Ossification Vesicles with Calcium Phosphate in the Eyes of the Insect Copium teucrii (Hemiptera: Tingidae) by Javier Garcia-Guinea, Alberto Jorge, Laura Tormo, Marta Furio, Elena Crespo-Feo, Virgilio Correcher, Pedro Prado-Herrero, Ana C. Soria, Jesus Sanz, Jose L. Nieves-Aldrey

“…Arthropod eyes are built of repeating units named ommatidia. Each single ommatidium unit contains a cluster of photoreceptor cells surrounded by support cells and pigment cells. …”
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Evaluation of intranasal TLR2/6 agonist INNA-051: safety, tolerability and proof of pharmacology by Francesca A. Mercuri, Scott White, Hayley A. McQuilten, Charlotte Lemech, Stephan Mynhardt, Rana Hari, Ping Zhang, Nicole Kruger, Grant McLachlan, Bruce E. Miller, Nicholas P. West, Ruth Tal-Singer, Christophe Demaison

“…The first dose-escalation study assessed safety, tolerability and mechanistic biomarkers following single and repeated intranasal administrations of INNA-051. The second was an influenza A viral challenge study assessing the impact of treatment on host defence biomarkers and viral load. …”
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Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

“…To understand this enhanced in vivo effectiveness, Blimp-1 KO CAR T cells were characterized after being repeatedly challenged with tumor cells in vitro. In this setting, Blimp-1 KO CAR T cells maintained a highly active state with high expression of memory markers, but, crucially, demonstrated enhanced effector function and increased energetic capacity. …”
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Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant... by Azadeh Kiumarsi, Amirarsalan Alaei, Mohsen Nikbakht, Saeed Mohammadi, Mohammad Reza Ostad-Ali, Zahra Rasti, Tahereh Rostami

“…Complete donor chimerism was assessed using the short tandem repeat (STR) PCR technique. By day +28 after the transplant, the expression of the leukocyte adhesion molecules CD18, CD11b, and CD11c on the patient’s peripheral blood neutrophils had recovered to over 99%. …”
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Structure of a Sulfated Capsular Polysaccharide from the Marine Bacterium <i>Cobetia marina</i> KMM 1449 and a Genomic Insight into Its Biosynthesis by Maxim S. Kokoulin, Yulia V. Savicheva, Alina P. Filshtein, Ludmila A. Romanenko, Marina P. Isaeva

“…The following new structure of the CPS from <i>C. marina</i> KMM 1449 was established and consisted of sulfated and simultaneously phosphorylated disaccharide repeating units: →4)-α-L-Rha<i>p</i>2S-(1→3)-β-D-Man<i>p</i>6PGro-(1→. …”
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Optimized framework for evaluating F3 transgressive segregants in cayenne pepper by Ifayanti Ridwan, Muh Farid, Feranita Haring, Nuniek Widiayani, Ahmad Yani, Nirwansyah Amier, Muhammad Alfan Ikhlasul Amal, Jekvy Hendra, Nawab Ali, Mekhled Mohamed Alenazi, Mahmoud F. Seleiman, Willy Bayuardi Suwarno, Muhammad Fuad Anshori

“…This research was designed with a randomized completed block design with 16 transgressive segregant genotypes and three check varieties. Each genotype was repeated three times, resulting in 57 experimental units. …”
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Five-year carry-over effects in dune slack vegetation response to hydrology by Lisanne van Willegen, Hilary Wallace, Angela Curreli, Ciara Dwyer, John Ratcliffe, Davey L. Jones, Graham Williams, Martin Hollingham, Laurence Jones

“…The data were drawn from 453 relevées in 17 dune slacks, using permanent quadrats and co-located piezometers, set up in 2010 with vegetation monitoring repeated six times until 2019. Within our study we found a strong relationship between multiple hydrology metrics and the plant community response, but this displayed inter-annual variation with different patterns and correlations between years. …”
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Return to play following craniotomy for non-traumatic brain lesions by Jovanna A. Tracz, Matthew L. Farmer, Mark Hughes, Debraj Mukherjee, Paul M. Brennan

“…Future work to develop consensus guidelines will benefit from objective data about outcomes, particularly in relation to repeat imaging prior to RTP.…”
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Chaetoceros muelleri sulfated polysaccharides: chain conformation, physical characteristics, and morphology by Valeria Miranda-Arizmendi, Jorge Marquez-Escalante, Agustin Rascon-Chu, Karla Martínez-Robinson, Francisco Brown-Bojorquez, Elizabeth Carvajal-Millan

“…The biopolymer registered weight-average molar mass, intrinsic viscosity ([η]), radius of gyration (RG), hydrodynamic radius (Rh), and sulfate degree of substitution of 1933 kDa, 577 mL/g, 62 nm, 44 nm, and 0.5 (sulfates per disaccharide repeat unit), respectively. The exponent α and the coefficient K in the Mark-Houwink-Sakurada (MHS) equation were 0.76 and 9.76 x 10−3 mL/g, respectively. …”
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A Case of Ileocecal IgG4-Related Sclerosing Mesenteritis Diagnosed by Endoscopic Ultrasound-Guided Fine Needle Aspiration using Forward-Viewing Linear Echoendoscope by Yuichi Takano, Fumitaka Niiya, Takahiro Kobayashi, Eiichi Yamamura, Naotaka Maruoka, Tomoko Norose, Nobuyuki Ohike, Masatsugu Nagahama

“…The patient experienced abdominal pain for 4 days with repeated vomiting episodes; therefore, she was transferred to our hospital by an ambulance. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Prokinetics can be used in combination with PPIs for their properties to recover normal functionality of esophagus through affecting pathogenetic mechanisms of GERD.Complicated patients (repeated bleedings, peptic esophageal strictures) are recommended anti-reflux surgery with prior examination of esophageal functionality using pH-impedance and high-resolution manometry.Conclusion. …”
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Evaluation of throwing ability after coracoid transfer in non-overhead athletes by Ryota Yokoi, DP, Takayuki Kawasaki, MD, PhD, Yuuki Hirai, DP, Hiroki Tanabe, MD, Tomohiko Tateishi, MD, PhD, Nobukazu Maki, DP, Daichi Morikawa, MD, PhD, Muneaki Ishijima, MD, PhD

“…In the primary analyses, we compared the maximum ball velocity and long-throw distance between the groups using the repeated 2-way analysis of variance. In secondary analyses, all other measurements were compared between the groups using the Mann–Whitney U test. …”
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Application of human-in-the-loop hybrid augmented intelligence approach in security inspection system by Ying Huang, Ying Huang, XiaoKan Wang, XiaoKan Wang, Yong Zhang, Yong Zhang, Li Chen, Li Chen, HongJi Zhang

“…Recognizing that humans excel at learning, reasoning, and collaborating, while artificial intelligence offers normative, repeatable, and logical processing, we propose a human-in-the-loop hybrid augmented intelligence approach. …”
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21st century Latin American synthetic peptides for their application in antivenom production by Jésica A. Rodríguez, Gabriela R. Barredo-Vacchelli, Joaquin A. Eloy, Silvia A. Camperi

“…The antivenoms used for its treatment are produced by immunizing horses repeatedly with sublethal doses of animal venoms along with the adjuvant. …”
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Effect of knee extension constraint training on walking biomechanics 6 months after anterior cruciate ligament reconstruction: a double-blind randomized controlled clinical trial by Tianyu Gao, Hongshi Huang, Yuanyuan Yu, Hui Liu, Yingfang Ao

“…The peak for knee flexion angle (KFA), knee extension moment (KEM), and vertical ground reaction force (vGRF) were compared by 2 (time) x 3 (group) repeated-measures analysis of covariance (ANCOVA), and pairwise comparisons were conducted. . …”
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Genetic diversity atlas of Brucella melitensis strains from Sichuan Province, China by Wenbo Li, Linzi Zeng, Rongmei Yuan, Teng Qi, Hongyu Liao, Yuhangxi Cao, Shu Huang, Zhiguo Liu, Zhenjun Li

“…In this study, bacteriology, conventional bio-typing, multi-locus sequence typing (MLST), and multiple locus variable-number tandem repeat analysis (MLVA) were applied to preliminarily characterize the strains in terms of genetic diversity and epidemiological links. …”
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From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases by Qing Zhao, Linxin Wei, Youxin Chen

“…The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein (Cas) has emerged as a promising tool for treating ocular diseases through gene editing and expression regulation. …”
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Safety of Digestive Endoscopy following Acute Coronary Syndrome: A Systematic Review by Alastair Dorreen, Sarvee Moosavi, Myriam Martel, Alan N. Barkun

“…Overall, 108 peri- and postprocedural complications occurred (9.1%; 95% CI 7.6–10.9%), with hypotension (24.1%; 95% CI 17.0–32.9%), arrhythmias (8.1%; 95% CI 4.5–18.1%), and repeat ACS (6.5%; 95% CI 3.1–12.8%) as the most frequent. …”
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Analysis of different therapeutic schemes combining cyclophosphamide and doublestranded DNA preparation for eradication of Krebs-2 primary ascites in mice by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, A. V. Kozel, O. S. Taranov, V. V. Omigov, E. I. Vereschagin, D. B. Petrov, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…Further, we demonstrate that repeated rounds of CP+dsDNA injections result in dramatic anticancer effect. …”
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Transcranial direct current stimulation for patients with walking difficulties caused by cerebral small vessel disease: a randomized controlled study by Qiaoqiao Xu, Qiaoqiao Xu, Wenwen Yin, Xia Zhou, Shuo Wang, Sishi Chen, Jiajia Yang, Chunhua Xi, Zhongwu Sun

“…We investigated the effects of long-term, repeated tDCS on local brain perfusion, network connectivity, cognition, and gait in patients with CSVD and gait disorders (CSVD-GD).MethodsThis prospective, single-blind, multicenter, randomized controlled study enrolled 66 patients with CSVD-GD, categorized into the tDCS and Sham groups. …”
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