The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem D... by Fawzia Bardag-Gorce, Richard H. Hoft, Andrew Wood, Joan Oliva, Hope Niihara, Andrew Makalinao, Jacquelyn Thropay, Derek Pan, Imara Meepe, Kumar Tiger, Julio Garcia, Amanda Laporte, Samuel W. French, Yutaka Niihara

“…In conclusion, E cadherin high expression contributed to CAOMECS tight and gap junction protein recruitment at the cell membrane, thus promoting cellular adhesion and a functional barrier to protect the ocular surface.…”
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YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution by Farhoud Faraji, Sydney I. Ramirez, Lauren M. Clubb, Kuniaki Sato, Valeria Burghi, Thomas S. Hoang, Adam Officer, Paola Y. Anguiano Quiroz, William M. G. Galloway, Zbigniew Mikulski, Kate Medetgul-Ernar, Pauline Marangoni, Kyle B. Jones, Yuwei Cao, Alfredo A. Molinolo, Kenneth Kim, Kanako Sakaguchi, Joseph A. Califano, Quinton Smith, Alon Goren, Ophir D. Klein, Pablo Tamayo, J. Silvio Gutkind

“…YAP-mediated tumor initiating cell programs included activation of oncogenic transcriptional networks and mTOR signaling, and recruitment of myeloid cells to the invasive front contributing to tumor infiltration. …”
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Complement 3a receptor 1 on macrophages and Kupffer cells is not required for the pathogenesis of metabolic dysfunction-associated steatotic liver disease by Edwin A Homan, Ankit Gilani, Alfonso Rubio-Navarro, Maya A Johnson, Odin M Schaepkens, Eric Cortada, Renan Pereira de Lima, Lisa Stoll, James C Lo

“…The role of complement receptors in macrophage activation and recruitment in MASLD remains poorly understood. In human and mouse, C3AR1 in the liver is expressed primarily in Kupffer cells, but is downregulated in humans with MASLD compared to obese controls. …”
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How to build a framework to establish a patient research partner network in rheumatology research: a report of a 2-year implementation project by Maarten de Wit, Oliver Distler, Cosimo Bruni, Anna-Maria Hoffmann-Vold, Muriel Elhai, Rucsandra Dobrota, Adrian Ciurea, Caroline Ospelt, Raphael Micheroli, Dania Diem, Stefan Dudli, Kristina Buerki, Stacey Grealis, Melpomeni Toitou, Silke Ludwig, Chantal Britt, Florian Klett, Isabelle Steeb, Tanja Maletic, Andreas Eisenring, Penelope Jane Timpert-Argust, Eva Camarillo-Retamosa

“…Enhancing PRP engagement requires a clear understanding of the necessary steps.Objective This study aims to show steps to achieve successful collaboration between PRPs and researchers in clinical and transitional research in rheumatology.Methods We established a PRP network by following five main steps: setting up infrastructure, recruitment, training, PRP involvement at an early stage, and ongoing support. …”
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Preliminary effectiveness of social prescription and virtual patient information in increasing tertiary prevention among cancer patients (ESPRIT): protocol for a single-centre, ran... by Karen Steindorf, Michael Koller, Michael Leitzmann, Wolfgang Herr, Daniel Heudobler, Lisa Boyer, Anne Herrmann, Tobias Pukrop, Christine Bernardi, Sabine Einhell

“…Physical activity will be assessed using accelerometers and measured by average steps per day within the last 2 weeks after recruitment and at follow-up visits (3, 6 and 12 months). …”
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Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8+ T cells by Madison R. Mix, Stephanie van de Wall, Mohammad Heidarian, Elizabeth A. Escue, Cori E. Fain, Lecia L. Pewe, Lisa S. Hancox, Sahaana A. Arumugam, Cassie M. Sievers, Vladimir P. Badovinac, John T. Harty

“…Despite these differences, repetitively stimulated brain TRM provide similar protection against intracranial infection as primary populations with superior recall-based recruitment of peripheral lymphocytes. As CD8+ T cells may distinctly seed the brain with each repeated infection of the same host, these findings point to heterogeneity in the brain TRM pool that is dictated by prior peripheral antigen stimulation history.…”
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Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: a computational study by Hossein Shamohammadi, Liam Weaver, Sina Saffaran, Roberto Tonelli, Marianna Laviola, John G. Laffey, Luigi Camporota, Timothy E. Scott, Jonathan G. Hardman, Enrico Clini, Declan G. Bates

“…Higher levels of PEEP could be beneficial if they lead to alveolar recruitment and improved lung compliance, but could cause alveolar overdistension if they do not, motivating the close monitoring of the effects of HFNC on lung mechanics. …”
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Does semaglutide reduce alcohol intake in Danish patients with alcohol use disorder and comorbid obesity? Trial protocol of a randomised, double-blinded, placebo-controlled clinica... by Jens Juul Holst, Tina Vilsbøll, Claus Thorn Ekstrøm, Helene Benveniste, Nora D Volkow, Anders Fink-Jensen, Gitte M Knudsen, Mette Kruse Klausen, Tugba Kuzey, Julie Niemann Pedersen, Signe Keller Justesen, Line Rasmussen, Ulla B Knorr, Graeme Mason, George Koob

“…Secondary endpoints include changes from baseline to week 26 in alcohol consumption, smoking status, quality of life, fibrosis-4 score, plasma concentration of phosphatidylethanol, brain gamma-aminobutyric acid (GABA) levels, alcohol cue reactivity, functional connectivity and white matter tract integrity.Status Recruitment started in June 2023.Ethics and dissemination The study is approved by the Ethics Committee of the Capital Region of Denmark, the Danish Board of Health and the Danish Data Protection Agency. …”
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Direct collaboration between hospitals and NGOs, an essential tool to reinforce linkage to care in people living with HIV by Teresa Aldámiz-Echevarria, Chiara Fanciulli, Mónica Lopez, Leire Perez, Francisco Tejerina, David Sanchez, Blanca Lodeiros, Juan Carlos López, Juan Berenguer, Jose Maria Bellon, Maria Ferris, Mario Blazquez, Almudena Calvo, Mario Domene, Oswaldo Vegas, Carmen Rodriguez, Patricia Muñoz, Paloma Gijon, Pedro Montilla, Elena Bermudez, Maricela Valerio, Roberto Alonso, Belen Padilla, Critina Ventimilla, Cristina Diez

“…Abstract With the aim of improving access and engagement to healthcare in people living with HIV (PLHIV), in 2022 Gregorio Marañón Hospital and the NGO COGAM developed a circuit for recruitment and referral to hospital. Program targeted PLHIV who were neither receiving antiretroviral treatment (ART) nor on medical follow-up (FU); but also, individuals at risk who underwent screening tests at the NGO and, if positive, were referred for confirmation. …”
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Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey by Hong-jin Liu, Yong Lin, Wang Li, Hai Yang, Wen-yue Kang, Pei-lei Guo, Xiao-hui Guo, Ning-ning Cheng, Jie-chao Tan, Yi-na He, Si-si Chen, Yan Mu, Xian-wen Liu, Hui Zhang, Mei-fang Chen

“…The most common thresholds of intraoperative respiration monitoring were peripheral oxygen saturation (SpO2) of 90–94%, end-tidal CO2 of 45 to 55 mm Hg, and an airway pressure of 30 to 34 cm H2O. Recruitment maneuvers were traditionally performed by 94% of the respondents. …”
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Yoga programme for type-2 diabetes prevention (YOGA-DP) among high risk people in India: a multicentre feasibility randomised controlled trial protocol by Mark Hamer, Dorairaj Prabhakaran, Kavita Singh, Nikhil Tandon, Sanjay Kinra, Kaushik Chattopadhyay, Tess Harris, Pallavi Mishra, Sheila Margaret Greenfield, Sarah Anne Lewis, Nandi Krishnamurthy Manjunath, Rukamani Nair, Somnath Mukherjee, David Ross Harper

“…Important parameters, needed to design the main RCT, will be estimated, such as SD of the outcome measure (fasting plasma glucose level at 6-month follow-up), recruitment, intervention adherence, follow-up, potential contamination and time needed to conduct the study. …”
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Adaptive Just-in-Time Intervention to Reduce Everyday Stress Responses: Protocol for a Randomized Controlled Trial by Jillian A Johnson, Matthew J Zawadzki, Martin J Sliwinski, David M Almeida, Orfeu M Buxton, David E Conroy, David Marcusson-Clavertz, Jinhyuk Kim, Robert S Stawski, Stacey B Scott, Christopher N Sciamanna, Paige A Green, Emily M Repka, Meynard John L Toledo, Nicole L Sturges, Joshua M Smyth

“…ResultsInitial participant recruitment for the trial was initiated on August 15, 2022, and enrollment was completed on June 9, 2023. …”
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Modulation of brain activity in brain-injured patients with a disorder of consciousness in intensive care with repeated 10-Hz transcranial alternating current stimulation (tACS): a... by David Williamson, Francis Bernard, Stefanie Blain-Moraes, Caroline Arbour, Virginie Williams, Louis de Beaumont, Catherine Duclos, Béatrice P De Koninck, Daphnee Brazeau, Amelie A Deshaies, Marie-Michele Briand, Charlotte Maschke

“…Both phases will be conducted in medically stable brain-injured adult patients (traumatic brain injury and hypoxic-ischaemic encephalopathy), with a Glasgow Coma Scale score ≤12 after continuous sedation withdrawal. Recruitment will occur at the intensive care unit of a Level 1 Trauma Centre in Montreal, Quebec, Canada. …”
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Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study by Dominique Tremblay, Thomas Joly-Mischlich, Annick Dufour, Marie-Claude Battista, Djamal Berbiche, José Côté, Marco Décelles, Catherine Forget, Brigitte Guérin, Manon Larivière, Frédéric Lemay, Manon Lemonde, Éric Maillet, Nathalie Moreau, Michel Pavic, Sara Soldera, Catherine Wilhelmy

“…A steering committee with 3 working groups was established to oversee the technological, clinical, and evaluation aspects of this study. Recruitment of patients for ePROMs started in February 2024, and data collection is expected to continue until March 2025. …”
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Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol by Cristina Ardura-Garcia, Max Bachmann, Alejandro Rodriguez, Philip Cooper, Michael Richard Perkin, Irina Chis Ster, Natalia Cristina Romero, Martha E Chico, Alvaro Cruz, Diana Morillo, Santiago Mena-Bucheli, Angélica Ochoa, Claudia Rodas, Augusto Maldonado, Karen Arteaga, Jessica Alchundia, Karla Solorzano, Camila Figueiredo

“…In addition, the following are being measured at baseline and during follow-up: lung function and reversibility by spirometry before and after salbutamol; fractional exhaled nitric oxide (FeNO); and presence of IgG antibodies to SARS-CoV-2 in blood. Recruitment started in 2019 but because of severe disruption to emergency services caused by the COVID-19 pandemic, eligibility criteria were modified to include asthmatic children with uncontrolled symptoms and registered with collaborating hospitals. …”
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Sangre Por Salud (SPS) Biobank: cohort profile by Richard R Sharp, Euijung Ryu, Janet E Olson, Karen Meagher, James R Cerhan, Davinder Singh, Suzette Bielinski, Emmil Zarrugh, Marlene E Girardo, Giovanna Moreno Garzon, Valentina Hernandez, Sharon Levey, Crystal Gonzalez, Daniela B Pompa, Gabriel Q Shaibi, Lawrence Mandarino, Steven Thibodeau, Elena De Filippis

“…Purpose The Sangre Por Salud (SPS) Biobank was established to facilitate biomedical research opportunities for the Latino community by creating an easily accessible prospective cohort for scientists interested in studying health conditions and health disparities in this population.Participants Individuals self-identifying as Latino, aged 18–85 years, were prospectively recruited from the primary care Internal Medicine clinic at Mountain Park Health Center in Phoenix, Arizona. …”
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ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial by R Kneen, M Lim, A Vincent, A J Pollard, W K Chong, L-M Yu, M A Iro, M Sadarangani, M Absoud, C A Clark, A Easton, V Gray, M Pike, T Solomon, L Willis

“…Recruitment will be over a 42-month period and follow-up of each participant will be for 12 months post randomisation. …”
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Life history, reproductive, and demographic parameters for bottlenose dolphins (Tursiops truncatus) in Sarasota Bay, Florida by Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. McHugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

“…Mean annual fecundity was 0.182 births/adult female (defined as females 6 yrs or older). Recruitment rate through reproduction was estimated to be 0.050 based on calves surviving their first year. …”
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Feasibility and Acceptability of Antenatal Hepatitis C Screening: A Pilot Study by Joseph Valamparampil, Jaswant Sira, Maxine Brown, Saket Singhal, Deirdre Kelly

“…This was a pilot study targeting a single hospital-based antenatal clinic in Birmingham, initially conducted for eight weeks with a further extension of the study period to enhance recruitment to meet the feasibility target of 500 patients. …”
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The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy by Felice Gragnano, Simona Sperlongano, Enrica Golia, Francesco Natale, Renatomaria Bianchi, Mario Crisci, Fabio Fimiani, Ivana Pariggiano, Vincenzo Diana, Andreina Carbone, Arturo Cesaro, Claudia Concilio, Giuseppe Limongelli, Mariagiovanna Russo, Paolo Calabrò

“…The VWF/ADAMTS13 axis is implicated in the pathogenesis of atherosclerosis, promoting plaque formation and inflammation through macrophage and neutrophil recruitment in inflamed lesions. Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis. …”
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