PPAR-γ Signaling Crosstalk in Mesenchymal Stem Cells by Ichiro Takada, Alexander P. Kouzmenko, Shigeaki Kato

“…Among other functions, PPAR-γ acts as a key regulator of the adipogenesis. Since several cytokines (IL-1, TNF-α, TGF-β) had been known to inhibit adipocyte differentiation in mesenchymal stem cells (MSCs), we examined the effect of these cytokines on the transactivation function of PPAR-γ. …”
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Obesity and Chronic Inflammation: Implications for Rheumatoid Arthritis, Spondyloarthritis, and Ulcerative Colitis by Ada Corrado, Ilaria Guadagni, Giovanna Picarelli, Angela Variola

“…This includes lifestyle modifications aimed to regulate weight gain, paving the way for comprehensive strategies to manage IMIDs in the context of obesity.…”
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Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment by Fatih Ciftci, Ali Can Özarslan, İmran Cagri Kantarci, Aslihan Yelkenci, Ozlem Tavukcuoglu, Mansour Ghorbanpour

“…These systems serve as drug carriers and regulate the timing of release. Despite having many advantageous features, these systems have limitations in thoroughly treating complex diseases such as cancer. …”
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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is tightly regulated and plays critical roles in mediating cell proliferation, growth, and survival. …”
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The Expansion of CD25highIL-10highFoxP3high B Regulatory Cells Is in Association with SLE Disease Activity by Zahava Vadasz, Regina Peri, Nasren Eiza, Gleb Slobodin, Alexandra Balbir-Gurman, Elias Toubi

“…In sum we show that CD25highFoxP3high are an additional subtype of Bregs, involved in regulating SLE disease activity. Being IL-10 expressing, we may assume that they are one of the sources of increased serum IL-10 in SLE patients. …”
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The roles of pleiotrophin in brain injuries: a narrative review of the literature by Yupeng Lei, Ruixi Zhou, Qian Mao, Xia Qiu, Dezhi Mu

“…Besides, PTN interacts with receptors, such as, Z-type protein tyrosine phosphatase receptor and syndecan-3, regulating related pathways in these events.Conclusion It suggests PTN as a promising candidate for the treatment of brain injuries clinically. …”
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Study on the impact parameters of convective heat transfer in industrial-scale Siemens reactor by Xingping Yuan, Dan Zhao, Yanqing Hou, Ni Yang, Wenhui Ma, Fengyang Chen, Gang Xie

“…In industrial-scale Siemens reactors, convective heat transfer (CHT) plays a crucial role in regulating the uniformity of the reactor's temperature distribution and ensuring the quality of the polysilicon products. …”
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Effects of resistant starch III on the serum lipid levels and gut microbiota of Kunming mice under high-fat diet by Xuhui Chen, Zhirong Wang, Di Wang, Jianquan Kan

“…This study aimed to investigate the role of RS3 in lowering serum lipids and regulating gut microbiota by administering Novelose 330 to Kunming (KM) mice. …”
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Tendon-Derived Stem Cell Differentiation in the Degenerative Tendon Microenvironment by Chang Liu, Jing-wan Luo, Ke-ke Zhang, Long-xiang Lin, Ting Liang, Zong-ping Luo, Yong-qing Zhuang, Yu-long Sun

“…So in this study, the regulating effects of the degenerative tendon microenvironment on differentiation of TDSCs were investigated. …”
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Flavonoids in Juglans regia L. Leaves and Evaluation of In Vitro Antioxidant Activity via Intracellular and Chemical Methods by Ming-Hui Zhao, Zi-Tao Jiang, Tao Liu, Rong Li

“…They have potent antioxidant properties, which have been related to regulating immune function and enhancing anticancer activity. …”
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MCU expression in hippocampal CA2 neurons modulates dendritic mitochondrial morphology and synaptic plasticity by Katy E. Pannoni, Quentin S. Fischer, Renesa Tarannum, Mikel L. Cawley, Mayd M. Alsalman, Nicole Acosta, Chisom Ezigbo, Daniela V. Gil, Logan A. Campbell, Shannon Farris

“…While mitochondria are essential for synaptic transmission and synaptic plasticity, the mechanisms regulating mitochondria to support normal synapse function are incompletely understood. …”
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Effect of Mechanical Force Stress on the Inflammatory Response in Human Periodontal Ligament Cells by Thira Rojasawasthien, Supreda Suphanantachat Srithanyarat, Wajathip Bulanawichit, Thanaphum Osathanon

“…Moreover, hPDLSCs, together with contiguous hPDL cells, respond to various mechanical forces by regulating the immune function of several immune cells. …”
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Dipeptidyl-Peptidase 4 Inhibitor Sitagliptin Ameliorates Hepatic Insulin Resistance by Modulating Inflammation and Autophagy in ob/ob Mice by Wenbin Zheng, Jing Zhou, Shasha Song, Wen Kong, Wenfang Xia, Lulu Chen, Tianshu Zeng

“…Furthermore, sitagliptin decreased inflammatory responses by regulating macrophage M1/M2 polarization and inhibiting the activities of NF-κB and JNK. …”
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Nuciferine relieves type 2 diabetes mellitus via enhancing GLUT4 expression and translocation by Tongxi Zhou, Guanjun Song, Di Tian, Qinghua Liu, Jinhua Shen, Xinzhou Yang, Ping Zhao

“…In this study, the in vitro studies indicated that nuciferine-induced GLUT4 translocation was regulated by G protein-PLC-PKC and AMPK pathways and nuciferine-enhanced intracellular Ca2+ was mediated by G protein-PLC-IP3-IP3R pathway, the increase in intracellular Ca2+ caused by nuciferine was not directly related to GLUT4 translocation, but both promote glucose uptake. …”
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Identification of new process-related impurity in the key intermediate in the synthesis of TCV-116 by Testen Ana, Plevnik Miha, Štefane Bogdan, Cigić Irena Kralj

“…Therefore, synthesis should be regulated so as to minimize impurity production. Analysis of the final product indicated that the amount of impurity did not exceed 50 mg L−1, which represents the detection limit, determined according to the signal/noise ratio.…”
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How do Islamic corporate social responsibility and environmental performance relate to company value? by Dini Rahmayanti, Ziinatul Arifah, Putri Jamilah

“…Implications – This study suggests that, to enhance credibility, companies should prioritize financial stability, credibility in financial reporting, social responsibility, and environmental regulations. They should identify the best investment opportunities and collaborate with the government to achieve environmental sustainability. …”
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Carbon Monoxide Inhibits Tenascin-C Mediated Inflammation via IL-10 Expression in a Septic Mouse Model by Md. Jamal Uddin, Chun-shi Li, Yeonsoo Joe, Yingqing Chen, Qinggao Zhang, Stefan W. Ryter, Hun Taeg Chung

“…Additionally, administration of CORM-2 dramatically reduced LPS-induced TN-C and proinflammatory cytokines production while expression of IL-10 was significantly increased. In conclusion, CO regulated IL-10 expression and thus inhibited TN-C-mediated inflammation in vitro and in vivo.…”
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3D printed biodegradable hydrogel-based multichannel nerve conduits mimicking peripheral nerve fascicules by Woo-Youl Maeng, Yerim Lee, Szu-Han Chen, Kyung Su Kim, Daeun Sung, Wan-Ling Tseng, Gyu-Nam Kim, Young-Hag Koh, Yuan-Yu Hsueh, Jahyun Koo

“…The addition of a food-grade dye to the printing solution can prevent overcuring by adjusting the optical path length of light and regulating the polymerization rate. This work further demonstrates that the addition of dyes can enable high-resolution printing, resulting in the achievement of fine multichannels with a diameter of 200 μm. …”
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Processing and Validation of Whey-Protein-Coated Films and Laminates at Semi-Industrial Scale as Novel Recyclable Food Packaging Materials with Excellent Barrier Properties by E. Bugnicourt, M. Schmid, O. Mc. Nerney, J. Wildner, L. Smykala, A. Lazzeri, P. Cinelli

“…Coated films were validated for storing various food products showing that the shelf life and sensory attributes were maintained similar to reference packaging films while complying with food safety regulations. The developed whey coating could be enzymatically removed within 2 hours and is therefore compatible with plastic recycling operations to allow multilayer films to become recyclable by separating the other combined layers. …”
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A Statistical Approach for Comparative Assessment of the Effect of Smoke Exposure in In Vivo Experiments: A Case Study of an OECD 90-Day Inhalation Study Including 3R4F and 1R6F Re... by Kondylis Athanasios, Kogel Ulrike, Ho Jenny, Wong EeTsin, Phillips Blaine, Hoeng Julia, Vanscheeuwijck Patrick

“…Most in vivo toxicology studies are conducted in a heavily regulated environment, in accordance with sound scientific principles, and in an ethical manner. …”
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