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12681
ABA enhances the apoptotic effect of docetaxel in the multidrug-resistant DU145 prostate cancer cell line
Published 2024-01-01“…RT-PCR analysis showed that treatment of resistant cells with 50.07 nM docetaxel and 500 μM ABA (ABA) resulted in the following changes in gene expression: heat shock protein (HSP) 70 (0.63-fold), glucose-regulated protein 94 (GRP94) 0.33-fold, inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) 1.62-fold, ER degradation- enhancing alpha-mannosidase-like 1 (EDEM1) 1.77-fold, X-box binding protein 1 (XBP1) 1.53-fold, p21 (2.53-fold), cellular tumor antigen p53 (p53) 2.49-fold, bcl-2-like protein 4 (Bax) 2.7-fold, and tumor necrosis factor (TNF-α) 6.35-fold. …”
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12682
Exploring the Orca Predation Algorithm for Economic Dispatch Optimization in Power Systems
Published 2024-09-01“…The sensitivity analysis of the parameters regulating the exploration-exploitation balance in Orca Predation Algorithm demonstrated substantial performance enhancements. …”
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12683
Verbal and Nonverbal Languages in Online Thesis Examinations: An Illocutionary Act Study
Published 2024-02-01“…Further findings, 3) The nonverbal language found were gestures; illustrator, regulator, emblem, or adaptor: facial expressions found based on linguistic terms are syntactic display, speaker semantic display, and listener semantic adaptor. …”
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12684
Classification of Visual Cortex Plasticity Phenotypes following Treatment for Amblyopia
Published 2019-01-01“…This experience-dependent plasticity has become a model for studying the mechanisms, especially glutamatergic and GABAergic receptors, that regulate amblyopia. Less is known, however, about treatment-induced changes to those receptors and if those changes differentiate treatments that support the recovery of acuity versus persistent acuity deficits. …”
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12685
Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease
Published 2025-01-01“…Hepcidin, a liver-derived peptide, has been identified as the key systemic regulator of iron homeostasis. Our study highlights the potential diagnostic role of serum hepcidin in the evaluation of anemia in elderly. …”
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12686
Risk Evaluation of Pyrolyzed Biochar from Multiple Wastes
Published 2019-01-01“…The degree of environmental risk assessment of HM pollution in biomass and biochars has been determined by using potential ecological risk index and RAC while organic contaminant degradation by EPFRs was considered when assessing the environmental roles of biochar in regulating the fate of contaminants removal. The magnitude of technologies’ net benefit must be considered in relation to the associated risks.…”
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12687
Geopolitical Concerns Arising From Mining Activities in Some Parts of Nigeria and Cameroon
Published 2020-06-01“…The study concludes that with regulations of the negative effect of mining, mining can be very beneficial to the people because the negative geopolitical concerns raised are less than the benefits derived.…”
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12688
IMPROVING THE LEGISLATION OF THE RUSSIAN FEDERATION IN THE FIELD OF COMBATING CRIMES ARISING FROM MARRIAGE AND FAMILY RELATIONS
Published 2024-06-01“…Based on the analysis of these forms and methods, problems of preventing and combating crimes arising from marriage and family relations are identified; it is concluded that the main problem is the presence of gaps in the current legislation regulating the area of legal relations under consideration. …”
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12689
Arrested Puberty in an Adolescent Male with Anorexia Nervosa Successfully Resumed with Multidisciplinary Care
Published 2021-01-01“…The normal development of puberty depends on the specific pulsatility of gonadorelin, which is finely regulated by genetic and environmental factors. In the published literature, eating disorders figure as a cause of pubertal delay/arrest in females but are rarely considered in males with disordered puberty. …”
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12690
Extracellular Vesicle-Loaded Oncogenic lncRNA NEAT1 from Adipose-Derived Mesenchymal Stem Cells Confers Gemcitabine Resistance in Pancreatic Cancer via miR-491-5p/Snail/SOCS3 Axis
Published 2023-01-01“…Collectively, the findings from our study found a new potential strategy for gemcitabine resistance in PCa by illustrating the mechanistic insights of oncogenic ADSC-derived EVs-loaded NEAT1 via regulating the miR-491-5p/Snail/SOCS3 axis.…”
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12691
Multisectoral actions in primary health care: A realist synthesis of scoping review.
Published 2023-01-01“…At the macro-level, themes included influence on the policy rules and regulations for governance, and health in all policies for collaborative decision makings. …”
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12692
Smokeless, not harmless: Understanding Naswar's cardiovascular risks in the northwestern Pakistan
Published 2025-02-01“…Conclusions: This study adds to the body of literature on significant association between Naswar use and CAD, emphasizing the necessity of regulating SLT products like Naswar to mitigate cardiovascular risks.…”
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12693
Interaction of the National Police of Ukraine and civil society institutions: concept and legal framework
Published 2023-09-01“…Based on the results of a multidisciplinary generalisation of the scholars’ achievements in the field of Administrative Law, it has been determined that in a broad sense, interaction between the National Police of Ukraine and civil society institutions should be understood as their joint coordinated activities regulated and carried out in accordance with the requirements of current legislation, which may take various forms and is embodied in a large number of measures whose overall purpose is to ensure the formation of a secure environment in the State. …”
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12694
The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights
Published 2025-01-01“…In addition, other inflammasomes such as Nucleotide-binding oligomerization domain, Leucine rich Repeat (NLR) and Pyrin (NLRP) 6 and 12 (NLRP6 and NLRP12, respectively) regulate HCC onset and progression, although more experimental evidence is required. …”
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12695
Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses
Published 2022-01-01“…Meanwhile, network analysis of these differential proteins suggested that protein Galectin-1 (Gal-1) could regulate the apoptosis process (15 related proteins), which played an essential role in the potential targets of DBDCT-induced hepatotoxicity. …”
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12696
Inflammatory Cytokines, Adipocytokines, and Th17/Treg Balance in Patients with Nonalcoholic Fatty Liver Disease following Administration of Dahuang Zhechong Pills
Published 2022-01-01“…Administration of DHZCPs regulates the immune function of NAFLD patients by keeping Th17/Treg balance and affecting the levels of inflammatory cytokines and adipocytokines.…”
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12697
MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer
Published 2022-01-01“…This study aims to determine the clinical significance of MAIP1 in EC and explores its potential molecular mechanisms regulating tumor immune infiltration. Methods. We obtained RNA-seq datasets and corresponding clinical data for EC patients from the Cancer Genome Atlas (TCGA) database via the UCSC Xena browser to extract MAIP1 expression and plot survival curves to determine their prognosis. …”
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12698
Countering hostile sabotage and reconnaissance groups by the National Police of Ukraine units in the context of martial law
Published 2024-03-01“…The author identifies additional powers of the police under the martial law regime, including the following: conducting joint operations against sabotage and reconnaissance forces of the aggressor (enemy) and paramilitary or armed groups which are not regulated by the laws of Ukraine. To address the objectives of the study, the analysis of the sources of international and national law providing for the use of sabotage and reconnaissance groups by the parties to the conflict is carried out, the essence and hierarchical structure of these groups are revealed, and the objects against which the use of sabotage measures is prohibited are identified. …”
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12699
Financial and legal bases for the formation of territorial communities capable budgets
Published 2021-09-01“…Based on the historical experience of budget relations in Ukraine and foreign experience, the need to form viable budgets at the expense of alternative revenues , namely by providing UTC rights to establish indirect taxes, regulate benefits and tax rates, income from business activities, and the use of intergovernmental transfers in the required amounts and for specific purposes is proved. …”
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12700
Voluntary Disclosures and their Drivers: A Study of MDA Reports in India
Published 2024-05-01“…The outcomes of this research offer valuable insights for regulators, policymakers, and listed companies in India, aiding in the enhancement of MD&A reporting quality. …”
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