Biologics for eosinophilic oesophagitis: a systematic review and meta-analysis by Beibei Zeng, Doudou Jia, Shengen Li, Xuna Liu, Boxu Zhu, Yanqi Zhang, Yan Zhuang, Fei Dai

“…Key outcomes of this meta-analysis include the following: Anti-IL-5 biologics exhibited statistically significant benefits in histological remission (RR 2.03 [CI 1.45–2.85]; p < 0.0001) compared to the placebo, but there was no significant difference in symptom relief (RR 1.06 [CI 0.88 to 1.28]; p = 0.53); anti-IL-4/13 biologics had significant effects on histologic improvement (RR 10.48 [CI 5.54–19.82]; p < 0.00001) and symptom related score reduction (RR 1.44 [CI 1.08–1.93]; p = 0.01), with a better outcome for endoscopic remission than with placebo (SMD–1.06 [CI–1.26–0.86], p < 0.00001); no statistically significant differences in adverse effects were observed between the intervention and control groups.Conclusions Our findings suggest that the biologics currently being investigated are considered safe and effective treatments for EoE, while their efficiency varies. …”
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Water Birth – Benefits, Risks, and Controversies by Julia Górny, Alicja Kapciak, Katarzyna Naja, Jakub Zwardoń, Artur Hawajski, Natalia Jankowska, Oliwia Kamieniecka, Adrianna Świerzyńska, Weronika Mazur, Natalia Pawelec

“… Introduction:  Water birth, involving immersion in water during childbirth, has gained popularity for its potential benefits, such as pain relief and comfort. While widely practiced in some countries, concerns regarding its safety, particularly for neonates, remain. …”
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The Acute VertEbRal AugmentaTion (AVERT) study: protocol for a randomised controlled, feasibility trial of spinal medial branch nerve block in hospitalised older patients with vert... by Avril Drummond, Opinder Sahota, Simon Bishop, Dritan Pasku, Apostolos Fakis, Anastasios Bastounis, Chia Wei Tan, Maribel Cameron, Yuriy Arlachov, Michal Czernicki

“…It is also costly and not readily accessible in many UK hospitals.A recent retrospective study reported that spinal medial branch nerve block (MBNB), typically used to treat facet arthropathy, had similar efficacy in terms of pain relief compared with VP for the treatment of painful VFF. …”
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Characteristics and Surgical Results of Patients with Hypertrophic Obstructive Cardiomyopathy without Intrinsic Mitral Valve Diseases Undergoing Mitral Subvalvular Procedures durin... by Qiang Ji, YuLin Wang, Ye Yang, LiMin Xia, WenJun Ding, Kai Song, ChunSheng Wang

“…During a median follow-up of 10 months, no deaths or reoperations were observed with the symptom of relief and NYHA class I or II in either group. Patients in the combined group as compared to the alone group had lower outflow tract gradients and a lower incidence of residual systolic anterior motion (SAM) syndrome. …”
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GEOMORPHIC RESPONSES TO LANDUSE CHANGES ON STEEP SLOPES IN TIMBERLINE ENVIRONMENT; CENTRAL ALPS, AUSTRIA by ERICH STOCKER

“…Die Wirkung der natürlichen Variablen auf die Prozesse des Abtrags wie Geologie, Klima, Relief, Boden und Vegetation kann sich dadurch deutlich verschieben. …”
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Research on shale dynamic and static elastic modulus and anisotropy based on pressurization history by Di Zhang, Di Zhang, YaFeng Li, YaFeng Li, YaNan Guo, YaNan Guo, HanLin Xia, HanLin Xia, YanXin Liu, YanXin Liu, JiaShen Yan, JiaShen Yan, Fei Wang, YinTing Wu

“…Dynamic and static stiffness coefficient, elastic modulus and acoustic wave velocity change under different directions of pressure and pressure relief. The results indicate that the P-wave velocity, fast shear wave velocity, slow shear wave velocity, dynamic and static Young’s modulus exhibit an increase as the confining pressure rises, and the parameters are greater during the unloading process than during loading process. …”
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Primary repair vs arthroscopic reconstruction for proximal anterior cruciate ligament tears: a comparative study by Sergey A. Gerasimov, Ekaterina A. Morozova, Daria A. Naida, Denis O. Kolmakov, Andrey A. Zykin, Ekaterina V. Khramtsova

“…Chondrolabral defects were observed in 15.5±0.04% of patients with primary repair, and in 10.5±0.03% of patients from the reconstruction group. Pain relief therapy in the form of opioid analgesics received 46.03±0.06% patients in Group 2 and 25.35±0.05% in Group 1 (p0.05). …”
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Medical insurance-related professionals’ identification of the benefits of the medical insurance system in Northeast China: a cross-sectional study by Zili Zhou, Huan Liu, Linghan Shan, Ye Li, Xin Zhang, Jiahui Wang, Zheng Kang, Mingli Jiao, Yanhua Hao, Yangguang Chen, Qunhong Wu

“…Four significant factors (P < 0.05) contributing to a high IBMIS include: “Relief of financial burden for people with serious diseases” (OR = 2.288, 95% CI: 1.740–3.007), “Medical insurance’s ability to address major problems that people expect” (OR = 1.565, 95% CI: 1.175–2.085), “Governance capacity of the medical insurance administrative agencies and management institutions” (OR = 1.472, 95% CI: 1.111–1.951), and “Effectiveness of governance for off-site medical reimbursement issues” (OR = 1.445, 95% CI: 1.036–2.014). …”
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Sushi Reverses Course: Consuming American Sushi in Tokyo by Matthew Allen, Rumi Sakamoto

“…The nascent American sushi trend brings into relief aspects of Japan-US relations that are seldom articulated in the context of discourse about food – in particular the continued symbolic dominance of the US in Japanese eyes;3 and it also is emblematic of how Japan engages aspects of globalisation, in this case fetishising a mundane product that has become something new in its reimported form. …”
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To cool or not to cool: understanding and improving cooling centre use in metro vancouver through community-based participatory action research by Liv Yoon, Giulia Belotti, Rachel Stern, Katherine White, Aida Mohajeri, Abby Zhou, Eduardo Rosales Miranda, Erika Siao, Thanh Le, Jeff Masuda, Eun-young Lee, Chris Buse

“…The paper recommends leveraging existing public spaces, enhancing social networks, improving tenant protections, and fostering ‘right to cool’ initiatives to balance immediate relief with long-term systemic reform, particularly around the rental housing crisis and tenant insecurity. …”
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Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain by Binglin Chen, Jiabao Guo, Chan Gong, Chenchen Zhu, Yang Wu, Shengbo Wang, Yili Zheng, Haixia Lu

“…In conclusion, this study provides new evidence that active physical activity can accelerate the relief of hyperalgesia after NP. Proteomic analyses revealed the potential target proteins and pathways for this process, offering valuable data resources and new insights into the pathogenesis and therapeutic targets of NP.…”
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The revival of spiritual practices: factors influencing the “seeking deities and offering prayers” behavior of China’s Generation Z on social media in an atheistic context by Jing Wang, Balamuralithara Balakrishnan, Xiaohui Wan, Qirui Yu, Qiqi Ye

“…Therefore, digital religion can, to some extent, be viewed as a form of social-technological empowerment, providing contemporary youth with a new “pressure valve” to facilitate emotional relief, comfort, and tension alleviation.…”
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Clinical observation on holographic meridian scraping therapy combined with auricular bloodletting therapy in treating primary hypertension in the elderly (全息经络刮痧联合耳尖放血疗法治疗老年高血压病临床... by ZHEN Chao (郑超), LI Ning (李宁), CAO Hongjing (曹红京)

“…Conclusion The holographic meridian scraping therapy combined with auricular bloodletting therapy is potentially effective to reduce the blood pressure and relief the TCM syndrome in patients with primary hypertension. …”
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Pharmacist-led DE-eSCALation of opioids post-surgical dischargE (DESCALE) – A multi-centre, non-randomised, feasibility study protocol [version 2; peer review: 1 approved, 2 approv... by Ellie Santer, Julie H Hedayioglu, Vanessa J Short, Sabina Hulbert, Emma L Veale, Melanie Rees-Roberts, Johanna Theron

“…Used appropriately, opioids deliver extremely favourable pain relief. Used longer than 90-days, however, can result in health complications, including unintentional overdose and addiction. …”
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Impact of Nasal Anatomical Variation Subtype on Surgical Outcomes for Rhinogenic Contact Point Headache by Salvatore Lavalle, Annalisa Pace, Giuseppe Magliulo, Mario Lentini, Jerome Rene Lechien, Christian Calvo-Henriquez, Federica Maria Parisi, Giannicola Iannella, Antonino Maniaci, Daniela Messineo

“…This study provides new evidence that preoperative CT scans should be considered a non-invasive gold standard for analyzing nasal subtypes as they significantly influence surgical success, with concha bullosa associated with worse pain relief. Larger studies should validate these findings to optimize RCPH management.…”
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Efficacy of small-diameter core decompression with platelet-rich plasma in early osteonecrosis of the femoral head: a retrospective study by Haiwei Tang, Yahao Lai, Enze Zhao, Kai Zhou, Gang Chen, Zongke Zhou

“…Conclusion The application of PRP following CD results in significant pain relief, improved short-term functional outcomes, and enhanced quality of life compared to CD alone. …”
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Assessments of prostate cancer cell functions highlight differences between a pan‐PI3K/mTOR inhibitor, gedatolisib, and single‐node inhibitors of the PI3K/AKT/mTOR pathway by Adrish Sen, Salmaan Khan, Stefano Rossetti, Aaron Broege, Ian MacNeil, Ann DeLaForest, Jhomary Molden, Laura Davis, Charles Iversrud, Megan Seibel, Ross Kopher, Stephen Schulz, Lance Laing

“…Co‐targeting the PAM/AR pathways is a promising mCRPC treatment strategy but is hampered by reciprocal negative feedback inhibition or feedback relief. Most PAM inhibitors selectively spare (or weakly inhibit) one or more key nodes of the PAM pathway, potentiating drug resistance depending on the PAM pathway mutation status of patients. …”
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Effect of low-dose radiation pre-irradiation on postoperative local chest wall recurrence of breast cancer—A retrospective study by Ruifang Zeng, Hanyu Wang, Xiaojun Cai, Junhao Lin, Pengfei Li, Shan Zeng, Aimin Li

“…Compared with the non LDR group, the complete response rates were 42.3% vs. 38.5%, p = 0.777, the partial response rates were 53.8% vs. 50.0%, p = 0.781, and the objective relief rates were 96.2% vs. 88.5%, p = 0.833, respectively. …”
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Ecological and forestry assessment of the compliance of the composition of forest crops designed for afforestation with the types of forest site conditions in the Steppe climate of... by Svitlana Raspopina, Anastasiia Suska, Yulia Belay, Vitalii Goroshko

“…For example, it is recommended to use Robinia pseudoacacia more widely in dry relatively fertile forest site conditions (FSC – C1) and in realtively infertile conditions (В1) (except for lowland relief elements). In dry relatively fertile or fertile forest site conditions (C1, D1), Quercus robur should be supplemented with Prunus armeniaca and Morus alba, which exhibit high drought and heat resistance. …”
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Efficacy of laparoscopic cardiectomy combined with side overlap anastomosis for the treatment of terminal achalasia by Jing-Tao Wang, Yu-Xiang Sun, Rui-Xin Li, Yun-Fei Zhang, Heng-Xuan Ding, Guo-Jun Wang, Bu-Lang Gao

“…Seven patients maintained an Eckardt score 0 with complete relief of their symptoms. The effective rate was 100% for type St, 88.8% for type Sg, and 75% for type aSg. …”
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