Hydrogen Peroxide-Induced DNA Damage and Repair through the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells by Mahara Valverde, Jonathan Lozano-Salgado, Paola Fortini, Maria Alexandra Rodriguez-Sastre, Emilio Rojas, Eugenia Dogliotti

“…Several studies have addressed their use in regenerative medicine; however, little is known regarding their response to DNA damage and in particular to the reactive oxygen species (ROS) that are present in the microenvironment of implantation. …”
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Emerging biotechnologies for engineering liver organoids by Junqi Zhao, Yue Zhi, Haozhen Ren, Jinglin Wang, Yuanjin Zhao

“…Further, we introduce the applications of liver organoids in disease modeling, drug screening and regenerative medicine. Lastly, we overview the current obstacles and forward-looking perspectives on the future of engineered liver organoids. …”
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Tppp3 is a novel molecule for retinal ganglion cell identification and optic nerve regeneration by Mishal Rao, Ziming Luo, Chia-Chun Liu, Chi-Yu Chen, Shining Wang, Michael Nahmou, Bogdan Tanasa, Aman Virmani, Leah Byrne, Jeffrey L. Goldberg, José-Alain Sahel, Kun-Che Chang

“…Our findings advance regenerative medicine by developing a new therapeutic strategy for RGC neuroprotection and axon regeneration.…”
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Biomaterial-based strategies: a new era in spinal cord injury treatment by Shihong Zhu, Sijun Diao, Xiaoyin Liu, Zhujun Zhang, Fujun Liu, Wei Chen, Xiyue Lu, Huiyang Luo, Xu Cheng, Qiang Liao, Zhongyu Li, Jing Chen

“…With advancements in tissue engineering and regenerative medicine, emerging strategies for spinal cord injury repair now involve nanoparticle-based nanodelivery systems, scaffolds, and functional recovery techniques that incorporate biomaterials, bioengineering, stem cell, and growth factors as well as three-dimensional bioprinting. …”
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A chitosan/acellular matrix-based neural graft carrying mesenchymal stem cells to promote peripheral nerve repair by Zhifa Zhang, Molin Li, Gang Cheng, Peng Wang, Chunhui Zhou, Yang Liu, Xiaofeng Duan, Jing Wang, Fang Xie, Yaqiong Zhu, Jianning Zhang

“…Abstract Background Treatment of peripheral nerve defects is a major concern in regenerative medicine. This study therefore aimed to explore the efficacy of a neural graft constructed using adipose mesenchymal stem cells (ADSC), acellular microtissues (MTs), and chitosan in the treatment of peripheral nerve defects. …”
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Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc by Bin Chen, Jing Yu, Qianqian Wang, Yuanyuan Zhao, Li Sun, Changgen Xu, Xiangdong Zhao, Bo Shen, Mei Wang, Wenrong Xu, Wei Zhu

“…The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. However, safety concerns over hBM-MSCs limit their clinical application. …”
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Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases by Simona Delia Nicoară, Sergiu Șușman, Oana Tudoran, Otilia Bărbos, Gabriela Cherecheș, Simion Aștilean, Monica Potara, Olga Sorițău

“…One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine. The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye. …”
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Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival by Guona Chen, Xiaoting Liang, Qian Han, Cong Mai, Linli Shi, Zhuang Shao, Yimei Hong, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang

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Ectopic expression of the cation-chloride cotransporter KCC2 in blood exosomes as a biomarker for functional rehabilitation by L. Caccialupi Da Prato, A. Rezzag Lebza, A. Consumi, M. Tessier, A. Srinivasan, C. Rivera, C. Rivera, J. Laurin, C. Pellegrino

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Mechanism of hyperbaric oxygen therapy downregulating H-type angiogenesis in subchondral bone of knee osteoarthritis through the PHD2/HIF-1α pathway by Jianjian Wang, Wen Yu, Yuxin Zhang, Bo Chen, Zhaoxiang Meng

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Peripheral Blood Derived Mononuclear Cells Enhance the Migration and Chondrogenic Differentiation of Multipotent Mesenchymal Stromal Cells by Niina Hopper, John Wardale, Daniel Howard, Roger Brooks, Neil Rushton, Frances Henson

“…In conclusion, PBMCs increase both MSC migration and differentiation suggesting that they are an ideal candidate for inclusion in regenerative medicine therapies aimed at cartilage repair.…”
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Effectiveness, speed of action and safety of brodalumab in elderly psoriasis patients: a multicenter real-world study – IL PSO (Italian Landscape Psoriasis) by D. Orsini, D. Graceffa, M. Burlando, A. Campanati, E. Campione, C. Guarneri, A. Narcisi, P. Pella, P. Romita, M. Travaglini, L. Zichichi, L. M. H. Arancio, G. Baggini, R. Balestri, L. Bianchi, A. M. G. Brunasso, A. E. Cagni, Giacomo Caldarola, G. Calianno, A. Carpentieri, M. Carriero, A. Carugno, F. Cona, A. Costanzo, E. Cozzani, Giacomo Dal Bello, Giovanni Carlo Lazzaro Danzuso, A. Dattola, A. Di Tano, F. Diotallevi, M. Donnarumma, E. De Col, M. Esposito, C. S. Fiorella, M. Galluzzo, F. Graziola, M. Licciardello, A. Legori, P. Malagoli, Federica Mola, G. Moretta, A. Muracchioli, A. Musumeci, M. L. Musumeci, G. Pagnanelli, V. Panasiti, E. Provenzano, D. Rizzo, M. Rubatto, Oriele Sarno, D. Strippoli, F. Vaira, M. C. Fargnoli

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Synthesis of Zinc Oxide (ZnO)-Titanium Dioxide (TiO2)-Chitosan-Farnesol Nanocomposites and Assessment of Their Anticancer Potential in Human Leukemic MOLT-4 Cell Line by Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok, Suresh Kumar Subbiah

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Knowledge, Attitude, Awareness, and Practice Regarding Demodex Mites Among the Thai Population by Paichitrojjana A, Paichitrojjana A

“…Anon Paichitrojjana,1 Anand Paichitrojjana2 1School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok, Thailand; 2Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Anon Paichitrojjana, Email anonpaic@gmail.comBackground: Demodex mites are common ectoparasites in humans and can cause various skin disorders known as demodicosis, ranging from nonspecific facial dermatitis to conditions resembling eczema, seborrheic dermatitis, folliculitis, and acne. …”
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Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery by Anh Khoa Nguyen, Thi Hiep Nguyen, Bui Quoc Bao, Long Giang Bach, Dai Hai Nguyen

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Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype by Austin Sovar, Matthew D. Patrick, Ramkumar T. Annamalai

“…This mechanobiological approach presents a promising strategy for precision immunomodulation in regenerative medicine.…”
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Integrating AI into Cancer Immunotherapy—A Narrative Review of Current Applications and Future Directions by David B. Olawade, Aanuoluwapo Clement David-Olawade, Temitope Adereni, Eghosasere Egbon, Jennifer Teke, Stergios Boussios

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Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues by Ioannis Alexandros Charitos, Andrea Ballini, Stefania Cantore, Mariarosaria Boccellino, Marina Di Domenico, Elisa Borsani, Riccardo Nocini, Michele Di Cosola, Luigi Santacroce, Lucrezia Bottalico

“…The ethical-scientific debate on this type of cells has taken on great interest both for their application in regenerative medicine and for the potential possibilities in the field of cell and gene therapy. …”
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Shear Stress Promotes Arterial Endothelium-Oriented Differentiation of Mouse-Induced Pluripotent Stem Cells by Yan Huang, Xiaofang Chen, Jifei Che, Qi Zhan, Jing Ji, Yubo Fan

“…Taken together, our results indicate that exposure to appropriate shear stress facilitated the differentiation of mouse iPSCs towards arterial ECs via Notch signaling pathways, which have potential applications for both disease modeling and regenerative medicine.…”
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Isolation and Characterisation of Mesenchymal Stem Cells from Rat Bone Marrow and the Endosteal Niche: A Comparative Study by Norhayati Yusop, Paul Battersby, Amr Alraies, Alastair J. Sloan, Ryan Moseley, Rachel J. Waddington

“…Such findings support further comparisons of human CB-MSCs and BM-MSCs, facilitating selection of optimal MSC populations for regenerative medicine purposes.…”
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