Mesenchymal stem cells from perinatal tissues promote diabetic wound healing via PI3K/AKT activation by Jiawei Huang, Qingwen Deng, Lai Ling Tsang, Guozhu Chang, Jinghui Guo, Ye Chun Ruan, Chi Chiu Wang, Gang Li, Hon Fai Chan, Xiaohu Zhang, Xiaohua Jiang

“…In vitro studies demonstrated that the MSC-derived secretome enhanced keratinocyte proliferation and migration, endothelial cell function and stem cell recruitment, indicating robust paracrine effects. Mass spectrometry revealed a conserved set of proteins including THBS1 (thrombospondin 1), SERPINE1 (serpin family E member 1), ANXA1 (annexin A1), LOX (lysyl oxidase), and ITGB1 (integrin beta-1) which are involved in extracellular matrix (ECM) organization and wound healing, with the PI3K/AKT signaling pathway playing a central role. …”
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Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomi... by Alexandre Sabaté-Elabbadi, Armand Mekontso-Dessap, François Lionnet, Aline Santin, Charlotte Verdet, Paul-Louis Woerther, Julien Lopinto, Matthieu Turpin, Alexandra Rousseau, Romane Lacoste-Badie, Keyvan Razazi, Guillaume Voiriot, Muriel Fartoukh

“…This trial was registered on ClinicalTrial.gov (NCT03919266) and is closed to recruitment. Findings: From June 2020 to September 2022, 72 patients were assigned to the interventional (n = 37) or conventional strategy (n = 35). …”
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Tadalafil treatment for fetuses with early-onset growth restriction: a protocol for a multicentre, randomised, placebo-controlled, double-blind phase II trial (TADAFER IIb) by Hiroaki Tanaka, Yasuhiro Tanaka, Yoichi Aoki, Masayuki Endo, Tomoaki Ikeda, Shintaro Maki, Masafumi Nii, Kayo Tanaka, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Tomomi Kotani, Akihiko Sekizawa, Masahiko Nakata, Koji Nakamura, Kenji Nagao, Ichiro Yasuhi, Hiroshi Kawamura, Sho Takakura, Mayumi Kotera, Takafumi Ushida, Norihiko Kikuchi, Tadatsugu Kinjo, Mayumi Takano, Sachie Suga, Michi Kasai, Osamu Yasui, Yuka Maegawa, Shigeru Aoki, Yoshio Yoshida

“…Written informed consent will be obtained from all mothers before recruitment. Our findings will be widely disseminated through peer-reviewed publications.Trial registration jRCTs041190065.…”
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Real-time mechanism-based interventions for daily alcohol challenges: Protocol for ecological momentary assessment and intervention by Shuyan Liu, Matthias Haucke, Rika Groß, Kay Schneider, Jaekyung Shin, Fabian Arntz, Patrick Bach, Tobias Banaschewski, Christian Beste, Lorenz Deserno, Ulrich Ebner-Priemer, Tanja Endrass, Marvin Ganz, Ali Ghadami, Marco Giurgiu, Andreas Heinz, Falk Kiefer, Reinhold Kliegl, Bernd Lenz, Marta Anna Marciniak, Andreas Meyer-Lindenberg, Andreas B. Neubauer, Michael Rapp, Michael N. Smolka, Jens Strehle, Rainer Spanagel, Gianna Spitta, Heike Tost, Henrik Walter, Hilmar Zech, Dominic Reichert, Markus Reichert

“…Using a Within-Person-Encouragement-Design and Just-In-Time-Adaptive-Interventions, we will manipulate the contexts of loneliness and alcohol craving with cognitive reappraisal and physical activity interventions against a control condition (working memory task). Results Recruitment started in June 2024, with data collection and processing expected by June 2027. …”
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Public and patient involvement (PPI) in the design, execution and dissemination of a trial: the BISTRO trial by David Coyle, Paula Ormandy, Nancy Fernandes da Silva, Simon Davies

“…To support patient recruitment and participation in the research, a Patient Advisory Group was set up by the Trial Management Group led by a co-applicant with lived experience of dialysis who in the pre-funding design stage led the kidney failure patient network, hosted by the National Institute for Health and Care Research Devices for Dignity Medtech Co-operative. …”
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Variation in seed traits among different eelgrass populations in China by Mingjie Liu, Xinhua Wang, Xiaochen Liu, Yu Zhang, Shidong Yue, Xiaomei Zhang, Shaochun Xu, Yi Zhou

“…Sexual reproduction plays a crucial role in eelgrass population recruitment. Their seeds are important sexual reproduction organs and seed traits influence the maintenance and extension of eelgrass populations. …”
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Safety of a co-designed cognitive behavioural therapy intervention for people with type 1 diabetes and eating disorders (STEADY): a feasibility randomised controlled trialResearch... by Marietta Stadler, Natalie Zaremba, Amy Harrison, Jennie Brown, Divina Pillay, Jacqueline Allan, Rachael Tan, Salma Ayis, Emmanouela Konstantara, Janet Treasure, David Hopkins, Khalida Ismail

“…Findings: Of the 98 screened, 40 participants with T1DE were randomised (recruitment rate: 40.81%; 95% CI: 31.60%, 50.72%): 38 women, 1 man, 1 trans man (37 White, 1 White/Asian, 1 Black; 39 ± 11 years old, diabetes duration 22 ± 15 years, HbA1c 9.1 ± 2.6%). …”
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Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial): pragmatic, multicentre, parallel group, randomised controlled trial by Fiona Jones, Nick Sevdalis, Adrian Edwards, Bernadette Sewell, Monica Busse, Philip Pallmann, Rachel Lowe, Shaun Harris, Aloysius Niroshan Siriwardena, Jessica Fish, Claire Potter, Muhammad Riaz, Fiona J Leggat, Andrea Jane Longman, Jackie McRae

“…The limited understanding of how much change is clinically meaningful in this population along with the unblinded design, the use of self-referral as a recruitment method and variable usual care may have introduced unintended bias and thus limits robust conclusions about this intervention. …”
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Study protocol for an observational cohort study of heat stress impacts in pregnancy in The Gambia, West Africa [version 2; peer review: 1 approved, 2 approved with reservations] by Jane E Hirst, Ana Bonell, Abdul Sesay, Leonidas G. Ioannou, Bubacarr Bah, Kris A. Murray, Andy Haines, Sophie E. Moore, David Jeffries, Neil S Maxwell, Ana Vicero-Cabrera, Apolline Saucy, Cally Tan, Emmanuel Okoh, Dorothy Watters, Bakary Sonko, Williams Oluwatosin Adefila, Yahaya Idris, Mam Leigh-Nabou, Jarra Manneh, Andreas Flouris, Sainabou Bojang, Amanda N Sferruzzi-Perri, Andrew Prentice

“…Microclimate mapping of the area of recruitment will give detailed exposure measurements. …”
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Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells by Luciana Melo Garcia, Achintyan Gangadharan, Pinaki Banerjee, Ye Li, Andy G.X. Zeng, Hind Rafei, Paul Lin, Bijender Kumar, Sunil Acharya, May Daher, Luis Muniz-Feliciano, Gary M. Deyter, Gabriel Dominguez, Jeong Min Park, Francia Reyes Silva, Ana Karen Nunez Cortes, Rafet Basar, Nadima Uprety, Mayra Shanley, Mecit Kaplan, Enli Liu, Elizabeth J. Shpall, Katayoun Rezvani

“…CRISPR-Cas9 deletion of CD226 led to reduced LFA-1 recruitment, poor synapse formation, and decreased NK cell anti-leukemic activity. …”
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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy by James Dooley, Bart Neyns, Elizabeth Allen, Frank Tacke, Louis Boon, Damya Laoui, Julia Katharina Schwarze, Helena Van Damme, Bruno Dombrecht, Máté Kiss, Heleen Roose, Eva Van Overmeire, Daliya Kancheva, Liesbet Martens, Aleksandar Murgaski, Pauline Madeleine Rachel Bardet, Gillian Blancke, Maude Jans, Evangelia Bolli, Maria Solange Martins, Yvon Elkrim, Kiavash Movahedi, Niels Vandamme, Sebahat Ocak, Isabelle Scheyltjens, Lars Vereecke, Frank Aboubakar Nana, Pascal Merchiers, Jo Agnes Van Ginderachter

“…CCR8 expression resulted from TCR-mediated Treg triggering in an NF-κB-dependent fashion, but was not essential for the recruitment, activation nor suppressive capacity of these cells. …”
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“Holding on to Hope”: follow up qualitative findings of a tobacco treatment intervention for people experiencing mental health conditions by Tessa-May Zirnsak, Kristen McCarter, Melissa L. McKinlay, Ashleigh Guillaumier, Nadine Cocks, Catherine Brasier, Laura Hayes, Amanda L. Baker, Donita E. Baird, Billie Bonevski, Ron Borland, Ron Borland, David Castle, Erin Forbes, Peter J. Kelly, Catherine Segan, Catherine Segan, Rohan Sweeney, Alyna Turner, Alyna Turner, Jill M. Williams, Lisa Brophy, Lisa Brophy

“…The purpose of this paper is to report on the medium- and longer-term findings from interviews conducted at 5 and 8 months.MethodsAs a part of the broader Quitlink study, participants were invited to qualitative interviews at 2, 5 and 8 months following recruitment, in line with quantitative follow-up time points. …”
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Effect of Interleukin-17 in the Activation of Monocyte Subsets in Patients with ST-Segment Elevation Myocardial Infarction by Montserrat Guadalupe Garza-Reyes, Mónica Daniela Mora-Ruíz, Luis Chávez-Sánchez, Alejandra Madrid-Miller, Alberto Jose Cabrera-Quintero, José Luis Maravillas-Montero, Alejandro Zentella-Dehesa, Luis Moreno-Ruíz, Selene Pastor-Salgado, Erick Ramírez-Arias, Nataly Pérez-Velázquez, Adriana Karina Chávez-Rueda, Francisco Blanco-Favela, Wendy Guadalupe Vazquez-Gonzalez, Alicia Contreras-Rodríguez

“…Additionally, IL-17 had a powerful effect on the recruitment of CD14++CD16+/CD14+CD16++ monocytes derived from patients post-STEMI compared with the monocytes from patients with STEMI, suggesting that IL-17 recruits monocytes with inflammatory activity post-STEMI. …”
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N6-methyladenosine RNA modification regulates the transcription of SLC7A11 through KDM6B and GATA3 to modulate ferroptosis by Haisheng Zhang, Cheng Yi, Jianing Li, Yunqing Lu, Haoran Wang, Lijun Tao, Jiawang Zhou, Yonghuang Tan, Jiexin Li, Zhuojia Chen, Gholamreza Asadikaram, Jie Cao, Jianxin Peng, Wanglin Li, Junming He, Hongsheng Wang

“…METTL3 decreased the precursor mRNA stability of GATA3 through m6A/YTHDF2-dependent recruitment of the 3′-5′ exoribonuclease Dis3L2. Targeted demethylation of KDM6B and GATA3 m6A using the dm6ACRISPR system significantly increased the expression of SLC7A11. …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

“…He discovers strong social ties between young party members and suggests that this indicates “a certain exclusivity in recruitment patterns of political parties”. In addition, his analysis also points out that a highly homogenous network composition is a statistically significant predictor of joining a political party. …”
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Identification of new candidate genes for the hereditary predisposition to uveal melanoma: IGCMU trial by Mélanie Godiveau, Mélanie Godiveau, Mélanie Godiveau, Angeline Ginzac, Angeline Ginzac, Angeline Ginzac, Yannick Bidet, Yannick Bidet, Flora Ponelle-Chachuat, Flora Ponelle-Chachuat, Maud Privat, Maud Privat, Xavier Durando, Xavier Durando, Xavier Durando, Xavier Durando, Mathias Cavaillé, Mathias Cavaillé, Mathis Lepage, Mathis Lepage

“…The study has begun in October 2024, with patient recruitment lasting 12 months. No follow-up period is planned, but the duration of the genetic analyses is estimated at six months, with the final study report expected by October 2026.DiscussionThe identification of novel hereditary predisposition genes for UM could significantly enhance genetic counselling and surveillance strategies for families affected. …”
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Effectiveness of a physiotherapist-led triage and treatment service on WAITing time for adults with musculoskeletal pain referred to Australian public hospital physiotherapy clinic... by Ian A Harris, Andrew Lawson, Bethan Richards, Chris G Maher, Laurent Billot, David Roberts, Chris Needs, David Anderson, Nadine E Foster, Danielle Coombs, Marnee McKay, Joshua R Zadro, Tarcisio F de Campos, Michael Swain, Daniel Treacy, Lisa A Harvey, Gustavo Machado, Jackie Chu, Christopher S Han, Andrew R Gamble, Timothy Shaw, Mark Halliday, Joshua M Hutton, Tom Lung, Lisa Gridley, Joshua Wakefield

“…We will recruit adult patients newly referred to a public hospital physiotherapy outpatient clinic with a musculoskeletal condition that is typically managed by a physiotherapist (eg, back or neck pain, osteoarthritis, rehabilitation postorthopaedic surgery and sporting injuries). …”
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Editorial by Ann-Kristin Kölln, Antony Mason, Maria Lenk, Jörg Tremmel, Markus Rutsche

“…Drawing on theories of party politics, the authors argue for five different factors that could possibly explain the share of young MPs: the age of the party leader, the age of the party, the size of party support, the party’s ideology, and the party’s formal recruitment procedure for candidates. In other words, the authors theorise that having a young network, a large outreach, and an ideology or organisational structure that attracts the young should increase a party’s share of young MPs. …”
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Fasting for male fertility—a mixed methods study by Katharina T. May, Jocelyn Behling, Katharina Sochiera-Plegniere, Katharina Batschari, Christian S. Kessler, Christian S. Kessler, Christian S. Kessler, Andreas Michalsen, Andreas Michalsen, Farid I. Kandil, Sarah B. Blakeslee, Michael Jeitler, Michael Jeitler, Michael Jeitler, Wiebke Stritter, Daniela A. Koppold, Daniela A. Koppold, Daniela A. Koppold

“…Semi-structured interviews were conducted in a subgroup and evaluated by structured content analysis.ResultsRecruitment proved difficult, with 18 out of only 22 recruited participants completing all visits. …”
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NSUN5 Facilitates Hepatocellular Carcinoma Progression by Increasing SMAD3 Expression by Hexu Han, Chengcheng zhang, Wenbo Shi, Jiawei Wang, Wenhui Zhao, Yanping Du, Zhibin Zhao, Yifan Wang, Maosong Lin, Lei Qin, Xiaoxue Zhao, Qianqian Yin, Yiyi Liu, Zhongqi Wang, Jing Zhang, Xiaomin You, Guoxiong Zhou, Honghui Wu, Jun Ye, Xianzhong He, Weizhong Tian, Hong Yu, Yin Yuan, Qiang Wang

“…Mechanistically, high levels of NSUN5 promote the enrichment of trimethylated histone H3 at lysine 4 (H3K4me3) at the promoter region of SMAD3 through recruitment of the WDR5, thereby facilitating HCC metastasis via SMAD3‐mediated EMT pathways. …”
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