Genome-wide association mapping and genomic prediction analyses reveal the genetic architecture of grain yield and agronomic traits under drought and optimum conditions in maize by Manigben Kulai Amadu, Yoseph Beyene, Vijay Chaikam, Pangirayi B. Tongoona, Eric Y. Danquah, Beatrice E. Ifie, Juan Burgueno, Boddupalli M. Prasanna, Manje Gowda

“…Drought tolerance is a complex trait regulated by multiple genes, making direct grain yield selection ineffective. …”
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Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Single-cell analysis indicated that SLC7A1 was predominantly expressed in osteosarcoma cells and correlated with various malignant tumor characteristics. SLC7A1 also regulate interactions between tumor cells and macrophages, as well as modulate macrophage function through multiple pathways. …”
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An Ultra-Low Power, Adaptive All-Digital Frequency-Locked Loop With Gain Estimation and Constant Current DCO by Imran Ali, Hamed Abbasizadeh, Muhammad Riaz Ur Rehman, Muhammad Asif, Seong Jin Oh, Young Gun Pu, Minjae Lee, Keum Cheol Hwang, Youngoo Yang, Kang-Yoon Lee

“…The low power and constant current DCO operates in sub-threshold region and its power consumption is minimized by <inline-formula> <tex-math notation="LaTeX">$g_{m}/I_{D}$ </tex-math></inline-formula> methodology optimization, constant current source for limiting current in DCO core through adaptive low-dropout regulator (LDO) and lowering the supply voltage. The proposed design is integrated in an ADPLL for BLE transceiver and it is fabricated with 1P6M TSMC 55 nm CMOS technology. …”
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Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interacti... by Francesco Verona, Sebastiano Di Bella, Roberto Schirano, Camilla Manfredi, Francesca Angeloro, Giulia Bozzari, Matilde Todaro, Matilde Todaro, Giuseppe Giannini, Giuseppe Giannini, Giorgio Stassi, Veronica Veschi

“…The aggressive behavior of CSCs is guided by several intracellular signaling pathways such as WNT, NF-kappa-B, NOTCH, Hedgehog, JAK-STAT, PI3K/AKT1/MTOR, TGF/SMAD, PPAR and MAPK kinases, as well as extracellular vesicles such as exosomes, and extracellular signaling molecules such as cytokines, chemokines, pro-angiogenetic and growth factors, which finely regulate CSC phenotype. In this scenario, tumor microenvironment (TME) is a key player in the establishment of a permissive tumor niche, where CSCs engage in intricate communications with diverse immune cells. …”
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Synthetic CB1 Cannabinoids Promote Tunneling Nanotube Communication, Cellular Migration, and Epithelial–Mesenchymal Transition in Pancreatic PANC-1 and Colorectal SW-620 Cancer Cel... by David A. Bunsick, Leili Baghaie, Yunfan Li, Abdulrahman M. Yaish, Emilyn B. Aucoin, Elizabeth Skapinker, Rashelle Aldbai, Myron R. Szewczuk

“…During this reprogramming process, cancer cells’ metabolism and other cellular activities are integrated and mutually regulated by tunneling nanotube communications to alter their specific metabolic functional drivers of tumor growth and progression. …”
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Oncometabolite D-2HG drives tumor metastasis and protumoral macrophage polarization by targeting FTO/m6A/ANGPTL4/integrin axis in triple-negative breast cancer by Siyue Zhang, Ning Zhang, Tong Wan, Yinqiao He, Jie Hao, Yiwei Liu, Yidong Liu, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Chao Gao, Qifeng Yang

“…A joint MeRIP-seq and RNA-seq strategy was used to identify the target genes regulated by D-2HG-mediated N6-methyladenosine (m6A) modification. …”
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Analysis of acute non-pharmaceutical toxic exposures in children: a 5-year retrospective study by Yanning Qu, Rui Tang, Zhuyan Duan, Mengyi Sheng, Hui Wang, Shuang Liu, Jiao Li, Linlin Guo, Linying Guo, Si Zheng, Si Zheng

“…Advocating for enhanced safety regulations or educations and public health initiatives to mitigate the incidence of such exposures is still important for protecting children's health.…”
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Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling by Huiling Cai, Huiling Cai, Cheng Yu, Xiuchuan Li, Xuenan Wang, Xuenan Wang, Yongjian Yang, Yongjian Yang, Yongjian Yang, Cong Lan, Cong Lan

“…While small noncoding microRNAs (miRNAs) are crucial regulators of RV remodeling, the biomarker potential of serum miRNAs in this process is little known. …”
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PLGA-based biocompatible nanoparticles improved anti-breast tumor efficacy of 1,25(OH)2D3 through the SOCS3/STAT3/EMT signaling axis by JinJing Pan, Ping Wang, Linghong Xiong, Wenqing Yang, Jie Li, Kai Yang, Bingyan Li

“…Considering that epithelial-mesenchymal transition (EMT) is downstream of the SOCS3/STAT3/PI3K pathway, our findings also revealed that 1,25(OH)2D3 markedly regulated the expression of EMT markers. Additionally, the inhibitor of STAT3 exhibited inhibitory effects on EMT progression in breast cancer cells. …”
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Biochemical, Histological, and Multi-Omics Analyses Reveal the Molecular and Metabolic Mechanisms of Cold Stress Response in the Chinese Soft-Shelled Turtle (<i>Pelodiscus sinensis... by Liqin Ji, Qing Shi, Chen Chen, Xiaoli Liu, Junxian Zhu, Xiaoyou Hong, Chengqing Wei, Xinping Zhu, Wei Li

“…Combined transcriptomic and metabolomic data revealed that pyrimidine metabolism, amino acid metabolism, and pyruvate metabolism were the most significant pathways regulated by the low-temperature exposure. Overall, this work suggests that 14 °C and 7 °C cold stress could induce obvious morphological damage and apoptosis in the liver at 4 dps. …”
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Diversity and Functional Insights into Endophytic Fungi in Halophytes from West Ordos Desert Ecosystems by Xingzhe Wang, Yan Zhang, Jingpeng Li, Yiteng Ding, Xiaodan Ma, Peng Zhang, Haijing Liu, Jie Wei, Yuying Bao

“…Redundancy analysis (RDA) and Mantel tests demonstrated that soil factors such as organic matter, available sulfur, and urease significantly influenced fungal diversity, richness, and evenness, suggesting that soil physicochemical properties play a critical role in regulating fungal–plant symbiosis. Functional predictions indicated that endophytic fungi play important roles in metabolic pathways such as nucleotide biosynthesis, carbohydrate degradation, and lipid metabolism, which may enhance plant survival in saline–alkaline and arid environments. …”
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A Pattern for Iron Ore Mines Financing by Mehdi Ali Hosseini, Mohammad Hashem Botshekan, Amir Hossein Mozayani, Moslem Peymanifurushani

“…The most important solutions have been presented to solve the budget deficit, adjust the policies of the central bank, manage risk, increase the efficiency of the industry, improve the rules and regulations, and make the institutions more efficient.Keywords: Financing Model, Mines, Iron Ore Mines, Iran. …”
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Presenting a model to explain unfavorable risk and favorable risk according to psychological variables in predicting market fluctuations in the Iranian capital market. by Hasan Rezaeikangi, Mahdi Mohammad Bagheri, Hojat Babaei, Ali Raeispour Rajabali

“…The research components include: financing, marketing communications, information accuracy, bankruptcy financial indicators, bankruptcy non-financial indicators, political factors, interpretation of fluctuations, economic factors, factors related to the stock market, factors related to the company, brokerages, personality, optimistic behavior, over-trusting behavior, risk-averse behavior, emotional behavior, financial education, monitoring and evaluation, rules and regulations, economic added value, company value, individual satisfaction, and economic growth. …”
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Possible scenarios of sustainable supply chain in dairy industry with future research approach by Meysam Abedini, Narges Mohammadalipour, Ashraf Shahmansouri, Mahnaz Rabiei

“…According to the findings of the research, the factors influencing the driving forces and key uncertainties on the future of the sustainable supply chain in the dairy industry were identified, which include: foreign trade and communication regulations, the state of competition laws, attention to health and safety issues and standards, attention to Inventory maintenance for each product unit, foreign exchange rate fluctuations, inflation rate fluctuations, the cost of raw material production, the cost of spoilage of dairy products, and the motivation and willingness amount of private investors to invest in the dairy industry. …”
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Identifying factors affecting delivery points, risk transfer and costs in international trade with an emphasis on Incoterms 2020 by Morteza Babaie, Firouze Haji Aliakbari, Fereshte Lotfizade, Arshad Farahmandian

“…These findings will be able to provide a tool for senior executives of international interactions in effective planning for the use of Incoterms Regulations to optimize delivery points, risk transfer and costs in international supply chain management, given the buyer and seller's relationships in transboundary transactions.ConclusionThe purpose of this study was to identify factors affecting the delivery points, risk transfer, and costs in international commerce with emphasis on Incoterms 2020. …”
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Designing a cyber insurance implementation model using foundational data theory by Behzad Esmaeilifar, manouchehr Ansari

“…The existence of a database, the role of the government, insurance attitude, insurance company performance, and insurance regulations are known as central categories. The upcoming obstacles are divided into two main categories: "lack of mastery of the subject", and "lack of government support". …”
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Diagnosis of tuberculosis in buffaloes in Argentina: intradermoreaction, compatible lesions and bacteriological culture by Emilia Irina Martínez, Fabiana Cipolini Galarza, Nolly María Monzón, Ana Gabriela Espasandin, José Luis Konrad, Elvira Falzoni, Soledad Barandiaran, Jimena Marfil, Marcela Martínez Vivot, Diana Elina Martínez

“…Because of the lack of standardized parameters for this species, two interpretation criteria were applied, a qualitative one (reactive, when any size increase was evident in the inoculation area/non-reactive), and the quantitative one following cattle-regulated criteria (positive reaction of more than 5mm, suspicious from 3 to 5mm and negative up to 3mm). …”
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Analyzing Iran's Legislative Criminal Policy in Dealing with Environmental Terrorism, Emphasizing the Need for Criminalization and Preventive Measures by behrouz sepehri, Nourooz Kargari, mohammad ashouri, ghassem ghassemi

“…However, in the set of regulations in various fields, some deterrent criminal contrivances are visible in the form of obstruction crimes, which are effective in the process of preventing environmental terrorism and play an effective role in the effectiveness of the criminal policy of counteraction.…”
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Designing an Innovative Human Resources Model Based on Perceived Organizational Support Case Study of Qazvin's Government organizations by Hossein Rasouli, Morteza Mousakhani, Mahdi Alvani, parham azimi

“…This adaptation drew extensively from an in-depth review of pertinent laws, regulations, and foundational documents. Conclusion One of the paramount achievements of this research is the formulation of a multi-level model that proficiently measures the optimal combination of organizational support factors and innovative human resources within Qazvin's government organizations. …”
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Pengaruh Diet Tinggi Minyak Sawit Terhadap Sel Hepatosit Tikus by Susila Sastri, Husnil Kadri

“…Fatty acid oxidation system in the liver is controlled by peroxisome proliferator-activated receptor-α (PPAR-α) regulated mitochondrial and peroxisomal. Ineffective PPAR-α sensing can lead to reduced oxidation resulting accumulation of fat vacuole that can manifests as hepatic steatosis. …”
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