A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications by Francesca Conserva, Loreto Gesualdo, Massimo Papale

“…Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20–40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive impairment of glomerular filtration and the development of Kimmelstiel-Wilson lesions leading to end-stage renal failure (ESRD). The causes and molecular mechanisms mediating the onset of T2DM chronic complications are yet sketchy and it is not clear why disease progression occurs only in some patients. …”
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Patellar Tendon Rupture after Lateral Release without Predisposing Systemic Disease or Steroid Use by S. De Giorgi, A. Notarnicola, G. Vicenti, B. Moretti

“…Nevertheless, in case of systemic diseases (LES, rheumatoid arthritis, and chronic renal insufficiency) that can weaken collagen structures, bilateral patellar tendon ruptures are described. …”
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Relapse of Multiple Myeloma Presenting as Extramedullary Plasmacytomas in Multiple Organs by Murat Köse, Ersida Buraniqi, Timur Selçuk Akpinar, Seyit Mehmet Kayacan, Tufan Tükek

“…Some patients have slowly progressive disease while others have aggressive clinical behavior by extramedullary involvement. In addition to renal failure, anemia, hypercalcemia, lytic bone lesions, and immunodeficiency, it also affects multiple organ system, such as pancreas, adrenal glands, kidney, skin, lung, liver, spleen, lymph nodes, and bone. …”
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Traumatic Page Kidney Induced Hypertension in Critical Care: Immediately Resolved or Long-Term Resistant Problem by E. Brotfain, L. Koyfman, A. Frenkel, A. Smolikov, A. Zlotnik, M. Klein

“…Page kidney is a well-known phenomenon causing hypertension, due to compression of renal parenchyma by a subcapsular hematoma, of either traumatic or non-traumatic origin. …”
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Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report by Tomohiko Asakawa, Mea Asou, Shigeo Hara, Takashi Ehara, Makoto Araki

“…Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. …”
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Giant Ectopic Ureter Mimicking Pelvic Organ Prolapse: A Case Report by Adnan Simsir, Fuat Kizilay, Bilbasar Yildiz, Oktay Nazli

“…In such cases with nonfunctioning renal segment draining proximally, the chance of cure can be obtained without a need for a comprehensive intervention such as total abdominal ureterectomy.…”
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Bullous Lupus: An Atypical Case of Refractory Disease in a Patient with Sulfa Allergy by Maria Salgado Guerrero, Oscar Mena Miranda, Ana B. Arevalo, Nevena Barjaktarovic, Barbara Mendez

“…In this case report, we present a case of a 22-year-old African American woman with BSLE and impaired renal function with subsequent nephrotic range proteinuria concerning for lupus nephritis and autoimmune hemolytic anemia, refractory to systemic corticosteroids, immunoglobulin, and mycophenolate mofetil, requiring dapsone after careful desensitization due to prior history of angioedema with sulfa drugs. …”
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Resistant Hypertension in Nondialysis Chronic Kidney Disease by Silvio Borrelli, Luca De Nicola, Giovanna Stanzione, Giuseppe Conte, Roberto Minutolo

“…Recently we have demonstrated that “true” RH represents an independent risk factor for renal and cardiovascular outcomes in CKD patients.…”
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Case of the Diffuse Form of Xanthogranulomatous Pyelonephritis by Tateki Yoshino, Hiroyuki Moriyama

“…Abdominal CT revealed left hydronephrosis with staghorn renal calculi and thin cortex of the left kidney. …”
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Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney by Zechen Wang, Jiajia Shen, Kun Ye, Jingjie Zhao, Shaoang Huang, Siyuan He, Yujuan Qin, Lingzhang Meng, Jie Wang, Jian Song

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Advances in sodium-glucose transporter protein 2 inhibitors and tumors by Jiaqi Wang, Wenyong Yang

“…Sodium-glucose transporter protein 2 (SGLT2) inhibitors are a new type of glycemic control drugs, which are widely used in clinical practice because of their effects on weight reduction and protection of cardiac and renal functions. SGLT2 has been found to be overexpressed in many tumors and involved in tumorigenesis, progression and metastasis, suggesting that SGLT2i has a wide range of applications in tumor therapy. …”
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HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature by Michael J. Grant, Mitchell E. Horwitz

“…The existing literature links GAVE to patients with cirrhosis, scleroderma, bone marrow transplantation, and chronic renal failure among other associations, but its pathophysiology remains ill-defined. …”
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Solitary Pulmonary Nodule: A Diagnostic Dilemma by Pardeep Masuta, Ioana Amzuta

“…She had negative rheumatological testing including MPO ANCA, PR-3 ANCA, and rheumatoid factor. She did not have renal failure, hemoptysis, weight loss, arthralgia, or upper airway inflammation. …”
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Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus by Ranadheer R. Dande, Vasil Peev, Mehmet M. Altintas, Jochen Reiser

“…Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) worldwide. DN typically manifests by glomerular hyperfiltration and microalbuminuria; then, the disease progresses to impaired glomerular filtration rate, which leads to ESRD. …”
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Features of pregnancy after simultaneous pancreas-kidney transplantation in patient with type 1 diabetes mellitus. Case report by Madina I. Yevloyeva, Darya U. Savitskaya, Anastasia S. Severina, Minara S. Shamkhalova, Natalia P. Trubitsyna, Marina V. Shestakova

“…Simultaneous pancreas and kidney transplantation the best way to restore normoglycemia and renal function in patients with type 1 diabetes mellitus and terminal chronic kidney disease. …”
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Cytokines in Endocrine Dysfunction of Plasma Cell Disorders by Eva Feigerlová, Shyue-Fang Battaglia-Hsu

“…Monoclonal gammopathies (MG) are classically associated with lytic bone lesions, hypercalcemia, anemia, and renal insufficiency. However, in some cases, symptoms of endocrine dysfunction are more prominent than these classical signs and misdiagnosis can thus be possible. …”
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Terapi Denervasi Ginjal pada Pasien Hipertensi Resisten by Meidianaser Putra, Yerizal Karani

“…Insidensnya berkisar antara 5 – 30% dengan 10% di antaranya yang termasuk kategori resisten sesungguhnya (true resistant), lebih sering pada wanita, kelompok lansia, obesitas, diabetes, dan insufisiensi renal. Terapi denervasi ginjal dilakukan dengan “membakar” secara permanen sebagian besar saraf simpatetik ginjal, sehingga menjadi alternatif terapi yang dapat dilakukan untuk mengontrol tekanan darah pasien. …”
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Heterogeneity in NK Cell Subpopulations May Be Involved in Kidney Cancer Metastasis by Zhengfang Liang, Fengwei Nong, Jingjie Zhao, Dalong Wei, Qianli Tang, Jian Song, Lingzhang Meng

“…In this study, natural killer (NK) cell populations were isolated using signature genes from the single-cell sequencing data of clear cell renal cell carcinoma (ccRCC) and normal kidney tissues and divided into three subpopulations according to the differences in gene expression profiles: NK(GZMH), NK(EGR1), and NK(CAPG). …”
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Exacerbation of Congenital Hydronephrosis as the First Presentation of COVID-19 Infection in Children by Masoumeh Mohkam, Mahnaz Jamee, Farshid Kompani, Mitra Khalili, Atena Seifi, Leily Mohajerzadeh

“…Infection with COVID-19 in children with antenatal hydronephrosis may exacerbate the degree of hydronephrosis and renal APD in ultrasonography, which itself may be mediated by the increase in inflammatory mediators.…”
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Unexpected Abscess Localization of the Anterior Abdominal Wall in an ADPKD Patient Undergoing Hemodialysis by Nikos Sabanis, Eleni Paschou, Eleni Gavriilaki, Maria Mourounoglou, Sotirios Vasileiou

“…Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders and the leading inheritable cause of end-stage renal disease worldwide. Cystic and noncystic extrarenal manifestations are correlated with variable clinical presentations so that an inherited disorder is now considered a systemic disease. …”
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