Parabrachial CGRP neurons modulate active defensive behavior under a naturalistic threat by Gyeong Hee Pyeon, Hyewon Cho, Byung Min Chung, June-Seek Choi, Yong Sang Jo

“…These findings expand the understanding of CGRP neurons in the PBN as a critical alarm system, capable of dynamically regulating active defensive behaviors by amplifying threat perception, and ensuring adaptive responses to varying levels of danger.…”
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Discovery of MicroRNAs and Their Target Genes Related to Drought in Paulownia “Yuza 1” by High-Throughput Sequencing by Minjie Deng, Yabing Cao, Zhenli Zhao, Lu Yang, Yanfang Zhang, Yanpeng Dong, Guoqiang Fan

“…Understanding the role of miRNAs in regulating the molecular mechanisms responsive to drought stress was studied in Paulownia “yuza 1.” …”
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Interleukin-1 signaling and CD4+ T cells control B cell recruitment to the lungs in chronic beryllium disease by Joseph M. Gaballa, Caley Valdez, Douglas G. Mack, Faiz Minhajuddin, Masoom Raza, Tabrez A. Mohammad, Allison K. Martin, Andrew Getahun, Charles A. Dinarello, Andrew P. Fontenot, Shaikh M. Atif

“…In BeO-exposed mice, lung B cells down-regulate IgM but showed an increased IgD and CD44 surface expression. …”
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TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease by Yunxia Du, Ming Wu, Shan Song, Yawei Bian, Yonghong Shi

“…Taken together, these findings suggest that TXNIP deficiency ameliorates renal fibrosis by regulating mTORC1/TFEB-mediated autophagy in diabetic kidney diseases.…”
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An Open-source Python Tool for Traction Force Microscopy on Micropatterned Substrates by Artur Ruppel, Vladimir Misiak, Martial Balland

“…Cell-generated forces play a critical role in driving and regulating complex biological processes, such as cell migration and division and cell and tissue morphogenesis in development and disease. …”
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Er-Xian Decoction Stimulates Osteoblastic Differentiation of Bone Mesenchymal Stem Cells in Ovariectomized Mice and Its Gene Profile Analysis by Shufen Liu, Jianhua Huang, Jing Wang, Yongjian Zhao, Sheng Lu, Yongjun Wang, Qin Bian

“…We studied the bone mesenchymal stem cells (bMSCs) and gene profiles regulated by Er-Xian Decoction (EXD), a traditional Chinese herbal formula widely used for postmenopausal osteoporosis treatment. …”
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Creating visualizations using generative AI to guide decision-making in street designs: A viewpoint by Gabriel Valença, Carlos Azevedo, Filipe Moura, Ana Morais de Sá

“…We believe that integrating generative AI street design participation tools into urban planning processes has yet to be thoroughly understood, particularly in their impact on people's creativity and problem-solving, adaptability to different contexts, alignment with recent AI regulations, and implications for equity.…”
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A Double Resistive–Capacitive Approach for the Analysis of a Hybrid Battery–Ultracapacitor Integration Study by Adrian Chmielewski, Piotr Piórkowski, Krzysztof Bogdziński, Paweł Krawczyk, Jakub Lorencki, Artur Kopczyński, Jakub Możaryn, Ramon Costa-Castelló, Stepan Ozana

“…This study proposes a novel approach to analysing the set of differential equations of a substitute model of HESS and validates a model-based approach to investigate the performance of an HESS composed of a Valve-Regulated Lead Acid (VRLA) Absorbent Glass Mat (AGM) battery and a Maxwell ultracapacitor in a parallel configuration. …”
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Temperature Effect Study on Growth and Survival of Pathogenic Vibrio parahaemolyticus in Jinjiang Oyster (Crassostrea rivularis) with Rapid Count Method by Yuan Wang, Hai-yan Zhang, Essy Kouadio Fodjo, Cong Kong, Run-Run Gu, Feng Han, Xiao-Sheng Shen

“…The results indicate that inhibition or promotion effect could be regulated under different storage temperature for both pathogenic and nonpathogenic strains. …”
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A Smart Nanomedicine Unleashes a Dual Assault of Glucose Starvation and Cuproptosis to Supercharge αPD‐L1 Therapy by Yiming Xu, Yuan Wu, Xinjie Zheng, Dongxue Wang, Hangqi Ni, Weiyu Chen, Kai Wang

“…Here, alteration in glucose and copper metabolisms is found to synergistically regulate PD‐L1 expression in lung cancer cells. Thus, an intelligent biomimetic nano‐delivery system is synthesized by camouflaging lung cancer cell membranes onto glucose oxidase‐loaded Cu‐LDHs (CMGCL) for cancer metabolism targeted interference. …”
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Oxidative Stress in Hypertensive Patients Induces an Increased Contractility in Vein Grafts Independent of Endothelial Function by Claudio Joo Turoni, Rodrigo Marañón, Maria Karbiner, Juan Muntaner, Víctor Proto, María Peral de Bruno

“…Extraendothelial NO counter-regulates contractility in SV. However, this action could be altered in hypertensive situations by an increased oxidative stress or a decreased ability of nNOS to produce NO. …”
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Designing a Web Page to Improve Tutors’ Role in Nursing Students Formation by Juan Carlos Alvarado Peruyero, Zulema Bos Rodríguez, Nancy Ester Sosa Botana, Lourdes Montenegro Arias, Ariel Barceló Bos

“…<strong>Results:</strong> A website containing skills for each year and subject , curricula, skills control cards, existing resolutions and circulars, training strategies for work-related education, tutor’s functions, career curriculum, regulations for nursing practice, methodological instructions, organization of nursing curriculum and training to develop work-related education typologies was created. …”
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Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway by Wei Zhang, Hong He, Hujie Song, Junjie Zhao, Tao Li, Leitao Wu, Xiaojun Zhang, Jianzong Chen

“…Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3β pathway. The current study aims to increase our understanding of the protective mechanisms of Sal in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine- (MPTP-) induced PD mouse model. …”
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Biphasic Chromatin Structure and FISH Signals Reflect Intranuclear Order by Jyoti P. Chaudhuri, Eva Kasprzycki, Mathew Battaglia, John R. McGill, Anton Brøgger, Joachim-U. Walther, Albrecht Reith

“…Background and Aim: One of the two parental allelic genes may selectively be expressed, regulated by imprinting, X-inactivation or by other less known mechanisms. …”
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Network Pharmacology Analysis of the Identification of Phytochemicals and Therapeutic Mechanisms of Paeoniae Radix Alba for the Treatment of Asthma by Jingwei Wang, Ling Peng, Lu Jin, Huiying Fu, Qiyang Shou

“…The enrichment analysis of GO and KEGG pathways found that the treatment of asthma by PRA may be related to the process of TNF (tumor necrosis factor) release, which can regulate and inhibit multiple signaling pathways such as ceramide signaling. …”
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Neuroplasticity of Acupuncture for Stroke: An Evidence-Based Review of MRI by Jinhuan Zhang, Chunjian Lu, Xiaoxiong Wu, Dehui Nie, Haibo Yu

“…This review focuses on the evidence on the possible mechanisms underlying mechanisms of acupuncture therapy in treating stroke by regulating brain plasticity. We found that acupuncture reorganizes not only motor-related network, including primary motor cortex (M1), premotor cortex, supplementary motor area (SMA), frontoparietal network (LFPN and RFPN), and sensorimotor network (SMN), as well as default mode network (aDMN and pDMN), but also language-related brain areas including inferior frontal gyrus frontal, temporal, parietal, and occipital lobes, as well as cognition-related brain regions. …”
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The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels by Guanglei Zhao, Jinyang Lyu, Xin Huang, Gangyong Huang, Feiyan Chen, Yibing Wei, Siqun Wang, Jun Xia, Jie Chen, Jingsheng Shi

“…The ability of DPSC-exosomes to partially regulate autophagy was blocked upon inhibition of miR-31. …”
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Urban product in view of the commercial activities in Algiers by Abbas Faiza, Lamri Naziha, Berghout Karima, Bachouche Nassima

“…Consequently, local authorities are striving to regulate anarchic free trade to preserve designated urban areas outlined in Algiers' urbanization plan for future organized urban uses.…”
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The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes as Immunomodulatory Agents for COVID-19 Patients by Faisal A. Alzahrani, Islam M. Saadeldin, Abrar Ahmad, Dipak Kumar, Esam I. Azhar, Arif Jamal Siddiqui, Bassem Kurdi, Abdulrahim Sajini, Abdulmajeed F. Alrefaei, Sadaf Jahan

“…However, the use of MSCs or MSCs-Exo for treating COVID-19 should strictly adhere to the appropriate manufacturing practices, quality control measurements, preclinical safety and efficacy data, and the proper ethical regulations. This review highlights the available clinical trials that support the therapeutic potential of MSCs or MSCs-Exo in severely affected COVID-19 patients.…”
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Downregulation of HBx Restrains Proliferation, Migration, and Invasion of HepG2 Cells by Chaoqun Huang, Wei Liu, Xiaochuan Zhao, Libin Zhao, Fuxiang Wang

“…Mechanistic study revealed that HBx could bind to and positively regulate XB130 in HepG2 cells. Subsequently, HBx expression was knocked down, while XB130 was overexpressed in HepG2 cells in order to observe the specific role of HBx/XB130 in liver cancer in vitro. …”
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