Association of uric acid with the decline in estimated glomerular filtration rate in middle-aged and elderly populations: evidence based on the China Health and Retirement Longitud... by Ying Liang, Ming Lei, Liu Lin, Peijia Liu, Sini Cui, Kaiyuan Hu, Xinning Shao

“…Objective Whether uric acid (UA) has an effect on renal function remains controversial. We aimed to investigate the association between serum UA with the decline in estimated glomerular filtration rate (eGFR) in middle-aged and elderly populations in the China Health and Retirement Longitudinal Study (CHARLS).Design Longitudinal cohort study.Setting This was a second analysis of a public dataset (CHARLS).Participants In this study, 4538 middle-aged and elderly individuals were screened after removing individuals younger than 45 years old, with kidney disease, malignant tumour and missing values.Outcome measures Blood tests were performed both in 2011 and 2015. …”
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The Role of Humoral Alloreactivity in Liver Transplantation: Lessons Learned and New Perspectives by Elaine Y. Cheng

“…In this article the evidence on the clinicopathologic effects of donor-specific alloantibodies in liver transplantation will be examined and interpreted in parallel with lessons learned from renal transplantation. The unique anatomic and immunologic features of the liver will be reviewed to gain new insights into the complex interactions between humoral immune system and the liver allograft.…”
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Spontaneous Tumor Lysis Syndrome due to Uterine Leiomyosarcoma with Lung Metastases by Vivek Alaigh, Debapriya Datta

“…These metabolic derangements can lead to seizures, cardiac arrhythmias, renal failure, and death. TLS is usually seen after the initiation of chemotherapy for hematologic malignancies. …”
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The Hidden Cost of Untreated Paragangliomas of the Head and Neck: Systemic Reactive (AA) Amyloidosis by Erkan Dervisoglu, Murat Ozturk, Mehmet Tuncay, Gulhatun Kilic Dervisoglu, Yesim Gurbuz, Serhan Derin

“…He refused radiotherapy and renal replacement therapy. Paragangliomas, although rare, should be considered one of the tumors that can result in AA amyloidosis.…”
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Dermatomyositis Sine Myositis with Membranoproliferative Glomerulonephritis by Mohammad Bagher Owlia, Roya Hemayati, Shokouh Taghipour Zahir, Mohammad Moeini Nodeh

“…Pathological examination of renal biopsy showed membranoproliferative glomerulonephritis. …”
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Lower Gastrointestinal Bleeding in Chronic Hemodialysis Patients by Fahad Saeed, Nikhil Agrawal, Eugene Greenberg, Jean L. Holley

“…We review the literature on common causes of lower gastrointestinal bleeding (LGI) in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. We suggest an approach to diagnosis and management of this problem.…”
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Prune Belly Syndrome in a Female Newborn following In Vitro Fertilization-Induced Pregnancy: A Case Report and Literature Review by Ibraheem M. Alkhawaldeh, Jaber H. Jaradat, Mohammad Al-Jafari, Abdulqadir J. Nashwan, Samer Irshaid Alrahamneh

“…Clinical symptoms can range from stillbirth to significant renal and respiratory abnormalities to almost normal children. …”
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A Rare Case of Extensive Eggshell Intestinal Wall Peritoneal Calcification in a Long-Term Continuous Peritoneal Dialysis Patient by Erasmia Sampani, Chrysostomos Dimitriadis, Efstratios Kasimatis, Evangelos Memmos, Aikaterini Papagianni

“…We report a case of a 55-year-old female patient with Down syndrome and end-stage renal disease (ESRD) on long-term peritoneal dialysis (PD) with extensive intestinal peritoneal calcifications and a rather uncomplicated long follow-up.…”
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An 11-Year-Old Child with Autosomal Dominant Polycystic Kidney Disease Who Presented with Nephrolithiasis by Fatih Firinci, Alper Soylu, Belde Kasap Demir, Mehmet Turkmen, Salih Kavukcu

“…The rate of nephrolithiasis in these patients is 5–10 times the rate in the general population, and both anatomic and metabolic abnormalities play role in the formation of renal stones. However, nephrolithiasis is rare in childhood age group. …”
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Pancreatitis with Electrocardiographic Changes Mimicking Acute Myocardial Infarction by Paul Khairy, Pierre Marsolais

“…A 64-year-old woman with mild acute pancreatitis presented with epigastric pain, nausea and vomiting while undergoing hemodialysis for chronic renal insufficiency. Serial electrocardiograms revealed new onset ST segment elevations in leads V2 to V4 mimicking an anterior myocardial infarction, followed by diffusely inverted deep T waves. …”
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Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature by Gunjan Shah, Hanah Yamin, Hedy Smith

“…Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. …”
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A Case of Congenital Cutis Laxa (Generalized Elastolysis) by Paul Champion, Frank Ryan

“…The authors report a patient who had end-stage renal failure related to heavy chain disease, a recognized association of cutis laxa. …”
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Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient by Jana Lass, Kadri Tamme, Karin Kipper, Joel Starkopf

“…We demonstrate that ertapenem 1,5 g i.v. once daily provided adequate drug exposure for susceptible bacteria in a 250 kg patient with normal renal function. The case suggests the usefulness of therapeutic drug monitoring of antibiotics, especially in critically ill patients.…”
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Hypothyroidism Complicating Nephropathy in a Diabetes Patient by Jayaprakash Sahoo, Ilangovan Veerappan, Anila Abraham, Somasundaram Hariharan

“…Both hypothyroidism and rhabdomyolysis were asymptomatic in this case as evidenced by lack of classical clinical features of hypothyroidism despite elevated serum TSH and absent pigment cast in renal biopsy. The combination of diabetes mellitus and hypothyroidism is common in the general population and should not be forgotten in patients with diabetes and kidney disease.…”
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Behçet Disease-Like Symptoms with a Novel COPA Mutation by E. Anderson, J. Hatch, J. Cardinal, D. Langguth, D. Coman

“…The clinical phenotype of COPA syndrome primarily comprised pulmonary disease, arthritis, and renal disease secondary to immune dysregulation, with onset of symptoms commonly in the first decade of life. …”
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The History of Cystinosis: Lessons for Clinical Management by Paul Goodyer

“…Major conceptual break-throughs include (a) its discovery in 1903, (b) recognition of the renal Fanconi syndrome, (c) realization that tissue accumulation of cystine reflects a defective channel in the lysosomal membrane, (d) translation of this discovery to trials of cysteamine, (e) discovery of the CTNS gene, and (f) report of successful stem cell therapy in the cystinotic mouse. …”
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Thrombotic Thrombocytopenic Purpura: A Case Presenting with Acute Ischemic Colitis by Joseph R. H. See, Tarek Sabagh, Christopher J. Barde

“…Thrombotic thrombocytopenic purpura (TTP) consists of the pentad of thrombocytopenia, hemolytic anemia, fever, neurologic abnormalities, and renal disease. We present a case report of acute TTP following a bout of ischemic colitis. …”
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Posttransplant Lymphoproliferative Disease Presenting as an Extracranial Mass by Reuben J. Arasaratnam, Alejandro Restrepo

“…Early recognition of the disease is important in facilitating timely therapy and improving long-term outcomes. We report a renal transplant recipient presenting with an extracranial frontoparietal soft tissue mass that was subsequently diagnosed as a B-cell lymphoma. …”
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When a Seemingly Harmless Prescription Turns into Toxicity by Zurab Azmaiparashvili, Kevin Bryan Lo, Nawal Habib, Annie Hsieh

“…Valacyclovir neurotoxicity is commonly seen in the elderly and those with impaired renal function. Differential diagnosis can be challenging as a myriad of medical conditions, including herpes zoster virus associated encephalitis, may present in a similar fashion. …”
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