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11861
THE ROLE OF THE NORTH SEA OIL RESOURCES IN NORWAY’S ECONOMY
Published 2015-08-01“…At the same time, the North Sea is the most regulated area, besides it is the so called "homeland" of the oil production in Norway. …”
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11862
The Problem of Spurious Emissions in 5G FR2 Phased Arrays, and a Solution Based on an Upmixer With Embedded LO Leakage Cancellation
Published 2024-01-01“…Transmitters are not perfect, and therefore, there are regulations that limit the transmitted energy outside the intended transmission frequencies. …”
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11863
Respectful Pruning Improves Grapevine Development: A Case Study in Young Vineyards
Published 2024-01-01“…Grapevine pruning is an agronomical operation required to regulate growth and yield, improve fruit quality, and maintain plant health and vigour. …”
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11864
HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells
Published 2025-01-01“…KW-2478 inhibited the activation of Akt, extracellular regulated protein kinase 1/2, and c-Jun N-terminal kinase 1/2 in imatinib-resistant and -sensitive CML cells by promoting Met and BCR::ABL1 degradation. …”
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11865
The effect of soy isoflavones in brain development: the emerging role of multiple signaling pathways and future perspectives
Published 2024-04-01“…Endogenous estrogen plays a crucial role in brain development through binding to estrogen receptors (ERs) or G protein-coupled estrogen receptors 1 (GPER1) and regulates morphogenesis, migration, functional maturation, and intracellular metabolism of neurons and glial cells. …”
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11866
MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing
Published 2019-01-01“…We further showed that the miR-223, derived from exosomes of MSCs, regulated macrophage polarization by targeting pknox1. …”
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11867
Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer
Published 2018-01-01“…The differentially expressed genes were significantly overlapped with gene modules regulating cell cycle and cell adhesion. The cell cycle-related lncRNAs were consistently downregulated in breast cancer. …”
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11868
Methimazole disrupted skeletal ossification and muscle fiber transition in Bufo gargarizans larvae
Published 2025-01-01“…Our results indicated that MMI treatment down-regulated the expression levels of ossification-related genes (e.g., BMPs, MMPs, and Wnt9a) in cartilage, thereby delaying chondrocyte apoptosis and inhibiting hindlimb ossification. …”
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11869
Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity
Published 2025-02-01“…Additionally, MP promoted gut microbiota diversity and regulated SCFA concentrations, contributing to an improved intestinal microenvironment and alleviation of colitis symptoms.DiscussionOur findings highlight the superior effectiveness of Meconopsis polysaccharides in alleviating DSS-induced colitis and open new avenues for targeted therapeutic strategies in the treatment of IBD.…”
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11870
FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury
Published 2017-01-01“…Previous studies indicated that FGF2’s neuroprotective effects might be related to its function of regulating autophagy. The present study investigated FGF2’s beneficial effects in the early stage of rat mild TBI and the underlying mechanisms. …”
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11871
Blockade of Piezo2 Pathway Attenuates Inflammatory and Neuropathic Pain in the Orofacial Area
Published 2024-01-01“…Although previous studies suggest that Piezo2 regulates chronic pain in the orofacial area, few studies have reported the direct evidence of Piezo2’s involvement in inflammatory and neuropathic pain in the orofacial region. …”
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11872
Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a “three birds with one stone” strategy
Published 2025-02-01“…The in vivo and in vitro evaluation showed that micelles precisely targeted the inflammatory site, thus inhibiting the expression of pro-inflammatory cytokines, reversing the polarization of M1 macrophages, inhibiting the invasion and migration of proliferative FLSs, and, at the same time, regulating the seeds and soils of RA. This “three birds with one stone” approach targeted multiple aspects of RA, opening new horizons for comprehensive treatment of RA.…”
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11873
Consumption of a High-Fat Diet Alters Perineuronal Nets in the Prefrontal Cortex
Published 2018-01-01“…PNNs contribute to synaptic stabilization, protect against oxidative stress, regulate the ionic microenvironment within cells, and modulate regional excitatory output. …”
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11874
Input-Output Budget of Nitrogen and the Effect of Experimentally Changed Deposition in the Forest Ecosystems in Central Japan
Published 2001-01-01“…SO42– output below 20-cm soil layer changed depending on the input, while NO3– output was regulated mainly by the internal cycle and effect of manipulation was undetected. …”
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11875
Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in db/db Mice by Quantitative Proteomics
Published 2013-01-01“…Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomics, we identified differentially expressed proteins involved in cardiac lipid metabolism, mitochondrial function, and cardiomyopathy, suggesting that phlorizin may prevent the development of diabetic cardiomyopathy by regulating the expression of key proteins in these processes. …”
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11876
TNF-α Promotes IFN-γ-Induced CD40 Expression and Antigen Process in Myb-Transformed Hematological Cells
Published 2012-01-01“…Tumour necrosis factor-α, interferon-γ and interleukin-4 are critical cytokines in regulating the immune responses against infections and tumours. …”
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11877
Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity
Published 2018-01-01“…Bone marrow stromal cells (BMSCs) represent an important cellular component of the bone marrow microenvironment, which play an important role in supporting and regulating the proliferation and differentiation of hematopoietic stem/progenitor cells (HSPCs). …”
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11878
New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication
Published 2013-01-01“…This observation has led to the proposal of the potential utility of “old players” for the treatment of type 2 diabetes and metabolic syndrome as new cancer adjuvant therapeutics. Androgen-regulated pathways drive proliferation, differentiation, and survival of benign and malignant prostate tissue. …”
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11879
Regulatory role of S1P and its receptors in sepsis-induced liver injury
Published 2025-01-01“…Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphingosine-1-phosphate receptors (S1PR) to regulate downstream signaling pathways involved in the pathophysiological processes of sepsis, including endothelial permeability, cytokine release, and vascular tone. …”
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11880
Hormonal Contraceptives and Athletic Outcomes - analysis of potential effects of oral contraceptives on strength, endurance, mood, and overall competitive results
Published 2025-02-01“… Introduction Hormonal contraceptives, particularly oral contraceptives (OC), are commonly used by female athletes to regulate menstrual cycles, manage hormonal fluctuations, and prevent unwanted pregnancies. …”
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