The Balance of Th1/Th2 and LAP+Tregs/Th17 Cells Is Crucial for Graft Survival in Allogeneic Corneal Transplantation by Shang Li, Jing Yu, Chungang Guo, Ying Jie, Zhiqiang Pan

“…CD4+LAP+ T cells are newly discovered regulatory T cells (Tregs). The aim of this study is to investigate the balance of Th1/Th2 and LAP+Tregs/Th17 in mice after allogeneic corneal transplantation. …”
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Evaluation of Clinical and Immunological Responses: A 2-Year Follow-Up Study in Children with Allergic Rhinitis due to House Dust Mite by Heleen Moed, Roy Gerth van Wijk, Rudi W. Hendriks, J. C. van der Wouden

“…Allergic rhinitis is a disease with polarization towards Th2 and a defect of regulatory T cells. Immunological changes have been reported after immunotherapy treatment. …”
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T-Cell Traffic Jam in Hodgkin's Lymphoma: Pathogenetic and Therapeutic Implications by Claudio Fozza, Maurizio Longinotti

“…The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described. …”
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Immunity and Tolerance Induced by Intestinal Mucosal Dendritic Cells by Julio Aliberti

“…Under steady-state conditions, these cells have high tolerogenic potential, triggering differentiation of regulatory T cells to protect the host from unwanted proinflammatory immune responses to innocuous antigens or commensals. …”
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Insights into the Roles of B Cells in Patients with Sepsis by Xijie Dong, Hao Tu, Shuang Qin, Xiangjun Bai, Fan Yang, Zhanfei Li

“…This article focuses on the significance of B-cell subsets, including regulatory B cells, in sepsis and how the counts and function of circulating B cells are affected in patients with sepsis. …”
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Tolerance in Kidney Transplantation: What Is on the B Side? by Laura Carreras-Planella, Francesc E. Borràs, Marcella Franquesa

“…Regulatory B cells (Breg) are in the spotlight for their role in immune homeostasis maintenance and tolerance achievement as in the last years the correlation with functional and increased Breg numbers in autoimmune diseases and transplantation has been extensively proven. …”
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The role of the cytokines IL-27 and IL-35 in cancer by Avner Friedman, Kang-Ling Liao

“…CD8$^+$ T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8$^+$ T cells via TGF-$\beta$ production. …”
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The Crosstalk between Myeloid Derived Suppressor Cells and Immune Cells: To Establish Immune Tolerance in Transplantation by Chao Zhang, Shuo Wang, Cheng Yang, Ruiming Rong

“…., natural killer cells, dendritic cells, macrophages, natural killer T cells, and regulatory T cells) and its role in the establishment and maintenance of immune tolerant microenvironment in transplantation. …”
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A Case of Recalcitrant Plantar Warts Associated with Statin Use by Aaron G. Wernham, Shireen S. Velangi

“…This case correlates with emerging literature demonstrating a link between statin medication and proliferation of HPV through increased levels of FOXP3+ regulatory T cells.…”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…While mature dendritic cells (DCs) present donor antigen to the immune system, triggering rejection, regulatory DCs interact with regulatory T cells to promote immune tolerance. Intravenous injection of immature DCs of either donor or host origin at the time of transplantation have prolonged allograft survival in solid-organ transplant models. …”
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INBRX-120, a CD8α-targeted detuned IL-2 that selectively expands and activates tumoricidal effector cells for safe and durable in vivo responses by Jason Ho, Chelsie Macedo, Garrett Cyprus, Rajay Pandit, Anya Polovina, Nadja Kern, Abrahim Hussain, Sae Jeong Ahn, William Crago, Emily Rowell, Florian J Sulzmaier, John C Timmer, Brendan P Eckelman

“…Despite promising activity in a subset of patients, wider therapeutic utility of IL-2 (aldesleukin) has been hampered by severe dose-limiting toxicities, the expansion of immunosuppressive regulatory T cells and a poor pharmacokinetic (PK) profile. …”
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Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma by Kayo Tokeji, Sachi Sakaguchi, Tomoko Kurimoto, Junya Fujimura, Toshiaki Shimizu

“…Drug-induced immunomodulation with a reduction of regulatory T cells might have contributed to the development of ITP in our case.…”
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IgG4 Cholangiopathy by Yoh Zen, Yasuni Nakanuma

“…A Th2-dominant immune response or the activation of regulatory T cells seems to be involved in the underlying immune reaction. …”
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The Histone Modification Code in the Pathogenesis of Autoimmune Diseases by Yasuto Araki, Toshihide Mimura

“…Autoimmune diseases are chronic inflammatory disorders caused by a loss of self-tolerance, which is characterized by the appearance of autoantibodies and/or autoreactive lymphocytes and the impaired suppressive function of regulatory T cells. The pathogenesis of autoimmune diseases is extremely complex and remains largely unknown. …”
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Regulatory Immunotherapy in Bone Marrow Transplantation by Vanessa Morales-Tirado, Wioleta Luszczek, Marié van der Merwe, Asha Pillai

“…In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.…”
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Investigating the dual causative pathways linking immune cells and venous thromboembolism via Mendelian randomization analysis by Ning Qi, Zhuochen Lyu, Lu Huang, Yun Zhao, Wan Zhang, Xinfeng Zhou, Yang Zhang, Jiasen Cui

“…Specifically, secreting CD4 regulatory T cells (OR = 0.9084; 95% CI: 0.8418–0.9804; P = 0.0135; FDR = 0.7339) and activated and resting CD4 regulatory T cells (OR = 0.9275; 95% CI: 0.8622–0.9977; P = 0.0433; FDR = 0.8048) suggested a potential protective trend against VTE. …”
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Toll-Like Receptor 2 as a Regulator of Oral Tolerance in the Gastrointestinal Tract by Matthew C. Tunis, Jean S. Marshall

“…This review focuses on recent advances in our understanding of the relationship between TLR2 and oral tolerance, with an emphasis on regulatory T cells, eosinophils, B cells, IgA, intestinal regulation, and commensal microbes.…”
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Glucocorticoid-Induced TNFR-Related (GITR) Protein and Its Ligand in Antitumor Immunity: Functional Role and Therapeutic Modulation by Theresa Placke, Hans-Georg Kopp, Helmut Rainer Salih

“…Initially thought to be critically involved in governing functions of regulatory T cells, GITR and its ligand GITRL have meanwhile been found to modulate the reactivity of various different cell types and to influence a broad variety of immunological conditions including the immune response against tumors. …”
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Global Trends in Research of Amino Acid Metabolism in T Lymphocytes in Recent 15 Years: A Bibliometric Analysis by Jiaona Xu, Yinan Yu, Shijie Li, Fanghui Qiu

“…Recent research has focused on the correlation between the metabolism of several amino acids and regulatory T cells (Tregs) and CD8+ T cells. Overall, this research offers a comprehensive exhibition on the field of amino acid metabolism in T cells, which will help researchers to study this domain more effectively and intuitively.…”
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Research progress of HIF-1a on immunotherapy outcomes in immune vascular microenvironment by Shaoyan Shi, Xuehai Ou, Chao Liu, Hao Wen, Jiang Ke

“…HIF-1α regulates critical pathways, including the expression of vascular endothelial growth factor and immune checkpoint upregulation, leading to tumor-infiltrating lymphocyte dysfunction and recruitment of immunosuppressive cells like regulatory T cells and myeloid-derived suppressor cells. …”
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