Evaluation of Pain Intensity Caused by Nickel-Titanium Archwires of Different Sizes in the First Stage of Fixed Orthodontic Treatment: A Double-Blind Randomized Clinical Trial by Aydin Sohrabi, Shabnam Tahamtan, Sana Seyed Shariatdoust, Ali Rafighi

“…Pain assessment at each time point was evaluated at four intervals- at placement, 3 hours, 24 hours, and 3 days after the placement of wire. The Repeated Measures ANOVA test was used to evaluate the effects of archwire size and time after placement on reported pain levels.Results: The results showed that the pain reported in the superelastic nickel-titanium archwires of 0.012, 0.014, and 0.016 inches did not differ significantly from each other during the bonding session, 4 weeks, and 8 weeks after that (with p values of 0.404, 0.181, and 0.800, respectively). …”
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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections by Merlis P. Alvarez-Berrios, Lisa M. Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

“…Although they have the ability to reduce the main side effects of free AmB, their high cost, necessity of repeated intravenous injections for successful treatment, and incidence of pulmonary toxicity have limited their use. …”
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Investigating uncertainty and parameter sensitivity in bedform analysis by using a Monte Carlo approach by J. Reich, A. Winterscheid

“…We therefore developed a workflow to quantify this influence by performing a Monte Carlo simulation. By repeating the calculations many times with varying input parameter settings, the possible range of results is revealed, and thus the procedure-specific uncertainties can be quantified. …”
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Comparison of the Effects of Static-Stretching and Tubing Exercises on Acute Shoulder Range of Motion in Collegiate Baseball Players by Andrew M Busch, Jackson Browstein, Richard Ulm

“…Dominant arm internal rotation (IR), external rotation (ER) and TRROM were measured before, immediately after, 30-minutes after, and 60-minutes after each treatment session. A two-way repeated measures analysis of variance (ANOVA) compared the effect of SS and DT over time on IR, ER and TRROM…”
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A Toxicological Evaluation of Methylliberine (Dynamine®) by Timothy S. Murbach, Róbert Glávits, John R. Endres, Amy E. Clewell, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné

“…A (1) bacterial reverse mutation test, (2) in vitro mammalian chromosomal aberration test, (3) in vivo mammalian micronucleus test, and (4) 90-day repeated-dose oral toxicity study in rats with a 28-day recovery period were conducted. …”
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Epidemiology of clinically significant migraine in Israel: a retrospective database study by A. Shifrin, E. Domany, M. Tirosh, D. Davidovici, S. Vinker, I. Forschner, A. Israel

“…Clinically significant migraine patients were identified using stringent criteria, including repeated diagnostic codes for migraine, confirmation by a neurologist, or the use of migraine-specific therapies. …”
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A 22 Billion M⊙ Black Hole in Holmberg 15A with Keck KCWI Spectroscopy and Triaxial Orbit Modeling by Emily R. Liepold, Chung-Pei Ma, Jonelle L. Walsh

“…Both SMBHs lie significantly above the mean M _BH – σ scaling relation. Repeating the orbit modeling with the axisymmetrized version of TriOS produces worse fits to the KCWI kinematics and increases M _BH to (2.55 ± 0.20) × 10 ^10 M _⊙ , which is still significantly below the M _BH = (4.0 ± 0.8) × 10 ^10 M _⊙ reported in a prior axisymmetric study of H15A.…”
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Comparing the Effectiveness of Schema Therapy and Acceptance and Commitment Therapy on Suicidal Behaviors in Depressed Patients with Bereavement by Maral Moraveji, Zahra Bagherzadeh Golmakani, Mahdi Akbarzadeh

“…The data were analyzed using repeated measures analysis of variance (ANOVA) and the Bonferroni post-hoc test.Results: The results indicated that suicidal behaviors decreased from pre-test to post-test and follow-up in both the schema therapy and acceptance and commitment therapy groups (P<0.001). …”
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The Effects of Soft Tissue Flossing on Hamstring Range of Motion and Lower Extremity Power by Zachary Maust, Debbie Bradney, Sean M Collins, Caroline Wesley, Thomas G Bowman

“…Hip flexion range of motion, via the straight leg raise, and power (single-leg vertical jump) were compared from pre-test to post-test using a 3x2 repeated measures ANOVA. # Results There was a significant interaction between time and session for hamstring flexibility (F~(2,40)~=17.54, *p*<0.001, η^2^=0.47). …”
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Optimal Adaptation Period for Metabolic Cage Experiments in Mice at Different Developmental Stages by TAN He, YANG Xiaohui, ZHANG Daxiu, WANG Guicheng

“…Statistical differences were compared using repeated measures ANOVA combined with t-test to determine the optimal adaptation period. …”
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Egfr Amplification Specific Gene Expression in Phyllodes Tumours of the Breast by Konstantin Agelopoulos, Christian Kersting, Eberhard Korsching, Hartmut Schmidt, Arno Kuijper, Christian August, Pia Wülfing, Joke Tio, Werner Boecker, Paul J. van Diest, Burkhard Brandt, Horst Buerger

“…Methods: In order to gain further insights into regulation mechanisms associated with egfr amplifications and EGFR expression in phyllodes tumours, we performed global gene expression analysis (Affymetrix A133.2) on a series of 10 phyllodes tumours, of these three with and seven without amplifications of an important regulatory repeat in intron 1 of egfr (CA-SSR I). The results were verified and extended by means of immunohistochemistry using the tissue microarray method on an extensively characterized series of 58 phyllodes tumours with antibodies against caveolin-1, eps15, EGF, TGF-α, pErk, pAkt and mdm2. …”
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Economic and Humanistic Burden of Moderate and Severe Hemophilia A and B in Spain: Real-World Evidence Insights from the CHESS II Study by Carmen Peral, Alfonso De Lossada Juste, Nadia Lwoff, Nataly Espinoza-Cámac, Miguel Ángel Casado, Tom Burke, Jose Alvir, Sheena Thakkar, Enrico Ferri Grazzi

“…**Background:** Hemophilia is a congenital disorder characterized by deficiency or absence of clotting factor VIII in hemophilia A (HA) or clotting factor IX in hemophilia B (HB), resulting in frequent, repeated, and prolonged spontaneous or traumatic bleeding into joints or soft tissue. …”
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Radiological assessment of cup anteversion with a novel 3D-printed highly-porous titanium dual mobility cup by Nicole Puteo, Edoardo Matteo Valentino, Vittorio Davidoni, Domenico Tigani

“…Conclusions RA measurements are more consistent, repeatable and accurate with a titanium DMC than standard DMC, due to the minor radiopacity of the former cup which enable RA measurements on AP radiographs. …”
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Myeloid-related proteins 8/14 failed to act as theragnostic biomarker in axial spondyloarthritis patients on combination disease-modifying anti-rheumatic drugs therapy by Arvind Ganapati, Jayakanthan Kabeerdoss, Mahasampath Gowri, Belavendra Antonisamy, Debashish Danda

“…Methods: Serum MRP 8/14 was assayed using enzyme-linked immunosorbent assay platforms (R&D systems, USA) at baseline in 83 AxSpA patients satisfying ASAS 2009 criteria meeting the predefined eligibility criteria; treated with a combination of methotrexate, sulfasalazine at optimum tolerated doses with on-demand nonsteroidal anti-inflammatory agents and 30 healthy age-matched controls. Repeat measurement was done at 3 months in 60 patients. …”
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Glymphatic system clearance and Alzheimer’s disease risk: a CSF proteome-wide study by Natalia Cullell, Giovanni Caruana, Andrea Elias-Mas, Ariane Delgado-Sanchez, Cristina Artero, Maria Teresa Buongiorno, Marta Almería, Nicola J. Ray, Sonia A. L. Correa, Jerzy Krupinski

“…These were compared with demographic-only models for identifying participants with aMCI(-) and aMCI/AD( +) vs controls. This analysis was repeated to determine if the models could identify those with aMCI/AD( +) from both aMCI(-) and controls. …”
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Pulmonary function in swimmers exposed to disinfection by-products: a narrative review by Michał Boraczyński, Tomasz Balcerek, Nikola Rożkiewicz, Monika Pabiszczak, Michał Harasymczuk, Aneta Sławska, Przemysław Lutomski

“…Thus, the combination of intense and repeated physical endurance training over extended periods, along with suboptimal environmental conditions, may contribute to the development of rhinitis, asthma and bronchial hyperresponsiveness in athletes. …”
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Development of a Copro-RPA-CRISPR/Cas12a assay to detect Echinococcus granulosus nucleic acids isolated from canine feces using NaOH-based DNA extraction method. by Guoqing Shao, Xiaowei Zhu, Ruiqi Hua, Yanxin Chen, Guangyou Yang

“…<h4>Methods</h4>We combined recombinase polymerase amplification (RPA) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) with a CRISPR-associated protein 12a (Cas12a) system, forming the RPA-CRISPR/Cas12a assay. …”
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Oral delivery of the non-β-blocking R-carvedilol enantiomer for skin cancer chemoprevention in SKH-1 mice by Pabitra K. Sardar, Steven Yeung, Ruby Tow, Jacqueline Luga, Matthew Huang, Ayaz Shahid, Bradley T. Andresen, Ying Huang

“…Methods Efficacy of orally delivered R-carvedilol was examined in SKH-1 mice exposed to repeated UV radiations for 25 weeks. Pharmacokinetic studies were conduced in mice to evaluate the drug levels in plasma and skin tissues. …”
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Research on the Simulation Model of Dynamic Shape for Forest Fire Burned Area Based on Grid Paths from Satellite Remote Sensing Images by Xintao Ling, Gui Zhang, Ying Zheng, Huashun Xiao, Yongke Yang, Fang Zhou, Xin Wu

“…After analyzing the validation results of models which showed temperature as a non-significant variable, the training and validation process of models above was repeated after excluding temperature. The results show that RF is the optimal model with 49.55 m for root mean square error (RMSE), 29.19 m for mean absolute error (MAE) and 0.9823 for coefficient of determination (R²). …”
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Effectiveness and utilization of a cognitive screening program for primary geriatric care by David P. Salmon, Anna Malkina, Melanie L. Johnson, Christina Gigliotti, Emily A. Little, Douglas Galasko

“…Screening tests were repeated after two years in a subset of 69 patients. …”
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