Edaravone dexborneol alleviates pericyte-mediated fibrosis depositing extracellular matrix through TGF-β1/IL-11 in cerebral small vessel disease by Qingrui Duan, Zhiyang Liu, Yuxuan Xing, Haifeng Huang, Lin Zhu, Jiaxuan Liu, Peikun He, Guixian Ma, Yuhu Zhang, Kun Nie, Yuyuan Gao, Lijuan Wang

“…EDB could improve symptoms and the underlying pathogenesis of CCH mice and decrease the expression of the fibrous profiles of pericytes and ECM proteins, which may be regulated by TGF-β1/ IL-11. EDB treatment, targeting pericytes fibrosis, may be a novel therapeutic strategy for CSVD.…”
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NMDA Reduces Tau Phosphorylation in Rat Hippocampal Slices by Targeting NR2A Receptors, GSK3β, and PKC Activities by Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicotte

“…The molecular mechanisms that regulate Tau phosphorylation are complex and currently incompletely understood. …”
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Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity by Jiaxing Yang, Kechen Yue, Jingwen Sun, Changjie Pan, Xintong Wu, Yongjun Cheng, Xiaomeng Wu, Haifeng Shi

“…Objective: Here we investigated changes in topological properties of functional brain networks among individuals with Crohn’s disease (CD) and to determine whether these changes are related to CD severity, as well as CD-associated anxiety and depression, which are regulated by the brain–gut axis mechanism. Methods: In total, 31 individuals with CD, 21 with irritable bowel syndrome (IBS), and 20 healthy controls underwent functional magnetic resonance imaging. …”
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A Cornflower Extract Containing N-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX by Christophe Carola, Andrew Salazar, Christin Rakers, Franck Himbert, Quoc-Tuan Do, Philippe Bernard, Joerg von Hagen

“…Thymus and Activation-Regulated Chemokine (TARC/CCL17) and Macrophage-Derived Chemokine (MDC/CCL22) are two key chemokines exerting their biological effect via binding and activating a common receptor CCR4, expressed at the surface of type 2 helper T (Th2) cells. …”
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Soil moisture controls over carbon sequestration and greenhouse gas emissions: a review by Yuefeng Hao, Jiafu Mao, Charles M. Bachmann, Forrest M. Hoffman, Gerbrand Koren, Haishan Chen, Hanqin Tian, Jiangong Liu, Jing Tao, Jinyun Tang, Lingcheng Li, Laibao Liu, Martha Apple, Mingjie Shi, Mingzhou Jin, Qing Zhu, Steve Kannenberg, Xiaoying Shi, Xi Zhang, Yaoping Wang, Yilin Fang, Yongjiu Dai

“…Abstract This literature review synthesizes the role of soil moisture in regulating carbon sequestration and greenhouse gas emissions (CS-GHG). …”
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms by Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu

“…Key Scientific Concepts of Review: This review is focused on three key notions: Firstly, gut microbiota has become a new target for regulating health status and lifespan, and its changes are closely related to age. …”
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Chemotherapy in synergy with innate immune agonists enhances T cell priming for checkpoint inhibitor treatment in pancreatic cancer by Nan Niu, Keyu Li, Junke Wang, Vanessa Funes, Birginia Espinoza, Pan Li, Jianxin Wang, Melissa Lyman, Mengni He, Brian Herbst, Michael Wichroski, Ruslan Novosiadly, Sami Shoucair, Yiping Mou, Lei Zheng

“…The NLRP3 agonist-mediated T cell activation is likely through regulating the nitrogen metabolism pathways. Conclusion This study supports the clinical testing of both STING and NLRP3 agonists, respectively, in combination with chemotherapy to sensitize PDAC patients for ICI treatments.…”
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Effects of straw amendment on the bioavailability of selenite in soil and its mechanisms by Mingxing Qi, Dan Wang, Hui Zhai, Fei Zhou, Hao Wu, Wanchen Zhao, Rongxin Ren, Jingyi Shi, Dongli Liang

“…These findings could provide a basis for regulating Se bioavailability during biofortification in soils.…”
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Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells by Hyun-Jae Jang, Kang-Hoon Kim, Eun-Jae Park, Jeong A. Kang, Bong-Sik Yun, Seung-Jae Lee, Chan Sun Park, Soyoung Lee, Seung Woong Lee, Mun-Chual Rho

“…Its inhibitory activity of proinflammatory mediators is contributed by suppressing the activation of nuclear transcription factor- (NF-) κB and mitogen-activated protein kinase (MAPK) signaling cascades including p65, inhibition of NF-κB (IκB), extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38. …”
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L-Theanine Extends the Lifespan of <i>Caenorhabditis elegans</i> by Reducing the End Products of Advanced Glycosylation by Zhihang Huang, Haiming Jing, Yan Pan, Hongxia Cai, Wenjing Zhang, Jingyuan Zhu, Nan Zhang, Dan Wu, Wentao Xu, Hexiang Qiu, Huihui Bao, Guojun Li, Junyu Ning, Bo Xian, Shan Gao

“…In summary, this study identified L-theanine as a potential anti-aging intervention that extends the lifespan by reducing AGE accumulation and regulating insulin-like signaling pathways. These findings provide new insights for developing anti-aging strategies and lay the groundwork for further research on the potential benefits of L-theanine in mammals. …”
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TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress by Veronica Tisato, Stefania Gallo, Elisabetta Melloni, Claudio Celeghini, Angelina Passaro, Giorgio Zauli, Paola Secchiero, Carlo Bergamini, Alessandro Trentini, Gloria Bonaccorsi, Giuseppe Valacchi, Giovanni Zuliani, Carlo Cervellati

“…The oxinflammatory pathway has been recently suggested to play a crucial role in regulating the activity of TNF-related apoptosis-inducing ligand (TRAIL), a TNF superfamily member that can mediate multiple signals in physiological and pathological processes. …”
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Synthesis of Amino Acid Schiff Base Nickel (II) Complexes as Potential Anticancer Drugs In Vitro by Yang Li, Jianfang Dong, Peiran Zhao, Ping Hu, Dawei Yang, Lei Gao, Lianzhi Li

“…Additionally, complex 2 can regulate the Bcl-2 family and autophagy-related proteins.…”
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Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024 by Zhilin Huang, Song Li, YiHao Zhou, Anhong Dai, Yi Zhang, Meifang Liu, Mengqi Le, Jing Shi

“…This study aimed to explore the current state of research and recent trends in the regulating of oxidative stress by acupuncture using bibliometric methods. …”
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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. …”
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Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models by Ling Xiong, Dustin Beyer, Na Liu, Tina Lehmann, Sophie Neugebauer, Sascha Schaeuble, Oliver Sommerfeld, Philipp Ernst, Carl-Magnus Svensson, Sandor Nietzsche, Sebastian Scholl, Tony Bruns, Nikolaus Gaßler, Markus H. Gräler, Marc Thilo Figge, Gianni Panagiotou, Michael Bauer, Adrian T. Press

“…Sepsis is a life-threatening organ failure resulting from a poorly regulated infection response. Organ dysfunction includes hepatic involvement, weakening the immune system due to excretory liver failure, and metabolic dysfunction, increasing the death risk. …”
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The Maternal Cytokine and Chemokine Profile of Naturally Conceived Gestations Is Mainly Preserved during In Vitro Fertilization and Egg Donation Pregnancies by Alicia Martínez-Varea, Begoña Pellicer, Vicente Serra, David Hervás-Marín, Alicia Martínez-Romero, José Bellver, Alfredo Perales-Marín, Antonio Pellicer

“…The main outcome measures were, firstly, to follow up plasma levels of interleukin (IL) 1beta, IL2, IL4, IL5, IL6, IL8, IL10, IL17, interferon gamma, tumor necrosis factor-alpha (TNFα), transforming growth factor-beta (TGFβ), regulated upon activation normal T-cell expressed and secreted (RANTES), stromal cell-derived factor 1 alpha (SDF1α), and decidual granulocyte-macrophage colony-stimulating factor (GM-CSF) during the three trimesters of pregnancy during the three trimesters of pregnancy; secondly, to evaluate if the cytokine and chemokine pattern of ED pregnant women differs from that of those with autologous oocytes and, thirdly, to assess if women with preeclampsia show different cytokine and chemokine profile throughout pregnancy versus women with uneventful pregnancies. …”
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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…This study underscores the potential of PD in regulating TAMs, providing new insights into its potential use in cancer therapy.…”
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Effect of Exogenous Melatonin on the Quality of Soybean and Natto Products under Drought Stress by Liang Cao, Fang Kou, Mingcong Zhang, Xijun Jin, Chunyuan Ren, Gaobo Yu, Yuxian Zhang, Mengxue Wang

“…Melatonin can directly or indirectly eliminate reactive oxygen species, regulate hormone levels, and improve drought-stressed soybean crop resistance, yield, and quality. …”
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Interleukin 10 Plays an Important Role in Neonatal Rats with Hypoxic-Ischemia Associated with B-Cell Lymphoma 2 and Endoplasmic Reticulum Protein 29 by Xue Bai, Liu-Lin Xiong, Chang-Le Fang, Hao-Li Zhou, Lu-Lu Xue, Yue Hu, Qing-Jie Xia, Jia Liu, Jun-Yan Zhang, Ting-Hua Wang, Si-Jin Yang

“…Our findings revealed that IL-10 exerted its antiapoptotic and neuroprotective effects by regulating the expression of Bcl-2 and ERp29, indicating that IL-10 may be a promising molecule target for HIE treatment.…”
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Grem1 inhibits osteogenic differentiation of MBMSCs in OVX rats through BMP/Smad1/5 signaling pathway by Shan-shan Yang, Min LinHu, Xiao-hua Hu, Si-si Jiang, Wen-yue Hu, Xiao-hong Yang

“…Objective: This study aims to explore how Grem1 regulates the differentiation and signaling activity of mandibular bone marrow mesenchymal stem cells (MBMSCs), affecting their osteogenic differentiation capacity and participating in the pathophysiological mechanism of postmenopausal mandibular osteoporosis. …”
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