Enhanced bone regeneration using sodium alginate and polyvinyl alcohol incorporating TiO2 nanoparticles composite film for orthopedic application by Guoying Zhang, Xunkai Hou, Zhen Geng, Mahani Yusoff, Nur Adibah Roslan, Mohd Hasmizam Razali

“…This scalable, cost-effective material holds substantial potential for advancing regenerative medicine by addressing critical orthopaedic challenges and offering a sustainable solution for bone tissue repair. …”
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Development and Optimization of Nano-Hydroxyapatite Encapsulating Tocotrienol-Rich Fraction Formulation Using Response Surface Methodology by Anis Syauqina Mohd Zaffarin, Shiow-Fern Ng, Min Hwei Ng, Haniza Hassan, Ekram Alias

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Osteoblastic Differentiation and Mitigation of the Inflammatory Response in Titanium Alloys Decorated with Oligopeptides by Aroa Álvarez-López, Raquel Tabraue-Rubio, Rafael Daza, Luis Colchero, Gustavo V. Guinea, Martine Cohen-Solal, José Pérez-Rigueiro, Daniel González-Nieto

“…These results highlight the potential of peptide decoration on R-THAB^® functionalized surfaces to expedite the development of novel metallic biomaterials with enhanced biocompatibility properties, thereby advancing the field of regenerative medicine.…”
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Genetic Markers Can Predict Chondrogenic Differentiation Potential in Bone Marrow-Derived Mesenchymal Stromal Cells by Masami Kanawa, Akira Igarashi, Katsumi Fujimoto, Yukihito Higashi, Hidemi Kurihara, Masaru Sugiyama, Tania Saskianti, Yukio Kato, Takeshi Kawamoto

“…The precise predictions of the differentiation direction and potential of mesenchymal stromal cells (MSCs) are an important key to the success of regenerative medicine. The expression levels of fate-determining genes may provide tools for predicting differentiation potential. …”
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Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift by Yuxin Zhang, Wei Wang, Liang Chen, Heng Wang, Dong Dong, Jingjing Zhu, Yu Guo, Yiqun Zhou, Tianyi Liu, Wei Fu

“…Abstract Diabetic wounds present a significant challenge in regenerative medicine due to impaired healing, characterized by prolonged inflammation and deficient tissue repair, primarily caused by a skewed pro‐inflammatory macrophage phenotype. …”
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Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

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Development of Bifunctional Three-Dimensional Cysts from Chemically Induced Liver Progenitors by Yu Huang, Yusuke Sakai, Takanobu Hara, Takeshi Katsuda, Takahiro Ochiya, Tomohiko Adachi, Masaaki Hidaka, Wei-Li Gu, Susumu Eguchi

“…Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. …”
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Demographics and outcomes of acute type A aortic dissection in young adults in southeastern China: impact of syndromic heritable thoracic aortic disease by Xin-fan Lin, Hang-qi Gao, Qing-song Wu, Yu-ling Xie, Liang-wan Chen, Lin-feng Xie

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Defining patient-reported outcomes in diabetes, obesity, cardiovascular disease, and chronic kidney disease for clinical practice guidelines - perspectives of the taskforce of the... by Katharine Barnard-Kelly, Tadej Battelino, Frank C. Brosius, Antonio Ceriello, Francesco Cosentino, James R. Gavin, Francesco Giorgino, Jennifer Green, Linong Ji, Monika Kellerer, Sue Koob, Mikhail Kosiborod, Nebojsa Lalic, Nikolaus Marx, Prashant Nedungadi, Christopher G. Parkin, Helena W. Rodbard, René D. Rötzer, Lars Rydén, Wayne Huey-Herng Sheu, Eberhard Standl, Britta Tendal Jeppesen, Pinar Topsever, Per Olav Vandvik, Christoph Wanner, Oliver Schnell

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Assessing Donor Site Morbidity and Impact on Quality of Life in Free Flap Microsurgery: An Overview by Florin-Vlad Hodea, Cristian-Sorin Hariga, Eliza-Maria Bordeanu-Diaconescu, Andrei Cretu, Catalina-Stefania Dumitru, Vladut-Alin Ratoiu, Ioan Lascar, Andreea Grosu-Bularda

“…Furthermore, the integration of regenerative medicine strategies, such as stem cell therapy and fat grafting, and technological innovations, including virtual reality rehabilitation and biofeedback devices, has shown promise in enhancing recovery and minimizing long-term complications. …”
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DNA-encoded dynamic hydrogels for 3D bioprinted cartilage organoids by Ziyu Chen, Hao Zhang, Jingtao Huang, Weizong Weng, Zhen Geng, Mengmeng Li, Jiacan Su

“…Constructing high-fidelity cartilage organoids through three-dimensional (3D) bioprinting to replicate the structure and physiological functions of cartilage is crucial for regenerative medicine, drug screening, and disease modeling. …”
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STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation by Yu Qian Wong, Hongyan Xu, Qiang Wu, Xinyu Liu, Chengchen Lufei, Xiu Qin Xu, Xin-Yuan Fu

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Enhanced biomechanical and biological performance of titanium scaffolds with gradient in pore sizes by Ara Jung, Jinju Jang, Hun Yeong Ban, Hee Jin Kim, Bomi Gweon, Dohyung Lim

“…With the rapid advancement of metal 3D printing technologies, porous metal implants are increasingly explored for regenerative medicine. Among various methods, powder bed fusion (PBF) stands out for its precision in implant design and fabrication. …”
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Innovative Hydrogel Design: Tailoring Immunomodulation for Optimal Chronic Wound Recovery by Chun‐Mei Lai, Wei‐Ji Chen, Yuan Qin, Di Xu, Yue‐Kun Lai, Shao‐Hua He

“…Thus, this alteration in macrophage polarization presents an enticing avenue within the realm of regenerative medicine. Recent advancements have entailed the integration of a myriad of cellular and molecular signals into hydrogel‐based constructs, enabling the fine‐tuning of immune cell activities during different phases. …”
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Theophylline Revisited. Mechanisms, Challenges, and New Horizons by Jakub Szarłowicz, Michał Mazur, Dorota Waz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…Materials and Methods A detailed analysis of 23 peer-reviewed studies from scientific databases, including PubMed, focused on theophylline’s pharmacokinetics, pharmacodynamics, clinical safety, and novel applications in areas such as immunomodulation, metabolic disorders, and regenerative medicine. Results Theophylline shows anti-inflammatory effects, mitochondrial support, and modulation of key pathways (e.g., PI3K/Akt, NF-κB). …”
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Safety and Feasibility of Repeated Intrathecal Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells in Patients with Neurological Diseases by Kuang Pan, Lingna Deng, Peiying Chen, Qingxia Peng, Jingrui Pan, Yanfeng Wu, Yidong Wang

“…Mesenchymal stromal cells (MSCs) have become the most commonly used adult stem cells in regenerative medicine. Preclinical studies have shown that MSCs-based therapy is a potential new treatment approach for neurological diseases. …”
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Ex Vivo Expansion of Murine MSC Impairs Transcription Factor-Induced Differentiation into Pancreatic β-Cells by Dario Gerace, Rosetta Martiniello-Wilks, Rosaline Habib, Binhai Ren, Najah Therese Nassif, Bronwyn Anne O’Brien, Ann Margaret Simpson

“…Due to their impressive immunomodulatory properties, in addition to their ease of expansion and genetic modification ex vivo, mesenchymal stem cells (MSCs) are an attractive alternative source of adult stem cells for regenerative medicine. To overcome the aforementioned limitation of current therapies, we assessed the utility of ex vivo expanded bone marrow-derived murine MSCs for their persistence in immune-competent and immune-deficient animal models and their ability to differentiate into surrogate β-cells. …”
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Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

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Basic research for ultrasound-guided injection into skeletal muscle lesions in an experimental animal model by KiyomitsuFujimoto, TakashiKanamoto, ShunyaOtani, RyoMiyazaki, KosukeEbina, KenNakata

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Thermal performance analysis of a parabolic trough collector based solar water heater using revolving absorber tube by Rasaiah Naveenkumar, Pradeep Kumar Singh, Manickam Ravichandran, Vinayagam Mohanavel, Rajaraman Venkateshkumar, Ankit Kedia, Sathish Kannan, Manzoore Elahi M. Soudagar

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