Synergistic Stimulation with Different TLR7 Ligands Modulates Gene Expression Patterns in the Human Plasmacytoid Dendritic Cell Line CAL-1 by Tobias Hilbert, Folkert Steinhagen, Christina Weisheit, Georg Baumgarten, Andreas Hoeft, Sven Klaschik

“…This effect was due to a stronger stimulation of already regulated genes (by monostimulation) as well as to recruitment of thus far unregulated genes. …”
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Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis by Ping Gao, Yong Huang, Yanmei Hou, Qian Li, Haimei Wang

“…Mechanism investigations claimed that circ-ITCH exerted its metastasis-inhibitory activity via sponging miR-106b-5p and regulating the expression of PDCD4. Conclusively, circ-ITCH suppresses ccRCC metastasis by enforcing PDCD4 expression through binding miR-106b-5p. circ-ITCH may function as a novel diagnostic target to suppress ccRCC metastasis.…”
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Post-Disaster Temporary Shelter Area Selection and Planning by Using Delphi Method: Izmir/Seferihisar Case by Hande Dayanır, Ali Kemal Çınar, Yenal Akgün, Özşen Çorumluoğlu

“…Although the "Directive on the Establishment, Management and Operation of Temporary Shelter Centers" released by AFAD in 2015 mostly defines the national criteria, it is not as detailed as the regulations revealed in the international literature. …”
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Nursing of a patient with gout of damp-heat stagnation syndrome combined with erosive gastritis treated with auricular acupoint therapy combine with pricking and cupping therapy (耳... by ZHU Jianmei (朱建妹), CHEN Hui (陈慧), ZHANG Xiaolin (张小林), LIAO Xuefeng (廖雪锋)

“…In addition to routine nursing, individualized auricular acupoint treatment including auricular bloodletting and pressing combined with pricking and cupping therapy were carried out, aiming at relieving heat and detoxification at early stage of disease, promoting blood circulation, dredging collaterals and regulating qi at midterm and invigorating spleen and warming kidney Yang and end stage of treatment. …”
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MAPK4 inhibits the early aberrant activation of B cells in rheumatoid arthritis by promoting the IRF4-SHIP1 signaling pathway by Pei Huang, Guangli Yang, Pingping Zhang, Yin Zhu, Yaning Guan, Jian Sun, Qian Li, Yang An, Xiaoqi Shi, Juanjuan Zhao, Chaohong Liu, Zhixu He, Yan Chen, Zuochen Du

“…In summary, this study reveals the diverse roles of MAPK4 in regulating of B cell functions, with potential implications for developing therapeutic strategies for RA and related autoimmune diseases.…”
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Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients by Kai Bartkowiak, Parinaz Mossahebi Mohammadi, Paula Nissen, Stefan Werner, David Agorku, Antje Andreas, Maria Geffken, Sven Peine, Karl Verpoort, Thomas M. Deutsch, Laura L. Michel, Andreas Schneeweiss, Verena Thewes, Andreas Trumpp, Olaf Hardt, Volkmar Müller, Sabine Riethdorf, Hartmut Schlüter, Klaus Pantel

“…This resulted in upregulation of ER-alpha, the tumor progression protein GRP78 (78-kDa glucose-regulated protein) and downregulation of the tumor suppressor protein PDCD4 (programmed cell death protein 4). …”
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Differences in Transcriptional Activation by the Two Allelic (L162V Polymorphic) Variants of PPARα after Omega-3 Fatty Acids Treatment by Iwona Rudkowska, Mélanie Verreault, Olivier Barbier, Marie-Claude Vohl

“…Omega-3 fatty acids (FAs) have the potential to regulate gene expression via the peroxisome proliferator-activated receptor α (PPARα); therefore, genetic variations in this gene may impact its transcriptional activity on target genes. …”
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Benchmarking Vision-Based Object Tracking for USVs in Complex Maritime Environments by Muhayy Ud Din, Ahsan Baidar Bakht, Waseem Akram, Yihao Dong, Lakmal Seneviratne, Irfan Hussain

“…Among the control algorithms evaluated, the linear quadratic regulator controller (LQR) demonstrated the most robust and smooth control, allowing for stable tracking of the USV. …”
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Deoxycholic Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Exacerbates DSS-Induced Colitis through Promoting Cathepsin B Release by Shengnan Zhao, Zizhen Gong, Xixi Du, Chunyan Tian, Lingyu Wang, Jiefei Zhou, Congfeng Xu, Yingwei Chen, Wei Cai, Jin Wu

“…Meanwhile, DCA-induced NLRP3 inflammasome activation is at least partially achieved through stimulating extracellular regulated protein kinases (ERK) signaling pathway downstream of S1PR2 followed by promoting of lysosomal cathepsin B release. …”
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The trend of suicide and self-harm in the Chinese population from 2018 to 2022 based on ambulance medical emergency cases: a retrospective study by Ruizhe Yang, Jinsu Zhou, Francis Manyori Bigambo, Wu Yan, Xu Wang, Haibo Yang

“…Key strategies include regulating pesticides and psychotropic drugs, increasing access to mental health resources, and launching community awareness campaigns. …”
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Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast by Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu

“…FoxO1 was validated as the key gene which regulates osteogenic differentiation and redox status. …”
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Microplastics in freshwaters: Comparing effects of particle properties and an invertebrate consumer on microbial communities and ecosystem functions by Ze Hui Kong, Tong Liu, Francis J. Burdon, Amélie Truchy, Martyn Futter, Mirco Bundschuh, Rachel Hurley, Stefan Bertilsson, Brendan G. Mckie

“…The effects of microplastic (MP) accumulation in freshwaters on organisms and ecosystem functions are poorly understood, as are the roles of MP particle properties in regulating these effects. In freshwater microcosms, we quantified variation in microbial communities and ecosystem functions and compared effects of MP concentration (0, 1000, 50000 particles/kgsediment), shape (sphere, fragment, fibre), and polymer (polyethylene, polyethylene terephthalate, polypropylene, polystyrene) with those of a model invertebrate consumer (Chironomus riparius). …”
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Complexity of near-surface deformation and subsurface structure of the Chihshang creeping fault-line scarp, eastern Taiwan: insights from integration of geological and geophysical... by W. J. Huang, M. T. Fitrianto, C. C. Chen, P. Y. Chang, I. C. Yen, M. Le Béon, S. T. Lu

“…Abstract The precise position and geometry of a fault and the recognition of contemporary active strands are pivotal elements for formulating regulations for earthquake fault zones and fault setbacks. …”
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Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs by Ming-Xia Duan, Heng Zhou, Qing-Qing Wu, Chen Liu, Yang Xiao, Wei Deng, Qi-Zhu Tang

“…Hence, Andr may be involved in regulating HG-induced injury by activating PI3K/AKT-eNOS signalling in HUVECs.…”
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Flammulina velutipes polysaccharide-iron(III) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters by Chenying Shi, Chen Cheng, Xiaotong Lin, Yanfang Qian, Yufeng Du, Guitang Chen

“…FVP1-Fe(III) could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. …”
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Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension by Christos Papageorgiou, Efstathios Manios, Eleftheria Tsaltas, Eleni Koroboki, Maria Alevizaki, Elias Angelopoulos, Meletios-Athanasios Dimopoulos, Charalabos Papageorgiou, Nikolaos Zakopoulos

“…These findings provide a starting point for increasing our understanding of the complex relationships between cerebral activation and cardiovascular functioning involved in regulating blood pressure changes.…”
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Expression of EZH2 and H3K27me3 predicts tumor biology of urothelial carcinoma by Rasheeda Mohamedali, Suvradeep Mitra, Swarnendu Mandal, Prasant Nayak, Amit K. Adhya, Suvendu Purkait

“…Conclusions: This study establishes an important role of the key epigenetic regulators EZH2 and H3K27me3 in the pathobiology of urothelial carcinomas. …”
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Identification of the BBX gene family in blueberry at different chromosome ploidy levels and fruit development and response under stress by Yujian Xue, Jiazhuo Chen, Jia Hao, Xiaoyu Bao, Luodan Kuang, Dong Zhang, Chengwen Zong

“…These findings will support further investigation of how BBX genes are involved in regulating hormone treatment and light stress during the growth and development of blueberry.…”
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Methodical approaches in experimental modelling of non-alcoholic fatty liver disease by N. V. Bivalkevich, Yu. K. Denisenko, T. P. Novgorodtseva

“…Genetic models of NAFLD developing on background of obesity and metabolicsyndrome represent the second category (animals, with leptin gene deletion – ob/ob, mice resistant to leptin action, – db/db and transgenic mice with excessive expression of styrene-regulating element of protein-1 isoform. Diet-induced models of NAFLD are engendered by modulation of various alimentary factors. …”
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Public health and clinical implications of Dobbs v. Jackson for patients and healthcare providers: A scoping review. by David T Zhu, Lucy Zhao, Tala Alzoubi, Novera Shenin, Teerkasha Baskaran, Julia Tikhonov, Catherine Wang

“…Wade, empowering individual states to regulate abortion care. This aftermath of this ruling has given rise to widespread bans, limiting the accessibility of abortion services for patients and impeding providers' ability to deliver a comprehensive spectrum of reproductive health services. …”
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