Prevalence and predictors of infected diabetic foot ulcers (DFU) and DFU-related osteomyelitis amongst industrial workers wearing occupational safety footwear by Sunetra Mondal, Moushumi Lodh, Sambit Sahoo, Kaushik Paul, Debasis Biswas, Chaitanya Krishna, Ashok Parida, Arunangshu Ganguly, Riddhi DasGupta

“…Existing national standards for OF manufacturing and regulations regarding their use in India are inadequate and must be made more stringent for professionals with diabetes, especially those at high risk for DFU like the elderly, history of past amputation or those with LOPS. …”
Get full text

Rapid Detection of microRNA-122 in Serum and Finger Blood Using a Lateral Flow Nucleic Acid Biosensor by Min Zhang, Meijing Ma, Jiahui Wang, Yurui Zhou, Xueji Zhang, Guodong Liu

“…An expanding body of research has demonstrated that miR-122 is a critical regulator in both the initiation and progression of a wide range of liver diseases. …”
Get full text

Eksplorasi ABAC dan XACML untuk Design Access Control pada Resource Digital by Fauzan Natsir, Imam Riadi, Yudi Prayudi

“…Hasil analisis dengan pendekatan ABAC dengan model XACML ini menyajikan suatu keamanan sistem dengan model akses kontrol berbasis atribut dari policy statement untuk menjadi solusi model akses kontrol yang dibuat sebelumnya dan mendukung model akses kontrol yang relevan untuk resource digital Abstract Digital resources require a mechanism to regulate policy against controls to get access rights to a system. …”
Get full text

Linear Active Disturbance Rejection Control-Based Voltage Controller for Buck and Boost DC/DC Converters in DC Distribution Grids by Asimenia Korompili, Oemer Ekin, Marija Stevic, Veit Hagenmeyer, Antonello Monti

“…A linear active disturbance rejection control (L-ADRC) model is proposed, consisting of an augmented Kalman filter for the state and disturbance estimation, an adaptive state reference trajectory generator and a linear quadratic regulator as feedback controller. This L-ADRC model is formulated according to the generalised ADRC concept, making the voltage controller applicable to converters of the non-minimum phase (NMP) class, like the boost DC/DC converters in voltage control mode, and suitable for matched and mismatched disturbances, opposite to the original ADRC, which exists mostly in literature of converter controllers. …”
Get full text

Preliminary exploration of mRNA, lncRNA, and miRNA expressions in the bovine jejunum unveils novel aspects of Mycobacterium avium subspecies paratuberculosis infections by Yahui Gao, Jie Cao, Bo Han, Dongxiao Sun

“…Our results demonstrated that not only mRNAs but also lncRNAs and miRNAs played important roles in regulating MAP infection in dairy cattle. This study provided a valuable resource for understanding the molecular basis of JD, potentially contributing to the genetic improvement of JD resistance in dairy cattle.…”
Get full text

Transcriptome-Wide Identification of miRNAs and Their Targets During Riboflavin-Promoted Dormancy Release in <i>Lilium</i> ‘Siberia’ by Xiaoping Xu, Chenglong Yang, Yiping Zheng, Wenjie Guo, Zhongxiong Lai, Shaozhong Fang

“…Our study revealed that miRNAs and their target genes might regulate the primary metabolic pathway, promote the accumulation of endogenous riboflavin and acetyl-CoA, and affect protein acetylation during the riboflavin-promoted release of dormancy and flower bud differentiation in the <i>Lilium</i> Oriental hybrid ‘Siberia’.…”
Get full text

An Ontology for Digital Medicine Outcomes: Development of the Digital Medicine Outcomes Value Set (DOVeS) by Benjamin Rosner, Matthew Horridge, Guillen Austria, Tiffany Lee, Andrew Auerbach

“…An outcomes-based DHT ontology could therefore be valuable not only for health systems seeking to evaluate tools that influence certain outcomes, but also for regulators and vendors seeking to ascertain potential substantial equivalence to predicate devices. …”
Get full text

Simple hypertrophic tonsils have more active innate immune and inflammatory responses than hypertrophic tonsils with recurrent inflammation in children by Qun Huang, Hu Hua, Wei Li, Xi Chen, Lei Cheng

“…These differences, together with the patient’s clinical manifestations, suggest that tonsillar hypertrophy might be regulated by diverse immune and/or inflammatory mechanism through which novel therapeutic strategies might be created.…”
Get full text

Potential Strategies Applied by <i>Metschnikowia bicuspidata</i> to Survive the Immunity of Its Crustacean Hosts by Ji Zhang, Bingyu Li, Bingnan Zuo, Xiaodong Li

“…Through comprehensively analyzing the differentially expressed genes (DEGs), both the most regulated ones and the ones involved in crucial enriched KEGG pathways, we found that certain processes might be required for <i>M. bicuspidata</i>’s survival under hemocyte stress. …”
Get full text

Replacement of Dietary Fishmeal Protein with Degossypolized Cottonseed Protein on Growth Performance, Nonspecific Immune Response, Antioxidant Capacity, and Target of Rapamycin Pat... by Sheng Chen, Yuhang Tang, Zhou Zhang, Jichang Zheng, Yuliang He, Zhen Wang, Kangsen Mai, Qinghui Ai

“…As to the target of rapamycin (TOR) pathway, the transcription of hepatic target of rapamycin (tor) and ribosomal protein (s6) was significantly up-regulated, while the transcription of hepatic eukaryotic translation initiation factor 4E binding protein 1 (4e-bp1) gene was significantly downregulated in the DCP group compared with the control group (P<0.05). …”
Get full text

Combined Ventilation of Two Subjects with a Single Mechanical Ventilator Using a New Medical Device: An In Vitro Study by Ignacio Lugones, Matías Ramos, María Fernanda Biancolini, Roberto Orofino Giambastiani

“…The aims of this study are (a) to determine the efficacy of DuplicARⓇ to independently regulate the peak and positive-end expiratory pressures in each subject, both under pressure-controlled ventilation and volume-controlled ventilation and (b) to determine the ventilation mode in which DuplicARⓇ presents the best performance and safety. …”
Get full text

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…Plain Language Summary This article combines the latest research literature at home and abroad to review the sphingosine 1‐phosphate signaling pathway and epileptogenesis, drug‐resistant epilepsy, epilepsy comorbidities, other diseases that can cause epilepsy, as well as the sphingosine‐1‐phosphate signaling pathway regulators and epilepsy, with the expectation of providing a certain theoretical basis for finding potential epilepsy treatment targets and/or epileptogenic biomarkers in the sphingosine‐1‐phosphate signaling pathway.…”
Get full text

A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study by M. H. Malmberg, F. H. Mose, E. B. Pedersen, J. N. Bech

“…The final dilution of urine is regulated via aquaporin-2 water channels in the distal part of the nephron. …”
Get full text

The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…These findings revealed that STAT3 is an important regulator of DC maturation. Furthermore, the interactional binding sites between the 3′-untranslated region (3′-UTR) of STAT3 mRNA and miR-106a/20b were predicted by bioinformatics and verified by a dual-luciferase assay. …”
Get full text

Genome-resolved year-round dynamics reveal a broad range of giant virus microdiversity by Yue Fang, Lingjie Meng, Jun Xia, Yasuhiro Gotoh, Tetsuya Hayashi, Keizo Nagasaki, Hisashi Endo, Yusuke Okazaki, Hiroyuki Ogata

“…ABSTRACT Giant viruses are crucial for marine ecosystem dynamics because they regulate microeukaryotic community structure, accelerate carbon and nutrient cycles, and drive the evolution of their hosts through co-evolutionary processes. …”
Get full text

The development of the research on the history of libraries: a handful of reflections from the French perspective by Jean-Dominique Mellot

“…They continue to accommodate in one cultural space – that becomes more and more comfortable and friendly – both readers and visitors that learn to “live together” within this space, conforming at the same time to applicable rules and regulations. Despite their seemingly disadvantageous situation, one may though assume that modern libraries will continue to provide fresh and stimulating material for historical research for long years to come …”
Get full text

Study of wheat (<i>Triticum aestivum</i> L.) breeding material potential for (<i>Triticum aestivum</i> L.)androgenesis by N. V. Petrash, T. N. Kapko, V. V. Sovetov

“…Induction of androgenesis in vitro was carried out in anther culture in growth medium Chu (N6) containing 1 mg/l of growth regulator 2,4-D. The studied samples showed different responses to induction. …”
Get full text

Identification, prevalence and pathogenicity of Colletotrichum species causing anthracnose of Capsicum annuum in Asia by Dilani D. de Silva, Johannes Z. Groenewald, Pedro W. Crous, Peter K. Ades, Andi Nasruddin, Orarat Mongkolporn, Paul W. J. Taylor

“…The existence of new, highly aggressive exotic species, such as C. javanense, poses a biosecurity risk to production in countries which do not have adequate quarantine regulations to restrict the entry of exotic pathogens.…”
Get full text

Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…This study investigated the role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), a pivotal regulator of glycolysis, in PARPi resistance and explored its potential as a therapeutic target to overcome PARPi resistance. …”
Get full text

Emodin Improves Juvenile Largemouth Bass (<i>Micropterus salmoides</i>) Liver Health Through Nrf2/NF-κB Pathway and Fat Metabolism: Growth Performance, Immune Response and Resistan... by Zhenxin Zhao, Fei Zhao, Tianxun Luo, Zhou Zhou, Xianbo Zhang

“…Additionally, EM-1000 could up-regulate the expressions of nuclear factor erythroid 2-associated factor 2 (<i>Nrf2</i>) and heme oxygenase-1 (<i>HO-1</i>) in livers compared with controls and boost antioxidant enzymes activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), along with a lower content of reactive oxygen species (ROS) and malondialdehyde (MDA). …”
Get full text