EPIMR: Prediction of Enhancer-Promoter Interactions by Multi-Scale ResNet on Image Representation by Qiaozhen Meng, Yinuo Lyu, Xiaoqing Peng, Junhai Xu, Jijun Tang, Fei Guo

“…Prediction of enhancer-promoter interactions (EPIs) is key to regulating gene expression and diagnosing genetic diseases. …”
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Metabonomic-Transcriptome Integration Analysis on Osteoarthritis and Rheumatoid Arthritis by Ningyang Gao, Li Ding, Jian Pang, Yuxin Zheng, Yuelong Cao, Hongsheng Zhan, Yinyu Shi

“…TRAF3-acetoacetate interaction may be involved in regulating inflammation in OA and RA by the NF-kappa B and IL-17 pathway.…”
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Reciprocal Effects of Oxidative Stress on Heme Oxygenase Expression and Activity Contributes to Reno-Vascular Abnormalities in EC-SOD Knockout Mice by Tomoko Kawakami, Nitin Puri, Komal Sodhi, Lars Bellner, Toru Takahashi, Kiyoshi Morita, Rita Rezzani, Tim D. Oury, Nader G. Abraham

“…Heme oxygenase (HO) system is one of the key regulators of cellular redox homeostasis which responds to oxidative stress (ROS) via HO-1 induction. …”
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Surface topography modulates initial platelet adhesion to titanium substrata by Cecilia Yan Guo, Raymond Mo, Hugh Kim

“…We conclude that while surface topography can be engineered to modulate initial platelet adhesion, granule secretion is likely regulated as a separate and independent process.…”
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Cecropin AD ameliorates pneumonia and intestinal injury in mice with mycoplasma pneumoniae by mediating gut microbiota by Bowen Li, Mingming Liu, Wenjing Du, Shuaidong Wang, Zekang Xu, Xiaoqian Zhang, Yang Zhang, Song Hua

“…Antimicrobial peptides are characterized by their bactericidal, anti-inflammatory, and intestinal flora-regulating properties. However, the effect of cecropin AD (CAD) against mycoplasma pneumonia remains unclear. …”
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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

“…ABSTRACT Background The Ets‐1 transcription factor plays a primordial role in regulating the expression of numerous genes implicated in cancer progression. …”
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Oral Fusobacterium nucleatum resists the acidic pH of the stomach due to membrane erucic acid synthesized via enoyl-CoA hydratase-related protein FnFabM by Xiaocong Li, Shipeng Zhang, Huafang Sheng, Yan Zhen, Buling Wu, Zhuang Li, Dingqiang Chen, Hongwei Zhou

“…Inhibition of FnFabM expression by cerulenin reduced the C22:1(n9) content and decreased the colonization efficiency of F. nucleatum in the stomach and jejunum of mice.Conclusions Oral F. nucleatum translocate to the intestine by resisting the acidic environment owing to the presence of erucic acid in its cell membrane, which is regulated by FnFabM. These results provide novel insights into the mechanisms underlying the oral bacteria survival in acidic environments and their potential to colonize the intestine; thus, shedding light on the oral-gut axis and its implications on human health.…”
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Bifunctional copper ion/melittin incorporated hydrogel with antimicrobial and antioxidant capabilities for infected skin wound healing by Jun Yao, Xiao Li, Minjie Lin, Zhuoqi Han, Xiaonan Wang, Jingjing Guo, Bing Wu, Jiajie Xia

“…Therefore, bacterial infections must be treated while the accompanying inflammation and oxidative stress are regulated. Owing to the ongoing global increase in bacterial resistance, in this study, hydrogel co-loaded with bio-antimicrobial peptides and copper ions is designed, which exhibits antimicrobial, anti-inflammatory, and antioxidant properties. the proposed, sodium alginate@copper hydrogel (SA@Cu) is formed through the cross-linking of sodium alginate and Cu2+. …”
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Dietary Chicory Inulin-Rich Meal Exerts Greater Healing Effects than Fructooligosaccharide Preparation in Rats with Trinitrobenzenesulfonic Acid-Induced Necrotic Colitis by Bartosz Fotschki, Adam Jurgoński, Joanna Fotschki, Michał Majewski, Katarzyna Ognik, Jerzy Juśkiewicz

“…Both chicory preparations beneficially regulated physiological parameters in the lower part of the rat intestinal tract after TNBS-induced colitis, however the dietary treatment with chicory meal showed stronger reduction of mucosal disturbances caused by colitis. …”
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A Wireless Power Conversion Chain With Fully On-Chip Automatic Resonance Tuning System for Biomedical Implants by Mohammad Javad Karimi, Menghe Jin, Catherine Dehollain, Alexandre Schmid

“…Moreover, the power conversion chain delivers an optimized rectified voltage along with a regulated voltage of 1.8 V.…”
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Ultrasound-assisted enzyme extraction of Dendrobium Officinale polysaccharides: Extraction process, characterization, immunomodulatory effects by Hengpu Zhou, Yingjie Dong, Zhangyun Wu, Xi Peng, Meiqiu Yan, Suhong Chen, Guiyuan Lv

“…It mitigates damage to the thymus and spleen tissues, increases white blood cell counts, regulates the ratio of T lymphocytes and the levels of related factors, enhances macrophage phagocytic function to improve nonspecific immune responses, and boosts the levels of immunoglobulins IgA and IgG to enhance specific immune function. …”
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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever by Yizhen Yuan, Qian Chen, Zhe Li, Fangzhou Cai, Dan Li, Wei Wang

“…Results Our result showed CTLs were significantly activated in the severe liver injury group but the immune function‐related signal pathway was down‐regulated. The reason may be that the excessive immune response in the severe group at the late stage of DENV infection induces the polarization of macrophages into M2 type, and the macrophages then inhibit T cell immunity through the TGF‐β signaling pathway. …”
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The ERK1/2 Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina by Ghulam Mohammad, Mohammad Mairaj Siddiquei, Mohammad Imtiaz Nawaz, Ahmed M. Abu El-Asrar

“…This study was conducted to determine the expression of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a time-dependent manner and the effect of extracellular-signal-regulated kinases-1/2 (ERK1/2) inhibition on the expressions of MMP-9, TIMP-1, and inflammatory biomarkers in the retinas of diabetic rats. …”
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Effect of Tumor Necrosis Factor Family Member LIGHT (TNFSF14) on the Activation of Basophils and Eosinophils Interacting with Bronchial Epithelial Cells by Huai Na Qiu, Chun Kwok Wong, Jie Dong, Christopher Wai-Kei Lam, Zhe Cai

“…Results showed that LIGHT could significantly promote intercellular adhesion, cell surface expression of intercellular adhesion molecule-1, release of airway remodeling-related IL-6, CXCL8, and MMP-9 from BEAS-2B cells upon interaction with basophils/eosinophils, probably via the intercellular interaction, cell surface receptors HVEM and LTβR on BEAS-2B cells, and extracellular signal-regulated kinase, p38 mitogen activated protein kinase, and NF-κB signaling pathways. …”
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Exploration of the mechanism of 5-Methylcytosine promoting the progression of hepatocellular carcinoma by Qiyao Zhang, Zhen Cao, Yuting He, Ziwen Liu, Wenzhi Guo

“…Finally, using RIP and molecular interaction analysis, we demonstrated that YBX1 binds to TPM3 in an m5C dependent manner and regulates HCC progression. Widespread m5C sites were identified and found to be differentially distributed in HCC compared with adjacent tissues. …”
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A review of photovoltaic/thermal (PV/T) technology applied in building environment control by Xuhui Cao, Niansi Li, Yulin Li, Lei Che, Bendong Yu, Huifang Liu

“…The present work mainly investigates the application of PV/T in building environment in the past ten years, and reports a variety of application cases of PV/T technology combined with building systems to regulate indoor comfort and improve indoor environment. …”
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What Drives the H i Content of Central Galaxies—A Comparison between Hydrodynamic Simulations and Observations Using Random Forest by Xiao Li, Cheng Li, H. J. Mo

“…This result can be understood from the fact that the H i gas is regulated mainly by thermal-mode AGN feedback in TNG and by stellar feedback in EAGLE. …”
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Applying baseflow approach to the environmental flow needs of the Similkameen River Watershed in British Columbia, Canada by Hongli Chen, Qiang Li, Qiaoqiao Wang, Xuanjiao Chai, Yaping Wang

“…It is a tributary to the Columbia River, which is the heavily regulated watershed in North America. Study focus: Assessing Environmental Flow Needs (EFN) is imperative for preserving the socio-ecological balance and sustainability. …”
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Unraveling the function of TSC1-TSC2 complex: implications for stem cell fate by Shuang Wang, Ruishuang Ma, Chong Gao, Yu-Nong Tian, Rong-Gui Hu, Han Zhang, Lan Li, Yue Li

“…These genes produce proteins that regulate mTORC1 activity, essential for cell function and metabolism. …”
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DNA Methylation Is Involved in the Expression of miR-142-3p in Fibroblasts and Induced Pluripotent Stem Cells by Siti Razila Abdul Razak, Yukihiro Baba, Hiromitsu Nakauchi, Makoto Otsu, Sumiko Watanabe

“…MicroRNAs are differentially expressed in cells and regulate multiple biological processes. We have been analyzing comprehensive expression patterns of microRNA in human and mouse embryonic stem and induced pluripotent stem cells. …”
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