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11341
Free Triiodothyronine and Cholesterol Levels in Euthyroid Elderly T2DM Patients
Published 2012-01-01“…Thyroid function regulates lipid metabolism. Despite the fact that T2DM is more prevalent in the elderly, often associates with thyroid dysfunction and increases cardiovascular risk both per se and via high TC and LDL-C levels, the association of the latter with FT3 and FT4 levels has not yet been fully investigated in T2DM. …”
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11342
State of Change-Related Hybrid Energy Storage System Integration in Fuzzy Sliding Mode Load Frequency Control Power System with Electric Vehicles
Published 2025-01-01“…Weighting coefficients are set for the generators, HESSs and EVs, respectively, to show their different abilities to regulate the power system. A fuzzy logic-based sliding mode control approach is designed to ensure the stable performance of the LFC power system integrated with HESSs and EVs. …”
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11343
Increasing GLP-1 Circulating Levels by Bariatric Surgery or by GLP-1 Receptor Agonists Therapy: Why Are the Clinical Consequences so Different?
Published 2016-01-01“…During the absorption of meals, the gut is thought to regulate insulin secretion by secreting a specific factor that targets pancreatic beta cells. …”
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11344
The Experimental Validation of a Digital Filter Mathematical Modelling for Nuclear Fuel Vibration Monitoring System
Published 2022-01-01“…Aiming at vehicles will produce shocks and vibrations for various reasons in the process of transportation and handling, any shock and vibration that exceeds the regulations would cause damage to the nuclear fuel being transported. …”
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11345
Computational Study of Trisindoline 5 Against Overexpressed EGFR Protein on Breast Cancer Stem Cell
Published 2025-01-01“…The existing inhibitory drugs used to treat the EGFR that act as the master regulator of the signaling network still have a limited response in breast cancer. …”
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11346
Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides
Published 2018-01-01“…GLP prevented inflammation, maintained intestinal homeostasis, and regulated the intestinal immunological barrier functions in mice with DSS-induced colitis.…”
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11347
Alteration of fecal microbiome and metabolome by mung bean coat improves diet-induced non-alcoholic fatty liver disease in mice
Published 2022-09-01“…Non-targeted metabolomic analysis indicated a metabolism disorder that was obviously improved by MBC via regulating sphingolipid metabolism and α-linolenic acid metabolism. …”
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11348
Development of a computational model of glucose toxicity in the progression of diabetes mellitus
Published 2016-06-01“…Diabetes mellitus is a disease characterized by a range of metabolic complications involving an individual's blood glucose levels, and its main regulator, insulin. These complications can vary largely from person to person depending on their current biophysical state. …”
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11349
V.N. TATISHCHEV’S BUSINESS LETTERS IN THE GENRE ASPECT (BASED ON THE DOCUMENTS OF THE NATIONAL ARCHIVE OF THE REPUBLIC OF KALMYKIA)
Published 2024-12-01“…They perform the informing and regulating functions, thus implementing the corresponding modality, and have a similar structure with a stable set of elements and the order of their sequence in the text. …”
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11350
Investigating Non-steroidal Anti-Inflammatory Drugs as Potential Cancer Adjuncts: A Novel Approach to Cancer Therapy
Published 2025-02-01“…These drugs reduce inflammation and regulate key biological pathways involved in cancer progression, offering new avenues for prevention and therapy. …”
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11351
Effect of Soil Salinity on Thermal Behavior of Sandy Soils Under a Sahara Climate
Published 2025-01-01“…These results emphasize the intricate interaction between soil composition and salinity in regulating temperature patterns, providing important knowledge for enhancing soil management practices that are customized to particular soil types and environmental factors, with potential implications for geothermal applications. …”
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11352
Study on Medicinal Forest Plants in Ifo, Ogun State, Nigeria, and Factors Shaping Usage Patterns
Published 2024-03-01“…As a recommendation, the study suggests the need for effective legislation to regulate the harvesting and trade of medicinal plants. …”
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11353
Design, synthesis, and apoptotic antiproliferative action of new benzimidazole/1,2,3-triazole hybrids as EGFR inhibitors
Published 2025-01-01“…Compounds 6i and 10e were also examined for their apoptotic potential, revealing that these compounds promote apoptosis by activating caspase-3, caspase-8, and Bax, while down-regulating the anti-apoptotic protein Bcl-2. Molecular docking experiments are thoroughly examined to validate the binding interactions of the most active hybrids, 6i and 10e, with the EGFR active site. …”
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11354
Interaction of Herbal Compounds with Biological Targets: A Case Study with Berberine
Published 2012-01-01“…PANTHER analysis of berberine targets showed that the most classes of molecular functions include receptor binding, kinase activity, protein binding, transcription activity, DNA binding, and kinase regulator activity. Based on the biological process classification of in vitro berberine targets, those targets related to signal transduction, intracellular signalling cascade, cell surface receptor-linked signal transduction, cell motion, cell cycle control, immunity system process, and protein metabolic process are most frequently involved. …”
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11355
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer’s disease
Published 2025-01-01“…We ascertained the master transcriptional regulators associated with these endotypes, including REST, ASCL1, and ZIC family members (activation), and NRF1 (repression). …”
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11356
WGCNA and integrative network analysis identify CHRNA5 and CTLA4 as potential therapeutic targets against angiosarcoma
Published 2024-01-01“…WGCNA analysis identified five significant modules, with the most enriched module being associated with angiogenesis and cell junction regulators. The intersection of true hub genes from MCC analysis of WGCNA modules and high-degree nodes from an unclustered network revealed eight consistently overexpressed genes in all angiosarcoma samples.Among the eight enriched genes, CHRNA5 and CTLA4, are exclusively overexpressed in angiosarcoma and not in other cancers of the same tissue origin, with significant drug-protein interactions suggesting their potential as therapeutic targets.…”
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11357
Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria
Published 2011-01-01“…Indications are that the females are able to regulate their metabolism in the liver in such a way to maintain homeostasis in the blood. …”
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11358
Sustainable Immunomodulatory via Macrophage P2Y12 Inhibition Mediated Bioactive Patche for Peritendinous Antiadhesion
Published 2025-01-01“…In vitro experiments showed that CA, when specifically bound to the P2Y12 receptor, down‐regulated the expression and function of active P2Y12, effectively inhibiting the aberrant activation of macrophages and the secretion of inflammatory chemokines. …”
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11359
Diffusion-programmed catalysis in nanoporous material
Published 2025-02-01“…Porous catalysts, including metal-organic and covalent organic frameworks, confront formidable obstacles in regulating reactant diffusion rates. Consequently, the chemical functionality of the catalysts typically governs turnover frequency and geometric selectivity. …”
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11360
Serum and Cerebrospinal Fluid Cytokine Biomarkers for Diagnosis of Multiple Sclerosis
Published 2020-01-01“…Leukocyte activation is regulated by cytokines, which are readily detected in MS serum and cerebrospinal fluid (CSF). …”
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