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24721
Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
Published 2025-02-01“…Conclusions Overall, this integrative transcriptomic approach identified several new shared and disparate genes associated with regional vulnerability with increased biological interpretation including overlap with synaptic density maps and pathologically-specific gene expression. …”
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24722
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81
Published 2024-11-01“…Based on the MICs range of Qs (24–256 mg/L) and FQs (0.24–128 mg/L) breakpoint by EUCAST, we categorized these E. coli isolates into three resistance profiles (I, II, and III) associated with the patterns of chromosomal mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC and the plasmid-mediated quinolone resistance encoding genes (PMQRs) detected by PCR-based assay and sequencing; MICs increase in an escalation step according to the co-occurrence of multiple molecular mechanisms. …”
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24723
Flexible and wireless metasurface coils for knee and elbow MRI
Published 2025-01-01“…Methods Knee and elbow MRI routine sequences were applied at 1.5 T, implementing four coil scenarios: (1) 15-channel transmit/receive knee coil; (2) four-channel multipurpose coil (flex coil); (3) MC + spine coil; and (4) MC + multipurpose coil. Three regions of interest (ROIs) at different anatomical depths were compared. …”
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24724
Characterizing populations prioritized for PrEP in 19 African countries: a review of national guidance
Published 2025-01-01“…ABSTRACT Introduction While African countries have expanded access to HIV pre‐exposure prophylaxis (PrEP) since 2015, regional targets for PrEP uptake remain unmet. Understanding which populations are prioritized for PrEP at the policy level is an important step in determining the scope of PrEP distribution across Africa and identifying gaps in programme implementation. …”
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24725
Magnitude of opportunistic infections and associated factors among HIV-infected individuals attending care and treatment clinics in Dar es Salaam, Tanzania: a hospital-based cross-...
Published 2025-01-01“…Objectives This study aims to assess the magnitude of opportunistic infection (OI) and to identify factors associated with OIs among people living with HIV (PLHIV) on antiretroviral treatment (ART), attending HIV care and treatment clinics.Design A hospital-based cross-sectional study.Setting The study was conducted at Muhimbili National Hospital, Mwananyamala and Temeke Regional Referral Hospitals, in Dar es Salaam, Tanzania.Participants We enrolled 382 PLHIV on ART who were attending HIV care and treatment clinics in Dar es Salaam. …”
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24726
Co-Infection of <i>Culex tarsalis</i> Mosquitoes with Rift Valley Fever Phlebovirus Strains Results in Efficient Viral Reassortment
Published 2025-01-01“…This can have severe implications in areas where RVFV is endemic and convolutes our ability to anticipate transmission and circulation in novel geographic regions. Previously, we evaluated the frequency of RVFV reassortment in a susceptible ruminant host and observed low rates of reassortment (0–1.7%). …”
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24727
Assessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej
Published 2025-01-01“…Sutlej in frost-sensitive regions. However, the application rate of KNO3 needs to be optimized in order to use its maximal frost stress tolerance potential.…”
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24728
Bifurcation analysis of multistability and hysteresis in a model of HIV infection
Published 2023-12-01“…The macrophage activation rate constant is considered as a bifurcation parameter. The regions in the model parameter space, in particular, for the rate of activation of innate immune cells (macrophages), in which the properties of bi-, multistability and hysteresis are expressed, have been identified, and the features cha rac terizing transition kinetics between stable equilibrium states have been explored. …”
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24729
Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat...
Published 2020-01-01“…What’s more, SalD inhibited HMGB1 cytoplasmic translocation in neurons, astrocytes, and microglia in both the cortex and hippocampus regions of I/R rats. In conclusion, SalD can alleviate I/R-induced cerebral injury in rats and increase the PC12 cell viability affected by OGD/R. …”
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24730
Comprehensive genomic surveillance reveals transmission profiles of extensively drug-resistant tuberculosis cases in Pará, Brazil
Published 2025-01-01“…We recommend greater attention from the regional public health authorities to detect and track resistance to new drugs, especially in areas with pre-XDR and XDR cases. …”
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24731
In-Season Automated Mapping of Xinjiang Cotton Based on Cumulative Spectral and Phenological Characteristics
Published 2025-01-01“…Further analysis revealed that the CSP index can accurately and effectively distinguish cotton from other features and contemporaneous crops and that the Otsu–Sauvola automatic threshold method has robustness and regional consistency, thus providing an automatic and effective method for large-scale mapping of cotton in the early growing season.…”
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24732
Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa
Published 2025-01-01“…Objective: Women with anorexia nervosa (AN) have been shown to demonstrate differences in functional connectivity in brain regions associated with cognitive control, somatosensory processing, and emotion regulation. …”
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24733
Soil Organic Carbon Estimation and Transfer Framework in Agricultural Areas Based on Spatiotemporal Constraint Strategy Combined with Active and Passive Remote Sensing
Published 2025-01-01“…The proposed SOC estimation and transfer framework, based on active and passive remote sensing data, provides guidance for high-resolution regional-scale SOC mapping and applications.…”
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24734
The influence of legal compliance in farmer group on the growth and development of sustainable mangrove ecosystem
Published 2024-07-01“…The organizational significance lies in prioritizing regional law enforcement and fostering inclusive and comprehensive communication with the community.…”
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24735
Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease
Published 2025-06-01“…We extracted and analyzed differences in regional cerebral blood flow (rCBF), magnetic susceptibility, and gray matter density parameters between the two groups. …”
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24736
Using the HBSC Symptom Checklist to measure junior secondary school students’ psychosomatic complaints in the Chinese Mainland: Rasch-based validation, population-based norm, and n...
Published 2025-02-01“…Methods Data were collected from a two-wave cross-sectional survey conducted between June 20 and July 11, 2022, across eight Chinese Human Geography Regions (CHGRs). The sample included 3290 junior secondary school students, obtained through convenience sampling (first wave) and multistage, stratified, cluster sampling (second wave). …”
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24737
The First Large Identification of 3ANX and NX Producing Isolates of <i>Fusarium graminearum</i> in Manitoba, Western Canada
Published 2025-01-01“…Using the same rice culture, genomic DNA was isolated, and the <i>Tri1</i> coding sequence along with its flanking regions (upstream and downstream of the <i>Tri1</i> gene) was amplified and sequenced. …”
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24738
Acceptability of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine plus dihydroartemisinin-piperaquine in Papua New Guinea: a qualitative stu...
Published 2025-01-01“…Abstract Background In moderate-to-high malaria transmission regions, the World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) alongside insecticide-treated bed nets to reduce the adverse consequences of pregnancy-associated malaria. …”
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24739
High-resolution 4D electrical resistivity tomography and below-ground point sensor monitoring of High Arctic deglaciated sediments capture zero-curtain effects, freeze–thaw transit...
Published 2025-01-01“…<p>Arctic regions are under immense pressure from a continuously warming climate. …”
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24740
Chemical composition and insecticidal potential of botanical fractionation extracts for the management of Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) in stored...
Published 2025-02-01“…The weevil Sitophilus zeamais (Motschulsky, 1855) (Coleoptera: Curculionidae) is a destructive pest of stored maize, particularly in warm and humid tropical regions. The objective of this study was to analyze the chemical composition and evaluate the insecticidal potential of fractionated extracts of Eucalyptus globulus, Tagetes minuta and Annona squamosa used as natural alternatives to synthetic insecticides in the management of S. zeamais. …”
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