Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease by Tianle Chen, Yuanjia Wang, Yanyuan Ma, Karen Marder, Douglas R. Langbehn

“…Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of CAG repeats in the IT15 gene. The age-at-onset (AAO) of HD is inversely related to the CAG repeat length and the minimum length thought to cause HD is 36. …”
Get full text

A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTD by Tristan X. McCallister, Colin K. W. Lim, Mayuri Singh, Sijia Zhang, Najah S. Ahsan, William M. Terpstra, Alisha Y. Xiong, M. Alejandra Zeballos C, Jackson E. Powell, Jenny Drnevich, Yifei Kang, Thomas Gaj

“…Abstract An abnormal expansion of a GGGGCC (G4C2) hexanucleotide repeat in the C9ORF72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two debilitating neurodegenerative disorders driven in part by gain-of-function mechanisms involving transcribed forms of the repeat expansion. …”
Get full text

CAG Expansion in Androgen Receptor Gene of Infertile Men in Erbil Governorate by Dashne Abdulla Salih, Karim Jalal Karim

“…Men with infertility had CAG repeats in their AR gene, ranging from (17-26) repeats, with a mean (21.3 ±0.16). …”
Get full text

Adherence to CRC Screening and Surveillance Guidelines when Using Split-Dose Bowel Preparation by Stacy B. Menees, H. Myra Kim, Grace H. Elta, Sheryl Korsnes, Philip Schoenfeld

“…To prospectively assess physician recommendations for repeat colonoscopy in an average-risk screening cohort. …”
Get full text

Olfactory transport efficiency of the manganese oxide nanoparticles (II) after their single or multiple intranasal administrations by A. V. Romashchenko, M. B. Sharapova, D. V. Petrovskii, M. P. Moshkin

“…Based on the data, the accumulation of MnO-NPs in the olfactory bulb of mice was reduced after repeated intranasal application. In addition, the decrease in the efficiency of olfactory transport observed after repeated administration of MnO-NPs was partially restored by intranasal application of mucolytic (0.01 M N-acetyl-L-cysteine). …”
Get full text

Retrograde Percutaneous Coronary Intervention in a Case of Takayasu Arteritis with Left Main Coronary Artery Chronic Total Occlusion by Prathap Kumar, Blessvin Jino, Stalin Roy, Manu Rajendran

“…Drug-coated balloons help in repeat revascularization after stent failure in TA. …”
Get full text

Improving children’s cooperativeness during magnetic resonance imaging using interactive educational animated videos: a prospective, randomised, non-inferiority trial by Evelyn Gabriela Utama, Seyed Ehsan Saffari, Phua Hwee Tang

“…Introduction: A previous prospective, randomised controlled trial showed that animated videos shown to children before magnetic resonance imaging (MRI) scan reduced the proportion of children needing repeated MRI sequences and improved confidence of the children staying still for at least 30 min. …”
Get full text

CENP-A/CENP-B uncoupling in the evolutionary reshuffling of centromeres in equids by Eleonora Cappelletti, Francesca M. Piras, Marialaura Biundo, Elena Raimondi, Solomon G. Nergadze, Elena Giulotto

“…CENP-B boxes are present in a previously undescribed repeat which is not the major satellite bound by CENP-A. …”
Get full text

The complete chloroplast genome sequences of monotypic genus Pseudogalium, and comparative analyses with its relative genera by Wei Yu, Xiao-Juan Li, Zhen Lv, Li-E Yang, De-Li Peng

“…Additionally, we identified 60 dispersed repeat sequences, 61–63 simple sequence repeats, and 30 codons within the 82 protein-coding genes that exhibited RSCU values greater than one. …”
Get full text

Genome-wide microsatellite characterization and their marker development and transferability in Broussonetia Species by Xiaowen Jia, Hanyu Li, Ying Han, Lu Wang, Chanjuan Lai, Xi Liu, Pan Li, Zupei Lei, Yonghua Zhang

“…Additionally, the predominant repeat motifs in the SSRs of the three Broussonetia species were composed of ‘A’ and ‘T’ repeats. …”
Get full text

Chaos and Control of Game Model Based on Heterogeneous Expectations in Electric Power Triopoly by Weizhuo Ji

“…A dynamic repeated game model has been established based on heterogeneous expectations in electric power triopoly. …”
Get full text

IL-1RN VNTR Polymorphism in Adult Dermatomyositis and Systemic Lupus Erythematosus by Zornitsa Kamenarska, Gyulnas Dzhebir, Maria Hristova, Alexey Savov, Anton Vinkov, Radka Kaneva, Vanio Mitev, Lyubomir Dourmishev

“…Only three alleles were identified in both patients and controls ((1) four repeats, (2) two repeats, and (3) five repeats). The IL-1RN*2 allele (P=0.02, OR 2.5, and 95% CI 1.2–5.4) and the 1/2+2/2 genotypes were found prevalent among the SLE patients (P=0.05, OR 2.6, and 95% CI 1–6.3). …”
Get full text

Comparative transcriptomics and metabolomics provide insight into degeneration‐related physiological mechanisms of Morchella importuna after long‐term preservation by Ying Chen, Xuelian Cao, Liyuan Xie, Jie Tang, Lixu Liu, Di Wang, Xiang Wu, Tianhai Liu, Yang Yu, Yong Wang, Francis Martin, Weihong Peng, Hao Tan

“…A diverse set of cellular biochemical processes related to carbon metabolism were altered by repeated subculturing under nutrient‐rich conditions, whereas glycerophospholipid and purine metabolism were key functions affected by repeated subculturing under nutrient‐limited conditions. …”
Get full text

Patient-Tailored, Imaging-Guided, Long-Term Temozolomide Chemotherapy in Patients with Glioblastoma by Norbert Galldiks, Lutz W. Kracht, Lothar Burghaus, Roland T. Ullrich, Heiko Backes, Anna Brunn, Wolf-Dieter Heiss, Andreas H. Jacobs

“…Our data suggest that repeated MET- and FLT-PET imaging provide information on the biologic activity of a tumor that is highly useful to monitor and detect changes in activity.…”
Get full text

THE HETEROPLASMIC AND HOMOPLASMIC STATES OF MITOCHONDRIAL AND CHLOROPLAST DNA REGIONS IN THE PROGENIES OF WIDE HYBRIDS OF COMMON WHEAT OF DIFFERENT ORIGINS by N. V. Trubacheeva, L. A. Kravtsova, E. P. Devyatkina, T. T. Efremova, M. G. Sinyavskaya, V. K. Shumny, L. A. Pershina

“…The heteroplasmic state of the 18S/5S repeat, which was a result of biparental mtDNA transmission, is observed in rye × wheat hybrids and in their progenies possessing rye cytoplasm. …”
Get full text

A guide to selecting high-performing antibodies for Huntingtin (UniProt ID: P42858) for use in western blot, immunoprecipitation, and immunofluorescence [version 2; peer review: 2... by Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran

“…Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. …”
Get full text

Role of IgM testing in the diagnosis and post-treatment follow-up of syphilis: a prospective cohort study by Tania Crucitti, Irith De Baetselier, Hilde Smet, Kara K Osbak, Achilleas Tsoumanis, Marjan Van Esbroek, Chris R Kenyon

“…Objectives The diagnosis of repeat syphilis and its follow-up remains challenging. …”
Get full text

Outcomes following intradetrusor onabotulinumtoxinA in a national cohort of nursing home residents by Leo D. Dreyfuss, Farnoosh Nik‐Ahd, Lufan Wang, Abigail Shatkin‐Margolis, Kenneth Covinsky, W. John Boscardin, Anne M. Suskind

“…The primary outcome was treatment success, defined as repeat onabotulinumtoxinA injection within 1 year of index injection. …”
Get full text

Ultrasound‐assisted minimally invasive technique for tissue collection from bovine mammary glands by Alysia L. Vang, Waneska S. Frizzarini, Haylee H. Webster, Thiago O. Cunha, Kathryn M. Nelson, Joao R. R. Dorea, Laura L. Hernandez

“…A subset of 36 animals had repeated mammary gland biopsies through the first lactation. …”
Get full text

Complete chloroplast genomes of 13 species of the Impatiens genus for genomic features and phylogenetic relationships studies by Qinqin Yong, Meijun Li, Zhi Li, Chao Luo, Jinling Zhang, Xinxiang Bai

“…SSRs mainly consist of A/T repeats and AT/AT repeats, while INEs mainly consist of positive repeats and palindromic repeats. …”
Get full text