Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…Results NR2 ameliorated albuminuria, renal function and renal pathology in db/db mice. …”
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Factors Associated with the Decline of Kidney Function Differ among eGFR Strata in Subjects with Type 2 Diabetes Mellitus by Shu Meguro, Masuomi Tomita, Yusuke Kabeya, Takeshi Katsuki, Yoichi Oikawa, Akira Shimada, Toshihide Kawai, Hiroshi Itoh, Yoshihito Atsumi

“…There is no report about risk factors for renal deterioration according to the clinical stage, divided by the estimated glomerular filtration rate (eGFR) in type 2 diabetes. …”
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Familial Adenomatous Polyposis and Desmoid Tumor Treated with Multivisceral Transplantation and Kidney Autotransplantation: Case Report and Literature Review by Libor Janousek, Robert Novotny, Michal Kudla, Martin Oliverius, Petr Wohl, Joan Minguet, Jan Martinek, Tomas Hucl, Jiri Fronek

“…In patients with DT closely associated with renal structures but without end-stage kidney disease, concomitant excision of the patient’s own kidney, ex vivo tumour resection with nephron-sparing surgery, or autotransplantation has been proposed. …”
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Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats by Vijay K. Bharti, R. S. Srivastava, H. Kumar, S. Bag, A. C. Majumdar, G. Singh, S. R. Pandi-Perumal, Gregory M. Brown

“…There were significantly P<0.05 high levels of lipid peroxidation and catalase and low levels of reduced glutathione, superoxide dismutase, glutathione reductase, and glutathione peroxidase in cardiac, hepatic, and renal tissues of F-treated rats. Administration of BEP and MEL in F-treated rats, however, significantly P<0.05 attenuated these adverse changes in all the target components of antioxidant defense system of cardiac, hepatic, and renal tissues. …”
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GADD45β Determines Chemoresistance and Invasive Growth of Side Population Cells of Human Embryonic Carcinoma by Toshihiko Inowa, Keiichi Hishikawa, Yumi Matsuzaki, Takayuki Isagawa, Takumi Takeuchi, Hiroyuki Aburatani, Tadaichi Kitamura, Toshiro Fujita

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Therapeutic Approaches in Mitochondrial Dysfunction, Inflammation, and Autophagy in Uremic Cachexia: Role of Aerobic Exercise by Yumei Zhang, Yuqing Liu, Xiao Bi, Chun Hu, Feng Ding, Wei Ding

“…C57BL/6J mice were randomly allocated into 3 different experimental groups: Sham, CKD, and CKD+aerobic exercise (CKD+AE). Renal function was assessed via serum creatinine and urea levels, and histological PAS and Masson staining were performed. …”
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A clinical study on the efficacy and safety of poly-herbal formulation in managing functional dyspepsia by Debasish Hota, Anand Srinivasan, Manas Kumar Panigrahi, Snigdha Suman Dalua, Poorva Tiwari, Ramachandran Valavan

“…Additionally, the study found no abnormal elevations in liver and renal function parameters in blood or any abnormal changes in hemogram, indicating the safety for use in patients with functional dyspepsia. …”
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JNK Signaling Pathway Suppresses LPS-Mediated Apoptosis of HK-2 Cells by Upregulating NGAL by Mei Han, Yuxia Pan, Mengying Gao, Junli Zhang, Fan Wang

“…The JNK signaling pathway inhibits LPS-mediated apoptosis of renal tubular epithelial cells by upregulating NGAL.…”
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Synergistic action between a synthetic cannabinoid compound and tramadol in neuropathic pain rats by Quiñonez-Bastidas Geovanna Nallely, Osuna-Martínez Ulises, Reda-Licea Ana Laura, López-Ortíz Manuel, Regla Ignacio, Navarrete Andrés

“…On the other hand, changes in renal and hepatic functions were not observed. Likewise, analysis of liver, kidney and heart histology showed no alterations compared with controls. …”
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The burden of Alagille syndrome: uncovering the potential of emerging therapeutics – a comprehensive systematic literature review by Philip Bufler, Robin Howard, Lucia Quadrado, Guy Lacey, Jolan Terner-Rosenthal, Andrea Goldstein, Pamela Vig, Deirdre Kelly

“…Clinical symptoms of cholestasis include debilitating pruritus, xanthomas, fatsoluble vitamin deficiencies, growth failure, renal disease and impaired health-related quality of life (HRQoL). …”

Bellini Duct Carcinoma Misdiagnosed with Urothelial Papillary Carcinoma by Joey El Khoury, Maher Abdessater, Rami Halabi, Fadi Nasr, Johnny Boustany, Anthony Kanbar, Charbel El Hachem, Raghid El Khoury

“…Computed tomography revealed a 5 cm solid mass of the left renal pelvis and multiple infracentimetric perihilar lymph nodes. …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

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Alterations in gut‐derived uremic toxins before the onset of azotemic chronic kidney disease in cats by Laurens Van Mulders, Ellen Vanden Broecke, Ellen De Paepe, Femke Mortier, Lynn Vanhaecke, Sylvie Daminet

“…Abstract Background Although gut‐derived uremic toxins are increased in azotemic chronic kidney disease (CKD) in cats and implicated in disease progression, it remains unclear if augmented formation or retention of these toxins is associated with the development of renal azotemia. Objectives Assess the association between gut‐derived toxins (ie, indoxyl‐sulfate, p‐cresyl‐sulfate, and trimethylamine‐N‐oxide [TMAO]) and the onset of azotemic CKD in cats. …”
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Elevated Urinary Connective Tissue Growth Factor in Diabetic Nephropathy Is Caused by Local Production and Tubular Dysfunction by Karin G. F. Gerritsen, Jan Willem Leeuwis, Maarten P. Koeners, Stephan J. L. Bakker, Willem van Oeveren, Jan Aten, Lise Tarnow, Peter Rossing, Jack F. M. Wetzels, Jaap A. Joles, Robbert Jan Kok, Roel Goldschmeding, Tri Q. Nguyen

“…Comparison of FE of endogenous and recombinant CTGF indicated that 60% of uCTGF had a direct renal source, while 40% originated from plasma CTGF. …”
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Pan-Cancer Analysis of Disulfidptosis-Related Genes Affecting Prognosis and Tumor Microenvironment by Jingyang SUN, Rongxuan JIANG, Liren HOU, Huanhuan DONG, Yihan LIN, Niuniu DONG, Guangjian ZHANG, Yanpeng ZHANG

“…ResultsLRPPRC, NCKAP1, NDUFS1, and NUBPL had a better prognosis in renal clear cell carcinoma (P<0.001), whereas SLC7A11, NCKAP1, and SLC3A2 had a worse prognosis in hepatocellular carcinoma (P<0.001). …”
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Acid-Base Balance in Healthy Adults: Beneficial Effects of Bicarbonate and Sodium-Rich Mineral Water in a Randomized Controlled Trial: The BicarboWater Study by Katharina Mansouri, Theresa Greupner, Edda van de Flierdt, Inga Schneider, Andreas Hahn

“…Changes in venous blood gas and urinary acid-base parameters were measured over a short-term (3 days) and long-term (28 days) intervention period. Potential renal acid load (PRAL) and nutrient intake were calculated at baseline and after 28 days. …”
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Basiliximab is superior to low dose rabbit anti-thymocyte globulin in pediatric kidney transplant recipients: The younger, the better by Lan Zhu, Lei Zhang, Wenjun Shang, Wenhua Liu, Rula Sa, Zhiliang Guo, Longshan Liu, Jinghong Tan, Hengxi Zhang, Yonghua Feng, Wenyu Zhao, Wenqi Cong, Jianyong Wu, Changxi Wang, Gang Chen, Sihan Zhou

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Poor Control of Plasma Triglycerides Is Associated with Early Decline of Estimated Glomerular Filtration Rates in New-Onset Type 2 Diabetes in China: Results from a 3-Year Follow-U... by Chuan Wang, Lingshu Wang, Kai Liang, Fei Yan, Xinguo Hou, Fuqiang Liu, Li Chen

“…Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD). Even after strict control of obesity, hyperglycemia, and hypertension, some patients still progress rapidly. …”
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Rationale and Design of RNAFH Study: Effect of Rosuvastatin (10 mg/d) on Nonalcoholic Fatty Liver in Metabolic Syndrome Patients without Overt Diabetes Evaluated by 1H-Magnetic Res... by Fan Ping, Xuan Wang, Jing Yang, Mei-cen Zhou, Wei Li, Ling-ling Xu, Yu-xiu Li

“…Safety indicators will be monitored such as liver function, renal function, muscle stability, and glucose metabolism. …”
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SPAGRM: effectively controlling for sample relatedness in large-scale genome-wide association studies of longitudinal traits by He Xu, Yuzhuo Ma, Lin-lin Xu, Yin Li, Yufei Liu, Ying Li, Xu-jie Zhou, Wei Zhou, Seunggeun Lee, Peipei Zhang, Weihua Yue, Wenjian Bi

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