Assessing the Feasibility of Drone‐Mediated Vaccine Delivery: An Exploratory Study by Sumit Aggarwal, Prakamya Gupta, Sivaraman Balaji, Saurabh Sharma, Ajoy Kanti Ghosh, Simmy, Balram Bhargava, Samiran Panda

“…Methodology Due to the COVID‐19 pandemic restrictions and paucity of availability of rules and regulations related to drones in India in 2021, this study was conducted as a exploratory study for which number of regulatory approvals are obtained and it involves five drone missions within the premises of the Indian Institute of Technology (IIT), Kanpur, India on a confined airstrip of 3 km2 to transport simulated vaccine vials using a multi‐rotor top‐load UAS in the normal weather conditions in daylight where dummy vaccine vials (COVID‐19) were packed with cool packs to maintain the temperature. …”
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Effects of combined application of nitrogen, phosphorus, and potassium fertilizers on seed yield, seed quality and economic returns of Elymus nutans in alpine region by Jianchao Song, Hang Yang, Xiaojun Yu, Yanzhu Chen, Caiyan Yang, Youlong He, Haibo Wang

“…The seed yield of E. nutans was regulated by the seed yield components. Under different fertilization treatments, the number of fertile tillers and thousand kernel weight had a greater contribution to seed yield, followed by the number of spikelets per panicle. …”
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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…Because it is an inhibitor of the hepatic transporters OATP1B1 and OATP1B3, two uptake transporters regulating the intrahepatic availability of statins, it increases the systemic exposure of co-administered statins. …”
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Different lysine-to-methionine ratios in a low-protein diet affect the microbiome and metabolome, influencing the jejunal barrier function in Tibetan sheep by Fengshuo Zhang, Zhenling Wu, Yu Zhang, Quyangangmao Su, Kaina Zhu, Xuan Chen, Shengzhen Hou, Linsheng Gui

“…Several genes related to barrier function, such as Occludin and Muc- 2, were upregulated in the LP-L group (p < 0.05), while IL-6 and TNF-α were downregulated (p < 0.05).DiscussionCollectively, our results suggest that the dietary Met/ Lys ratio could affect the jejunal SCFA concentration by modulating the microbial community and regulating metabolism, thereby contributing to jejunal barrier function. …”
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Ontology of functional synergetics in virtual cognitive-semiotic design of information processes and systems by R. G. Bolbakov, V. A. Mordvinov, P. V. Berezkin, I. I. Sivitsky

“…Tracing what is happening in dynamics, in the inseparability of assessments and regulations of the set of properties, attributes, and manifestations of the analyzed processes to an even greater extent clarifies the essence and role of the concept introduced by the authors in the general classical theory of information processes and systems. …”
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Transcriptome Analysis Reveals Key Genes Involved in the Response of <i>Triticum urartu</i> to Boron Toxicity Stress by Gul Sema Uyar, Anamika Pandey, Mehmet Hamurcu, Tomas Vyhnanek, Mustafa Harmankaya, Ali Topal, Sait Gezgin, Mohd. Kamran Khan

“…The obtained results suggest that several mechanisms are involved in regulating the response of the studied <i>T. urartu</i> genotype toward B toxicity. …”
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Activity of trypsin inhibitors in common bean seeds (Phaseolus vulgaris L.) from the VIR collection: variability and source material for breeding by T. V. Buravtseva, G. P. Egorova, M. O. Burlyaeva, M. A. Nikishkina

“…The search for samples with high content of inhibitors is also relevant, since inhibitors play a crucial role in the functioning of the basic biochemical mechanisms that determine and regulate the physiological state of the cell.Materials and methods. …”
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MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis by Ruonan Li, Haotian Wang, Xiaolong Wang, Yanbin Yang, Kai Zhong, Xuemei Zhang, Heping Li

“…ST analysis of skin tissue from each group after wound healing revealed that MSC-EVs and UCB-EVs reduced the relative expression of marker genes in myofibroblasts, regulated wound healing, and decreased scar formation by reducing the expression of the TGF-β signaling pathway and increasing the expression of the Wnt signaling pathway. …”
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Buffalo milk quality in southern Italy: trace elements & endocrine disruptors. A One Health analysis by Luigi Jacopo D’Auria

“…Regarding the presence of metals, of the twenty trace elements analysed, only lead is regulated in the EU and no sample exceeded the maximum limit (LM = 0.02 mg/kg). …”
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Effectiveness of B-actin promoter on driving target gene expression in common carp transgenesis by Andi Aliah Hidayani, Odang Carman, . Alimuddin

“… Promoter in transgene construct plays an important role on regulating of transgene expression level in transgenic fish. …”
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Factors Influencing Telemedicine Adoption Among Health Care Professionals: Qualitative Interview Study by Fiona Schürmann, Daniel Westmattelmann, Gerhard Schewe

“…Practically, the findings guide stakeholders: policy makers should prioritize transparent regulations and data security, health care organizations should provide training and support for HCPs, and technology developers must design telemedicine solutions aligning with trust and usability needs. …”
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A Blueprint for the Problem Formulation Phase of EPA-Type Ecological Risk Assessments for 316(b) Determinations by Webster Van Winkle, William P. Dey, Steve M. Jinks, Mark S. Bevlhimer, Charles C. Coutant

“…The implications of the EPA’s recent (April 2002) proposed regulations for existing facilities on the applicability of this blueprint are briefly considered.…”
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Effects of Walnut Protein Peptides on Promotion of White Adipose Tissue Browning and Prevention of Obesity by Yankun FU, Yuzheng CAI, Zhiqiang FENG, Siru CHEN, Tianlin WANG, Lianjun SONG, Tiange LI

“…Western blot results showed that WPP significantly up-regulated the protein expression level of key factors involved in WAT browning uncoupling protein 1 (UCP1), peroxisomal proliferator-activated receptor γ coactivator-1α (PGC-1α), PR domain-containing 16 (PRDM16), and peroxisomal proliferator-activated receptor α (PPARα). …”
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Modulatory effects of selenium nanoparticles on gut microbiota and metabolites of juvenile Nile tilapia (Oreochromis niloticus) by microbiome-metabolomic analysis by Jing Ni, Lirong Ren, Ying Liang, Ying Ma, Hejian Xiong

“…In summary, 0.3 mg/kg SeNPs supplementation can regulate the intestinal microbiota, while 4.5 mg/kg SeNPs and 0.3 mg/kg Na2SeO3 can cause amino acid metabolism disorders. …”
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Integrated physiological and transcriptomic analysis uncovers the mechanism of moderate nitrogen application on promoting the growth and (-)-borneol accumulation of Blumea balsamif... by Yuan Yuan, Wei-Jie Tang, Wei-Jie Tang, Jia-Yuan Cao, Ke Zhong, Ke Zhong, Ze-Jun Mo, Ying Zhou, Yu-Xin Pang, Yu-Xin Pang

“…Nitrogen (N) is essential for regulating the growth of B. balsamifera and the biosynthesis of (-)-borneol; however, the molecular mechanisms by which N influences these processes remain inadequately understood. …”
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Anti-inflammatory and antioxidant properties of Camellia sinensis L. extract as a potential therapeutic for atopic dermatitis through NF-κB pathway inhibition by Min Jung Kim, Ye Jin Yang, Ga-Yul Min, Ji Woong Heo, Jae Dong Son, Young Zoo You, Hun Hwan Kim, Gon Sup Kim, Hu-Jang Lee, Ju-Hye Yang, Kwang Il Park

“…Treatment with CSE inhibited the mitogen-activated protein kinase (MAPK) pathway, which resulted in decreased phosphorylation of p38, Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). Exposure of TNF-α/IFN-γ- stimulated human keratinocytes (HaCaT) cells to CSE resulted in a 200 µg/mL dependent inhibition of p65 and signal transducer and activator of transcription 1 (STAT-1) translocation from the cytosol to the nucleus, as confirmed through immunofluorescence (IF) staining. …”
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Palmitic Acid Methyl Ester Induces G2/M Arrest in Human Bone Marrow-Derived Mesenchymal Stem Cells via the p53/p21 Pathway by Jian-Hong Lin, Pei-Ching Ting, Wen-Sen Lee, Hung-Wen Chiu, Chun-An Chien, Chin-Hung Liu, Li-Yi Sun, Kun-Ta Yang

“…The findings from the present study might help get insight into the physiological roles of PAME in regulating hBM-MSC proliferation.…”
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Mycotoxilogical monitoring. Part 2. Wheat, barley, oat and maize grain by G. P. Kononenko, A. A. Burkin, Ye. V. Zotova

“…These data support the need of their introduction in the group of regulated substances significant for public health. …”
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Biogeochemical cycling of sedimentary organic carbon and benthic nutrient fluxes in the semi-enclosed Jinhae Bay, Korea: insights into benthic-pelagic coupling by Sung-Uk An, Sung-Uk An, Kyung-Tae Kim, Sung-Han Kim, Sung-Han Kim, Ju-Wook Baek, Ju-Wook Baek, Hyun-Jeong Jeong, Hyun-Jeong Jeong, Chul-In Sun, Jin Young Choi, Jin Young Choi, Sokjin Hong, Dae In Lee, Jae Seong Lee, Jae Seong Lee

“…This process not only supports nutrient availability for primary production but also regulates the long-term storage of carbon within sediments. …”
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NCAPD3-mediated ferroptosis of 2,3,5,4’-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells by Jianfen Shen, Shuo Zhang, Shuo Zhang, Yan Song, Yan Song, Leiming Yang, Leiming Yang, Qi Huang, Qi Huang, Pengyu Wang, Pengyu Wang, Youzhi Zhang, Youzhi Zhang

“…Mechanically, we found that THSG inhibits the cell proliferation and clone formation in T47D cells, and Ncapd3 inhibition could inhibit (xCT and GPx4) proteins expression, which regulated THSG-suppressing effect in T47D cells.ConclusionTHSG could inhibit the proliferation in T47D cells by NCAPD3 -dependent ferroptosis, which provided novel insights into targeted strategy for breast cancer.…”
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