HDAC Inhibition Modulates Cardiac PPARs and Fatty Acid Metabolism in Diabetic Cardiomyopathy by Ting-I Lee, Yu-Hsun Kao, Wen-Chin Tsai, Cheng-Chih Chung, Yao-Chang Chen, Yi-Jen Chen

“…Peroxisome proliferator-activated receptors (PPARs) regulate cardiac glucose and lipid homeostasis. Histone deacetylase (HDAC) inhibitor has anti-inflammatory effects which may play a key role in modulating PPARs and fatty acid metabolism. …”
Get full text

The Role of Serum Vitamin D Levels and Vitamin D Receptor (<i>VDR</i>) Gene Variants on Dental Caries by Ece Şengün Berber, Feyza Umay Koç, Ayça Aykut, Burcu Barutçuoğlu, Fahinur Ertuğrul, Merve Tosyalı, Mert Pekerbaş, Arzu Aykut Yetkiner

“…Background/Objectives: Vitamin D helps the mineralization of bone, teeth, and other calcified tissues by regulating calcium–phosphate metabolism. The nuclear activation of the vitamin D receptor (<i>VDR</i>) gene is essential for the effectiveness of vitamin D. …”
Get full text

The Effect of the Glucosinolate Sinigrin on Alterations in Molecular Biomarkers of the Myocardium in Swiss Mice by Nikola Ferara, Vedran Balta, Domagoj Đikić, Dyana Odeh, Ana Mojsović-Ćuić, Lana Feher Turković, Dario Dilber, Anđelo Beletić, Irena Landeka Jurčević, Ivana Šola

“…This observation calls for further investigation into the mechanisms regulating the actions of glucosinolate hydrolysis products, their interactions with sex hormones, and the determination of permissible intake levels associated with both beneficial and adverse outcomes.…”
Get full text

Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer by Xiao-xiang Yu, Yi Liu, Rong-jiang Luo, Zi-xuan Song, Wen-kai Chen, Zeng-mi Mo, Feng-jing Wang

“…The protein–protein interaction (PPI) network analysis revealed that MYC was the central regulatory gene, with the intersected genes mainly involved in regulating cell adhesion and drug metabolism in prostate cancer (PCa). …”
Get full text

Multiple low-dose radiation ameliorates type-2 diabetes mellitus via gut microbiota modulation to activate TLR4/MyD88/NF-κB pathway by Lijing Qin, Rongrong Liu, Zhen Jia, Weiqiang Xu, Li Wang, Hongyuan Tian, Xinru Lian, Wen Li, Yali Qi, Huan He, Zhicheng Wang

“…In addition, in the gut, LDR regulated the relative abundance of Bacilli, Desulfobacterota, Verrucomicrobiota, and Proteobacteria. …”
Get full text

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available. …”
Get full text

Novel immunochromatographic test for rapid detection of anti-factor H autoantibodies with an assessment of its clinical relevance by Santiago Rodríguez de Córdoba, Andrea Reparaz, Daniel Sanchez, Sheila Pinto, Lucia Juana Lopez, Héctor Martin Merinero, Iria Calvete, Julian Perez-Perez, Sydney S. Jellison, Yuzhou Zhang, Richard J. H. Smith, Inmaculada Moreno, Mercedes Dominguez

“…Factor H (FH) is a crucial complement regulator that prevents complement-mediated injury to healthy cells and tissues. …”
Get full text

Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Furthermore, azvudine can suppress the growth of hepatocellular carcinoma (HCC) by regulating CD4+ T and CD8+ T cells in vivo. These findings suggest that azvudine therapy is not inferior to Paxlovid in hospitalized COVID-19 patients and has fewer adverse effects. …”
Get full text

6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARδ in HUVECs, HEK293, and Differentiated 3T3-L1 Cells by Yong-Jik Lee, Yoo-Na Jang, Yoon-Mi Han, Hyun-Min Kim, Hong Seog Seo

“…Lipid accumulation was attenuated by 6-gingerol treatment in differentiated 3T3-L1 cells. These effects were regulated via peroxisome proliferator-activated receptor delta (PPARδ). 6-Gingerol ameliorated the expression of biomarkers involved in the development of hypertension through PPARδ in HUVECs, HEK293, and differentiated 3T3-L1 cells.…”
Get full text

Crustacean Zooplankton Ingestion of Potentially Toxic <i>Microcystis</i>: In Situ Estimation Using <i>mcyE</i> Gene Gut Content Detection in a Large Temperate Eutrophic Lake by Helen Agasild, Margarita Esmeralda Gonzales Ferraz, Madli Saat, Priit Zingel, Kai Piirsoo, Kätlin Blank, Veljo Kisand, Tiina Nõges, Kristel Panksep

“…Grazing by zooplankton can regulate bloom-forming cyanobacteria but can also transfer toxin-producing cells, as well as toxic metabolites, to the food web. …”
Get full text

Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…Background: MAP/microtubule affinity-regulating kinase 4 (MARK4) is a serine-threonine kinase expressed in two spliced isoforms, MARK4L and MARK4S, of which MARK4L is a candidate for a role in neoplastic transformation. …”
Get full text

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia by Emmanuel Amabebe, Zheping Huang, Sukanta Jash, Balaji Krishnan, Shibin Cheng, Akitoshi Nakashima, Yitong Li, Zhixong Li, Ruizhi Wang, Ramkumar Menon, Xiao Zhen Zhou, Kun Ping Lu, Surendra Sharma

“…This review will also cover genetic polymorphisms in the ApoE alleles leading to dyslipidemia induction that may regulate the pathways causing preE or dementia-like features in the reproductive age or later in life, respectively.…”
Get full text

The Development of Methods of BLOTCHIP^®-MS for Peptidome: Small Samples in Tuberous Sclerosis by Kunio Yui, George Imataka, Kotaro Yuge, Hitomi Sasaki, Tadashi Shiohama, Kyoichi Asada, Hidehisa Tachiki

“…Therefore, ASD may develop due to TSC2 deficiency. TSC2 regulates microRNA biogenesis and Microprocessor activity via GSK3β. …”
Get full text

Audio-visual event localization with dual temporal-aware scene understanding and image-text knowledge bridging by Pufen Zhang, Jiaxiang Wang, Meng Wan, Song Zhang, Jie Jing, Lianhong Ding, Peng Shi

“…Additionally, a knowledge bridging (KB) module is proposed to simultaneously transfer the image-text representation and alignment knowledge of CLIP to AVEL task. This module regulates the ratio between audio-visual fusion features and CLIP’s visual features, thereby bridging the image-text alignment knowledge of CLIP and the audio-visual new knowledge for event category prediction. …”
Get full text

Increased IL-21 Expression Induces Granzyme B in Peripheral CD5+ B Cells as a Potential Counter-Regulatory Effect in Primary Sjögren’s Syndrome by Gábor Papp, Edit Gyimesi, Krisztina Szabó, Éva Zöld, Margit Zeher

“…Our results suggest that enhanced IL-21R expression of CD19+CD5+ B cells and production of IL-21 by iNKT cells may play an important role in the pathogenesis of pSS by regulating CD19+CD5+ B cell functions and increasing GrB production, presumably leading to a counter-regulatory effect in the disease.…”
Get full text

Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression by Li Xiang, Wenxu Pan, Huan Chen, Wenjun Du, Shuping Xie, Xinhua Liang, Fangying Yang, Rongwei Niu, Canxin Huang, Minan Luo, Yuxin Xu, Lanlan Geng, Sitang Gong, Wanfu Xu, Junhong Zhao

“…Real-time polymerase chain reaction, immunofluorescence, and western blotting were performed to analyze the effect of sorbitol-regulated M-cell differentiation in vivo and in vitro, and luciferase and chromatin Immunoprecipitation were used to reveal the mechanism through which sorbitol-modulated M-cell differentiation. …”
Get full text

Antiviral Activity and Underlying Mechanism of <i>Moslae herba</i> Aqueous Extract for Treating SARS-CoV-2 by Yan Feng, Qiong Ge, Jian Gao, Zhuoying Wu, Yunyi Zhang, Haiyan Mao, Beibei Wu, Changping Xu

“…Of the nine, the PNP and TPI1 were identified as core targets as AEMH treatment significantly regulated the mRNA expression level of the two genes on infected cells. …”
Get full text

Diversity of frontier processes in Amazonian subnational jurisdictions: Frontier metrics reveal major patterns of human–nature interactions by Guido Briceño, Julie Betbeder, Agnès Bégué, Guillaume Cornu, David Katz-Asprilla, Marie-Gabrielle Piketty, Solen Le Clech, Vinicius Silgueiro, Hélène Dessard, Lilian Blanc

“…This approach provides valuable insights for stakeholder to target interventions and policies adapted to each archetype, for example, payment for ecosystem services, command and control policies, land tenure regulations, land restoration strategies or land use intensification.…”
Get full text

Characterization of H460R, a Radioresistant Human Lung Cancer Cell Line, and Involvement of Syntrophin Beta 2 (SNTB2) in Radioresistance by Chang-Nim Im, Byeong Mo Kim, Eun-Yi Moon, Da-Won Hong, Joung Whan Park, Sung Hee Hong

“…In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and γ-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. …”
Get full text

Epidemiological analysis of reported acute glyphosate poisoning in Malaysia: identifying risk factors and high-risk groups (2006–2023) by Yin-Hui Leong, Noor Afiza Abdul Rani, Mohd Fadhli Razali, Nurul Iffah Amir Shah Ruddin, Fahim Mohamed, Nurul Izzah Ahmad

“…The study highlights the need for stricter regulations on glyphosate use and improved mental health support, to mitigate poisoning risks. …”
Get full text