Major Adverse Kidney Events in Hospitalized Older Patients With Acute Kidney Injury: Machine Learning–Based Model Development and Validation Study by Xiao-Qin Luo, Ning-Ya Zhang, Ying-Hao Deng, Hong-Shen Wang, Yi-Xin Kang, Shao-Bin Duan

“…Major adverse kidney events within 30 days (MAKE30), a composite of death, new renal replacement therapy, or persistent renal dysfunction, has been recommended as a patient-centered endpoint for clinical trials involving AKI. …”
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Acute Kidney Injury Complicating Critical Forms of COVID-19: risk Factors and Prognostic Impact [version 3; peer review: 2 approved] by Ghadhoune Hatem, Yosra Yahia, Olfa Hammami, Hend Allouche, Insaf Trabelsi, Jihene Guissouma, Hana Ben Ali

“…Thirteen patients underwent renal replacement therapy and renal function improved in seven cases. …”
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Effect of acute kidney injury care bundle on kidney outcomes in cardiac patients receiving critical care: a systematic review and meta-analysis by Fatma Refaat Ahmed, Nabeel Al-Yateem, Seyed Aria Nejadghaderi, Rawia Gamil, Mohannad Eid AbuRuz

“…Abstract Background Cardiac surgery is a major contributor to acute kidney injury (AKI); approximately 22% of patients who undergo cardiac surgery develop AKI, and among them, 2% will require renal replacement therapy (RRT). AKI is also associated with heightened risks of mortality and morbidity, longer intensive care stays, and increased treatment costs. …”
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Effect of total intravenous-based immediate extubation on patient outcomes in adult liver transplantation: A retrospective cohort study by Yan-Jun Chu, Hui Zhang, Bing-Xin Jin, Yu-Fan Liu, Yong-Xing Yao

“…No significant differences in continuous renal replacement therapy use (2.86 % vs 13.08 %; odds ratio, 0.195; P = 0.088), early mortality rate, percentage reduction of bilirubin, the incidence of exploratory laparotomy, pneumonia, or thrombosis were observed between groups. …”
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Prognosis of Elderly Japanese Patients Aged ≥80 Years Undergoing Hemodialysis by Shingo Hatakeyama, Hiromi Murasawa, Itsuto Hamano, Ayumu Kusaka, Takuma Narita, Masaaki Oikawa, Daisuke Noro, Kazuhisa Hagiwara, Hirofumi Ishimura, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hisao Saitoh, Tomihisa Funyu, Chikara Ohyama

“…From January 1988 to July 2013, 1144 consecutive patients with end-stage renal disease required renal replacement therapy at our institution; of these, 141 were aged ≥80 years. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…She was transferred to our department and was given invasive respiratory support, blood transfusion, continuous renal replacement therapy, capacity management, and other comprehensive treatments. …”
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Risk factors for renal insufficiency and survival implications after radical nephrectomy and thrombectomy in renal cell carcinoma with tumor thrombus: a systematic review by Zhigao Huang, Zhuo Liu, Lin Zhuo, Xin Ma, Zhenbin Jiang, Kewei Chen, Jiyuan Chen, Yuxuan Li, Guoliang Wang, Xiaojun Tian, Hongxian Zhang, Lei Liu, Lulin Ma, Kai Hong, Shudong Zhang

“…Necessary managements like supplying blood volume, diuretic therapy and renal replacement therapy should be applied. Conclusions The present incidence of postoperative renal insufficiency was underestimated. …”
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Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward by Sung Won Chang, Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Jae Jeong Shim, Jae Kyeom Sim

“…Twenty-two patients received continuous renal replacement therapy (CRRT) in the Less 30 group, whereas none received it in the More 30 group (27.8% vs. 0%). …”
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The combination of kidney function variables with cell cycle arrest biomarkers identifies distinct subphenotypes of sepsis-associated acute kidney injury: a post-hoc analysis (the... by Dimitri Titeca-Beauport, Momar Diouf, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Yoann Zerbib, Christophe Vinsonneau, Kada Klouche, Julien Maizel

“…We then compared the subphenotypes with regard to a composite outcome of in-hospital death or the initiation of renal replacement therapy (RRT).Results We included 184 patients presenting SA-AKI within 6 h of the initiation of catecholamines. …”
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Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study by Wei Wei, Caihong Liu, Guojiao Song, Letian Yang, Jian Li, Bo Wang, Ting Yin, Yingying Yang, Liang Ma, Ling Zhang, Ping Fu, Yuliang Zhao

“…For secondary outcomes, patients with high ΔNLR had increased risk of 30-d mortality (p = 0.004), need for renal replacement therapy (p = 0.011), and developing stage-3 AKI (p = 0.040) according to the adjusted models.Conclusions High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. …”
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Pregnancy and Postpartum Trends in Self‐Measured Blood Pressure and Derived Indices: The BOSHI Study by Seiya Izumi, Misato Nishimura, Noriyuki Iwama, Hasumi Tomita, Hirotaka Hamada, Taku Obara, Mami Ishikuro, Takahisa Murakami, Michihiro Satoh, Takuo Hirose, Masatoshi Saito, Takayoshi Ohkubo, Shinichi Kuriyama, Nobuo Yaegashi, Kazuhiko Hoshi, Yutaka Imai, Hirohito Metoki, the BOSHI Study Group

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The predictive value of the serum creatinine-to-albumin ratio (sCAR) and lactate dehydrogenase-to-albumin ratio (LAR) in sepsis-related persistent severe acute kidney injury by Xiaoxiao Luo, Dongyang Liu, Cuicui Li, Jia Liao, Wuyang Lv, Yuchen Wang, Ruxue Diao, Yingyu Jin

“…The model's predictive ability for secondary outcomes, such as renal replacement therapy (RRT), also improved with the addition of the Log(sCAR)_Log(LAR) score. …”
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Peripheral versus central cannulation of VA-ECMO for primary graft dysfunction after heart transplantation: A systematic review and meta-analysis by Eduard Ródenas-Alesina, MD, Aleix Olivella, MD, Ani Orchanian-Cheff, MiST, Farid Foroutan, PhD, Yasbanoo Moayedi, MD, MSc, Vivek Rao, MD, PhD, Filio Billia, MD, PhD, Heather J. Ross, MD, MHSc, Ana Carolina Alba, MD, PhD, Natasha Aleksova, MD, MSc

“…Peripheral cannulation decreased the risk of bleeding but increased the risk of limb ischemia and infection, with similar rates of stroke and need for renal replacement therapy. Overall, certainty of evidence was low. …”
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HMGB1 lactylation drives neutrophil extracellular trap formation in lactate-induced acute kidney injury by Li Zhu, Li Zhu, Qiang Zheng, Xiaodong Liu, Xiaodong Liu, Hao Ding, Mengqing Ma, Jiaxin Bao, Yawen Cai, Changchun Cao

“…RationaleAcute kidney injury (AKI) is a clinical syndrome associated with a multitude of conditions. Although renal replacement therapy (RRT) remains the cornerstone of treatment for advanced AKI, its implementation can potentially pose risks and may not be readily accessible across all healthcare settings and regions. …”
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Low Molecular Weight Heparin Induced Skin Necrosis without Platelet Fall Revealing Immunoallergic Heparin Induced Thrombocytopenia by Thomas Godet, Sébastien Perbet, Aurélien Lebreton, Guillaume Gayraud, Sophie Cayot, Aymeric Tremblay, Aurélie Ravinet, Sébastien Christophe, Renaud Guérin, Julien Pascal, Matthieu Jabaudon, Amr Hassan, Anne-Françoise Sapin, Jean-Etienne Bazin, Jean-Michel Constantin

“…Low molecular weight heparins (LMWH) are commonly used in the ICU setting for thromboprophylaxis as well as curative decoagulation as required during renal replacement therapy (RRT). A rare adverse event revealing immunoallergic LMWH induced thrombopenia (HIT) is skin necrosis at injection sites. …”
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Very low urinary marinobufagenin excretion reflects a high risk of disease progression in non-advanced CKD by Davide Bolignano, Davide Bolignano, Marta Greco, Marta Greco, Loredana Tripodi, Mario D’Agostino, Paola Cianfrone, Roberta Misiti, Roberta Misiti, Sara Pugliese, Mariateresa Zicarelli, Michela Musolino, Michela Musolino, Daniela Patrizia Foti, Daniela Patrizia Foti, Michele Andreucci, Michele Andreucci, Giuseppe Coppolino, Giuseppe Coppolino

“…The study (renal) endpoint was a composite of serum creatinine doubling, eGFR decline >25% from baseline values, or ESKD requiring chronic renal replacement therapy.ResultsDuring follow-up (mean 21 months), 32.4% of patients had progressive CKD. …”
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Cerium-based nanoplatform for severe acute pancreatitis: Achieving enhanced anti-inflammatory effects through calcium homeostasis restoration and oxidative stress mitigation by Tingyi Luo, Yujing Tang, Wangcheng Xie, Zhilong Ma, Jian Gong, Yonggui Zhang, Tingsong Yang, Xuyang Jia, Jia Zhou, Zhengyu Hu, Lin Han, Qigang Wang, Zhenshun Song

“…Current therapeutic approaches, including antibiotics, trypsin inhibitors, fasting, rehydration, and even continuous renal replacement therapy, yield limited clinical management efficacy. …”
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Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease S... by V. T. Ivashkin, V. P. Chulanov, N. A. Mamonova, M. V. Maevskaya, M. S. Zharkova, I. N. Tikhonov, P. O. Bogomolov, E. V. Volchkova, A. S. Dmitriev, O. O. Znojko, E. A. Klimova, K. V. Kozlov, I. E. Kravchenko, E. Yu. Malinnikova, R. V. Maslennikov, M. I. Mikhailov, K. E. Novak, I. G. Nikitin, V. E. Syutkin, E. V. Esaulenko, A. A. Sheptulin, E. N. Shirokova, N. D. Yushchuk

“…The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. …”
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TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se... by Sophie Zaloumis, Matthew J. Summers, Jeffrey J. Presneill, Rinaldo Bellomo, Lee-anne S. Chapple, Marianne J. Chapman, Adam M. Deane, Suzie Ferrie, Craig French, Sally Hurford, Nima Kakho, Matthew J. Maiden, Stephanie N. O’Connor, Sandra L. Peake, Emma J. Ridley, An Tran-Duy, Patricia J. Williams, Paul J. Young, Amalia Karahalios, on behalf of the TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group

“…Secondary outcomes include proportion of patients alive at day 90, survivor-only analysis of days free of the index hospital at day 90, duration of invasive ventilation, ICU and hospital length of stay, incidence of tracheostomy insertion, renal replacement therapy, and discharge destination. The statistical methods and models which will be used to estimate the effects for the primary and secondary outcomes are described. …”
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Assessing the role of Chemokine (C–C motif) ligand 14 in AKI: a European consensus meeting by Jay L. Koyner, Christian Arndt, Jaume Baldira Martinez de Irujo, Sílvia Coelho, Manuel Garcia-Montesinos de la Peña, Luca di Girolamo, Michael Joannidis, Pablo Jorge-Monjas, Christian Koch, Steven Lobaz, Alain Meyer, Marlies Ostermann, Nicoletta Pertica, John R. Prowle, Jon Silversides, Alexander Zarbock, Jorge Echeverri, Kai Harenski, Lui G. Forni

“…The highest level of concern to modify the treatment plan was for discussions on renal replacement therapy (RRT) initiation for CCL14 levels > 13 ng/mL. …”
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