TNF-α Enhances the Therapeutic Effects of MenSC-Derived Small Extracellular Vesicles on Inflammatory Bowel Disease through Macrophage Polarization by miR-24-3p by Huikang Xu, Jiamin Fu, Lijun Chen, Sining Zhou, Yangxin Fang, Qi Zhang, Xin Chen, Li Yuan, Yifei Li, Zhenyu Xu, Charlie Xiang

“…The microenvironment induced by inflammatory cytokines can promote mesenchymal stem cells (MSCs) to secrete more substances (including EVs) that could regulate inflammation. Inflammatory bowel disease (IBD) is a chronic idiopathic intestinal inflammation, the etiology and mechanism of which are unclear. …”
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Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

“…Results UDCA significantly attenuated LPS-induced renal histopathological damage and improved renal function, as evidenced by reduction in serum Cr, BUN, and urinary protein levels. UDCA also up-regulated the protein expression of zonula occludens-1 (ZO-1) and Ezrin in the kidney, and reduced the urinary levels of NGAL, KIM-1, NAG, and RBP. …”
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Impact of Early-Life Microbiota on Immune System Development and Allergic Disorders by Norbert Dera, Katarzyna Kosińska-Kaczyńska, Natalia Żeber-Lubecka, Robert Brawura-Biskupski-Samaha, Diana Massalska, Iwona Szymusik, Kacper Dera, Michał Ciebiera

“…The literature data suggest that there is evidence to confirm that the intestinal microbiota of the infant plays an important role in regulating the immune response associated with the development of allergic diseases. …”
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Animal experiments and network pharmacology to explore the anti-inflammatory mechanism of dapagliflozin in the treatment of polycystic ovary syndrome by Yong Liu, He Bai, Huilin Guan, Chunhua Wang, Xueqing Song, Zihao Yong, Xiaomeng Guo, Luxin Li, Zhen Zhang

“…However, the role of dapagliflozin in regulating PCOS remains unclear.Methods In this study, 24 six-week-old female Sprague Dawley (SD) rats were randomly divided into control, letrozole, and letrozole + dapagliflozin groups. …”
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The Promotion of Dark Septate Endophytes on the Performance and Active Ingredients Accumulation of <i>Dendranthema morifolium</i> Under Cd Stress by Meiling Wu, Gen Li, Simiao Wang, Ziteng Wang, Longfei Li, Li Han

“…Regarding impact stems and leaves, under sterile conditions, DSE7 and DSE15 effectively regulated the shoot biomass, plant height, chlorophyll level, and superoxide dismutase (SOD) content. …”
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Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients by Rick Wilbrink, Stefan F.H. Neys, Rudi W. Hendriks, Anneke Spoorenberg, Frans G.M. Kroese, Odilia B.J. Corneth, Gwenny M.P.J. Verstappen

“…Next, we explored B cell subset distribution and B-cell receptor (BCR) signaling responses in circulating B cells from 28 r-axSpA patients and 15 HCs, by measuring spleen tyrosine kinase, phosphoinositide 3-kinase and extracellular signal regulated kinase 1/2 phosphorylation upon α-Ig stimulation using phosphoflow cytometry. …”
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Cross-Platform Ecological Momentary Assessment App (JTrack-EMA+): Development and Usability Study by Mehran Sahandi Far, Jona M Fischer, Svea Senge, Robin Rathmakers, Thomas Meissner, Dominik Schneble, Mamaka Narava, Simon B Eickhoff, Juergen Dukart

“…It strongly commits to security and privacy and complies with the General Data Protection Regulations to safeguard user data and ensure confidentiality. …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…The results of molecular docking and rescue experiments indicated that rhein may exert its protective effects by targeting MARK4.Conclusion: Rhein may regulate the microtubule structure by targeting MARK4, thereby alleviating SAP-ALI and LPS-induced pulmonary endothelial cell injury. …”
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Bibliometric analysis of the impact of environmental degradation on women and the importance of women’s representation by Y.A. Pratama, M.Y.A. Kadir, A. Rivaldi, I.C. Mulya, S. Amirah, M. Iqhrammullah

“…This aspect is particularly important with a setback observed in the environmental management regulations in Indonesia, where the government ratified the Omnibus Law on Job Creation, which removes the stringent licensing process for environmentally impactful activities. …”
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Cell Morphology on Poly(methyl methacrylate) Microstructures as Function of Surface Energy by Matthias Katschnig, Boris Maroh, Natascha Andraschek, Sandra Schlögl, Ulrike Zefferer, Elisabeth Bock, Gerd Leitinger, Christa Trattnig, Maria Kaufmann, Werner Balika, Clemens Holzer, Ute Schäfer, Silke Patz

“…Whilst the significance of substrate topography as a regulator of cell function is well established, a systematic analysis of the principles underlying this is still unavailable. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Further research revealed the expression of STC2 in the endothelial cells (ECs), particularly plasmalemma vesicle associated protein (PLVAP) + ECs, and may regulate the reprogramming and function of macrophages. …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…Molecular characterization analysis of CRGs, including differential gene expression analysis, mutation analysis, copy number variation (CNV) analysis, Kaplan-Meier analysis, and immune regulator prioritization analysis, was implemented. …”
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Komunikasi Publik Intelijen dalam Mendukung Pemanfaatan Energi Nuklir di Indonesia by Rizkyagi Aanwijzi

“…The results of this study found that the construction of nuclear power plants in Indonesia faces a number of obstacles, including the lack of political will and strong regulations. Despite having fulfilled most aspects of required infrastructure, NPP has not yet become a priority issue. …”
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Sobre fogones y semáforos: Percepciones y analogías de dos geografías desencontradas. El caso del volcán Callaqui en la geografía ancestral pehuenche de Alto Biobío by Claudio Contreras Véliz

“…This text is based on an extensive ethnographic work, and it exposes the disagreement in the appreciation and appropriation of local geography, between the perception of the culture of the Pehuenche people who inhabit it, and the institutionality and emergency regulations that intervene in it.…”
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Legal regime of property registration: civil-legal aspect by Serdyuk R.

“…The article identifies the lack of a single approach to determining the branch affiliation of the legal regime of real estate registration due to the dominance of the approach of understanding this category as a “procedural legal relationship” regulated by mandatory acts of administrative legislation. …”
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Integrating urban building information modeling and circular economy framework for green sustainability by N. Andriyani, P. Suprobo, T.J.W. Adi, W.A.N. Aspar, A.D. Jatmiko, A.D. Santoso

“…The government should consider the green demolition framework when refining regulations to include Information Communication Technologies and circular economy concepts. …”
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Kualitas Air Minum Yang Diproduksi Depot Air Minum Isi Ulang Di Kecamatan Bungus Padang Berdasarkan Persyaratan Mikrobiologi by Rido Wandrivel, Netty Suharti, Yuniar Lestari

“…Kata kunci: Depot air minum isi ulang, pemeriksaan mikrobiologis Abstract Background: Every depot is obliged to do inspection of product quality prescribed by the regulations, but not one even also from nine drinking water depot in District of Bungus do the mentioned. …”
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Antibiotic knowledge and influencing factors among residents in China: a cross-sectional survey by Sixian DU, Yaqing LIU, Xiaoxu YIN, Haoran NIU, Feng JIANG, Liwen GONG

“…This study aims to provide reference data for national policymakers to develop more precise antibiotic usage regulations. MethodsFrom July to September 2023, we distributed 932 questionnaires to residents in 44 cities (counties) across 21 provinces (municipalities) in China. …”
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Creating a Digital Insurance Model: A Grounded Theory Approach by Mohammad Adabi, Nastaran Haji Heydari, Hamed Vares

“…Additionally, the development of digital culture in society, related organizations, and legal and regulatory institutions is necessary to support digital development and transformation in the insurance industry, and protection laws and amendments to laws and regulations that hinder digital transformation should be on the agenda. …”
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Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy Ameliorates Nonalcoholic Fatty Liver Disease in Obese Type 2 Diabetic Mice by Bing Li, Yu Cheng, Songyan Yu, Li Zang, Yaqi Yin, Jiejie Liu, Lin Zhang, Yiming Mu

“…Mechanistically, UC-MSCs were found to regulate lipid metabolism by increasing the expression of fatty acid oxidation-related genes and inhibiting the expression of lipogenesis-related genes, which were associated with the upregulation of the HNF4α-CES2 pathway. …”
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