An exergy-based analysis for the synthesis of aromatics from biomass by Mohammed Usman, Joseph Akintola, Gabriel Umoh, Joseph Akpan, Ekpotu Wilson, Queen Moses, Philemon Udom, Edose Osagie

“…The chemical process industry has been facing rising energy costs, increasing competition due to rapid globalization, and more stringent government regulations amid growing public concern for the environment, health, and safety. …”
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Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes by Andrey Yurkov, Artur Alves, Feng-Yan Bai, Kyria Boundy-Mills, Pietro Buzzini, Neža Čadež, Gianluigi Cardinali, Serge Casaregola, Vishnu Chaturvedi, Valérie Collin, Jack W. Fell, Victoria Girard, Marizeth Groenewald, Ferry Hagen, Chris Todd Hittinger, Aleksey V. Kachalkin, Markus Kostrzewa, Vassili Kouvelis, Diego Libkind, Xinzhan Liu, Thomas Maier, Wieland Meyer, Gábor Péter, Marcin Piątek, Vincent Robert, Carlos A. Rosa, Jose Paulo Sampaio, Matthias Sipiczki, Marc Stadler, Takashi Sugita, Junta Sugiyama, Hiroshi Takagi, Masako Takashima, Benedetta Turchetti, Qi-Ming Wang, Teun Boekhout

“…Names are critical for (clinical) diagnostics, legal compliance, and regulatory controls, such as biosafety, food security, quarantine regulations, and industrial applications. Consequently, the stability of the taxonomic system and the traceability of nomenclatural changes is crucial for a broad range of users and taxonomists. …”
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Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease by Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru

“…We further validated PTPRD as a STAT3 phosphatase in the liver, acting as a regulator of peroxisomal fatty acid metabolism. During MASH, low PTPRD led to increased liver steatosis in Ptprd+/− mice and a pronounced unfolded protein response, which impacts insulin signalling. …”
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Contribution of Spatial Heterogeneity and Temporal-Spatial Change of Ecosystems to the Thermal Environment of Tourist Destinations: A Case Study of Sichuan-Chongqing Region, China by Dechao Chen, Xinliang Xu, Huailong Jiang, Zongyao Sun, Luo Liu, Zhi Qiao

“…It is important to scientifically regulate the thermal environment effect on tourism destinations and maintain the comfort and sustainable development through identifying the source and sink ecosystems of the thermal environment, controlling the quantity and spatial arrangement of the heat source ecosystems, and fully enabling the cooling effect of the heat sink ecosystems.…”
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Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

“…Validation experiments further established that Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, along with p38 MAPK and Raf–MEK–ERK pathways, are the principal regulators of pro-inflammatory cytokine expression in monocytes and macrophages. …”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…Conclusion These findings exhibit the critical role of STAT6 in the pathogenesis of CIH induced PH by regulating Th2 immune response.STAT6 could be a significant therapeutic target for OSA-related PH.…”
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Impact of elexacaftor-tezacaftor-ivacaftor in lung transplantation for cystic fibrosis in the United States by Tahuanty A. Pena, MD, MS, Brittany Wright, PharmD, Kalpaj R. Parekh, MBBS, Julia Kleney-Tait, MD, PhD

“…The advent of CF transmembrane conductance regulator (CFTR) modulators, particularly elexacaftor-tezacaftor-ivacaftor (ETI), has significantly improved clinical outcomes for people with CF (pwCF), offering potential alterations in disease progression and transplantation needs. …”
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Nicotinamide Ameliorates Dextran Sulfate Sodium-Induced Chronic Colitis in Mice through Its Anti-Inflammatory Properties and Modulates the Gut Microbiota by Kai Kang, Yue Sun, Dan Pan, Bing Chang, Li-Xuan Sang

“…Our results suggest that NAM treatment could alleviate DSS-induced chronic colitis in mice by inhibiting inflammation and regulating the composition and function of gut microbiota.…”
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Verification of the Nutritional and Dietary Factors Associated with Skeletal Muscle Index in Japanese Patients with Nonalcoholic Fatty Liver Disease by Takashi Himoto, Keiko Miyatake, Takashi Maeba, Tsutomu Masaki

“…The nutritional and dietary factors that regulate loss of skeletal muscle mass were distinct between our male and female NAFLD patients. …”
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UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway by Lijie Yang, Penghui Si, Tuoheti Kuerban, Linfa Guo, Shanzhi Zhan, Yisha Zuhaer, Yingtong Zuo, Peixiang Lu, Xiaojie Bai, Tongzu Liu

“…UHRF1, as a critical epigenetic regulator, may play an essential role in the pathogenesis and progression of renal fibrosis and EMT. …”
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Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging by Oliver Lester Saldanha, Jiefu Zhu, Gustav Müller-Franzes, Zunamys I. Carrero, Nicholas R. Payne, Lorena Escudero Sánchez, Paul Christophe Varoutas, Sreenath Kyathanahally, Narmin Ghaffari Laleh, Kevin Pfeiffer, Marta Ligero, Jakob Behner, Kamarul A. Abdullah, Georgios Apostolakos, Chrysafoula Kolofousi, Antri Kleanthous, Michail Kalogeropoulos, Cristina Rossi, Sylwia Nowakowska, Alexandra Athanasiou, Raquel Perez-Lopez, Ritse Mann, Wouter Veldhuis, Julia Camps, Volkmar Schulz, Markus Wenzel, Sergey Morozov, Alexander Ciritsis, Christiane Kuhl, Fiona J. Gilbert, Daniel Truhn, Jakob Nikolas Kather

“…However, the development of AI models is often hindered by manual annotation requirements and strict data-sharing regulations between institutions. Methods In this study, we present an integrated pipeline combining weakly supervised learning—reducing the need for detailed annotations—with local AI model training via swarm learning (SL), which circumvents centralized data sharing. …”
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Spatiotemporal dynamics of soil organic carbon in desert region and its response to climate change: A case study of Heihe river by Yuqing Chen, Haiyang Xi, Wenju Cheng

“…Soil organic carbon (SOC) plays a vital role in regulating atmospheric CO2 levels. As global climate change intensifies, understanding the dynamics of the SOC pool becomes the key to assessing the potential for carbon sequestration in terrestrial ecosystems. …”
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tDCS cranial nerve Co-stimulation: Unveiling brainstem pathways involved in trigeminal nerve direct current stimulation in rats by Alireza Majdi, Liyi Chen, Lars E. Larsen, Robrecht Raedt, Myles Mc Laughlin

“…The TN projects to key brainstem nuclei that regulate neurotransmitter release throughout the central nervous system, but the specific pathways involved are not yet well understood. …”
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Single‐cell RNA‐sequencing and spatial transcriptomic analysis reveal a distinct population of APOE− cells yielding pathological lymph node metastasis in papillary thyroid cancer... by Guohui Xiao, Rongli Xie, Jianhua Gu, Yishu Huang, Min Ding, Dongjie Shen, Jiqi Yan, Jianming Yuan, Qiong Yang, Wen He, Siyu Xiao, Haizhen Chen, Dan Xu, Jian Wu, Jian Fei

“…APOE− tumor cells may promote tumor growth by interacting with dendritic cells and CD4+ T cells via CD99‐ rather than CD6‐regulated signaling. We established a machine learning‐based scRNA‐seq data, 13‐gene signature predictive of lymph node metastasis. …”
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Vaping – A Beneficial Alternative to Traditional Cigarettes or an Unexplored Danger? by Paulina Błasiak, Aleksandra Ślusarska, Patryk Mikołajec, Barbara Bilecka, Jolanta Mędyk, Małgorzata Wirkijowska, Jakub Wirkijowski, Yauheniya Patarocha, Michał Rogulski, Ruslan Huk

“…Particular concern arises from the unregulated composition of e-liquids, which are gaining popularity among youth, thereby promoting early nicotine addiction and normalizing the use of tobacco products. Efforts to regulate the composition of e-liquids and the use of harmful additives are crucial to mitigate the potential health risks associated with vaping. …”
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Construction of Recombinant Inbred Lines and Indentification of QTL for Grain Number Traits of Gaozhou Wild Rice by Xing HUO, Yongmei YU, Shuqing QIU, Dilin LIU, Le KONG, Wuge LIU, Feng WANG

“…Phenotypic observations revealed rich genetic diversity within the population and good potential for application in improving the grain number per panicle. Ten QTLs regulating the grain number per panicle in rice were detected, among which four QTLs were detected in 2022 and six QTLs were detected in 2023. …”
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Immune-mediated mechanisms in acute osteofascial compartment syndrome: insights from multi-omics analysis by Qinzhen Lu, He Ling, Yonghui Lao, Junjie Liu, Wei Su, Zhao Huang

“…In addition, genes associated with ferroptosis, a form of regulated cell death, are found to be upregulated in the rat model, with non-coding RNAs playing a role in regulatory interactions. …”
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Disentangling the effects of eutrophication and natural variability on macrobenthic communities across French coastal lagoons by Jones, Auriane G., Schaal, Gauthier, Boyé, Aurélien, Creemers, Marie, Derolez, Valérie, Desroy, Nicolas, Fiandrino, Annie, Mouton, Théophile L., Simier, Monique, Smith, Niamh, Ouisse, Vincent

“…Using correlograms, linear models and variance partitioning, we found that lagoon hydro-morphology (connection to the sea and lagoon surface), which affects the level of environmental variability (salinity and temperature), as well as lagoon-scale benthic habitat diversity (using macrophyte morphotypes) seemed to regulate macrofauna distribution, while eutrophication and associated stressors like low dissolved oxygen, acted upon the existing communities, mainly by reducing species richness and diversity. …”
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Clinical efficacy of low‐dose Perampanel correlates with neurophysiological changes in familial adult myoclonus epilepsy 2 by Antonietta Coppola, Claudia Cuccurullo, Gianmaria Senerchia, Marica Rubino, Liana Veneziano, Francesco Brancati, Luigi Baratto, Valentina Virginia Iuzzolino, Leonilda Bilo, Pasquale Striano, Raffaele Dubbioso

“…This study suggests that perampanel helps regulate abnormal brain signals and may help managing FAME2 symptoms.…”
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State of the literature discussing smoke-free policies globally: A narrative review by Jacqueline A. Teed, Meagan O. Robichaud, Michelle Duren, Hebe N. Gouda, Ryan David Kennedy

“…The sample included articles published in or about jurisdictions in each WHO region, in high- and low- and mediumincome countries, and articles that discussed policies regulating smoke-free indoor workplaces, indoor public places, public transport, outdoor/quasi-outdoor environments, and other (unspecified) public places. …”
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