Primary aldosteronism patients with previous cardiovascular and cerebrovascular events have high aldosterone responsiveness to ACTH stimulation by Eriko Nakano, Kosuke Mukai, Atsunori Fukuhara, Michio Otsuki, Iichiro Shimomura, Takamasa Ichijo, Mika Tsuiki, Norio Wada, Takashi Yoneda, Yoshiyu Takeda, Kenji Oki, Tetsuya Yamada, Yoshihiro Ogawa, Daisuke Yabe, Miki Kakutani, Masakatsu Sone, Takuyuki Katabami, Akiyo Tanabe, Mitsuhide Naruse, JPAS/JRAS Study Group

“…Aldosterone secretion in primary aldosteronism (PA) is often regulated by adrenocorticotropic hormone (ACTH) in addition to its autonomous secretion. …”
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Blended digital health intervention for adolescents at high risk with digital media use disorders: protocol for a randomised controlled trial within the Res@t-Consortium by Oliver Labrenz, Oliver Labrenz, Lucie Waedel, Lucie Waedel, Michael Kölch, Michael Kölch, Susanne Lezius, Christina Wacker, Antonia Fröhlich, Antonia Fröhlich, Kerstin Paschke, Rainer Thomasius, Olaf Reis, Olaf Reis

“…BackgroundDigital media use disorder (DMUD) is a prevalent problem among young people, which can result in adverse consequences and functional impairments across multiple domains of life due to a persistent inability to regulate one’s use, which can lead to the development of psychological problems. …”
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DNA methylation of ACADS promotes immunogenic cell death in hepatocellular carcinoma by Ze Qian, Yifan Jiang, Yacong Wang, Yu Li, Lin Zhang, Xiaofeng Xu, Diyu Chen

“…Abstract Background Altered metabolism has become an important characteristic of cancer, and acyl-CoA dehydrogenase short-chain (ACADS), a regulator of lipid synthesis, is involved in carcinogenesis-associated metabolic pathways. …”
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Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…It also effectively regulate the abundance and diversity of intestinal flora. …”
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Cloning and expression characterisation of LiDXS2 gene in Oriental Lily (Lilium 'Sorbonne') by Yu Jiaxuan, Wu Nana, Fu Ruyu, Xue Lili, Zhang Jinzhu, Dong Jie, Yang Tao, Fan Jinping

“…Collectively, these results suggest that LiDXS2 may play an important role in regulating Lilium ‘Sorbonne’ monoterpene synthesis and its floral flavour release.…”
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EFFORTS IN CONTROLLING COAL DUST HAZARDS IN THE STOCKPILE AREA OF A STEAM POWER PLANT (PLTU) by Alifiah Rizky Rosydah, Y. Denny Ardyanto Wahyudiono, Ahmad Imaduddin, Dani Nasirul Haqi, Meirina Ernawati

“…Further, OHS induction was conducted, together with safety talk, working hour regulations, toolbox meeting, training on the use of PPE, Medical Check Up (MCU), person authorization, preventive maintenance, and the use of PPE by workers. …”
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An environmental isolate of Pseudomonas, 20EI1, reduces Aspergillus flavus growth in an iron-dependent manner and alters secondary metabolism by Elizabeth M. Wyman, W. Scott Grayburn, Matthew K. Gilbert, Matthew D. Lebar, Jessica M. Lohmar, Jeffrey W. Cary, Thomas J. C. Sauters, Antonis Rokas, Ana M. Calvo

“…Expression of iron-related genes was altered in the presence of the bacteria and genes involved in the production of aflatoxin were down-regulated. Iron supplementation partially reestablished their expression. …”
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The Influence of the Cu-Al₂O₃ Ratio of the Receiving Tube in a 50 MW Hybrid Solar Plant by Guillermo Benítez-Olivares, Alejandro Torres-Aldaco, Raúl Lugo-Leyte, José Javier Valencia-López, Luis Alberto Romero-Vázquez, Helen D. Lugo-Méndez

“…The effect of the Cu-Al₂O₃ ratio on the receiver tube is evaluated, with Al₂O₃ serving as a thermal regulator to reduce temperature gradients and mitigate flow instability. …”
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Transcriptome analysis unveils the mechanisms of oxidative stress, immunotoxicity and neurotoxicity induced by benzotriazole UV stabilizer-328 in zebrafish embryos by Xinlu Yang, Yijing Gan, Menghuan Zhang, Shaolin Xie, Mingfu Lin, Lixiang Zhong, Mengke Song, Jun Wang, Yumei Huang

“…Moreover, the results of transcriptome analysis and qRT-PCR validation suggested that immune and nerve disorders were caused by UV-328 in zebrafish larvae through regulating the RIG-I-like receptor signaling pathway and neuroactive ligand-receptor interaction, respectively. …”
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Anti-Inflammatory and Antinociceptive Activities of Bufalin in Rodents by Lili Wen, Yang Huang, Xianbiao Xie, Wan Huang, Junqiang Yin, Wenqian Lin, Qiang Jia, Weian Zeng

“…Our data showed that bufalin (0.3 and 0.6 mg/kg, i.p.) potently decreased carrageenan-induced paw edema. Bufalin down regulated the expression levels of nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) during these treatments. …”
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Anti-Tumor Effect of Rutin on Human Neuroblastoma Cell Lines through Inducing G2/M Cell Cycle Arrest and Promoting Apoptosis by Hongyan Chen, Qing Miao, Miao Geng, Jing Liu, Yazhuo Hu, Lei Tian, Jingkun Pan, Yi Yang

“…These results suggest that rutin produces obvious antineuroblastoma effects via induced G2/M arrest in the cell cycle progression and induced cell apoptosis as well as regulating the expression of gene related to apoptosis and so on. …”
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Quasi-parallel Antisunward-propagating Whistler Waves Associated with the Electron Deficit in the Near-Sun Solar Wind: Particle-in-cell Simulation by Alfredo Micera, Daniel Verscharen, Jesse T. Coburn, Maria Elena Innocenti

“…Our findings are compared and validated against current PSP and SO observations: among others, our study provides a mechanism explaining the presence in the heliosphere of regularly observed parallel antisunward whistler waves, suggests why these waves are frequently observed concomitant with distributions presenting an electron deficit, and describes a noncollisional heat flux regulating process.…”
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Expression pattern of Calbindin-D28k, NeuN proteins, ATOH1 and EN2 genes in the human fetal cerebellum by Phanindra Prasad Poudel, Arnab Ghosh, Chacchu Bhattarai, Saman Pradhan, Nirmal Panthi, Dela Singh Joshi, Shanti Khadka, Sandhya Kumari, Guruprasad Kalthur, R. Vani Lakshmi, Sneha Guruprasad Kalthur

“…Series of events such as cell proliferation, migration, and differentiation occur during the development, which are tightly regulated by specific genes. Understanding the expression patterns of key genes involved in these processes during various stages of fetal development can provide valuable insights into the complex mechanisms of cerebellar development. …”
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ROS-ERK Pathway as Dual Mediators of Cellular Injury and Autophagy-Associated Adaptive Response in Urinary Protein-Irritated Renal Tubular Epithelial Cells by Jian-kun Deng, Xueqin Zhang, Hong-luan Wu, Yu Gan, Ling Ye, Huijuan Zheng, Zebing Zhu, Wei Jing Liu, Hua-feng Liu

“…ERK, an extracellular signal-regulated protein kinase, is involved in various biological responses, such as cell proliferation and differentiation, cell morphology maintenance, cytoskeletal construction, apoptosis, and canceration of cells. …”
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Crowdsourced Indicators of Flora and Fauna Species: Comparisons Between iNaturalist Records and Field Observations by Hyuksoo Kwon, Bumsuk Seo, Jungin Kim, Heera Lee

“…Cultural ecosystem services provide intangible benefits such as recreation and aesthetic enjoyment but are difficult to quantify compared to provisioning or regulating ecosystem services. Recent technologies offer alternative indicators, such as social media data, to identify popular locations and their features. …”
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Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT/IKKα/β/NF-κB Signaling Axis by Rahul Gupta, Dipanjan Roy, Arijit Ghosh, Yasmin Begum, Dipanjan Ghosh, Snehasikta Swarnakar

“…In addition, it reduced actin polymerization and down-regulated CSC markers (e.g., CD24, CD44, EpCAM). Moreover, MBZ suppressed MMP-9 activity and inhibited the EMT marker as judged by decreased N-Cadherin and Vimentin and increased E-Cadherin. …”
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Numerical Low-Back Booster Analysis in a 6-Year-Old Infant during a Dolly Rollover Test by I. L. Cruz-Jaramillo, C. R. Torres-San Miguel, L. Martínez-Sáez, V. Ramírez-Vela, G. M. Urriologoitia-Calderón

“…The border conditions were established for each study, in accordance with the regulations of Federal Motor Vehicle Safety Standards (FMVSS), and following the FMVSS 213 standard for the mounting and fastening of the infant, the FMVSS 208 for the dolly methodology test with the vehicle rollover was performed, implementing such analysis under the same conditions for a vehicle Toyota Yaris 2010. …”
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Effect of different initial C/N ratio of cow manure and straw on microbial quality of compost by M. A. Macias-Corral, J. A. Cueto-Wong, J. Morán-Martínez

“…This mix complied with current Mexican sanitary regulations for compost use. The composts produced from the other C/N ratios complied only with the limits for one or two of the microorganisms that were analyzed. …”
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NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense by Hui Li, Wei Han, Vasilly Polosukhin, Fiona E. Yull, Brahm H. Segal, Can-Mao Xie, Timothy S. Blackwell

“…Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain whether interventions targeting NF-κB would be beneficial in sepsis. …”
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A Multivent System for Non-Invasive Ventilation: Solving the Problem of Ventilator Shortage During the COVID-19 Pandemic by Shuai Ren, Xiaohan Wang, Liming Hao, Tao Wang, Zujin Luo

“…The close loop system consists of the proportional valve and the flow-pressure sensor can regulate the airway pressure and flow for each patient. …”
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