ERK1/2 Inhibition Alleviates Diabetic Cardiomyopathy by Suppressing Fatty Acid Metabolism by Erin McLean, Caroline De Roo, Annabel Maag, Megan Coble, Jefferson Cano, Ruijie Liu

“…Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) have been implicated in the metabolism of fatty acids in the liver and skeletal muscles. …”
Get full text

Optimal Vase Solution for <i>Gerbera hybrida</i> Cut Flower Keeping Fresh by Activating SA and Cytokinin Signaling and Scavenging Reactive Oxygen Species by Chaoshui Xia, Yiyang Cao, Weixin Gan, Huifeng Lin, Huayang Li, Fazhuang Lin, Zhenhong Lu, Weiting Chen

“…Transcriptome analysis indicated that the OS might extend VL by regulating phytohormone signaling pathways, such as cytokinin and salicylic acid signaling. …”
Get full text

Progression of ampC amplification during de novo amoxicillin resistance development in E. coli by Luyuan Nong, Martijs Jonker, Wim de Leeuw, Meike T. Wortel, Benno ter Kuile

“…We propose that the transposon IS1 contributes to the amplification ampC region, that the sigma factor 70 regulates ampC overexpression, and that these combined form the backbone of a putative mechanism for ampC amplification.…”
Get full text

Methyltransferase-like 7B participates in bladder cancer via ACSL3 m6A modification in a ferroptosis manner by Jiani He, Changming Dong, Xiandong Song, Zhongkai Qiu, Hao Zhang, Yuanjun Jiang, Tao Liu, Xiaojun Man

“…METTL7B may mediate m6A modification on ACSL3 mRNA to negatively regulate ferroptosis in BC cells, which provides a potential therapeutic target for BC via ferroptosis. …”
Get full text

Effects of Nutritional Strategies on Glucose Homeostasis in Gestational Diabetes Mellitus: A Systematic Review and Network Meta-Analysis by Shixiao Jin, Liyan Sha, Jianli Dong, Jing Yi, Yang Liu, Zhongxian Guo, Bing Hu

“…Vitamin D supplementation significantly reduced FPG and regulated HOMA-IR. Magnesium supplementation was superior in decreasing serum insulin than supplementation with other nutrients. …”
Get full text

Gains and pains: a qualitative study on the implications of value-based health care for professionals by Veerle van Engen, Igna Bonfrer, Fabio Mieris, Malou Ensink, Anne Stiggelbout, Kees Ahaus, Martina Buljac-Samardzic

“…In addition, it explores how these outcomes are regulated at both the individual and organizational levels. …”
Get full text

Interpretive structural modeling (ISM) of risk management in Iran's construction industry by Hamed Shokri, Abbas Afrazeh

“…Also, according to (D-R), the lowest value, the risk dimension of laws and regulations, is the most effective dimension of risk management in Iran's construction industry.Originality/Value: The current research is new in terms of the subject area, i.e. in the field of the construction industry of Iran, and in terms of the location area, i.e. companies active in the field of the construction industry of New Tehran. …”
Get full text

Staphylococcus aureus vesicles impair cutaneous wound healing through p38 MAPK-MerTK cleavage-mediated inhibition of macrophage efferocytosis by Jiaxin Ou, Kangxin Li, Hui Yuan, Shaohua Du, Tingting Wang, Qiannan Deng, Huimei Wu, Weiyan Zeng, Kui Cheng, Kutty Selva Nandakumar

“…SAVs inhibit efferocytosis by activating the TLR2-MyD88-p38 MAPK signaling pathway, which regulates efferocytosis receptor genes. This activation promoted cleavage and shedding of MerTK, a crucial receptor for macrophage-driven efferocytosis. …”
Get full text

The in ovo screening of 27 single essential oils showed selective effects on hatchability, performance and gene expression relevant to gut functions in broilers at hatch by Asad A. Khaskheli, Shahram Niknafs, Mila M.Y. Meijer, Xinle Tan, Peter R. Ferket, Eugeni Roura

“…Ylang ylang, clary sage, bergamot, lemon myrtle, and black pepper upregulated the expressions of biomarkers regulating gut integrity and barrier functions (ZO-1, ZO-2, CLDN1, MARVELD2, EGFR and EGF), nutrients transporters (EAAT3, PEPT1, I-FABP1, SGLT1), and digestive enzymes (APN, SI). …”
Get full text

Evaluation of municipal waste collection performance using operational data by G.M. Hoang, H.T.T. Ha, N.T.L. Le, N.D. Toan

“…Ineffective utilization of transfer stations could lead to high idle time, accounting for approximately 37.6 percent of a collection trip. The regulated estimating method for transportation costs is not comprehensively developed, which may cause mistakes in choosing collection vehicles for operation and transfer station usage.CONCLUSION: The research findings assess the performance and identify ineffective factors that require improvement of waste collection, aiming to enhance the solid waste management system. …”
Get full text

Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer by Giovanni Pecoraro, Ilaria Leone, Silvia Nuzzo, Santiago Negueruela, Giovanni Smaldone, Lorena Buono

“…Functional assays demonstrated that circPCDH11Y plays a role in regulating the expression of key neuroendocrine markers, including synaptophysin (SYP), neuron-specific enolase (ENO2), prostate-specific antigen (PSA), Brain-Specific Homeobox/POU Domain Protein 2 (BRN2) and the linear form of Protocadherin 11 Y-Linked (PCDH11Y). …”
Get full text

Age-related changes in DNA methylation in a sample of elderly Brazilians by Hayley Welsh, Caio M. P. F. Batalha, Weili Li, Nadja C. Souza-Pinto, Yeda A. O. Duarte, Michel S. Naslavsky, Esteban J. Parra

“…Abstract Background Age-related changes in DNA methylation (DNAm) play a critical role in regulating gene expression. However, most epigenome-wide association studies have predominantly focused on individuals of European descent. …”
Get full text

Associations between sedentary behaviour and sarcopenia among patients aged 40 and older with chronic obstructive pulmonary disease: a cross-sectional study by Dandan Wang, Ming Zhang, Jun Huang, Haihong Zhang, Si Chen, Kefang Wang

“…Regardless of their engagement in MVPA, it was crucial to regulate SB.…”
Get full text

Stage-specific milk yield losses and associated sweating, respiration, and rectal temperature responses under varying temperature-humidity index thresholds in lactating and dry cow... by P.A. Tu, Y.H. Yeh, Y.H. Chen, J.W. Shiau, T.Y. Lin, Thomas Banhazi, M.K. Yang

“…Therefore, comprehensive strategies, including not only cooling measures but also dietary adjustments and genetic improvements for heat tolerance, are required to help these animals regulate their body temperature and avoid HS. In addition, detecting HS signs is essential for both lactating and dry cows to ensure appropriate interventions. …”
Get full text

FENOMENA SPASIAL PADA FLY-OVER URIP SUMOHARJO KM.4 MAKASSAR by Muhammad Ajwad Muzdar, Bambang Heryanto, Arifuddin Akil

“…Space is an element that accommodates an activitry or an event happened, while time is an element that seemed to regulate, control and determine when the eventshappened and when it stopped. …”
Get full text

Effects of Glycyrrhizin (GL) Supplementation on Survival, Growth Performance, Expression of Feeding-Related Genes, Activities of Digestive Enzymes, Antioxidant Capacity, and Expres... by Yuntao Wang, Wenxuan Xu, Jianmin Zhang, Jiahui Liu, Zhen Wang, Yongtao Liu, Kangsen Mai, Qinghui Ai

“…Compared with the control, the mRNA expression of orexigenic factor genes including neuropeptide Y (npy) and agouti-related protein (agrp) were significantly increased in larvae fed the diet with 0.005% GL, while the mRNA expression of anorexigenic factor genes including thyrotropin-releasing hormone (trh), cocaine and amphetamine regulated transcript (cart), and leptin receptor (lepr) were significantly decreased in larvae fed the diet with 0.005% GL (P<0.05). …”
Get full text

Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress by Chao Du, Xinyu Ni, Mengjiao Yan, Qinghan Meng, Junying He

“…There were 2,134 and 1,739 DEGs enriched in 47 GO secondary categories and 129 KEGG pathways, respectively. 2 up-regulated DEGs were annotated to P5CS, a key enzyme in the biosynthesis of proline. 32 DEGs were annotated to various antioxidases and antioxidants. 81 DEGs were annotated to 8 plant hormone signaling pathways, in which the auxin and ABA signaling pathways exhibited dominant enrichment. 150 DEGs were annotated to 35 transcription factor families with the abundant enrichment of TF families containing WRKY, bZIP, ERF, bHLH, MYB, and NAC. …”
Get full text

Transcriptome, miRNA, and degradome sequencing reveal the leaf stripe (Pyrenophora graminea) resistance genes in Tibetan hulless barley by Yue Wang, Qian Hu, Youhua Yao, Yongmei Cui, Yixiong Bai, Likun An, Xin Li, Baojun Ding, Xiaohua Yao, Kunlun Wu

“…Using RNA-seq, small RNA sequencing (miRNA-seq) combined with degradome sequencing (degradome-seq), four pairs associated with leaf-stripe miRNAs and target genes were obtained, namely Hvu-miR168-5p and Argonaute1 (HvAGO1), Hvu-novel-52 and growth-regulating factor 6 (HvGRF6), Hvu-miR6195 and chemocyanin-like protein (CLP), and Hvu-miR159b and gibberellin-dependent MYB (GAMYB). …”
Get full text

Nicotinamide Mononucleotide Restores NAD⁺ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells by Mehboob Ahmed, Umair Riaz, Haimiao Lv, Muhammad Amjad, Sohail Ahmed, Shaokat Ali, Muhammad Usman Ghani, Guohua Hua, Liguo Yang

“…Mechanistically, this study found that NMN suppressed the activation of the TLR4/NF-κB/MAPK signaling pathways in GCs, which regulates inflammatory processes. In conclusion, the findings of this study revealed that NMN has the potential to reduce LPS-mediated inflammatory changes in GCs by modulating NAD⁺ metabolism and inflammatory signaling pathways. …”
Get full text

Efficacy of biocontrol agents against damping-off and Sclerotinia stem rot diseases and their role in eliciting defense in chickpea plants by Yaser H. El-Gammal, Salama A. S. El-Blasy, Neamat A. M. Khalifa, Shereen Abu El-Maaty, Sara B. H. Awaly

“…All three genes were up-regulated in combinations including (P. fluorescens + Serratia sp.), (T. atroviride + P. fluorescens), and (T. atroviride + Serratia sp.), demonstrating a collaborative impact on defense gene expression. …”
Get full text