The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population by Guoda Ma, Haiyang Wang, Guixi Mo, Lili Cui, You Li, Yiming Shao, Xin Liu, Yuliu Xie, Jia Li, Jiawu Fu, Hua Tao, Bin Zhao, Liangqing Zhang, Keshen Li

“…Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. …”
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TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…RNA-seq analysis of laser-captured micro-dissected endometrium and spatial transcriptomics revealed a key role for Krüppel-like factor (Klf9), a directly-regulated TR target gene, in normal endometrial differentiation. …”
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Validation of <i>Monilinia fructicola</i> Putative Effector Genes in Different Host Peach (<i>Prunus persica</i>) Cultivars and Defense Response Investigation by Lucia Landi, Annamaria Lucrezia D’Ortenzio, Sarah Mojela Makau, Rita Milvia De Miccolis Angelini, Gianfranco Romanazzi

“…All fungal isolates induced similar brown rot lesions on both cv.s whereas the modulation of effector genes was regulated mainly at 2, 6, and 10 hpi, when disease symptoms appeared on the fruit surface, confirming the involvement of effector genes in the early infection stage. …”
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Investigating automated accounting and auditing in the Blockchain platform with a fuzzy Delphi approach by Payam Noori Doabi, Fereydon Rahnamay Roodposhti, Hamidreza Kordlouie, Hashem Nikoomaram, Ghodratollah Talebnia

“…Automated as an evolution in the field of accounting and auditing due to the dissatisfaction caused by financial scandals, frauds, bankruptcies, and past failures; the situation and problems in professions, industries, and businesses; volume, type, and impact of existing laws, regulations and standards; social and political pressures according to the existing situation; the wishes, expectations, needs and requirements of customers, and the ever-increasing technological developments and capabilities of the blockchain platform as an undeniable and very important necessity for which the necessary conditions are ready. …”
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The <i>MCPH7</i> Gene Product STIL Is Essential for Dendritic Spine Formation by Tohru Matsuki, Hidenori Tabata, Masashi Ueda, Hideaki Ito, Koh-ichi Nagata, Yumi Tsuneura, Shima Eda, Kenji Kasai, Atsuo Nakayama

“…Dendritic spine formation/maintenance is highly dependent on actin cytoskeletal dynamics, which is regulated by small GTPases Rac1 and Cdc42 through their downstream p21-activated kinase/LIM-kinase-I/cofilin pathway. …”
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Characterization of the procoagulant phenotype of amniotic fluid across gestation in rhesus macaques and humans by Chih Jen Yang, Lyndsey E. Shorey-Kendrick, Cristina Puy, Ashley E. Benson, Phillip A. Wilmarth, Ashok P. Reddy, Keith D. Zientek, Kilsun Kim, Adam Crosland, Chaevien S. Clendinen, Lisa M. Bramer, Olivia L. Hagen, Helen H. Vu, Joseph E. Aslan, Owen J.T. McCarty, Joseph J. Shatzel, Brian P. Scottoline, Jamie O. Lo

“…Conclusion: Overall, our findings reveal that the addition of AF to plasma enhances coagulation in a manner dependent on phospholipids as well as the presence of proteases and other proteins that directly regulate coagulation. We describe a correlation between clotting time and expression of coagulation proteins and phosphatidylserine in both rhesus and human AF, supporting the use of rhesus models for future studies of AF biology.…”
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Accumulation and distribution of cadmium at organic-mineral micro-interfaces across soil aggregates by Qi Li, Linfeng Li, Bohao Yin, Xiaoyang Lin, Anwen Xiao, Weijie Xue, Hengjie Liu, Yichun Li

“…Soil amendments are crucial in regulating cadmium (Cd) distribution as aggregates of varying sizes have different capacities to retain soil Cd. …”
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Inflammatory biomarkers profiles and cognition among older adults by Aline Thomas, Jing Guo, Dolly Reyes-Dumeyer, Danurys Sanchez, Nikolaos Scarmeas, Jennifer J. Manly, Adam M. Brickman, Rafael A. Lantigua, Richard Mayeux, Yian Gu

“…However, inflammatory markers are regulated and influenced by each other, and it is therefore important to consider a more comprehensive panel of markers to better capture diverse immune pathways and characterize the overall inflammatory profile of individuals. …”
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Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence by Chengyu Liu, Tenghui Tian, Yujia Shi, Meiqi Li, Le Hong, Jing Zhou, Jia Liu, Yuan Zhong, Xue Wang, Zhenyu Wang, Xue Bai, Lin Wang, Chunyan Li, Zhennan Wu

“…This approach achieved near‐infrared light absorption while inhibiting radiation transitions, thereby regulating the generation of ROS. Notably, different‐sized AuNCs (Au10NCs, Au15NCs, Au25NCs) yielded varied ROS types, resulting from different energy level distributions and electron transfer rates. …”
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CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…GABAergic signaling in the brain plays a key role in regulating synaptic transmission, neuronal excitability, and cognitive processes. …”
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Hydrogen Sulfide Increases Nitric Oxide Production and Subsequent S-Nitrosylation in Endothelial Cells by Ping-Ho Chen, Yaw-Syan Fu, Yun-Ming Wang, Kun-Han Yang, Danny Ling Wang, Bin Huang

“…Further study indicated an increase of upstream regulator for eNOS activation, AMP-activated protein kinase (AMPK), and protein kinase B (Akt). …”
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MSC-derived exosome ameliorates pulmonary fibrosis by modulating NOD 1/NLRP3-mediated epithelial-mesenchymal transition and inflammation by Wei Chen, Jie Peng, Xiangyi Tang, Shao Ouyang

“…Further studies showed that MSC-exos regulated NOD1/NF-kB signaling pathway to suppress the activation of NLRP3 inflammasomes both in vivo and in vitro. …”
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Mitochondrial Mayhem: How cigarette smoke induces placental dysfunction through MMS19 degradation by Pei Zhou, Feng Jin, Shenshen Yao, Ben Sun, Ni Sun, Hongbo Guan, Xiaomei Liu

“…This study aims to investigate the impact of CS on trophoblast cell proliferation and regulated cell death (RCD) by examining its interference with iron-sulfur cluster (ISC) proteins and the CIA pathway. …”
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The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review by Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang

“…SUMOylation is a dynamic process finely regulated by SUMOylation enzymes and proteases to maintain a balance between SUMOylation and deSUMOylation. …”
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Advancing hydrological modeling through multivariate calibration of multi-layer soil moisture dynamics by Yan He, Huihui Mao, Chen Wang, Jinghao Hu, Sarawut Ninsawat, Xianfeng Song, Guifei Jing, Runkui Li, Mingyu Wang, Zheng Duan

“…These findings underscore the importance of using advanced multi-layer soil moisture data in models to regulate hydrological processes and control water distribution within the hydrological cycle.…”
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Enhancing Thermal Comfort in Historic Buildings by Wind-Driven Ventilation Systems—A Case Study of the Praterateliers in Vienna by Aida Shayegani, Viera Joklova, Katarina Kristianova, Juraj Illes

“…A novel focus is placed on integrating windcatchers with passive systems like earth tubes and solar ventilation to reduce reliance on mechanical cooling and achieve lower carbon emissions while adhering to heritage preservation regulations. Using DesignBuilder simulations and future climate data (2020–2030), this research evaluates the thermal performance of key zones within the Praterateliers under different operational scenarios. …”
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Human health risk assessment of aluminium in water treated with aluminium-based coagulants in a rural area by Fernando García-Ávila, Tatiana Encalada-Alvear, Luis M. Alvarez-Altamirano, Alex Avilés-Añazco, Lorgio Valdiviezo-Gonzalez, Emigdio Alfaro-Paredes

“…The results revealed significant variations in the concentration of aluminium between seasons, although all measurements remained within the limits allowed by Ecuadorian regulations and the WHO, which sets a limit of 0.2 mg/L for aluminium in drinking water. …”
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Study on factors influencing the transport and transformation of polycyclic aromatic hydrocarbons in soil–groundwater systems by Wenxiang Hu, Jie Zhang, Dan Li, Ying Yuan, Ying Tang, Kunlong Hui, Yu Jiang, Wenbing Tan

“…The migration and transformation of PAHs are mainly regulated by organic matter, soil depth, surface water, and microbial community. …”
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Similarities between Tumour Immune Response and Chronic Wound Microenvironment: Influence of Mesenchymal Stromal/Stem Cells by Kimberly Thando Peta, Melvin Anyasi Ambele, Michael Sean Pepper

“…Mesenchymal stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate the immune system, migrate to sites of inflammation, and are naturally immune-privileged, there have been contradictory reports on the role of these cells in the tumour microenvironment (TME). …”
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Relationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR) by Mariasole Antonietta Guerriero, Anna Dipace, Antonietta Monda, Antonella De Maria, Rita Polito, Giovanni Messina, Marcellino Monda, Marilena di Padova, Angelo Basta, Maria Ruberto, Emanuele Capasso, Fiorenzo Moscatelli, Pierpaolo Limone

“…An integrated approach combining different forms of exercise and strategies to regulate emotions could provide very effective effects on the mental well-being of students. …”
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