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13761
Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions
Published 2025-01-01“…Microglial purine sensing and motility capacities, regulated by P2RY12/P2RY13, displayed age-related alterations. …”
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13762
Mechanism of Exogenous Silicon in Enhancing Cold Stress Tolerance in <i>Solanum lycopersicum</i> L. Seedlings: Insights from Resistance and Quality Indicators
Published 2024-12-01“…The results show that compared with the control treatment, the plant height, stem diameter, and fresh weight of above-ground and underground parts of tomato seedlings decreased significantly by 46.52%, 42.53%, 28.81%, and 28.97%, respectively, after 15 days of low-temperature stress (<i>p</i> < 0.05), and in order to resist low temperature, the activity of antioxidant enzymes and the content of osmotic adjustment substances were up-regulated in seedlings. Ultimately, low-temperature stress inhibited the morphological growth, nutritional quality, and yield of fruits. …”
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13763
Predictive role of SLC1A5 in neuroblastoma prognosis and immunotherapy
Published 2025-01-01“…Additionally, SLC1A5 negatively regulated ST8SIA1, a gene crucial for GD2 biosynthesis, suggesting that SLC1A5 inhibition may enhance GD2-directed immunotherapies. …”
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13764
Analisis Kinerja Augmented Reality HyperText Markup Language (ARHTML) Melalui Pemanfaatan Web Graphics Library dan OpenGl Shading Language untuk Pengembangan 3D
Published 2024-10-01“…WebGL serves as the authoritative standard for 3D graphical rendering within web-based interfaces, whereas GLSL functions as the scripting language responsible for regulating the visual presentation produced by WebGL. …”
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13765
Exosomes Derived from Mesenchymal Stem Cells Ameliorate Hypoxia/Reoxygenation-Injured ECs via Transferring MicroRNA-126
Published 2019-01-01“…Stem cell-released exosomes (EXs) could modulate target cell functions by delivering their cargos, and exert therapeutic effects as their mother cells. miR-126 is an important regulator of EC functions and angiogenesis. In this study, we determined whether EXs released from MSC-EXs provided beneficial effects on hypoxia/reoxygenation- (H/R-) injured ECs by transferring miR-126. …”
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13766
Four weeks of slow-paced breathing: a longitudinal, randomized, placebo-controlled study of the autonomic nervous system
Published 2025-01-01“… Introduction The autonomic nervous system (ANS) relies on two essential feedback loops: respiratory sinus arrythmia (RSA) and arterial baroreflex which are both regulated by a complex interplay of sympathetic and parasympathetic activations. …”
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13767
AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate can...
Published 2025-01-01“…Additionally, liposomal-chitosan nanocomplex drug delivery systems were designed to explore AGD1’s role in regulating docetaxel treatment resistance in CRPC. Results AGD1 expression was upregulated in PCSCs and exosomes. …”
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13768
MAZ-mediated tumor progression and immune evasion in hormone receptor-positive breast cancer: Targeting tumor microenvironment and PCLAF+ subtype-specific therapy
Published 2025-02-01“…MAZ, identified as a key regulator, contributed to tumor progression, while the tumor microenvironment had a pivotal identity in immune evasion. …”
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13769
Bifurcation analysis of multistability and hysteresis in a model of HIV infection
Published 2023-12-01“…HIV-1 control efforts with reliance on immunotherapy remain at a conceptual stage due to the complexity of a set of processes that regulate the dynamics of infection and immune response. …”
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13770
Rescue of Mutant CFTR Channel Activity by Investigational Co-Potentiator Therapy
Published 2025-01-01“…<b>Background:</b> The potentiator VX-770 (ivacaftor) has been approved as a monotherapy for over 95 cystic fibrosis (CF)-causing variants associated with gating/conductance defects of the CF transmembrane conductance regulator (CFTR) channel. However, despite its therapeutic success, VX-770 only partially restores CFTR activity for many of these variants, indicating they may benefit from the combination of potentiators exhibiting distinct mechanisms of action (i.e., co-potentiators). …”
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13771
The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population
Published 2020-01-01“…MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and may act as both tumor suppressors and as oncogenes. …”
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13772
CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice
Published 2025-01-01“…Conclusions CEST imaging combined with 1H-MRS demonstrated the effectiveness of riluzole in modulating Glu- and GABA-related changes and improving cognitive function in 3xTg AD mice, potentially through regulating key proteins involved in neurotransmitter metabolism. …”
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13773
miR-26a-5p Attenuates Oxidative Stress and Inflammation in Diabetic Retinopathy through the USP14/NF-κB Signaling Pathway
Published 2024-01-01“…Moreover, miR-26a-5p targeted USP14 and inversely regulated USP14 expression. Additionally, HG-evoked activation of NF-κB signaling was suppressed by USP14 knockdown or miR-26a-5p upregulation. …”
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13774
Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma
Published 2025-01-01“…Disruptions in various oncogenic signaling pathways, such as Receptor Tyrosine Kinase (RTK)-Ras-Extracellular signal-regulated kinase (ERK) signaling, Phosphoinositide 3- Kinases (PI3Ks), tumor protein p53 (TP53), and Neurogenic locus notch homolog protein (NOTCH), contribute to the development of different tumor types, each exhibiting distinct morphological and phenotypic features that can be observed at a microscopic level. …”
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13775
Designing a Conceptual model for Evaluating the Performance of Software Developers in Fintech Organizations
Published 2024-11-01“…These sub-themes, listed in order of priority, include teamwork, quality of produced software, customer satisfaction, documentation skills, participation in knowledge sharing, commitment to scheduling, mastery of production tools, participation in goal realization, compliance with organizational regulations, adherence to technical standards, problem-solving ability, and frequency of software rewriting. …”
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13776
Effect of Whole Wheat Noodles on Biochemical Indexes and Histopathology of Type 2 Diabetic Rats
Published 2025-02-01“…Conclusion: Whole wheat noodle has a significant intervention effect on type 2 diabetes mellitus, manifested in slowing down weight loss, lowering blood glucose values, regulating lipid metabolism and oxidative stress levels in the body, eliminating inflammatory edema in the organs, and restoring cellular damage of the organs in several ways.…”
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13777
Analisis Penerimaan Learning Management System Institut Teknologi Garut Menggunakan Technology Acceptance Model
Published 2023-08-01“…In addition to complying with government regulations, the Garut Institute of Technology academic community also follows the development of interactive information technology-based education with the use of informative applications through electronic media in order to get efficient results, namely the Learning Management System. …”
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13778
Longitudinal genetic studies of cognitive characteristics
Published 2020-03-01“…The data on the correlation between transgenerational epigenetic inheritance of cognitive abilities and the insert of transposable elements in intergenic regions is discussed. Transposons regulate genes functioning in the brain due to the processing of their transcripts into non-coding RNAs. …”
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13779
Exploring anticancer, antioxidant, and antimicrobial potential of Aspergillus flavus, a fungal endophyte isolated from Dillenia indica leaf callus
Published 2025-02-01“…Methods: For callus initiation, leaf tissues of Dillenia indica were inoculated on Murashige and Skoog's medium supplemented with BAP (1mgl-1) and NAA (1mgl-1) plant growth regulators. To raise pure cultures of endophyte, fungal hyphae were isolated from the contaminated cultures and were grown on Potato Dextrose Agar medium. …”
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13780
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Published 2025-01-01“…However, the precise role of autophagy lysosomal signaling in astrocytes that regulates tau pathology remains unclear. Methods We investigated the expression of class IIa HDAC7 in astrocytes from AD patients and PS19 mice. …”
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