Human Neutrophil Defensins Disrupt Liver Interendothelial Junctions and Aggravate Sepsis by QiXing Chen, Yang Yang, YiHang Pan, LiHua Shen, Yan Zhang, Fei Zheng, Qiang Shu, XiangMing Fang

“…This study directly demonstrates that neutrophil defensins play a key role in regulating endothelial stability during sepsis development.…”
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Endogenous peptide CBDP1 inhibits clear cell renal cell carcinoma progression by targeting USP5/YTHDF2/TRPM5 axis by Yang Zhang, Wei Zhu, Ruijie Tao, Weijian Li, Chunming Jiang, Xiang Yan

“…Conclusion: These data indicate that CBDP1 exerts its antitumor effects by regulating the USP5/YTHDF2/TRPM3 axis. CBDP1 emerges as a promising candidate for the treatment of ccRCC.…”
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Genes of Inflammation and Placental Function GWAS Associated with Idiopathic Recurrent Miscarriage in the Kazakh Population by Alexandra Murtazaliyeva, Gulnara Svyatova, Galina Berezina, Gulfairuz Urazbayeva, Aigerim Sadyrbekova

“…One of the causes of this pathology is the occurrence of mutations both in pleiotropic and pathway-specific regulators and in structural genes. The simplest type of such mutations is single nucleotide polymorphisms. …”
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Using achievements of fruit crop genetics and breeding: a contribution from the Michurinsk Department of the Vavilov Society of Geneticists and Breeders by N. I. Savel’ev, N. N. Savel’eva

“…Some genes were identified for the first time. These are genes regulating Coccomyces hiemalis Higg. resistance (A), retarded growth habit in cherry (O2), astringency (Ta) and juiciness (Su) of fruit in pear. …”
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Chronotope of Engineering and Pedagogical Thinking by A. V. Feoktistov, A. G. Kislov, I. V. Shapko, V. E. Gorodilov

“…The scientific novelty lies in the justification, by the example of advancing to the theory of engineering and pedagogical thinking, of supplementing the competence approach with consideration of no less significant cultural and subcultural factors, including latent ones, which sometimes manifest themselves in very weak signals about the features of the chronotope of training engineers and technicians by engineers–teachers, not so much by virtue of official regulations as by virtue of singular acts of everyday life communication.…”
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Design of a public health emergency equipment system for bioterrorism events in public places based on literature review, scenario analysis and Delphi consultation by Xiaowen SUN, Yongzhong ZHANG, Chao ZHAO, Tianyang DENG, Song BAI

“…MethodsBased on domestic laws and regulations, domestic and international literature on health emergencies from 2004 to 2023, and survey data on the equipment configuration of domestic health emergency equipment enterprises and relevant emergency response teams, this study first used scenario analysis to explore the functional requirements of health emergency equipment from three aspects: the environment in which bioterrorism events occur, the survival and task requirements of personnel at the scene, and the methods of emergency response. …”
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Inhibition of high glucose-induced cardiac fibroblast activation: an effective treatment for diabetic cardiomyopathy using Chinese herbal medicine by Bin Wan, Jing Hu, Yue Luo, Yutong Han, Yaowen Zhang, Qinchuan Huang, Yulin Leng, Chunguang Xie, Chunguang Xie

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METHOD AND ALGORITHMS OF CALCULATION OF PARAMETERS OF RELIABILITY IN ACCORDANCE WITH MULTIVARIATE DATA by E. M. Farhadzadeh, A. Z. Muradaliyev, T. K. Rafiyeva, S. A. Abdullayeva

“…Assessments of the relevance of the kinds of attributes regulated by classifiers, evaluation of parameters of individual reliability, of parameters of reliability of multivariate data clusters relate to the primary problems the decision of which would make it possible to reduce operational expenses of electric power system objects. …”
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Pesticidal Activity of Sundarban Mangrove Plant Extracts against Sitophilus Pests and Identification of Active Constituents Using LC-MS by Md. Abdur Rahman, Rinku Rani Paul, Chaina Biswas, Hakima Akter, Razina Rouf, Sushmita Nath, Jamil A. Shilpi, Lutfun Nahar, Stayajit D. Sarker, Shaikh Jamal Uddin

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Analyzing factors of daily travel distances in Japan during the COVID-19 pandemic by Masaya Mori, Yuto Omae, Yohei Kakimoto, Makoto Sasaki, Jun Toyotani

“…Consequently, recent research has focused on identifying and analyzing factors that can effectively regulate human flow. However, among the multiple factors that are expected to have an effect, few studies have investigated those that are particularly associated with human flow during the COVID-19 pandemic. …”
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Promising Therapeutic Functions of Bone Marrow Mesenchymal Stem Cells Derived-Exosome in Asthma by Jia-Ying Yuan, Xiang-Yun Wang, Zhi-Ying Tong, Yu-Chao Dong, Jia-Yi Zhao, Yi Zhang, Yan Shang

“…Points also hold that BMMSC-Exo could interfere with airway inflammation and airway remolding in asthma via modulating the immune response, regulating gene expression, adjusting the phenotype of macrophage, etc. …”
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Physiotherapists’ perspectives on the implementation of direct access to physiotherapy services in Saudi Arabia: a cross-sectional study by Hosam Alzahrani, Razaz Shaheen, Osama Mohammed, Elaf Marouf

“…The primary barriers to DAPT identified were laws and regulations (mean=3.69, SD=1.21), physician support (mean=3.59, SD=0.99), entry-level education (mean=3.45, SD=1.17), patient beliefs (mean=3.38, SD=1.24), self-confidence (mean=3.35, SD=1.15) and professional autonomy (mean=3.34, SD=1.22).Conclusion Physiotherapists in Saudi Arabia demonstrate substantial awareness of direct access. …”
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Laxative Effect of Lacticaseibacillus rhamnosus Glory LG12: from the Perspective of the Stem Cell Factor/C-kit Signaling Pathway by XIANG Fangqin, LI Yuxing, LI Bailiang

“…In addition, both treatments elevated the serum levels of motilin (MTL), gastrin (Gas), substance P (SP), and interleukin 10 (IL-10), reduced the levels of endothelin-1 (ET-1), somatostatin (SS), vasoactive intestinal peptide (VIP), and IL-6, up-regulated the relative mRNA expression of SCF and C-kit in colonic tissue was (P < 0.01, P < 0.001), and restored damaged colonic barrier. …”
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Explore the Mechanism of Astragalus mongholicus Bunge against Nonalcoholic Fatty Liver Disease Based on Network Pharmacology and Experimental Verification by Lili Fu, Zhongming Wu, Yanjun Chu, Wenbin Chen, Ling Gao, Shumin Mu, Jiajun Zhao

“…Our results indicated that quercetin, as the main active component in AMB, exerts an anti-NAFLD effect by regulating the AMPK/MAPK/TNF-α and AMPK/ACC/CPT1α signaling pathways to inhibit inflammation and alleviate lipid accumulation.…”
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Synbiotics effects of d-tagatose and Lactobacillus rhamnosus GG on the inflammation and oxidative stress reaction of Gallus gallus based on the genus of cecal bacteria and their me... by Yuanqiang Lv, Jie Chu, Xiaoxiao Zhang, Xuan Li, Aijiao Yin, Industrial Microbiology Laboratory

“…The intestinal bacteria genera and metabolomics analysis results indicated that the abundance of beneficial bacteria genus was up-regulated, and the proportion of pathogenic bacteria genera decreased. …”
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On occurrence of some avian bacterial diseases and biosafety provision by T. V. Kurmakaeva, S. S. Kozak, E. S. Baranovich

“…It should be noted that in accordance with the requirements of Technical Regulations TR CU 021/2011 and TR EAEU 051/2021, no Salmonella is allowed in 25 g of poultry meat. …”
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Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway by Zilin Yu, Chunyang Fan, Yubo Mao, Xiexing Wu, Haiqing Mao

“…GEO analysis revealed significant alterations in miR-2355-5p expression, confirming its role in regulating the mTOR pathway and autophagy. Conclusions Autophagy, mediated by the miR-2355-5p/mTOR pathway, plays a protective role in AFCs degeneration. …”
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Ukrainian SSR police activities in combating crime in the late 1950s by V. A. Grechenko

“…Since the mid-1950s, legislative activity in Ukraine has become more intense, the number of new regulations has increased rapidly, and their quality has improved. …”
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Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan by Tayyaba Nisar, Kashan Arshad, Zahid Abbas, Maira Ali Khan, Sohail Safdar, Rehan Sadiq Shaikh, Ali Saeed

“…The glucokinase regulatory protein (GCKR) regulates glycogen metabolism and insulin secretion, and the GCKR rs1260326 is a putative single nucleotide polymorphism (SNP) associated with metabolic disorders including nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). …”
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The Effect of High Levels Carbohydrate on Intestinal Microbiota, Metabolites, and Health of Common Carp (Cyprinus carpio L.) by Jinrui Xiong, Liping Yang, Luming Wang, Shaoyang Zhi, Mengjuan Zhao, Chunchu Xu, Leya Qu, Xiaorui Guo, Xiao Yan, Chaobin Qin, Guoxing Nie

“…In summary, dietary carbohydrates might mediate intestinal flora to regulate their metabolites and affect intestinal inflammatory response.…”
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