Effects of Changes in Osmolarity on the Biological Activity of Human Normal Nucleus Pulposus Mesenchymal Stem Cells by Hua Zhang, Wei Li, YaoHong Wu, Shengquan Zhang, Jie Li, Letian Han, Haoyu Chen, Ziyu Wang, Cailiang Shen, Yinshun Zhang, Hui Tao

“…The expansion and maintenance of the NPMSC (nucleus pulposus mesenchymal stem cell) phenotype are considered as potential therapeutic tools for clinical applications in intervertebral disc tissue engineering and regenerative medicine. However, the harsh microenvironment within the intervertebral disc is the main limitation of its regeneration. …”
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Development of a Sensitive Quantum Dot-Linked Immunoassay for the Multiplex Detection of Biochemical Markers in a Microvolumeric Format by Kalvaityte U, Bagdonas E, Kirdaite G, Kausaite-Minkstimiene A, Uzieliene I, Ramanaviciene A, Popov A, Butkiene G, Karabanovas V, Denkovskij J, Mobasheri A, Bernotiene E

“…Ursule Kalvaityte,1 Edvardas Bagdonas,1 Gailute Kirdaite,2 Asta Kausaite-Minkstimiene,3,4 Ilona Uzieliene,1 Almira Ramanaviciene,3,4 Anton Popov,3,4 Greta Butkiene,1,5 Vitalijus Karabanovas,1,5 Jaroslav Denkovskij,1 Ali Mobasheri,1,6– 8 Eiva Bernotiene1,9 1Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 2Department of Personalised Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; 3Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Vilnius, LT-08406, Lithuania; 4NanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Vilnius, LT-03225, Lithuania; 5Biomedical Physics Laboratory, National Cancer Institute, Baublio 3b, Vilnius, LT-08406, Lithuania; 6Research Unit of Health Sciences and Technology, Faculty of Medicine, University of Oulu, Oulu, 90014, Finland; 7World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, B-4000, Belgium; 8Department of Joint Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 9Faculty of Fundamental Sciences, Vilnius Gediminas Technical University, Vilnius, LT-10223, LithuaniaCorrespondence: Eiva Bernotiene, Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariskiu G. 5, Vilnius, LT-08406, Lithuania, Tel +37068377130, Email eiva.bernotiene@imcentras.ltPurpose: For the diagnosis of various diseases, simultaneous sensitive detection of multiple biomarkers using low sample volumes is needed. …”
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COVID-19 and children with congenital anomalies: a European survey of parents’ experiences of healthcare services by Ingeborg Barisic, Carlos Matias Dias, Amanda Neville, Anna Pierini, Anke Rissmann, Joan K Morris, Judith Rankin, Ester Garne, Anna Latos-Bielenska, Elena Marcus, Anna Jamry-Dziurla, Ljubica Odak, Clara Cavero- Carbonell, Elly Den Hond, Lucas Genard, Ana João Santos, L Renée Lutke, Christina Neergaard Pedersen, Annika Niemann, Lucía Páramo-Rodríguez

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Acid-Unlocked Two-Layer Ca-Loaded Nanoplatform to Interfere With Mitochondria for Synergistic Tumor Therapy by Zheng Y, Williams GR, Hu R, Tong S, Xu J, Wang T, Zhang Y, Wu J, Li F, Cai Y, Zhu LM

“…Yilu Zheng,1 Gareth R Williams,2 Ran Hu,1 Sen Tong,3 Jianxiang Xu,1 Tong Wang,1 Yanyan Zhang,1 Junzi Wu,3 Fan Li,4 Yingyu Cai,4 Li-Min Zhu1 1College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China; 2UCL School of Pharmacy, University College London, London, WC1N 1AX, UK; 3The Key Laboratory of Microcosmic Syndrome Differentiation, Education Department of Yunnan, Yunnan University of Chinese Medicine, Kunming, 650500, People’s Republic of China; 4Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of ChinaCorrespondence: Yingyu Cai, Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People’s Republic of China, Email yingyu.cai@shgh.cn Li-Min Zhu, College of Biological Science and Medical Engineering, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, Donghua University, Shanghai, 201620, People’s Republic of China, Email lzhu@dhu.edu.cnBackground: The development of selective formulations able to target and kill tumor cells without the application of external energy has shown great promise for anti-tumor therapy.Methods: Here, we report a “nanobomb” that explosively increases Ca content within cells. …”
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Xeno-Free Strategies for Safe Human Mesenchymal Stem/Stromal Cell Expansion: Supplements and Coatings by M. Cimino, R. M. Gonçalves, C. C. Barrias, M. C. L. Martins

“…Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. …”
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Concomitant pheochromocytoma and hyperaldosteronism in a 47-year-old man: a case report by Fatemeh Majidi, Ali Shabbak, Shadi Nazarizadeh, Aryan Madady

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The use of hyaluronic acid fillers in patients with autoimmune endocrinopathies; in particular, women with Hashimoto’s disease – hints for aesthetic doctors by Katarzyna Bornikowska, Paweł Kubik, Wojciech Zgliczyński

“…One of the most prevalent autoimmune diseases is chronic lymphocytic thyroiditis, so-called Hashimoto’s disease, which affects one in every 5–10 women who visit a regenerative medicine doctor. Women in the perimenopausal and menopausal period, aged 40–54 years, were the single largest target group for aesthetic treatments. …”
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Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges by Vidhi Mathur, Prachi Agarwal, Meghana Kasturi, Varadharajan Srinivasan, Raviraja N Seetharam, Kirthanashri S Vasanthan

“…This review explores the innovative bioinks that are currently shaping the future of 3D bioprinting, focusing on their composition, functionality, and potential for tissue engineering, drug delivery, and regenerative medicine. The development of bioinks, incorporating natural and synthetic materials, offers unprecedented opportunities for personalized medicine. …”
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Functionalized conductive polymer composites for tissue engineering and biomedical applications- a mini review by V. Gayathri, Tabrej Khan, M. Gowtham, R. Balan, Tamer A. Sebaey, Tamer A. Sebaey

“…This approach’s flexibility enables the development of diverse biodegradable, conductive polymer scaffolds, which have been extensively explored in tissue engineering and regenerative medicine. While this technique successfully combines the advantages of both polymer types, it may face challenges such as potential compromises in conductivity and biodegradability. …”
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Deep Learning for an Innovative Photo Energy Model to Estimate the Energy Distribution in Smart Apartments by Komala C R, S. Vimal, G. Ravindra, P. Hariramakrishnan, Shaik Razia, S. Geerthik, K. Raja, V. Mohanavel, Nedumaran Arappali

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High throughput method for simultaneous screening of membrane permeability and toxicity for discovery of new cryoprotective agents by Nima Ahmadkhani, James D. Benson, Ali Eroglu, Adam Z. Higgins

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OBTAINING AND TESTING OF MG-CA-SR BIODEGRADABLE MATERIALS USED IN MEDICINE by Kamel Earar, Ion Ciucă, Cornel Munteanu, Norin Forna, Anton Knieling, Alina Calin, Gabriela Leata

“…Biodegradable magnesium (Mg), calcium (Ca), and strontium (Sr) alloys have garnered significant interest in regenerative medicine due to their unique mechanical properties, biocompatibility, and controlled degradation combination. …”
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Dynamic Mechanical Analysis of Banyan/Ramie Fibers Reinforced with Nanoparticle Hybrid Polymer Composite by T. Raja, V. Mohanavel, M. Ravichandran, S. Suresh Kumar, Munirah D. Albaqami, Reham Ghazi Alotabi, Mohanraj Murugesan

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Functional Multipotency of Stem Cells: What Do We Need from Them in the Heart? by Pablo Díez Villanueva, Ricardo Sanz-Ruiz, Alberto Núñez García, María Eugenia Fernández Santos, Pedro L. Sánchez, Francisco Fernández-Avilés

“…After more than ten years of human research in the field of cardiac regenerative medicine, application of stem cells in different phases of ischemic heart disease has come to age. …”
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Role of Matrix Metalloproteinase-2 in the Development of Atherosclerosis among Patients with Coronary Artery Disease by Nazirah Samah, Azizah Ugusman, Adila A. Hamid, Nadiah Sulaiman, Amilia Aminuddin

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The Four Pillars for Successful Regenerative Therapy in Endodontics: Stem Cells, Biomaterials, Growth Factors, and Their Synergistic Interactions by C. Brizuela, George T.-J. Huang, A. Diogenes, T. Botero, M. Khoury

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Advanced delivery systems for gene editing: A comprehensive review from the GenE-HumDi COST Action Working Group by Alessia Cavazza, Francisco J. Molina-Estévez, Álvaro Plaza Reyes, Victor Ronco, Asma Naseem, Špela Malenšek, Peter Pečan, Annalisa Santini, Paula Heredia, Araceli Aguilar-González, Houria Boulaiz, Qianqian Ni, Marina Cortijo-Gutierrez, Kristina Pavlovic, Inmaculada Herrera, Berta de la Cerda, Emilio M. Garcia-Tenorio, Eva Richard, Sergio Granados-Principal, Arístides López-Márquez, Mariana Köber, Marijana Stojanovic, Melita Vidaković, Irene Santos-Garcia, Lorea Blázquez, Emily Haughton, Dongnan Yan, Rosario María Sánchez-Martín, Loubna Mazini, Gloria Gonzalez Aseguinolaza, Annarita Miccio, Paula Rio, Lourdes R. Desviat, Manuel A.F.V. Gonçalves, Ling Peng, Cecilia Jiménez-Mallebrera, Francisco Martin Molina, Dhanu Gupta, Duško Lainšček, Yonglun Luo, Karim Benabdellah

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Dermoscopy and Ultraviolet-Enhanced Fluorescence Dermoscopy (UEFD) Increase the Accuracy of Diagnosis and Are Useful in Assessing the Effectiveness of <i>Kerion celsi</i> Treatment by Justyna Putek, Danuta Nowicka, Alina Jankowska-Konsur

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Manufacturing of Human Umbilical Cord Mesenchymal Stromal Cells on Microcarriers in a Dynamic System for Clinical Use by Florian Petry, J. Robert Smith, Jasmin Leber, Denise Salzig, Peter Czermak, Mark L. Weiss

“…The great properties of human mesenchymal stromal cells (hMSCs) make these cells an important tool in regenerative medicine. Because of the limitations of hMSCs derived from the bone marrow during isolation and expansion, hMSCs derived from the umbilical cord stroma are a great alternative to overcome these issues. …”
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A synthetic chronogenetic gene circuit for programmed circadian drug delivery by Lara Pferdehirt, Anna R. Damato, Kristin L. Lenz, Maria F. Gonzalez-Aponte, Daniel Palmer, Qing-Jun Meng, Erik D. Herzog, Farshid Guilak

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