Hereditary Tyrosinemia Type 1 in Jordan: A Retrospective Study by Noor A. Megdadi, Ahmad K. Almigdad, Mo’men O. Alakil, Shahrazad M. Alqiam, Sumaia G. Rababah, Moshera A. Dwiari

“…The accumulation of tyrosine toxic metabolites leads to progressive hepatic, renal, and neurological manifestations. Treatment of HT1 consists of tyrosine-restricted diets and nitisinone. …”
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Research Progress on the Pathological Mechanisms of Podocytes in Diabetic Nephropathy by Lili Zhang, Zhige Wen, Lin Han, Yujiao Zheng, Yu Wei, Xinmiao Wang, Qing Wang, Xinyi Fang, Linhua Zhao, Xiaolin Tong

“…Diabetic nephropathy (DN) is not only an important microvascular complication of diabetes but also the main cause of end-stage renal disease. Studies have shown that the occurrence and development of DN are closely related to morphological and functional changes in podocytes. …”
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Mechanistic insights toward progress in alogliptin beyond glycemic control: translational perspective by Faraha Ahmed, Syed Sufian Ahmad, M. Mumtaz Alam, M. Shaqiquzzaman, Abul Kalam Najmi, Mohammad Ahmed Khan

“…It has a good safety profile, well-tolerated in elderly patients and in patients with co-morbid conditions including risks of cardiovascular event, renal or hepatic insufficiency. Therefore, alogliptin is incessantly experimented and investigated for its therapeutic benefit. …”
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Successful Resection of Isolated Para-Aortic Lymph Node Recurrence from Advanced Sigmoid Colon Cancer following 156 Courses of FOLFIRI Regimen by Kaoru Takeshima, Kazuo Yamafuji, Atsunori Asami, Hideo Baba, Nobuhiko Okamoto, Hidena Takahashi, Chisato Takagi, Kiyoshi Kubochi

“…Four years after the operation, computed tomography (CT) revealed an enlarged PLN below the left renal vein. As PLN enlarged to 15 mm in the minor axis on a CT scan in 2014 after receiving a total of 156 courses of the FOLFIRI regimen, we considered the enlarged PLN to represent an isolated metastasis. …”
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Clustering long-term health conditions among 67728 people with multimorbidity using electronic health records in Scotland. by Adeniyi Francis Fagbamigbe, Utkarsh Agrawal, Amaya Azcoaga-Lorenzo, Briana MacKerron, Eda Bilici Özyiğit, Daniel C Alexander, Ashley Akbari, Rhiannon K Owen, Jane Lyons, Ronan A Lyons, Spiros Denaxas, Paul Kirk, Ana Corina Miller, Gill Harper, Carol Dezateux, Anthony Brookes, Sylvia Richardson, Krishnarajah Nirantharakumar, Bruce Guthrie, Lloyd Hughes, Umesh T Kadam, Kamlesh Khunti, Keith R Abrams, Colin McCowan

“…We identified five distinct clusters of conditions in the population with multimorbidity: alcohol misuse, cancer, obesity, renal failure, and heart failure. Clusters of long-term conditions differed by age, sex and socioeconomic deprivation, with some clusters not present for specific strata and others including additional conditions. …”
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Sestrin2 Signaling Pathway Regulates Podocyte Biology and Protects against Diabetic Nephropathy by Moein Ala

“…Consistently, overexpression of Sestrin2 ameliorated podocyte injury, mesangial proliferation, proteinuria, and renal fibrosis in animal models of diabetic nephropathy. …”
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Diabetes-Resistant NOR Mice Are More Severely Affected by Streptozotocin Compared to the Diabetes-Prone NOD Mice: Correlations with Liver and Kidney GLUT2 Expressions by S. Kahraman, C. Aydin, G. O. Elpek, E. Dirice, A. D. Sanlioglu

“…We also detected GLUT2 expression profiles in NOD and NOR hepatic and renal tissues by western blot analysis and observed considerably higher GLUT2 expression levels in liver and kidney tissues of NOR mice. …”
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The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy by Kosuke Yamahara, Mako Yasuda, Shinji Kume, Daisuke Koya, Hiroshi Maegawa, Takashi Uzu

“…Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. …”
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Diagnostic Challenge in a Patient with Severe Anion Gap Metabolic Acidosis by Eugene M. Tan, Ejaaz Kalimullah, M. Rizwan Sohail, Kannan Ramar

“…The approach to the patient with acute renal failure and elevated anion and osmolal gap is difficult. …”
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An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy by Vinay Minocha, Raafat Makary, Andreea Poenariu

“…Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0–20 units). A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. …”
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Following Clinical Practical Guidelines in Patients with Acute Myocardial Infarction with St Segment Elevation and its Relation with Clinical and Demographic Variables by Francisco de Jesús Valladares Carvajal, Yordano Carlos Ravelo Coma, Lázaro de la Cruz Avilés, Mario Isaac González

“…Regarding co-morbidities, the highest percentage of adequate adhesion corresponded to hypertension (77,2 %) and the lowest (69,0 %) to chronic renal disease. <strong><br />Conclusion:</strong> a high percentage of ¨graded adequate¨ in adhesion to clinical and practical guidelines was found in patients with acute myocardial infarction and ST segment elevation in the period of study, either in the total of patients so as in any age, sex, co-morbidities selected, discharged alive and deceased groups.…”
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The Efficacy of On-Site Integration Screening and Microelimination Programs for Chronic Hepatitis C in a Detection Center: A Comparison of the Treatment Outcomes and Characteristic... by Hsuan-Yuan Chang, Su-Hung Wang, Hsing-Tao Kuo, Ming-Jen Sheu, I-Che Feng, Chung-Han Ho, Jui-Yi Chen, Chi-Shu Sun, Chi-Hsing Chen, Cheng-Yi Lin, Chun-Chi Yang

“…The patients in the two groups did not differ significantly in terms of age, FIB-4 score, HCV RNA, HBV coinfection, hemogram findings, coagulation profiles, and renal function tests. However, the patients in the incarcerated group had a significantly different genotype distribution compared to the control group, significantly lower liver enzyme levels, and higher albumin and bilirubin levels compared to those in the control group. …”
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Sex Differences in the Relation between Comorbidities and Prognosis in Hospitalized Patients with COVID-19 by Noushin Mohammadifard, Fahimeh Haghighatdoost, Maryam Nasirian, Parisa Zakeri, Kamal Heidari, Shaghayegh Haghjooy Javanmard, Nizal Sarrafzadegan

“…Data on preexisting comorbid NCDs including hypertension, coronary heart disease (CHD), diabetes mellitus (DM), cancers, chronic renal disease (CRD), and chronic respiratory disease were collected through self-reported questionnaires. …”
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Targeting Fibrosis: From Molecular Mechanisms to Advanced Therapies by Xingpeng Di, Ya Li, Jingwen Wei, Tianyue Li, Banghua Liao

“…In this review, the organ‐specific molecular mechanisms of fibrosis is systematically summarized, including cardiac fibrosis, hepatic fibrosis, renal fibrosis, and pulmonary fibrosis. Some important signaling pathways associated with fibrosis are also introduced. …”
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Repair of Thoracoabdominal Aortic Aneurysm with Thrombosed Infrarenal Component: A Modified Hybrid Technique without Aortic Cross Clamping by Hussam Abou-Al-Shaar, Khaled J. Zaza, Muhammad Anees Sharif, Samer Koussayer

“…A single-stage, modified hybrid procedure involving an aortobifemoral bypass without aortic clamping, debranching of right renal, superior mesenteric, and celiac arteries as well as an endovascular repair of the thoracic aneurysm was performed. …”
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Treatment approaches for idiopathic retroperitoneal fibrosis: a systematic review with meta-analysis by Annik Steimer, Mike O. Becker

“…The lack of homogeneous data prevented a subgroup analysis for the primary outcome “improvement in renal function.” Results The search resulted in a total of 3818 articles, of which 108 were selected for qualitative analysis involving a total of 1408 patients. …”
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Proton Pump Inhibitor-Induced Galactorrhea in a Kidney Transplant Recipient: A Friend or Foe? by Marios Prikis, Julie MacDougall, Nina Narasimhadevara

“…In the setting of renal dysfunction, these metabolites will not be excreted from the body and will accumulate further causing kidney damage and inhibiting CYP enzymes to a greater extent. …”
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Acute Kidney Injury Caused by Superior Mesenteric Artery Syndrome by Nur Ezzaty Mohammad Kazmin, Lydia Kamaruzaman, Zhiqin Wong, Voon Ken Fong, Rozita Mohd, Ruslinda Mustafar

“…He was subsequently weaned off dialysis support as his renal function gradually improved and later on normalised. …”
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An Investigation of Electrospun Clerodendrum phlomidis Leaves Extract Infused Polycaprolactone Nanofiber for In Vitro Biological Application by Siranjeevi Ravichandran, Rajesh Jegathaprathaban, Jeyalakshmi Radhakrishnan, R. Usha, V. Vijayan, Aklilu Teklemariam

“…PCL-CPM mats exposed to oral cancer (HSC-3) and renal cell carcinoma (ACHN) cell lines displayed promising anticancer activity with less than 50% survival rate after 24 h of incubation. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay performed on PCL-CPM nanofibers revealed the antioxidant scavenging activity with maximum inhibition of 34% suggesting the role of the secondary metabolites release from scaffold. …”
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Características clínicas de pacientes con Lupus Eritematoso Sistémico, al debut y en recaídas by Dora Montiel Jarolin, Margarita Samudio

“…La mayoría de las pacientes eran mujeres jóvenes que debutaron la enfermedad con artralgias, seguida de la afectación renal. Las recaídas se presentaron con nefritis. …”
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