Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway by Xing Luo, Yi Duan, Jinwei He, CongGai Huang, Jun Liu, Yifan Liu, Mengdei Xu, Qiong Dai, Zhihui Yang

“…BackgroundThe Food and Drug Administration has approved the Serine/threonine-protein kinase B-raf (BRAF) inhibitor and Mitogen-activated extracellular signal-regulated kinase (MEK) inhibitor combo as the first-line treatment for individuals with metastatic melanoma, although the majority of these patients exhibit primary or secondary drug resistance in the clinic. …”
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Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…In this study, we suggested that the progression of atherosclerosis might be related to CD86, C1QB, CD53, C1QC, NCF2, and ITGAM and that it plays a role in regulating immune-competent cells such as T cell CD8 and macrophages M0 and M2. …”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Bioinformatic analyses, including Cell Ranger, Seurat, Monocle2, hdWGCNA, SCENIC and NicheNet, were utilized to identify distinct cell populations, transcriptional patterns, and co‐regulating gene modules. Results Our analysis revealed significant intratumoural heterogeneity in PCAS driven by diverse biological processes such as protein synthesis, degradation, and RIG‐I signalling inhibition. …”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…Conclusions This study identifies PRRG1 as a key regulator of pro‐tumorigenic signaling in PDAC, suggesting the potential of repurposing the anticoagulant warfarin as a therapeutic strategy. …”
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Prohexadione-Calcium Reduced Stem and Tiller Damage and Maintained Yield by Improving the Photosynthetic and Antioxidant Capacity of Rice (<i>Oryza sativa</i> L.) Under NaCl Stress by Wanqi Mei, Shaoxia Yang, Jian Xiong, Aaqil Khan, Liming Zhao, Xiaole Du, Jingxin Huo, Hang Zhou, Zhiyuan Sun, Xiaohui Yang, Nana Yue, Naijie Feng, Dianfeng Zheng

“…Prohexadione-calcium (Pro-Ca) has been extensively studied to regulate plant growth, development, and stress responses. …”
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Bone marrow mesenchymal stem cells derived cytokines associated with AKT/IAPs signaling ameliorate Alzheimer’s disease development by Yalan Lu, Yanfeng Xu, Li Zhou, Siyuan Wang, Yunlin Han, Kewei Wang, Chuan Qin

“…Using a cytokine antibody array, we identified three highly expressed AKT pathway regulated neuroprotective factors in BMMSCs: IGF1, VEGF, and Periostin2. …”
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Myostatin Levels and the Risk of Myopenia and Rheumatoid Cachexia in Women with Rheumatoid Arthritis by Fabiola Gonzalez-Ponce, Jorge Ivan Gamez-Nava, Eli Efrain Gomez-Ramirez, Melissa Ramirez-Villafaña, Heriberto Jacobo-Cuevas, Norma Alejandra Rodriguez-Jimenez, Eva Maria Olivas-Flores, Yussef Esparza-Guerrero, Alejandro Martelli-García, Aline Priscilla Santiago-Garcia, Cesar Arturo Nava-Valdivia, Alejandra Martinez-Hernandez, Sergio Antonio Gonzalez-Vazquez, Alfredo Celis, Carlos Enrique Cabrera-Pivaral, Sylvia Totsuka-Sutto, Ernesto German Cardona-Muñoz, Laura Gonzalez-Lopez

“…Background. Myostatin is a regulator of muscle size. To date, there have been no published studies focusing on the relation between myostin levels and myopenia in rheumatoid arthritis (RA). …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Runt-related transcription factor 2 (RUNX2), osteopontin (OPN) and osteocalcin (OCN) gene expression level were significantly up-regulated on VPA-GSH-treated Ti surfaces. Furthermore, low ROS fluorescence intensity in individual cells indicated their regulatory effects. …”
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Changes in target setting for major epidemic emergency response in China before and after COVID-19 epidemic: an official documents analysis by Yushu LI, Peiwu SHI, Qunhong SHEN, Chaoyang ZHANG, Zheng CHEN, Chuan PU, Lingzhong XU, Zhi HU, Anning MA, Zhaohui GONG, Tianqiang XU, Panshi WANG, Hua WANG, Chao HAO, Qingyu ZHOU, Chengyue LI, Mo HAO

“…MethodsWe systematically retrieved a total of 3 864 policy documents (including plans, laws and regulations, and work programs) related to the prevention and control of major epidemics issued by government agencies of 31 provincial-level administrative divisions (PLADs) in Chinese mainland from 2000 to 2020. …”
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Effects of Dietary Supplementation with <i>Lactobacillus reuteri</i> Postbiotics on Growth Performance, Intestinal Flora Structure and Plasma Metabolome of Weaned Piglets by Dongfeng Sun, Wenfei Tong, Shaochen Han, Mengjun Wu, Peng Li, Youguo Li, Yunxiang Liang

“…In conclusion, dietary supplementation with <i>Lactobacillus reuteri</i> postbiotics contributed to improving the antioxidant function and reducing the mortality of piglets by regulating the structure of intestinal flora and upregulating the content of coenzyme Q10 in serum.…”
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Lower Circulating miR-122 Level in Patients with HNF1A Variant-Induced Diabetes Compared with Type 2 Diabetes by Xiuting Huang, Siqian Gong, Yumin Ma, Xiaoling Cai, Lingli Zhou, Yingying Luo, Meng Li, Wei Liu, Simin Zhang, Xiuying Zhang, Qian Ren, Yu Zhu, Xianghai Zhou, Rui Zhang, Ling Chen, Xueying Gao, Fang Zhang, Yanai Wang, Xueyao Han, Linong Ji

“…miR-122, the expression of which is regulated by several transcription factors, such as HNF1A, was recently reported to be associated with type 2 diabetes (T2DM) and hepatocellular carcinoma. …”
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Progress in phase field research of dead lithium in lithium batteries by Jing LIU, Huiyi CHEN, Huiyu LIU, Shu LI

“…The highly active electrolyte can enhance the smooth deposition of lithium and inhibit the formation of dead lithium. These factors can regulate the deposition form of lithium to a certain extent and slow down or avoid the formation of lithium dendrites and dead lithium. …”
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Adolescent Youth Survey on HIV Prevention and Sexual Health Education in Alabama: Protocol for a Web-Based Survey With Fraud Protection Study by Henna Budhwani, Ibrahim Yigit, Josh Bruce, Christyenne Lily Bond, Andrea Johnson

“…However, in Alabama, school-based sexual health and HIV prevention education is strictly regulated and does not address the unique needs of sexual and gender minority teenagers. …”
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Effect of gonadectomy and estradiol on the expression of insulin signaling cascade genes in female and male mice by T. V. Iakovleva, N. E. Kostina, E. N. Makarova, N. M. Bazhan

“…Also, estradiol seems to regulate the transport of glucose in adipose tissue regardless of animal sex: in females and males, an increase in the blood estradiol level was associated with a decrease in the expression of the Slc2a4 gene in adipose tissue. …”
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L’échelon manquant ? Les archives municipales en Algérie : histoire de fonds et possibilités historiographiques by Thierry Guillopé

“…It highlights the new regulations governing them, their conditions of access, the state of the collections and their place in a longer history. …”
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Hsa-miR-532-3p protects human decidual mesenchymal stem cells from oxidative stress in recurrent spontaneous abortion via targeting KEAP1 by Hong Zhou, Jiaxin Zhou, ShanShan Liu, Jing Niu, Jinghua Pan, Ruiman Li

“…However, the miRNAs involved in regulating oxidative stress in hDMSCs remain unclear. …”
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Apoptosis induction and tumor growth suppression by hydroxyapatite nanoparticles–cisplatin combined treatment in Ehrlich solid carcinoma-bearing mice by Shaymaa M. Eissa, Asmaa M. Mahfouz, Saad M. El-Gendy, Al-shimaa Zakaria, Heba Effat, Hanan R. H. Mohamed

“…Conclusion Hydroxyapatite nanoparticles can provoke DNA damage and regulate apoptosis, selectively eliminating tumor cells. …”
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De la neuroplasticidad a las propuestas aplicadas: estimulación temprana y su implementación en Costa Rica / From Neuroplasticity to Applied Proposals: Early Stimulation and Its Im... by Johanna Sibaja-Molina, Tracy Sánchez-Pacheco, Mijail Rojas-Carvajal, Jaime Fornaguera-Trías

“…English The discussion about environmental influence on ontogeny has fueled the question about how much context manipulation can regulate individuals’ characteristics. Today, scientific evidence from different fields (e.g., developmental psychology, neuroscience) describes not only how environment can modulate brain development and function, but also the plastic mechanisms involved. …”
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Effect of environmental enrichment on relapse rates in patients with severe alcohol use disorder: protocol for a randomised controlled trial by Lila Barillot, Claudia Chauvet, Marc Besnier, Nematollah Jaafari, Marcello Solinas, Armand Chatard

“…During the first 20 min of these sessions, patients will practise mindfulness in multisensory VR, in virtual environments designed to practise mindfulness and use it to regulate craving induced by virtual cues or stress. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…Among the 4 types of CKD mouse models, the mRNA expression levels of LAMB3 and CDH3 were significantly (P< 0.05) up-regulated in the model group.Conclusion: We identified 6 hub genes that may serve as potential key biomarkers of Anoikis-related progression in CKD.Keywords: chronic kidney disease, bioinformatics analysis, anoikis, biomarkers…”
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