink (OH oxidation) compared to ACCMIP. …”
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Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…Results from this study will be disseminated through peer-reviewed journal articles, scientific conferences, summary reports to students and schools and stakeholder meetings.Trial registration number Australian Clinical Trials Registration Registry (ACTRN12622000600741).…”
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