Changes in Ownership and Ulayat Land Use in Lumban Rau Timur Village, Toba Samosir by Hidayat Hidayat, Lukitaningsih Lukitaningsih

“…The transformation of ulayat land ownership is caused by socio-cultural shifts, demographic pressures, openness information and communication as well as the state penetration via government regulations on natural resources under the development programs in the areas of Lake Toba.…”
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Sonic Hedgehog Signaling Drives Proliferation of Synoviocytes in Rheumatoid Arthritis: A Possible Novel Therapeutic Target by Mingxia Wang, Shangling Zhu, Weixiang Peng, Qiuxia Li, Zhaoxia Li, Minqi Luo, Xiaoxue Feng, Zhuofeng Lin, Jianlin Huang

“…Sonic hedgehog (Shh) signaling controls many aspects of human development, regulates cell growth and differentiation in adult tissues, and is activated in a number of malignancies. …”
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Genomic insights into ecological adaptation of oaks revealed by phylogenomic analysis of multiple species by Tian-Rui Wang, Xin Ning, Si-Si Zheng, Yu Li, Zi-Jia Lu, Hong-Hu Meng, Bin-Jie Ge, Gregor Kozlowski, Meng-Xiao Yan, Yi-Gang Song

“…Circadian rhythm and hormone-related genes may regulate the habits of evergreen and deciduous oaks. …”
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Deficient Autophagy in Microglia Aggravates Repeated Social Defeat Stress-Induced Social Avoidance by Mai Sakai, Zhiqian Yu, Ryo Hirayama, Masa Nakasato, Yoshie Kikuchi, Chiaki Ono, Hiroshi Komatsu, Miharu Nakanishi, Hatsumi Yoshii, David Stellwagen, Tomoyuki Furuyashiki, Masaaki Komatsu, Hiroaki Tomita

“…Furthermore, we identified that FKBP5, an early-stage autophagy regulator, was significantly increased in the PFC of resilient mice at the transcript and protein levels. …”
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The Role of Antioxidant Enzymes in Adaptive Responses to Sheath Blight Infestation under Different Fertilization Rates and Hill Densities by Wei Wu, Xuejie Wan, Farooq Shah, Shah Fahad, Jianliang Huang

“…Several agronomic practices, such as rational use of fertilizers and optimum planting density, involved in regulating antioxidant protective enzyme systems can be regarded as promising strategy to suppress the sheath blight development.…”
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Assessment of Physicochemical Properties of Rituximab Related to Its Immunomodulatory Activity by Mariana P. Miranda-Hernández, Carlos A. López-Morales, Nancy D. Ramírez-Ibáñez, Nelly Piña-Lara, Nestor O. Pérez, Aarón Molina-Pérez, Jorge Revilla-Beltri, Luis F. Flores-Ortiz, Emilio Medina-Rivero

“…The immunomodulatory activity of rituximab is closely related to critical quality attributes that characterize its chemical composition and spatial configuration, which determine the recognition of CD20 and the binding to receptors or factors involved in its effector functions, while regulating the potential immunogenic response. Herein, we present a physicochemical and biological characterization followed by a pharmacodynamics and immunogenicity study to demonstrate comparability between two products containing rituximab. …”
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Tuning of controller parameters for suppressing low frequency oscillations in electric railway traction networks using meta‐heuristic algorithms by Prasenjit Dey, Phumin Kirawanich, Chaiyut Sumpavakup, Aniruddha Bhattacharya

“…Controller parameters are tuned to minimise the integral time absolute error (ITAE) that regulates DC‐link capacitor voltage. Results obtained using CHIO are compared with those found using other well‐established algorithms like symbiotic organisms search (SOS) and particle swarm optimisation (PSO). …”
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Identification of the effective components in liability and compensation for marine pollution in the light of international law by Nahid Seyrafian, Mansour Pournouri, Hamidreza Ghaffarzadeh, Reza Simbar

“…Five intervening factors were national laws and regulations, international environmental law and international treaties, international sanctions and restrictions, governance approach and government policies, and arbitration conditions. …”
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Controlling Dielectric and Magnetic Properties of PVdF/Magnetite Nanocomposite Fibre Webs by A. P. Venugopal, O. Cespedes, S. J. Russell

“…The ability of filtration and separation media containing fibres to remove impurities from oil, water, and blood can be enhanced using magnetic fields. The ability to regulate the dielectric and magnetic behaviour of fibrous webs in terms of superparamagnetic or ferromagnetic properties by adjusting material composition is fundamental to meeting end-use requirements. …”
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Unignorable Emissions and Potential Health Effects of Unregulated Pollutants from Nonroad Engines Using Greener Fuels — A Review by Lulu Duan, Yu-Lun Hsieh, Sheng-Lun Lin, Wan Nurdiyana Wan Mansor, Muhammad Isyhraff Azhan Bin Mansor, Hyojun Lee, Chien-Er Huang, How-Ran Chao, Mengjie Song, Minseop Song

“…Countries worldwide have implemented stringent emission regulations targeting pollutants like CO, HC, NOx, and PM. …”
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A Multifunctional Cobalt‐Containing Implant for Treating Biofilm Infections and Promoting Osteointegration in Infected Bone Defects Through Macrophage‐Mediated Immunomodulation by Nongyang Yan, Hao Zhou, Penghe Jin, Tengfei Li, Qi Liu, Hao Ning, Zhixin Ma, Linfei Feng, Tao Jin, Youwen Deng, Zhengwei Wu

“…RNA sequencing analysis reveals the potential mechanism of Co2+ in regulating the polarization of macrophages toward the anti‐inflammatory M2 phenotype, which is crucial for creating an immune environment conducive to bone healing. …”
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Navigating the energy crisis: automakers’ coopetition strategies under dual credit policy by Yuan Kaifu, Wang Chuanji, Xiao Fang

“…Recommendations include optimizing subsidy policies, supporting low-carbon FVs, enhancing infrastructure, and strengthening DCP regulations to stabilize credit price expectations.…”
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Untargeted metabolomics and functional analyses reveal that the secondary metabolite quinic acid associates with Angelica sinensis flowering by Pei Liu, Weimeng Feng, He Yang, Guang Yu, Erxin Shang, Sen Zhang, Hui Yan, Jin-ao Duan

“…These results suggest that quinic acid may promote plant flowering primarily by regulating the expression of genes and proteins in the gibberellin and jasmonic acid pathways.…”
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Systematic qualitative proteome-wide analysis of lysine malonylation profiling in Platycodon grandiflorus by Qingshan Yang, Shaowei Xu, Weimin Jiang, Fei Meng, Shuting Wang, Zongping Sun, Na Chen, Daiyin Peng, Juan Liu, Shihai Xing

“…Subcellular localization showed that related proteins were enriched in chloroplasts, cytoplasm, and nuclei, indicating that this modification could regulate various metabolic processes. Motif analysis showed the enrichment of Alanine (A), Cysteine (C), Glycine (G), and Valine (V) amino acids surrounding malonylated lysine residues. …”
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Natural Enemies Acquire More Prey Aphids from Hormone-Treated Insect-Attracting Plants by Xiaosheng Jiang, Xingrui Zhang, Guodong Han, Shovon Chandra Sarkar, Feng Ge

“…Exogenous plant hormones regulate the agronomic and physiological performance of plants and thus can influence the abundance of insect groups. …”
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Structural basis for RNA-guided DNA degradation by Cas5-HNH/Cascade complex by Yanan Liu, Lin Wang, Qian Zhang, Pengyu Fu, Lingling Zhang, Ying Yu, Heng Zhang, Hongtao Zhu

“…Notably, we also find that divalent ions such as zinc, cobalt, and nickel down-regulate enzyme activity by destabilizing the Cascade complex. …”
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Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes by Daniel Espes, Mats Martinell, Per-Ola Carlsson

“…Future studies are clearly needed to delineate the exact role, if any, of betatrophin in regulating human beta-cell mass.…”
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Fecal metabolomics reveals the positive effect of ethanol extract of propolis on T2DM mice by Chunmei Wang, Huiting Zhao, Kai Xu, Yali Du, Jinjia Liu, Jinfei Wang, Yusuo Jiang

“…Metabolomics data identified 27 potential biomarkers in fecal samples. EEP effectively regulated the dysfunction in the metabolic pathways of glycerophospholipids, sphingolipids, riboflavins, and sterol lipids caused by T2DM. …”
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Targeting endoplasmic reticulum stress: an innovative therapeutic strategy for podocyte-related kidney diseases by Jiao Lv, Honghai Yu, Sasa Du, Pengyu Xu, Yunyun Zhao, Wenxiu Qi, Xiuge Wang

“…The kidneys play a crucial role in maintaining physiological functions by excreting metabolic waste, regulating blood volume, balancing electrolytes and acid-base levels, and secreting various bioactive substances. …”
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Trust in AI: progress, challenges, and future directions by Saleh Afroogh, Ali Akbari, Emmie Malone, Mohammadali Kargar, Hananeh Alambeigi

“…Trust and distrust in AI serve as regulators and could significantly control the level of this diffusion, as trust can increase, and distrust may reduce the rate of adoption of AI. …”
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