The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and me... by Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu

“…The metabolome analysis revealed that TLMPS significantly regulated specific metabolites in the liver, including organic acids, lipids, nucleosides, and organic oxygen compounds. …”
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Network analysis uncovers the master role of WRKY transcription factors in Arabidopsis thaliana response to N-acyl homoserine lactones by Yongming Duan, Min Han, Maja Grimm, Adam Schikora

“…We identified several key genes regulated in plants exposed to multiple AHL molecules. …”
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Tubular MYDGF Slows Progression of Chronic Kidney Disease by Maintaining Mitochondrial Homeostasis by Xiaohan Liu, Yang Zhang, Youzhao Wang, Yujie Yang, Zhe Qiao, Ping Zhan, Huiying Jin, Qianqian Xu, Wei Tang, Yu Sun, Yan Zhang, Fan Yi, Min Liu

“…Mechanistically, renal tubular MYDGF positively regulates the expression of isocitrate dehydrogenase 2 (IDH2), restores mitochondrial homeostasis, and slows CKD progression. …”
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Olive oil ameliorates allergic response in murine ovalbumin-induced food allergy by promoting intestinal mucosal immunity by Yu Ma, Ming Liu, Donghui Li, Jie Li, Zixin Guo, Yunjun Liu, Shengnan Wan, Yixiang Liu

“…An allergy model was subsequently constructed for analysis, the results of which showed that the olive oil reduced the scores of allergic symptoms in the mice, and up-regulated the hypothermia and the decline in the immune organ index. …”
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The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes by Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren

“…High-mobility group box 1 (HMGB1), a nonhistone nuclear protein regulating gene expression, was rediscovered as an endogenous danger signal molecule to trigger inflammatory responses when released into extracellular milieu in the late 1990s. …”
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Gap Junctions Are Involved in the Rescue of CFTR-Dependent Chloride Efflux by Amniotic Mesenchymal Stem Cells in Coculture with Cystic Fibrosis CFBE41o- Cells by Annalucia Carbone, Roberto Zefferino, Elisa Beccia, Valeria Casavola, Stefano Castellani, Sante Di Gioia, Valentina Giannone, Manuela Seia, Antonella Angiolillo, Carla Colombo, Maria Favia, Massimo Conese

“…Cx43 downregulation determined also a decrease in transepithelial resistance and an increase in paracellular permeability as compared with control cocultures, implying that GJIC may regulate CFTR expression and function that in turn modulate airway epithelium tightness. …”
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Machine Learning and Multi-Omics Integration to Reveal Biomarkers and Microbial Community Assembly Differences in Abnormal Stacking Fermentation of Sauce-Flavor <i>Baijiu</i> by Shuai Li, Yueran Han, Ming Yan, Shuyi Qiu, Jun Lu

“…This study provides a theoretical basis for regulating stacking fermentation and ensuring <i>Baijiu</i> quality.…”
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CELLULAR IMMUNITY AND CYTOKINE PROFILE IN PRE-FARROW AND LACTATING SOWS by A. G. Shakhov, S. V. Shabunin, L. Yu. Sashnina, M. I. Adodina, M. Yu. Zhejnes, K. V. Tarakanova, K. O. Kopytina

“…The cytokine profile of the sows was specified by the recovered numbers of interleukin-1β, tumor necrosis factor-α and γ-interferon, decreased level of interleukin-2 and interleukin-4 that regulate cellular and humoral immunity, respectively as well as their subsequent increase (in particular, interleukin-2) following animal immunization against parvoviral infection and erysipelas on day 7 post farrowing (Parvoruvax vaccine, Merial, France) and against classical swine fever on day 14 post farrowing (culture dry virus-vaccine LK-VNIVIPFIT). …”
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Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses to Chlamydophila pneumoniae by Sangeetha Prakash, Sudhanshu Agrawal, Dandan Ma, Sudhir Gupta, Ellena M. Peterson, Anshu Agrawal

“…Dendritic cells (DCs) are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans. …”
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Liver HLA-E Expression Is Associated with Severity of Liver Disease in Chronic Hepatitis C by Roberta C. Araújo, Fabricio C. Dias, Bruna C. Bertol, Deisy M. Silva, Patrícia H. Almeida, Andreza C. Teixeira, Fernanda F. Souza, Marcia G. Villanova, Leandra N. Z. Ramalho, Eduardo A. Donadi, Ana L. C. Martinelli

“…Human leukocyte antigen E (HLA-E) might regulate the antiviral function of immune response and contribute to the persistence of HCV and the severity of liver disease. …”
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Material management comparison between lot for lot and field actual condition by Atmaja Jajang, Natalia Monika, Masrilayanti, Ramadhani Siraj, Rahmadini Yessa, Sourkan Sulleyman

“…Project material management aims to regulate effective and efficient use materials because material is a resource the largest percentage of the total project cost. …”
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Comparative Analysis of Spontaneous and Stimulus-Evoked Calcium Transients in Proliferating and Differentiating Human Midbrain-Derived Stem Cells by Torben Johansen, Christina Krabbe, Sissel Ida Schmidt, Alberto Martínez Serrano, Morten Meyer

“…Using confocal microfluorimetry, we studied spontaneous calcium transients and calcium-regulating mechanisms in a human ventral mesencephalic stem cell line undergoing proliferation and neuronal differentiation. …”
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Cyber Security of the Economy and Public Finances: Historiography and Post-War Trajectory of Development by Petrukha Nina M., Petrukha Serhii V., Zhmaiev Anatolii Yu., Synkevych Maksym E.

“…It was found that the emergence and strengthening of the role of artificial intelligence allows for a closer level of correlation between trends in the development of the economy and public finances by adding new data to predictive models, bringing them to the level of big data, identifying threats and risks in them for the development of adaptive anti-crisis-colored regulatory behavioral models for the State regulators, including in terms of creating formal and informal institutional rules for countering cyber threats. …”
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Effect of Toll-Like Receptor 4 on Synovial Injury of Temporomandibular Joint in Rats Caused by Occlusal Interference by Jingjing Kong, Yingying Yang, Shuzhen Sun, Jianli Xie, Xuefen Lin, Ping Ji

“…The results prompted us that the activation of TLR4 may be involved in the inflammatory reactions and increased expression of IL-1β in patients with synovitis and participate in the mechanisms of the initiation and development of synovial injury by regulating the expression of inflammatory mediators like IL-1β in synovial membranes.…”
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Ongoing invasions by American bullfrogs and red-eared sliders in the Republic of Korea by Desiree Andersen, Amaël Borzée, Yikweon Jang

“…One of the first steps to their population regulations is to determine each species’ distribution in the country, which will allow for the identification of at-risk areas. …”
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Design, Modelling, and Implementation of a Fuzzy Controller for an Intelligent Road Signaling System by José Manuel Lozano Domínguez, Tomás de J. Mateo Sanguino

“…To contribute in this field, this paper presents the design, implementation, and testing of a smart prototype system applied to pedestrian crossings—not regulated by semaphores—which try to reduce the accident rate on roads. …”
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A SH3b domain-containing peptidoglycan recognition protein from Magallana gigas with broad recognition spectrum by Yinan Li, Hongbo Lu, Chuanyan Yang, Zhuyun Liu, Weilin Wang, Chang Liu, Lingling Wang

“…Both PGN and LPS stimulation could significantly up-regulated the expression level of MgPGRP5 mRNA in haemocytes (p < 0.05). …”
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Calcium Phosphate Coatings with Controlled Micro/Nano-Structures for Endothelial Cells Viability by Adil Elrayah, Ke Duan, Xiong Lu, Xiaob Lu, Jie Weng

“…Different micro/nano-structure and morphologies have been regulated on the surface of treated HA scaffolds. Plate-like compromise flower-like morphology was obtained with solution 1 (Ca-sufficient) i.e., ratio: Ca/Ca=1%; Ca/P=1.67. …”
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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…The ability of SIRT2 to regulate VEGFA expression has been demonstrated. In vivo experiments revealed that SIRT2, VEGFA, and HIF-1α were highly expressed in the kidneys of mice with diabetic nephropathy. …”
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Involvement of Inwardly Rectifying Potassium (Kir) Channels in the Toxicity of Flonicamid to <i>Drosophila melanogaster</i> by Xuan Liu, Yuying Gao, Tengfei Liu, Hailiang Guo, Jizu Qiao, Jianya Su

“…Inwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides. …”
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