Anatomical and Functional MRI Changes after One Year of Auditory Rehabilitation with Hearing Aids by M. R. Pereira-Jorge, K. C. Andrade, F. X. Palhano-Fontes, P. R. B. Diniz, M. Sturzbecher, A. C. Santos, D. B. Araujo

“…After HA use, increased cortical thickness was observed in multimodal integration regions, particularly the very caudal end of the superior temporal sulcus, the angular gyrus, and the inferior parietal gyrus/superior temporal gyrus/insula. …”
Get full text

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia by Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

“…Results The genetic and environmental stress models exhibited distinct neuroimaging patterns in subcortical and sensorimotor regions. Consistent patterns emerged in two neuroimaging subtypes identified across three independent depressed cohorts. …”
Get full text

Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications by Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono

“…IntroductionSpinal tuberculosis (TB), or Pott's disease, remains a significant global health issue, particularly in regions with high TB prevalence. Despite antitubercular drug therapy being the primary treatment, surgical intervention is often required in cases of spinal instability or neurological complications. …”
Get full text

Rapid diagnosis of bacterial vaginosis using machine-learning-assisted surface-enhanced Raman spectroscopy of human vaginal fluids by Xin-Ru Wen, Jia-Wei Tang, Jie Chen, Hui-Min Chen, Muhammad Usman, Quan Yuan, Yu-Rong Tang, Yu-Dong Zhang, Hui-Jin Chen, Liang Wang

“…Gradient-weighted class activation mapping (Grad-CAM) was used to highlight important regions in the images for prediction. Moreover, the CNN model was blindly tested on SERS spectra of vaginal fluid samples collected from 40 participants with unknown BV infection status, achieving a prediction accuracy of 90.75% compared with the results of the BVBlue Test combined with clinical microscopy. …”
Get full text

Combatting Salmonella: a focus on antimicrobial resistance and the need for effective vaccination by Junaid Nazir, Tasaduq Manzoor, Afnan Saleem, Ubaid Gani, Sahar Saleem Bhat, Shabir Khan, Zulfqarul Haq, Priyanka Jha, Syed Mudasir Ahmad

“…Results Salmonella infections result in approximately 95 million global cases annually, with an estimated 150,000 deaths. Regional variations were evident, with higher infection rates in low- and middle-income countries due to poor sanitation and food safety standards. …”
Get full text

Investigating ITM2B‐associated ataxia in a Taiwanese cerebellar ataxia cohort by Shih‐Yu Fang, Cheng‐Tsung Hsiao, Kang‐Yang Jih, Yu‐Sheun Tsai, Kuan‐Lin Lai, Cheng‐Ta Chou, Yi‐Chu Liao, Yi‐Chung Lee

“…Magnetic resonance imaging and spectroscopy revealed progressive extension of white matter hyperintensity over periventricular and subcortical regions, subtle hippocampal atrophy, preserved cerebellar volumes, and decreased N‐acetylaspartate/creatine ratio over the vermis. …”
Get full text

Preparation and characterization of new silica-based heterofunctional biocatalysts utilizing low-cost lipase Eversa® Transform 2.0 and evaluation of their catalytic performance in... by Wagner C. A. Carvalho, Rayane A. S. Freitas, Milson S. Barbosa, Ariela V. Paula, Ernandes B. Pereira, Adriano A. Mendes, Elton Franceschi, Cleide M. F. Soares

“…Deconvolution was performed to evaluate the secondary structure of the ET2.0 lipase and showed increases in the α-helix and β-sheet regions for all biocatalysts after the immobilization process. …”
Get full text

Assessing the role of genotype by environment interaction as determinants of maize grain yield and lodging resistance by Haiwang Yue, Tiago Olivoto, Junzhou Bu, Jianwei Wei, Pengcheng Liu, Wei Wu, Maicon Nardino, Xuwen Jiang

“…Given the backdrop of global climate change, understanding which climate variables and soil properties most significantly impact environmental similarity is essential for selecting hybrids with improved adaptability to regions with diverse climatic and soil conditions. …”
Get full text

Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Mechanistically, the administration of Clo induced the interaction of P53 with STING, which activated the non-canonical STING-NFκB pathway; consequently, NF-κB directly bound to the promoter regions of its target genes, including CCL5, CXCL10, HLAs and BAX. …”
Get full text

CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain by Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Tzer-Bin Lin, Dylan Chou, Hsueh-Hsiao Wang, Kuan-Hung Lin, Jen-Kun Cheng, Po-Sheng Yang, Hsien-Yu Peng

“…Subsequent investigation unveiled that Foxp1 recruits CtBP1 and associates with HDAC2 to regulate H3K9Ac binding to μ-opioid receptor chromatin regions in the DRG in SNL rats, implicating epigenetic mechanisms in neuropathic pain. …”
Get full text

MsCL-P1: A multifunctional C-type lectin from largemouth bass (Micropterus salmoides) with broad microbe binding and agglutination activities by Siyi She, Ying Ye, Fengyao Guo, Shun Yang, Mengmeng Huang, Hui Fei

“…The full-length cDNA of MsCL-P1 encodes a polypeptide of 789 amino acids, including one CRD, four coiled coil regions, and two collagen domains. Sequence analysis revealed high similarity among CRD domains from different species, suggesting conserved binding specificity. …”
Get full text

Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty by Tao Chen, Yi Lu, Yu Wang, Anna Guo, Xiaoling Xie, Yuchuan Fu, Bangli Shen, Wenxiao Lin, Di Yang, Lu Zhou, Xiaozheng Liu, Peining Liu, Zhihan Yan

“…Correlation analyses were used to assess the effects of pubertal hormones on brain regions with structural and functional differences between the groups. …”
Get full text

Genotyping of extended-spectrum beta-lactamase-producing Escherichia coli isolated from wastewater of dairy farms in East Java, Indonesia by Fidi Nur Aini Eka Puji Dameanti, Sheila Marty Yanestria, Mustofa Helmi Effendi, Hani Plumeriastuti, Wiwiek Tyasningsih, Emmanuel Nnabuike Ugbo, Rahayu Sutrisno, Muhammad Ali Akramsyah Safri

“…Materials and Methods: Wastewater samples (n = 342) were collected from six major dairy regions in East Java: Pasuruan, Malang, Tulungagung, Blitar, Batu, and Kediri. …”
Get full text

Evaluation of Yellow Fever Virus Infection in <i>Aedes aegypti</i> Mosquitoes from Pakistan with Distinct Knockdown Resistance Genotypes by Carlucio Rocha dos Santos, Caleb Guedes Miranda dos Santos, Dinair Couto-Lima, Bárbara Silva Souza, Rafi Ur Rahman, Marcos Dornelas Ribeiro, José Bento Pereira Lima, Ademir Jesus Martins

“…Background: Yellow fever (YF) is an acute hemorrhagic disease endemic to Africa and Latin America; however, no cases have been reported in Asian regions with high <i>Aedes aegypti</i> infestation. …”
Get full text

Critical signals for grassland desertification prediction in the transition zone between desert and typical steppe in InnerMongolia, China by Baoping Meng, Zhuoyan Jin, Jin Chen, Yili Kuang, Shuhua Yi, Yanyan Lv, Jinrong Li

“…Global climate change and intensifying human activities have driven an accelerated desertification of grasslands in arid and semi-arid regions. Recent theoretical investigations have proposed that vegetation patches can serve as indicators of desertification. …”
Get full text

The Instant Effects of Continuous Transcutaneous Auricular Vagus Nerve Stimulation at Acupoints on the Functional Connectivity of Amygdala in Migraine without Aura: A Preliminary S... by Wenting Luo, Yue Zhang, Zhaoxian Yan, Xian Liu, Xiaoyan Hou, Weicui Chen, Yongsong Ye, Hui Li, Bo Liu

“…Continuous taVNS at acupoints can modulate the FC between the bilateral amygdalae and pain-related brain regions in MwoA, involving the limbic system, default mode network, and pain matrix, with obvious differences between the left amygdala and the right amygdala. …”
Get full text

Genetic classification and geochemical evaluation of Upper Cretaceous carbonate reservoir oils in Dezful Embayment and Abadan Plain, SW Iran by Hossein Saadati, Ali Kadkhodaie, Mehrab Rashidi, Hossein Bahrami, Hashem Sarafdokht, Dmitriy A. Martyushev, Amir Abbass Jahangard

“…Abstract The Upper Cretaceous carbonate reservoir oils from the Abadan Plain and Dezful Embayment in southwest Iran underwent analysis utilizing GC, GC-MS, and stable carbon isotope methods to elucidate the regional genetic oil family distribution. The study encompassed oil-source rock correlation through biomarker and stable carbon isotope ratios of Sargelu, Garau, Kazhdumi, and Pabdeh rock extracts to assist in establishing the best relevant source rock. …”
Get full text

Clinically meaningful improvements after gene therapy for aromatic L-amino acid decarboxylase deficiency (AADCd) in the Peabody Developmental Motor Scale, Second Edition (PDMS-2) a... by Wuh-Liang Hwu, Hui-Min Lee, John Devin Peipert, Rongrong Zhang, Christian Werner, J. Rafael Sierra, Thomas O’Connell, Jonathan J. Woolley, Marjorie Crowell, Antonia Wang, Ioannis Tomazos

“…The gene therapy eladocagene exuparvovec has become available in some regions; pooled clinical trial results demonstrate continuous long-term improvement in motor development and cognitive function. …”
Get full text

In Vivo Structural and Functional Abnormalities of the Striatums Is Related to Decreased Astrocytic BDNF in Itpr2-/- Mice Exhibiting Depressive-Like Behavior by Shanmei Zeng, Kai Liu, Jingyu Zhang, Chunhui Chen, Yihua Xu, Yulan Wu, Yanjia Deng, Xuegang Sun, Ge Wen, Linlin Jing

“…Second, the sample of relevant changed brain regions was extracted to detect the expression of BDNF. …”
Get full text

Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies by A. Ahnaou, D. Rodriguez-Manrique, S. Embrechts, R. Biermans, N. V. Manyakov, S. A. Youssef, W. H. I. M. Drinkenburg

“…The olfactory bulb (OB) and the hippocampus, both regions of the brain considered critical for the processing of odors and spatial memory, are commonly affected by aging. …”
Get full text