Transcriptome analysis of muscle atrophy in Leizhou black goats: identification of key genes and insights into limb-girdle muscular dystrophy by Ke Wang, Mengning Xu, Xiaotao Han, Hu Liu, Jiancheng Han, Wei Sun, Hanlin Zhou

“…Genes such as PITX1, TBX1, SBK2, TCAP, and COLQ were identified as key regulators of muscle development and contributors to muscle atrophy. …”
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A bidirectional Mendelian randomization study integrating genome-wide association studies, expression quantitative trait locus, and methylation quantitative trait locus data reveal... by Zhou An, Meichun Zeng, Xianhua Wang

“…By incorporating consistent summary data-based Mendelian randomization associations between DNA methylation and smoke/Barrett’s esophagus, gene expression and smoke/Barrett’s esophagus, and DNA methylation and gene expression, we identified that the genetic variant-cg00935895-RBM43 (ENSG00000184898)-smoke/Barrett’s esophagus axis exerted an effect on smoke/Barrett’s esophagus by altering the DNA methylation level, which regulated the expression level of RBM43. Conclusions: Our study provides evidence of a bidirectional causal association between smoking and Barrett’s esophagus from a genetic perspective, which sheds new light on the potential role of RBM43 as a mediator in facilitating the impact of smoking and Barrett’s esophagus.…”
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LIFU Alleviates Neuropathic Pain by Improving the KCC2 Expression and Inhibiting the CaMKIV–KCC2 Pathway in the L4–L5 Section of the Spinal Cord by Ye-Hui Liao, Bin Wang, Mo-Xian Chen, Yao Liu, Li-Juan Ao

“…Western blotting (WB) and immunofluorescence (IF) were used to calculate the expression of phosphorylated extracellular signal–regulated kinase 1/2 (p-ERK1/2), calcium/calmodulin-dependent protein kinase type IV (CaMKIV), phosphorylated cyclic adenosine monophosphate response element-binding protein (p-CREB), and KCC2 in the L4–L5 portion of the spinal cord after the last behavioral tests. …”
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Essential oils from Amorpha fruticosa against hepatocellular carcinoma based on network pharmacology by Yixian Liu, Xiaojun Zhang, Jiacong Hao, Ying Zhao, Min Zou, Huiping Chen, Jintao Zhang

“…Conclusions AFLEO and AFFEO may suppress HCC by acting on multiple targets and regulating multiple pathways.…”
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Artificial Neural Networks as a Tool for High-Accuracy Prediction of In-Cylinder Pressure and Equivalent Flame Radius in Hydrogen-Fueled Internal Combustion Engines by Federico Ricci, Massimiliano Avana, Francesco Mariani

“…The automotive industry is under increasing pressure to develop cleaner and more efficient technologies in response to stringent emission regulations. Hydrogen-powered internal combustion engines represent a promising alternative, offering the potential to reduce carbon-based emissions while improving efficiency. …”
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EASTERN SPIRITUAL TRADITIONS THROUGH THE LENS OF MODERN SCIENTIFIC WORLDVIEW by Tetiana V. Danylova

“…In this world, people are seeking for reality regardless of any rules, regulations, notions, and concepts. Here artificial constructs of the human mind, such as Material – Ideal, Determinism - Indeterminism, Finiteness - Infinity, Necessity – Randomness, are united. …”
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European Union legislation regarding waste processing technology by Rymarchuk R., Mykhaniv V.

“…The environmental legislation of the European Union has been developed and improved over the last 30 years and today it includes about 300 legal acts, namely directives, regulations, decisions and recommendations. In addition to them, a large number of bulletins and other political documents related to the environmental legislation of the countries of the European Union are issued. …”
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Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients by Jingwen Gan, Jie Chen, Rui-lin Ma, Yan Deng, Xue-song Ding, Shi-yang Zhu, Ai-jun Sun

“…The COM group may act on the hypothalamic-pituitary-gonadal axis (HPO) and its bypass, regulate multiple metabolism pathways such as phospholipids, amino acids, fatty acids, carnitine, bile acids, and glucose directly or indirectly in obese PCOS patients.…”
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Using β-Elemene to reduce stemness and drug resistance in osteosarcoma: A focus on the AKT/FOXO1 signaling pathway and immune modulation by Shaochun Zhang, Zhijie Xing, Jing Ke

“…Additionally, AKT inhibits immune cell infiltration in osteosarcoma and suppresses immune responses during osteosarcoma progression. β-elemene may influence osteosarcoma progression by mediating TP53 to regulate PTEN and subsequently AKT1. In vitro experiments showed that β-elemene promotes M1 macrophage activation by inhibiting the Akt/FoxO1 signaling axis, thereby reducing the stemness of osteosarcoma stem cells. …”
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Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…Overall, this work not only presents an alternative approach for targeting PD-L1-dependent cancer immune evasion, but also provides a modularized strategy for discovering specific regulators for target proteins in various diseases.…”
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Integrated bioinformatics and experimental analysis of CHAF1B as a novel biomarker and immunotherapy target in LUAD by Wei Du, Xiao-Wei Wu, Qing-Feng Li, Bing-Yu Zhang, Jing Wu, Ya-Ping Xu, Xue Yi

“…We predicted that three miRNAs (miR-29c-3p, miR-145-5p, miR-1247-5p) and three lncRNAs (AL139287.1, NEAT1, SHG1) may be target miRNAs and target lncRNAs that regulate CHAF1B. In vitro tests showed that CHAF1B suppression decreased LUAD's migration, invasion, proliferation, and glycolysis. …”
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Eastern Spiritual Traditions Through the Lens of Modern Scientific Worldview by Tetiana V. Danylova

“…In this world, people are seeking for reality regardless of any rules, regulations, notions, and concepts. Here artificial constructs of the human mind, such as Material – Ideal, Determinism - Indeterminism, Finiteness - Infinity, Necessity – Randomness, are united. …”
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Controversies in the Application of AI in Radiology—Is There Medico-Legal Support? Aspects from Romanian Practice by Ana-Maria Ungureanu, Sergiu-Ciprian Matei, Daniel Malita

“…This narrative review manuscript analyzes the existing literature data regarding the medico-legal aspects of AI application in radiology, highlighting the controversial aspects and the lack of statutory legislative regulations in Romania. <b>Methods</b>: A detailed search was conducted across three electronic databases including MEDLINE/PubMed, Scopus, and Web of Science, with 53 papers serving as the literature corpus of our review. …”
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Protection of personal data of the employee by S. M. Gusarov, K. Yu. Melnyk

“…Problematic aspects of the Code of Labor Laws of Ukraine, the Law of Ukraine “On Protection of Personal Data” and the draft Law of Ukraine “On Labor” regarding the completeness of legal regulations on the protection of personal data of employees are outlined. …”
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Crime in Kharkiv and Its Counteraction in 1880 by V. A. Hrechenko, O. M. Honcharuk

“…The operation of whorehouses was regulated by the state, which understood its task only in combating the spread of sexually transmitted diseases and combating mischief in the locations of whorehouses. …”
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FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes by Tamara Vorobjova, Aili Tagoma, Ija Talja, Helis Janson, Anne Kirss, Raivo Uibo

“…Fatty acid-binding protein 4 (FABP4) is a regulator of lipid metabolism and is associated with obesity, insulin resistance, and type 2 diabetes. …”
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Association between Alpha- Klotho Protein, Calcium, and Phosphate concentrations in Adult Iraqi Patients with Beta-Thalassemia Major by Ahmed J. Kadhim, Hedef D. El-Yaseen, Ali M. Jawad

“…Alpha-Klotho protein is a protein that has anti-aging properties and is involved in several functions, including reducing oxidative stress, regulating energy metabolism through several routes, and managing calcium and phosphate metabolism. …”
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Ameliorative Effect of Hovenia dulcis Fruit Pedicel Polysaccharides on Alcohol-Induced Intestinal Injury in Mice Investigated Using 16S rRNA Sequencing and Metabolomics by ZHANG Yuchao, ZHU Sijie, LIU Liangyu, WANG Jianyun, ZHANG Jiaxin, SU Zexiong, CHEN Jiangyan, LIU Xudong

“…Metabolomics analysis found that HDPs could regulate bile acid metabolism and reduce the levels of bile acids (especially taurocholic acid and chenodeoxycholic acid) in the intestine of alcohol-exposed mice. …”
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Prevention and Control of Losses of Gaseous Nitrogen Compounds in Livestock Operations: A Review by A.A. Jongebreur, G.J. Monteny

“…For the entrepreneur, the strategy must be built on the regulations, the special conditions of his farm, and what is reasonably achievable.…”
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Bivalirudin exerts antiviral activity against respiratory syncytial virus-induced lung infections in neonatal mice by Zhuang Shihao, Tang Qiuyu, Chen Ping, Wang Chengyi, Liu Guanghua

“…At the same time, the down-regulated expression of miR-221 in RSV-infected mice compared to the control. …”
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