Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis by Jiaqi Yao, Yuhong Jiang, Pengcheng Zhang, Yifan Miao, Xiajia Wu, Hang Lei, Zhijun Xie, Yong Tian, Xianlin Zhao, Juan Li, Lv Zhu, Meihua Wan, Wenfu Tang

“…The results of glutathione-S-transferase (GST) pull-down and proteomics analyses revealed the involvement of HINT2 in regulating mitochondrial oxidative phosphorylation (OXPHOS) in AP mice. …”
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Expression and Function of Ephrin-B1 and Its Cognate Receptor EphB2 in Human Abdominal Aortic Aneurysm by Aiji Sakamoto, Masaaki Kawashiri, Hatsue Ishibashi-Ueda, Yuka Sugamoto, Tsuyoshi Yoshimuta, Takeo Higashikata, Hitoshi Ogino, Hayato Tada, Tetsuo Konno, Kenshi Hayashi, Masakazu Yamagishi

“…We examined the expression of ephrin-B1 and its cognate receptor EphB2, key regulators of angiogenesis and embryogenesis, in human abdominal aortic aneurysm (AAA) and analyzed their functional roles in cell migration. …”
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(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts: Suppression of SAPK/JNK by Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa

“…We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB- (PDGF-BB-) stimulated synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells while Akt and p70 S6 kinase negatively regulates the synthesis. In the present study, we investigated whether (-)-epigallocatechin gallate (EGCG), one of the major green tea flavonoids, affects the synthesis of IL-6 in these cells and the mechanism. …”
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3D printed magnesium silicate/β-tricalcium phosphate scaffolds promote coupled osteogenesis and angiogenesis by Lulu Wang, Mingkui Shen, Zhongxin Tang, Jun Tan, Kuankuan Li, Haijun Ma

“…Combined techniques of Transwell co-culture, we studied the effect of MS/β-TCP scaffold activated cell-level specific regulatory network, which promotes the osteogenic differentiation of MC3T3-E1 and the endothelial formation of HUVEC by significantly up-regulating the expression of related genes and proteins. …”
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Nationality, Gender, Age, and Body Mass Index Influences on Vitamin D Concentration among Elderly Patients and Young Iraqi and Jordanian in Jordan by Hanan Al-Horani, Wael Abu Dayyih, Eyad Mallah, Mohammed Hamad, Mohammad Mima, Riad Awad, Tawfiq Arafat

“…Vitamin D is necessary for maintaining and regulating calcium levels; thus, insufficiency of vitamin D increases the risk of many chronic diseases. …”
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Exploring the exoproteome of the parasitic nematode Anisakis simplex (s. s.) and its impact on the human host – an in vitro cross-talk proteomic approach by Robert Stryiński, Robert Stryiński, Ewa Fiedorowicz, Jesús Mateos, Aneta Andronowska, Elżbieta Łopieńska-Biernat, Mónica Carrera

“…In addition, a cross-talk proteomic approach was used to identify differentially regulated proteins (DRPs) in the proteome of the human intestinal epithelial cell line (Caco-2) co-cultured with L3 larvae of A. simplex (s. s.) or directly exposed to two concentrations (low or high) of Anis-EVs. …”
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Molecular insights into the functional role of PbNRT2.4 in potassium homeostasis and nutrient transport in Pyrus ussuriensis by Han Yang, Hao Xu, Yujie Shi, Liyan Chen, Lijuan Zhang, Liping Kan, Yumeng Jin, Xinlan Mei, Yangchun Xu, Nazir Ahmed, Caixia Dong

“…Predominantly expressed in the roots, PbNRT2.4, is finely regulated by potassium concentrations, as well as exogenous sugar levels. …”
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Online illegal wildlife trade in Indonesia: strengthening the regulatory framework and law enforcement by Krismanko Padang, Nuruliawati, Zahrah Afifah, Muhammad Irfan Andriansyah, Andina Auria Dwi Putri, Nur Hafizoh, Irma Hermawati, Ade Indah Muktamarianti, Syaras Yulianti, Niken Wuri Handayani, Sofi Mardiah

“…Our analysis of wildlife legislation, focus group discussions and expert interviews showed that the Government of Indonesia Trade Law (2014) and Law on Electronic Information and Transactions (2008) cannot be used to prosecute online illegal wildlife trade cases because these laws do not acknowledge regulations for protected species. Our study emphasizes the urgency of revising the Conservation Act and changing the definition of trade to include advertisements of protected species. …”
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A novel roseosiphovirus infecting dinoroseobacter shibae DFL12T represents a new genus by Nana Wei, Longfei Lu, Yingying Li, Bo Ding, Lanlan Cai, Yunlan Yang

“…Marine viruses, particularly those targeting Roseobacter, play crucial roles in regulating microbial communities and biogeochemical processes. …”
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IL-6-Inducing Peptide Prediction Based on 3D Structure and Graph Neural Network by Ruifen Cao, Qiangsheng Li, Pijing Wei, Yun Ding, Yannan Bin, Chunhou Zheng

“…Interleukin-6 (IL-6) is a potent glycoprotein that plays a crucial role in regulating innate and adaptive immunity, as well as metabolism. …”
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Techno-economic analysis of cutting-edge PV systems deployment and reconfigurations on rooftop industrial building in Saudi Arabia’s eastern region by Abdulrhman Klifa Al-Hanoot, Hazlie Mokhlis, Saad Mekhilef, Mohammad Alghoul, Hussain Shareef, Zaid Alotaibi

“…Installation costs, maintenance expenses, revenue estimates, and potential revenue sources are also factored in, considering local regulations and policies. By meticulously simulating and comparing five advanced PV technologies across various configurations, the research identifies the N-type Mono BIFACIAL module in the third configuration scenario as the most effective. …”
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What are the characteristics of disposable electronic cigarettes users in Switzerland? A quantitative study among 14–25 year olds by Luc Lebon, Karin Zürcher, Lorraine Chok, Diana Fernandes-Palhares, Jérémy Cros, Alexandre Dubuis, Cathy Berthouzoz, Yara Barrense-Dias

“…They also confirm the necessity to inform the public, denormalise use and strengthen regulations.…”
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STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation by Yu Qian Wong, Hongyan Xu, Qiang Wu, Xinyu Liu, Chengchen Lufei, Xiu Qin Xu, Xin-Yuan Fu

“…Taken together, the findings of this study indicated that InSTAT3 KO and InSTAT3 CA ESCs could provide a new tool to clarify the direct targets of STAT3 and its role in ESC maintenance, which will facilitate the elaboration of the mechanisms whereby STAT3 maintains ESC pluripotency and regulates ESC differentiation during mammalian embryogenesis.…”
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Correlation between malondialdehyde level and FOXO3 and CASP3 mRNA expression changed in early-onset preeclampsia placenta by Ni Made Wiasty Sukanty, Febriana Catur Iswanti, Syarifah Dewi, Muhammad Faruqi, Alyssa Shafa Andiana, Ani Retno Prijanti

“…Conclusion: These results indicate that cell integrity is still maintained through the autophagy process and the level of apoptosis in the EOPE placenta is regulated by ROS through FOXO3. …”
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Implementation of a Smart Home Intruder Detection System using a Vibrometer and ESP 32 CAM by Samuel Owoeye, Folasade Durodola, Adekunle Oyelami, Racheal Oladejo, Samuel Obasuyi, Ademola Qasim, Joshua Ogundairo

“…In the realm of lighting control, the ATMega328P regulates diverse light sources such as LEDs and smart bulbs. …”
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Development of a comprehensive sustainability index for extractive and mining companies: Integrating the Sustainable Development Goals by Marta Fernández-Hernández, Pedro Mora, Marcelo F. Ortega, Juan Pous Cabello

“…The practical application of this index is critical, providing a step-by-step guide for extractive and mining companies to adopt and utilize the sustainability index, aiding in compliance with future regulations.The results of this study show that the system of SDGs, targets, aspects, and metrics is naturally weighted towards social issues. …”
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High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota by Yu Xia, Yu Xia, Lulu Wang, Yanyan Qiu, Weihong Ge, Weihong Ge, Weihong Ge

“…Furthermore, oral administration of high-dose thiamine also regulated HFFD-induced gut microbiota dysbiosis by reshaping its structure and composition of gut microbiota, such as increasing the relative abundance of Actinobacteria and Bifidobacterium pseudolongum, and reducing the relative abundance of Proteobacteria and Ruminococcus gnavus, accompanied by decreased level of gut-derived endotoxin. …”
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Human Chorionic Plate-Derived Mesenchymal Stem Cells Restore Hepatic Lipid Metabolism in a Rat Model of Bile Duct Ligation by Yun Bin Lee, Jong Ho Choi, Eun Nam Kim, Jin Seok, Hyun-Jung Lee, Jung-Hwan Yoon, Gi Jin Kim

“…CPT1A expression was changed via microRNA-33—a posttranscriptional regulator of CPT1A—in a peroxisome proliferator-activated receptor α-independent manner. …”
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Perspectives on Structural, Physiological, Cellular, and Molecular Responses to Desiccation in Resurrection Plants by Yathisha Neeragunda Shivaraj, Plancot Barbara, Bruno Gugi, Maïté Vicré-Gibouin, Azeddine Driouich, Sharatchandra Ramasandra Govind, Akash Devaraja, Yogendra Kambalagere

“…Similarly, recent data show a major role of ABA, LEA proteins, and small regulatory RNA in regulating DT responses. Current progress in “-omic” technologies has enabled quantitative monitoring of the plethora of biological molecules in a high throughput routine, making it possible to compare their levels between desiccation-sensitive and DT species. …”
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Gene Expression Pattern and Regulatory Network of α-Toxin Treatment in Bombyx mori by Tieshan Feng, Ping Lin, Jiao Gong, Dong Cheng, Xi Yang, Quan Zhang, Tingcai Cheng

“…We compared the changes in gene expression in the midgut, fatbody, and hemocytes of silkworm and in the B. mori embryonic cell line (BmE) after treatment with α-toxin and identified 952 differentially expressed genes and 353 differentially expressed long noncoding RNAs (lncRNAs). These regulated genes in different tissues were found to be enriched in different pathways. …”
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